当前位置： SCI文献检索 > JOURNAL OF VASCULAR RESEARCH期刊下所有文献 > Lipoxin A4 mediates aortic contraction via RHOA/RHO kinase, endothelial dysfunction and reactive oxygen species.

Lipoxin A4 mediates aortic contraction via RHOA/RHO kinase, endothelial dysfunction and reactive oxygen species.

Abstract：

BACKGROUND:Lipoxin A4 (LXA4) is a biologically active product generated from arachidonic acid by lipoxygenase action. The production of lipoxins is enhanced by aspirin through acetylation of cyclooxygenase-2, via a mechanism known as 'aspirin-triggered lipoxin'. LXA4 has both anti-inflammatory and proinflammatory actions, the latter being related with reocclusion and restenosis after coronary angioplasty in patients treated with aspirin. However, little is known of the actions of LXA4 on the vasculature. We hypothesized that LXA4 promotes contractile responses and contributes to endothelial dysfunction. METHODS:We used aorta from Wistar rats to assess vascular function. Reactive oxygen species (ROS) production and contractile and regulatory proteins were investigated. RESULTS:LXA4 induced concentration-dependent contractions via formyl peptide receptor-2 activation and both RhoA/Rho kinase inhibitor and ROS scavenger decreased this contraction. Also, endothelium removal, and COX-2 and NAD(P)H oxidase inhibitors attenuate the LXA4-induced contraction. LXA4 potentiated phenylephrine-induced contraction and inhibited acetylcholine-induced relaxation. In the presence of LXA4, ROS production was increased and protein expression of RhoA, phospho-myosin light chain, COX-2 and p67phox was higher. CONCLUSION:LXA4 has a functional role in the vasculature and may contribute to further vascular damage in conditions where its production is exacerbated, such as in angioplasty-associated complications treated with aspirin.

journal_name

J Vasc Res

journal_title

Journal of vascular research

authors

Wenceslau CF,McCarthy CG,Szasz T,Webb RC

doi

10.1159/000371490

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

407-17

issue

6

eissn

1018-1172

issn

1423-0135

pii

000371490

journal_volume

51

pub_type

杂志文章

相关文献

JOURNAL OF VASCULAR RESEARCH文献大全
  • Anisodamine counteracts lipopolysaccharide-induced tissue factor and plasminogen activator inhibitor-1 expression in human endothelial cells: contribution of the NF-kappa b pathway.

    abstract：:In this study we aimed to investigate whether the therapeutic efficacy of anisodamine in the treatment of bacteraemic shock could--at least in part--be brought about by its direct interference with the lipopolysaccharide (LPS)-induced activation of endothelial cells. Thus, we investigated the effect of anisodamine on ...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000051025

    authors： Ruan QR,Zhang WJ,Hufnagl P,Kaun C,Binder BR,Wojta J

    更新日期：2001-01-01 00:00:00

  • Elastin organization in pig and cardiovascular disease patients' pericardial resistance arteries.

    abstract：:Peripheral vascular resistance is increased in essential hypertension. This involves structural changes of resistance arteries and stiffening of the arterial wall, including remodeling of the extracellular matrix. We hypothesized that biopsies of the human parietal pericardium, obtained during coronary artery bypass g...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000376548

    authors： Bloksgaard M,Leurgans TM,Nissen I,Jensen PS,Hansen ML,Brewer JR,Bagatolli LA,Marcussen N,Irmukhamedov A,Rasmussen LM,De Mey JG

    更新日期：2015-01-01 00:00:00

  • Effects of pH on vascular tension: which are the important mechanisms?

    abstract：:The pH has marked effects on the blood flow in several vascular beds but the underlying mechanisms remain incompletely understood. It is still not agreed, for example, whether it is the fall in extracellular pH or intracellular pH that is responsible for changes in tone resulting from hypercapnic acidosis. The issue h...

    journal_title：Journal of vascular research

    pub_type： 杂志文章,评审

    doi：10.1159/000159163

    authors： Aalkjaer C,Poston L

    更新日期：1996-09-01 00:00:00

  • Thrombospondin-1 induces endothelial cell apoptosis and inhibits angiogenesis by activating the caspase death pathway.

