The wall to lumen ratio of the radial artery in patients with Raynaud's phenomenon.

abstract：:The release of cytokines and chemokines from activated immune-competent cells plays a crucial role in determining the pathology of the atherogenic progress. We investigated the effect of bacterial lipopolysaccharide (LPS) on cytokine/chemokine expression in carotid lesions and normal renal arteries. The lesions or ren...

journal_title：Journal of vascular research

authors： Jatta K,Wågsäter D,Norgren L,Stenberg B,Sirsjö A

更新日期：2005-05-01 00:00:00

abstract：:Protein localization in endothelial cells is tightly regulated to create distinct signaling domains within their tight spatial restrictions including luminal membranes, abluminal membranes, and interendothelial junctions, as well as caveolae and calcium signaling domains. Protein localization in endothelial cells is a...

journal_title：Journal of vascular research

authors： Wolpe AG,Ruddiman CA,Hall PJ,Isakson BE

更新日期：2021-01-27 00:00:00

abstract：:Neointima formation participates in the pathophysiology of atherosclerosis and restenosis. Proliferation and migration of vascular smooth muscle cells (VSMC) are initial responses to vascular injury. The aim of the present study was to assess the effect of gliotoxin, an inhibitor of nuclear factor (NF)-kappaB, on migr...

journal_title：Journal of vascular research

authors： Pozo M,Izquierdo MC,de Nicolás R,Egido J,Ortiz A,González-Cabrero J

更新日期：2009-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a principal stimulator of angiogenesis. However, the downstream targets of VEGF in endothelial cells (ECs) are not entirely clarified. Survey of downstream targets of VEGF in human ECs identified a number of genes, including Down syndrome candidate region 1 (DSCR1). Here, w...

journal_title：Journal of vascular research

authors： Iizuka M,Abe M,Shiiba K,Sasaki I,Sato Y

更新日期：2004-07-01 00:00:00

abstract：:Fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF) exert their angiogenic activity by interacting with endothelial cells in a distinct manner. In this study, we investigated the morphological features of endothelial cells of the chick embryo chorioallantoic membrane (CAM) microvasculature ...

journal_title：Journal of vascular research

authors： Ribatti D,Nico B,Morbidelli L,Donnini S,Ziche M,Vacca A,Roncali L,Presta M

更新日期：2001-07-01 00:00:00

abstract：:During the early stage of angiogenesis, neovascular sprouts are composed primarily of endothelial cells. As they mature, microvessels acquire a coating of mural cells, which are critical for the development and maintenance of a functional vasculature. Though growth factor regulation of mural cell recruitment has been ...

journal_title：Journal of vascular research

authors： Zhu WH,Han J,Nicosia RF

更新日期：2003-03-01 00:00:00

abstract：:Cx40-deficient mice (Cx40-/-) are hypertensive due to increased renin secretion. We evaluated the renal expression of neuronal nitric oxide synthase (nNOS) and cyclooxygenases COX-1 and COX-2, three macula densa enzymes. The levels of nNOS were increased in kidneys of Cx40-/- mice, as well as in those of wild-type (WT...

journal_title：Journal of vascular research

authors： Krattinger N,Alonso F,Capponi A,Mazzolai L,Nicod P,Meda P,Haefliger JA

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:To determine: (1) whether variables of a pulse wave form analysis of ocular microcirculation shown by laser speckle flowgraphy (LSFG) correlate with left ventricular (LV) systolic dysfunction and (2) whether these variables correlate with LV diastolic dysfunction in subjects without LV systolic dysfunction as a...

journal_title：Journal of vascular research

authors： Shiba T,Takahashi M,Matsumoto T,Hori Y

更新日期：2018-01-01 00:00:00

abstract：:The effect of insulin on the vasoconstriction induced by norepinephrine is presently controversial. Therefore, the aims of our study were: (1) to evaluate the effect of low- and high-dose insulin on the concentration-response curve to norepinephrine in small resistance arteries of spontaneously hypertensive rats (SHR)...

journal_title：Journal of vascular research

authors： Rizzoni D,Porteri E,Piccoli A,Castellano M,Pasini G,Guelfi D,Muiesan ML,Rosei EA

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:We have developed an in vitro model by organ culture of rat mesenteric arteries to imitate vascular smooth muscle cell (VSMC) receptor changes in cardiovascular disease. By using this model, alteration of VSMC thromboxane A(2) (TP) receptors was studied. METHODS AND RESULTS:After organ culture of the arteri...

