Abstract:
:The aim of this study was to verify that subcutaneous lymph node transplantation inducing lymphatic regeneration is possible in healthy adult rats, in analogy to results obtained in other species. This rat model was used to determine the effects of lymph node fragmentation as well as sheep erythrocytes and platelet-rich plasma injection on the regeneration of the transplanted lymph nodes. The results show for the first time that the rat is an adequate model to study the regeneration of transplanted lymph nodes. Lymph node fragmentation seems to affect transplant regeneration negatively. An immune challenge by injection of sheep erythrocytes in the drainage area of the transplanted lymph nodes does not improve fragment regeneration. However, injection of syngeneic platelet-rich plasma containing several growth factors resulted in an improvement in regeneration. Lymph node fragment regeneration, although still experimental, could be relevant for lymphedema prevention. Acquired lymphedema has a high prevalence in developed countries as a consequence of the removal and/or radiotherapy of tumor-draining lymph nodes in cancer patients. This disease causes lifelong disability due to chronic swelling and increased risk of infections. It currently lacks an effective treatment.
journal_name
J Vasc Resjournal_title
Journal of vascular researchauthors
Hadamitzky C,Blum KS,Pabst Rdoi
10.1159/000194269subject
Has Abstractpub_date
2009-01-01 00:00:00pages
389-96issue
5eissn
1018-1172issn
1423-0135pii
000194269journal_volume
46pub_type
杂志文章abstract::Dynamic visualization of the intravascular events leading to the extravasation of leukocytes into tissues by intravital microscopy has significantly expanded our understanding of the underlying molecular processes. In contrast, the detailed observation of leukocyte transendothelial and interstitial migration in vivo h...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000073902
更新日期:2003-09-01 00:00:00
abstract::This study examines the ultrastructural features of diffuse intimal thickenings of human coronary arteries and correlates structural heterogeneity along the radial axis with the distribution and known actions of transforming growth factor beta 1 (TGF-beta 1). Morphometric and immunohistochemical data were collected fr...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000159008
更新日期:1993-09-01 00:00:00
abstract::We evaluated the effects of a simulated workday of prolonged sitting on blood pressure (BP) and pulse wave velocity (PWV) and examined whether posture (seated vs. supine) affected responses. Participants (n = 25) were adults, with overweight/obesity and elevated BP, and performed seated desk work for 7.5 h. BP and PWV...
journal_title:Journal of vascular research
pub_type: 杂志文章,随机对照试验
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更新日期:2020-01-01 00:00:00
abstract::Increased vascular disease occurs with low albumin (human serum albumin, HSA), possibly reflecting specific inhibition of endothelial apoptosis reported for tissue culture. Despite the reported specificity for endothelial protection by HSA, the high but physiological concentrations needed appear more consistent with n...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000101777
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:It has been reported that smoking is one of the strongest positive risk factors for abdominal aortic aneurysms (AAAs). Although many studies have been directed to decipher the effect of smoking on AAA, its effect on macrophage activation has not yet been explored. OBJECTIVES:We have reported the importance ...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000498893
更新日期:2019-01-01 00:00:00
abstract::The Ig-like cell adhesion molecule ICAM-3 is mainly expressed on human leukocytes and is involved in cell-cell interactions. Its expression on endothelium is observed during disorders such as Crohn's disease and in solid tumors. We found low but detectable expression of ICAM-3 on VE-cadherin-expressing cells from prim...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000076126
更新日期:2004-01-01 00:00:00
abstract::Migration of vascular smooth muscle cells (SMCs) leading to neointimal hyperplasia is an early and cardinal feature of atherogenesis. Migration of rat aortic SMCs from an upper chamber towards a lower one has been studied in a microchemotaxis (Boyden) chamber. Spontaneous migration of SMCs was practically prevented by...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000025580
更新日期:1998-05-01 00:00:00
abstract:BACKGROUND:We have developed an in vitro model by organ culture of rat mesenteric arteries to imitate vascular smooth muscle cell (VSMC) receptor changes in cardiovascular disease. By using this model, alteration of VSMC thromboxane A(2) (TP) receptors was studied. METHODS AND RESULTS:After organ culture of the arteri...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000153247
更新日期:2009-01-01 00:00:00
abstract::Inflammation is a highly regulated process with common but also specific characteristics in each tissue affected. Recruitment of leukocytes from the blood to the injured tissue is an important early step in the inflammatory cascade. This review highlights the role of connexins (Cxs) in the regulation of both acute and...