    abstract：:Thrombospondin-1 (TSP1) is a potent natural inhibitor of angiogenesis. Although TSP1 has been reported to induce endothelial cell apoptosis in vitro and to downregulate neovascularization in vivo, the molecular mechanisms that link these two processes have yet to be established. Here we report that TSP1 mediates endot...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000025733

    authors： Nör JE,Mitra RS,Sutorik MM,Mooney DJ,Castle VP,Polverini PJ

    更新日期：2000-05-01 00:00:00

  • New insight into abnormal muscle vasodilatory responses in aged hypertensive rats by in vivo nuclear magnetic resonance imaging of perfusion.

    abstract：OBJECTIVE:Increased peripheral arterial resistances and decreased maximum vasodilation are characteristic features of chronic hypertension. However, little data are available in the literature regarding the possible alterations in the temporal patterns of vasodilatory responses elicited by various stimuli. DESIGN:This...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000090944

    authors： Bertoldi D,Parzy E,Fromes Y,Wary C,Leroy-Willig A,Carlier PG

    更新日期：2006-01-01 00:00:00

  • Intracellular application of calmidazolium increases Ca2+ current through activation of protein kinase A in cultured vascular smooth muscle cells.

    abstract：:In the present study, we investigated the actions of calmodulin (CaM) and CaM-dependent protein kinase II (CaMK-II) on the L-type Ca2+ currents (ICa(L)) of cultured vascular smooth muscle (VSM) cells (A7r5 cell line), using the whole-cell voltage clamp method. The peak IBa (Ca2+ channel using 5 mM Ba2+ as charge carri...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000025599

    authors： Sunagawa M,Yokoshiki H,Seki T,Sperelakis N

    更新日期：1998-09-01 00:00:00

  • Both ICAM-1- and VCAM-1-integrin interactions are important in mediating monocyte adhesion to human saphenous vein.

    abstract：:Atherosclerosis underlies late occlusion of human saphenous vein (HSV) coronary artery bypass grafts. Monocyte infiltration is implicated, but its mechanisms are unclear given that HSV normally expresses the ICAM-1 but not the VCAM-1 adhesion molecule. To define the mechanisms underlying monocyte adhesion, samples of ...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000063687

    authors： Crook MF,Southgate KM,Newby AC

    更新日期：2002-05-01 00:00:00

  • Glucagon-Like Peptide-1 Receptor Activation Does not Affect Re-Endothelialization but Reduces Intimal Hyperplasia via Direct Effects on Smooth Muscle Cells in a Nondiabetic Model of Arterial Injury.

    abstract：UNLABELLED:Diabetic patients have an increased risk of restenosis and late stent thrombosis after angioplasty, i.e. complications that are related to a defective re-endothelialization. Exendin-4, a stable glucagon-like peptide (GLP)-1 receptor agonist, has been suggested to influence the formation of intimal hyperplasi...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000381097

    authors： Eriksson L,Saxelin R,Röhl S,Roy J,Caidahl K,Nyström T,Hedin U,Razuvaev A

    更新日期：2015-01-01 00:00:00

  • Focused in vivo delivery of plasmid DNA to the porcine vascular wall via intravascular ultrasound destruction of microbubbles.

    abstract：BACKGROUND:Safety concerns associated with drug-eluting stents have spurred interest in alternative vessel therapeutics following angioplasty. Microbubble contrast agents have been shown to increase gene transfection in vivo in the presence of ultrasound. OBJECTIVES/METHODS:The purpose of this study was to determine w...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000258905

    authors： Phillips LC,Klibanov AL,Bowles DK,Ragosta M,Hossack JA,Wamhoff BR

    更新日期：2010-01-01 00:00:00

  • Circulating Concentrations of Adipocytokines and Their Receptors in the Isolated Corpus Cavernosum and Femoral Artery from Trained Rats on a High-Fat Diet.