journal_title：Journal of vascular research

authors： Zhang W,Zhang Y,Edvinsson L,Xu CB

更新日期：2009-01-01 00:00:00

abstract：:Recent research in ultrasound technology has led to the development of a high-resolution echo-tracking device. The present study was performed to evaluate the accuracy in the measurement of human radial artery intima-media thickness with this new device. We determined the correlation between histological and ultrasoni...

journal_title：Journal of vascular research

authors： Girerd X,Mourad JJ,Acar C,Heudes D,Chiche S,Bruneval P,Mignot JP,Billaud E,Safar M,Laurent S

更新日期：1994-03-01 00:00:00

abstract：BACKGROUND:Hypoxia results in pulmonary hypertension and vascular remodeling due to induction of pulmonary artery cell proliferation. Besides pulmonary artery smooth muscle cells, pulmonary artery endothelial cells (PAECs) are also involved in the development of pulmonary hypertension, but the effect of hypoxia on PAEC...

journal_title：Journal of vascular research

authors： Yu L,Hales CA

更新日期：2011-01-01 00:00:00

abstract：:We investigated the possible interference of smooth muscle cells with monocyte response to LDL as well as with their adhesion and transmigration in a coculture of porcine endothelial and smooth muscle cells. Lysophosphatidylcholine (LPC), a component of oxidized LDL (oxLDL), stimulated the adhesion of THP-1 cells to e...

journal_title：Journal of vascular research

authors： Kinard F,Jaworski K,Sergent-Engelen T,Goldstein D,Van Veldhoven PP,Holvoet P,Trouet A,Schneider YJ,Remacle C

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:A new method was evaluated where local changes in oxygen tension were induced in a tissue while being studied under a microscope in vivo. We tested whether hypoxic vasodilation and hyperoxic vasoconstriction in arterioles in striated muscle are being propagated upstream, and whether the endothelium and smoot...

journal_title：Journal of vascular research

authors： Riemann M,Rai A,Ngo AT,Dziegiel MH,Holstein-Rathlou NH,Torp-Pedersen C

更新日期：2011-01-01 00:00:00

abstract：:The mechanosensitive nonselective cation channel (NSC(MS)) is a key player in vascular myogenic contraction. The functional channel density and pressure sensitivity of NSC(MS) in vascular myocytes were compared between pulmonary and systemic arteries (coronary, mesenteric and cerebral arteries) in the rabbit. In cell-...

journal_title：Journal of vascular research

authors： Park KS,Lee HA,Earm KH,Ko JH,Earm YE,Kim SJ

更新日期：2006-01-01 00:00:00

abstract：:Peripheral vascular resistance is increased in essential hypertension. This involves structural changes of resistance arteries and stiffening of the arterial wall, including remodeling of the extracellular matrix. We hypothesized that biopsies of the human parietal pericardium, obtained during coronary artery bypass g...

journal_title：Journal of vascular research

authors： Bloksgaard M,Leurgans TM,Nissen I,Jensen PS,Hansen ML,Brewer JR,Bagatolli LA,Marcussen N,Irmukhamedov A,Rasmussen LM,De Mey JG

更新日期：2015-01-01 00:00:00

abstract：:Actin cytoskeleton reorganization is regulated by various actin-binding proteins. Cofilin is the principal filament-depolymerizing protein, whose activity is reduced upon phosphorylation by LIMK. Thus, LIMK and cofilin comprise a signal transduction module regulating actin turnover and myogenic tone in healthy vascula...

journal_title：Journal of vascular research

authors： Bongalon S,Dai YP,Singer CA,Yamboliev IA

更新日期：2004-09-01 00:00:00

abstract：:The assembly of the vessel wall from its cellular and extracellular matrix components is a critical process in the development and maturation of the cardiovascular system. However, fundamental questions concerning the origin of vessel wall cells and the mechanisms that regulate their development and differentiation re...

journal_title：Journal of vascular research

authors： Hungerford JE,Little CD

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:Endothelial nitric oxide synthase (eNOS) is associated with caveolin-1 (Cav-1) in plasma membrane. We tested the hypothesis that eNOS activation by shear stress in resistance vessels depends on synchronized phosphorylation, dissociation from Cav-1 and translocation of the membrane-bound enzyme to Golgi ...

journal_title：Journal of vascular research

authors： Figueroa XF,González DR,Puebla M,Acevedo JP,Rojas-Libano D,Durán WN,Boric MP