journal_title:Journal of vascular research
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000159097
更新日期:1995-07-01 00:00:00
abstract::Previous studies demonstrated that maintenance of steady-state myogenic tone requires Ca(2+)-dependent myosin phosphorylation. The present studies furthered these observations by examining temporal relationships among Ca(2+), myosin phosphorylation and vessel diameter during acute increases in intraluminal pressure an...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000054089
更新日期:2000-11-01 00:00:00
abstract:BACKGROUND:Transfer of molecular signals from veins to adjacent arteries is an established mechanism of vascular communication in the uterine circulation, which ultimately depends on venous permeability. This study tests the hypotheses that: (1) uterine veins are permeable to intravenous solutes, using a 3-kDa dextran ...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000082976
更新日期:2005-01-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000025647
更新日期:1999-05-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000158994
更新日期:1993-07-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000051070
更新日期:2001-07-01 00:00:00
abstract::The D allele of the insertion (I)/deletion (D) polymorphism in the angiotensin-converting enzyme (ACE) gene and the C allele of the A1166-C polymorphism in the angiotensin II type 1 receptor (AGT1R) gene have been associated with altered vascular structure and with an increased risk of myocardial infarction. The aim o...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000025687
更新日期:1999-11-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000159037
更新日期:1994-03-01 00:00:00
abstract::The localization of dopamine receptor subtypes in the rabbit pulmonary circulation was investigated by using combined radioligand binding and light microscope autoradiography techniques. Dopamine D1-like receptors, probably belonging to the dopamine D1 receptor subtype, were demonstrated in sections of rabbit lung usi...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000159094
更新日期:1995-05-01 00:00:00
abstract:BACKGROUND:A new method was evaluated where local changes in oxygen tension were induced in a tissue while being studied under a microscope in vivo. We tested whether hypoxic vasodilation and hyperoxic vasoconstriction in arterioles in striated muscle are being propagated upstream, and whether the endothelium and smoot...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000318777
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Safety concerns associated with drug-eluting stents have spurred interest in alternative vessel therapeutics following angioplasty. Microbubble contrast agents have been shown to increase gene transfection in vivo in the presence of ultrasound. OBJECTIVES/METHODS:The purpose of this study was to determine w...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000258905
更新日期:2010-01-01 00:00:00
abstract::During the early stage of angiogenesis, neovascular sprouts are composed primarily of endothelial cells. As they mature, microvessels acquire a coating of mural cells, which are critical for the development and maintenance of a functional vasculature. Though growth factor regulation of mural cell recruitment has been ...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000070711
更新日期:2003-03-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
abstract::The vascular endothelium is the source of a number of vasodilator and vasoconstrictor autacoids and is thus a key regulator of vascular homeostasis. We studied the effects of altering the balance between protein tyrosine kinase and phosphatase activity on Ca2+ signalling and phosphotyrosine levels in cultured human en...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000159150
更新日期:1996-05-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章,评审
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更新日期:2013-01-01 00:00:00
abstract::Thrombospondin-1 (TSP1) is a potent natural inhibitor of angiogenesis. Although TSP1 has been reported to induce endothelial cell apoptosis in vitro and to downregulate neovascularization in vivo, the molecular mechanisms that link these two processes have yet to be established. Here we report that TSP1 mediates endot...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000025733
更新日期:2000-05-01 00:00:00
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journal_title:Journal of vascular research
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更新日期:1997-01-01 00:00:00
abstract::The Cytoscan Model E-II (Cytometrics Inc., Philadelphia, Pa., USA) is a newly developed instrument which functions as an intravital microscope and is small and easily portable. Through the use of orthogonal polarization spectral (OPS) imaging, the Cytoscan Model E-II delivers images of the microcirculation which are c...
journal_title:Journal of vascular research
pub_type: 杂志文章
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更新日期:2000-11-01 00:00:00
abstract::The effects of the close arterial infusion of histamine upon the microcirculation of facial and nasal tissues were examined in dogs. Blood flow through arteriovenous anastomoses (AVA flow), capillaries (CAP flow) and collaterals (COL flow) were determined by electromagnetic flowmetry and the tracer-microsphere techniq...
journal_title:Journal of vascular research
pub_type: 杂志文章
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更新日期:1993-01-01 00:00:00
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journal_title:Journal of vascular research
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更新日期:2007-01-01 00:00:00