    abstract：BACKGROUND:The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. METHODS:F...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000457800

    authors： Sponton AC,Silva FH,Araujo HN,Valgas da Silva CP,de Moraes C,Antunes E,Zanesco A,Delbin MA

    更新日期：2017-01-01 00:00:00

  • A simple method for rapid separation of endothelial and smooth muscle mRNA reveals Na/K+ -ATPase alpha-subunit distribution in rat arteries.

    abstract：BACKGROUND/AIMS:The endothelium has been recognized as a key component in the regulation of blood vessels. We designed a simple procedure to separate endothelial and smooth muscle RNA from rat aorta and mesenteric artery and used this method to establish the distribution of Na(+)/K(+)-ATPase alpha-subunit isoforms (NaK...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000095963

    authors： Krenek P,Hamaide MC,Morel N,Wibo M

    更新日期：2006-01-01 00:00:00

  • Wall shear stress--an important determinant of endothelial cell function and structure--in the arterial system in vivo. Discrepancies with theory.

    abstract：:It has been well established that wall shear stress is an important determinant of endothelial cell function and gene expression as well as of its structure. There is increasing evidence that low wall shear stress, as present in artery bifurcations opposite to the flow divider where atherosclerotic lesions preferentia...

    journal_title：Journal of vascular research

    pub_type： 杂志文章,评审

    doi：10.1159/000091648

    authors： Reneman RS,Arts T,Hoeks AP

    更新日期：2006-01-01 00:00:00

  • Mechanism of VEGF-induced uterine venous hyperpermeability.

    abstract：BACKGROUND:Transfer of molecular signals from veins to adjacent arteries is an established mechanism of vascular communication in the uterine circulation, which ultimately depends on venous permeability. This study tests the hypotheses that: (1) uterine veins are permeable to intravenous solutes, using a 3-kDa dextran ...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000082976

    authors： Celia G,Osol G

    更新日期：2005-01-01 00:00:00

  • Remodeling of Wall Mechanics and the Myogenic Mechanism of Rat Intramural Coronary Arterioles in Response to a Short-Term Daily Exercise Program: Role of Endothelial Factors.

    abstract：PURPOSE:Exercise elicits early adaptation of coronary vessels enabling the coronary circulation to respond adequately to higher flow demands. We hypothesized that short-term daily exercise induces biomechanical and functional remodeling of the coronary resistance arteries related to pressure. METHODS:Male rats were su...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000486571

    authors： Szekeres M,Nádasy GL,Dörnyei G,Szénási A,Koller A

    更新日期：2018-01-01 00:00:00

  • Inhibition of vascular smooth muscle cell migration by intact endothelium is nitric oxide-mediated: interference by oxidised low density lipoproteins.

    abstract：:Migration of vascular smooth muscle cells (SMCs) leading to neointimal hyperplasia is an early and cardinal feature of atherogenesis. Migration of rat aortic SMCs from an upper chamber towards a lower one has been studied in a microchemotaxis (Boyden) chamber. Spontaneous migration of SMCs was practically prevented by...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000025580

    authors： Gorog P,Kovacs IB

    更新日期：1998-05-01 00:00:00

  • Smooth muscle cells influence monocyte response to LDL as well as their adhesion and transmigration in a coculture model of the arterial wall.

    abstract：:We investigated the possible interference of smooth muscle cells with monocyte response to LDL as well as with their adhesion and transmigration in a coculture of porcine endothelial and smooth muscle cells. Lysophosphatidylcholine (LPC), a component of oxidized LDL (oxLDL), stimulated the adhesion of THP-1 cells to e...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000051081

    authors： Kinard F,Jaworski K,Sergent-Engelen T,Goldstein D,Van Veldhoven PP,Holvoet P,Trouet A,Schneider YJ,Remacle C

    更新日期：2001-09-01 00:00:00

  • Endothelial modulation of ouabain-induced contraction and sodium pump activity in aortas of normotensive Wistar-Kyoto and spontaneously hypertensive rats.

