Abstract:
:The D allele of the insertion (I)/deletion (D) polymorphism in the angiotensin-converting enzyme (ACE) gene and the C allele of the A1166-C polymorphism in the angiotensin II type 1 receptor (AGT1R) gene have been associated with altered vascular structure and with an increased risk of myocardial infarction. The aim of this study was to determine whether differences in vascular function could be demonstrated to link the previously described changes in structure and the disease outcome. 70 subjects were recruited at random from patients undergoing colonic resection, resistance arteries were excised and were mounted in a small vessel wire myograph. Vasomotor responses to potassium chloride, noradrenaline, prostaglandin F(2alpha), angiotensin I, angiotensin II, acetylcholine and substance P were performed in 30 subjects. Genotype was established in a blinded fashion after completion of myography. To exclude the possibility of masking of genetic influence by non-ACE conversion of angiotensin I, vasomotor responses were then performed to proline(10)-angiotensin I in a further 30 subjects and to angiotensin I in the presence of chymostatin in a further 10 subjects. No significant effect of the I/D polymorphism of the ACE gene was seen on vasomotor function. The C allele of the AGT1R gene was associated with an increase in sensitivity to prostaglandin F(2alpha) but not with alteration to the other vasoactive agents studied. The I/D ACE and A1166-C AGT1 receptor polymorphism do not appear to result in differences in vasomotor function in isolated human mesenteric resistance arterioles in subjects without evidence of underlying hypertensive or cardiovascular disease.
journal_name
J Vasc Resjournal_title
Journal of vascular researchauthors
Steeds RP,Toole LO,Channer KS,Morice AHdoi
10.1159/000025687keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
445-55; discussion 535-8issue
6eissn
1018-1172issn
1423-0135pii
25687journal_volume
36pub_type
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journal_title:Journal of vascular research
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abstract:BACKGROUND:The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. METHODS:F...
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journal_title:Journal of vascular research
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更新日期:2000-01-01 00:00:00
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更新日期:2009-01-01 00:00:00
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journal_title:Journal of vascular research
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更新日期:2009-01-01 00:00:00
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更新日期:2007-01-01 00:00:00
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journal_title:Journal of vascular research
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更新日期:2007-01-01 00:00:00
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doi:10.1159/000317399
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journal_title:Journal of vascular research
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更新日期:2005-05-01 00:00:00
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journal_title:Journal of vascular research
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doi:10.1159/000479873
更新日期:2017-01-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000094258
更新日期:2006-01-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章,评审
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更新日期:2006-01-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
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journal_title:Journal of vascular research
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journal_title:Journal of vascular research
pub_type: 杂志文章,评审
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更新日期:1998-03-01 00:00:00
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journal_title:Journal of vascular research
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doi:10.1159/000159196
更新日期:1997-01-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000320356
更新日期:2011-01-01 00:00:00
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journal_title:Journal of vascular research
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doi:10.1159/000054089
更新日期:2000-11-01 00:00:00
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pub_type: 杂志文章
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