    abstract：:The influence of vascular endothelium on ouabain-induced contractions and sodium pump activity in aortic segments of Wistar-Kyoto (WKY) and spontaneously hypertensive rat (SHR) was analyzed. De-endothelialization increased and reduced ouabain-induced contractions in WKY and SHR segments, respectively. The effects of d...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000159145

    authors： Ponte A,Marín J,Arribas S,González R,Barrús MT,Salaices M,Sánchez-Ferrer CF

    更新日期：1996-03-01 00:00:00

  • Hirulog-like peptide reduces balloon catheter injury induced neointima formation in rat carotid artery without increase in bleeding tendency.

    abstract：:Vascular restenosis is one of the major concerns for the management of coronary artery disease using therapeutic vascular procedures. Treatments with thrombin-specific inhibitors, hirudin or hirulog-1, reduced ischemic events in coronary artery disease patients. Early started and prolonged infusions of these thrombin ...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000051041

    authors： Xue M,Ren S,Welch S,Shen GX

    更新日期：2001-03-01 00:00:00

  • G proteins and phospholipase C mediate thrombin-induced generation of plasminogen activator inhibitor-1 from vascular smooth muscle cells.

    abstract：:The present study investigated transcellular signalling mechanism involved in thrombin-induced production of plasminogen activator inhibitor-1 (PAI-1) in cultured vascular baboon aortic smooth muscle cells (BASMC). Treatments with thrombin dose-dependently increased the steady state levels of PAI-1 mRNA and the genera...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000159205

    authors： Ren S,Cockell KA,Fenton JW 2nd,Angel A,Shen GX

    更新日期：1997-03-01 00:00:00

  • The Cytoscan Model E-II, a new reflectance microscope for intravital microscopy: comparison with the standard fluorescence method.

    abstract：:The Cytoscan Model E-II (Cytometrics Inc., Philadelphia, Pa., USA) is a newly developed instrument which functions as an intravital microscope and is small and easily portable. Through the use of orthogonal polarization spectral (OPS) imaging, the Cytoscan Model E-II delivers images of the microcirculation which are c...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000054079

    authors： Harris AG,Sinitsina I,Messmer K

    更新日期：2000-11-01 00:00:00

  • Interferon-beta is a potent inducer of interferon regulatory factor-1/2-dependent IP-10/CXCL10 expression in primary human endothelial cells.

    abstract：:Most virus-infected cells release interferon-beta (IFN-beta) as a powerful inducer of antiviral defense. Endothelial cells tightly regulate local immune cell recruitment by expression of adhesion molecules and chemokines. Here, we studied the transcriptional regulation of IFN-beta-induced chemokine expression in prima...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000097977

    authors： Buttmann M,Berberich-Siebelt F,Serfling E,Rieckmann P

    更新日期：2007-01-01 00:00:00

  • Role of endothelium sensitivity to shear stress in noradrenaline-induced constriction of feline femoral arterial bed under constant flow and constant pressure perfusions.

    abstract：:The effect of shear stress at the endothelium in the attenuation of the noradrenaline-induced constriction of the femoral vascular bed perfused at a constant blood flow was investigated in 16 anesthetized cats. It is known that the adrenergic vasoconstriction of the femoral vascular bed is considerably greater at a co...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000097750

    authors： Kartamyshev SP,Balashov SA,Melkumyants AM

    更新日期：2007-01-01 00:00:00

  • Localization of dopamine receptors in the rabbit lung vasculature.

    abstract：:The localization of dopamine receptor subtypes in the rabbit pulmonary circulation was investigated by using combined radioligand binding and light microscope autoradiography techniques. Dopamine D1-like receptors, probably belonging to the dopamine D1 receptor subtype, were demonstrated in sections of rabbit lung usi...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000159094

    authors： Kobayashi Y,Ricci A,Amenta F,Cavallotti C,Hattori K

    更新日期：1995-05-01 00:00:00

  • ICAM-3 activation modulates cell-cell contacts of human bone marrow endothelial cells.

    abstract：:The Ig-like cell adhesion molecule ICAM-3 is mainly expressed on human leukocytes and is involved in cell-cell interactions. Its expression on endothelium is observed during disorders such as Crohn's disease and in solid tumors. We found low but detectable expression of ICAM-3 on VE-cadherin-expressing cells from prim...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000076126

    authors： van Buul JD,Mul FP,van der Schoot CE,Hordijk PL

    更新日期：2004-01-01 00:00:00

  • Role of lysyl oxidases in neointima development in vascular allografts.

    abstract：BACKGROUND:Extracellular matrix deposition is the main factor inducing stenotic lesions in arterial grafts. Lysyl oxidases (LOX) play a key role in stabilizing collagen and elastin. OBJECTIVE:To examine the repair response to arterial allografts in terms of LOX expression and collagen/elastin deposition using LOX inhi...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000317399

    authors： Rodríguez M,Pascual G,Cifuentes A,Perez-Köhler B,Bellón JM,Buján J

    更新日期：2011-01-01 00:00:00

  • Association between plasma angiopoietin-like protein 3 and arterial wall thickness in healthy subjects.

    abstract：BACKGROUND:Angiopoietin-like protein 3 (ANGPTL3) is a liver-derived plasma protein that modulates plasma triglyceride clearance, angiogenesis and atherosclerosis in experimental models. So far, no study has examined its role in atherosclerosis in human subjects. We evaluated the possible association between plasma ANGP...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000098153

    authors： Hatsuda S,Shoji T,Shinohara K,Kimoto E,Mori K,Fukumoto S,Koyama H,Emoto M,Nishizawa Y

    更新日期：2007-01-01 00:00:00

  • Tumor Necrosis Factor Receptor-Associated Factor 5 Promotes Arterial Neointima Formation through Smooth Muscle Cell Proliferation.

    abstract：:Tumor necrosis factor (TNF) receptor-associated factors (TRAFs) are cytoplasmic adaptor proteins of the TNF/interleukin (IL)-1/Toll-like receptor superfamily. Ligands of this family such as TNFα, CD40L, and IL-1β promote chronic inflammatory processes such as atherosclerosis and restenosis, the latter being a common a...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000501615

    authors： Willecke F,Rupprecht B,Gissler MC,Pfeiffer K,Anto-Michel N,Stachon P,Wolf D,Hilgendorf I,Hoppe N,Bode C,Zirlik A

    更新日期：2019-01-01 00:00:00

  • Gliotoxin inhibits neointimal hyperplasia after vascular injury in rats.

    abstract：:Neointima formation participates in the pathophysiology of atherosclerosis and restenosis. Proliferation and migration of vascular smooth muscle cells (VSMC) are initial responses to vascular injury. The aim of the present study was to assess the effect of gliotoxin, an inhibitor of nuclear factor (NF)-kappaB, on migr...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000176043

    authors： Pozo M,Izquierdo MC,de Nicolás R,Egido J,Ortiz A,González-Cabrero J

    更新日期：2009-01-01 00:00:00

  • Human vascular reactivity and polymorphisms of the angiotensin-converting enzyme and the angiotensin type 1 receptor genes.

    abstract：:The D allele of the insertion (I)/deletion (D) polymorphism in the angiotensin-converting enzyme (ACE) gene and the C allele of the A1166-C polymorphism in the angiotensin II type 1 receptor (AGT1R) gene have been associated with altered vascular structure and with an increased risk of myocardial infarction. The aim o...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000025687

    authors： Steeds RP,Toole LO,Channer KS,Morice AH

    更新日期：1999-11-01 00:00:00

  • Cardiovascular protective effects of synthetic isoflavone derivatives in apolipoprotein e-deficient mice.

    abstract：:Dietary flavonoids are thought to protect against cardiovascular disease. We have studied the effects of bioactive isoflavone metabolites on hyperlipidemia, endothelial dysfunction and the development of atherosclerotic lesions in apolipoprotein E-deficient (apoE(0)) mice fed a Western high-fat diet. Supplementation w...

    journal_title：Journal of vascular research

    pub_type： 杂志文章

    doi：10.1159/000071891

    authors： Jiang F,Jones GT,Husband AJ,Dusting GJ

    更新日期：2003-05-01 00:00:00