更新日期：2013-01-01 00:00:00

abstract：:Conduit arteries of hypertensive rats are thicker and stiffer than those of normotensive controls. The possible role played by collagen type I and II subtypes in the mechanism of arterial stiffness remains unknown. The carotid and aortic arterial wall of rats of Japanese (Wistar-Kyoto and spontaneously hypertensive ra...

journal_title：Journal of vascular research

authors： Chamiot Clerc P,Renaud JF,Blacher J,Legrand M,Samuel JL,Levy BI,Sassard J,Safar ME

更新日期：1999-03-01 00:00:00

abstract：:Dietary flavonoids are thought to protect against cardiovascular disease. We have studied the effects of bioactive isoflavone metabolites on hyperlipidemia, endothelial dysfunction and the development of atherosclerotic lesions in apolipoprotein E-deficient (apoE(0)) mice fed a Western high-fat diet. Supplementation w...

journal_title：Journal of vascular research

authors： Jiang F,Jones GT,Husband AJ,Dusting GJ

更新日期：2003-05-01 00:00:00

abstract：:Coronary bypass vessels, saphenous vein (SV) and internal thoracic artery (ITA), differ in susceptibility to atherosclerosis and medium- to long-term patency. Whereas most ITA remain patent (90% at 10 years), 20% of SV grafts fail in the first year and approximately 45% fail within 10 years. Reasons for these differen...

journal_title：Journal of vascular research

authors： Scott L,Kerr A,Haydock D,Merrilees M

更新日期：1997-09-01 00:00:00

abstract：:We examined the growth of the right common carotid artery of young rabbits after ligating the left common carotid artery at 3 weeks of age, a procedure that approximately doubled right carotid blood flows. Flow increased from 0.065 +/-0.003 to 0.096+/-0.009 ml/s within 1 h and, at 15 weeks of age, carotid blood flows ...

journal_title：Journal of vascular research

authors： Di Stefano I,Koopmans DR,Langille BL

更新日期：1998-01-01 00:00:00

abstract：:The circadian clock is rhythmically expressed in blood vessels, but the interaction between the circadian clock and disturbed blood flow remains unclear. We examined the relationships between BMAL1 and CLOCK and 2 regulators of endothelial function, AKT1 and endothelial nitric oxide synthase (eNOS), in vascular region...

journal_title：Journal of vascular research

authors： Shang X,Pati P,Anea CB,Fulton DJ,Rudic RD

更新日期：2016-01-01 00:00:00

abstract：:Peroxynitrite is an endothelium-independent vasodilator that induces relaxation via membrane hyperpolarization. The activation of IP3 receptors triggers the opening of potassium channels and hyperpolarization. Previously we found that relaxation to peroxynitrite was maintained during the development of atherosclerosis...

journal_title：Journal of vascular research

authors： Ewart MA,Ugusman A,Vishwanath A,Almabrouk TAM,Alganga H,Katwan OJ,Hubanova P,Currie S,Kennedy S

更新日期：2017-01-01 00:00:00

abstract：:Mesenteric endothelial cell function and immunoreactivity for substance P and nitric oxide synthase (NOS) were examined in control rats and rats treated with capsaicin as neonates to destroy primary afferent nerves. Endothelial vasodilator function was examined pharmacologically in the methoxamine raised-tone isolated...

journal_title：Journal of vascular research

authors： Ralevic V,Dikranian K,Burnstock G

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND/AIMS:Endothelial colony-forming cells (ECFCs) have the potential to be used in regenerative medicine. Dysfunction of ECFCs is correlated with the onset of cardiovascular disorders, especially coronary artery disease (CAD). Binding of vascular endothelial growth factor A (VEGFA) to vascular endothelial growth...

journal_title：Journal of vascular research

authors： Su SH,Wu CH,Chiu YL,Chang SJ,Lo HH,Liao KH,Tsai CF,Tsai TN,Lin CH,Cheng SM,Cheng CC,Wang HW

更新日期：2017-01-01 00:00:00

abstract：UNLABELLED:Diabetic patients have an increased risk of restenosis and late stent thrombosis after angioplasty, i.e. complications that are related to a defective re-endothelialization. Exendin-4, a stable glucagon-like peptide (GLP)-1 receptor agonist, has been suggested to influence the formation of intimal hyperplasi...

journal_title：Journal of vascular research

authors： Eriksson L,Saxelin R,Röhl S,Roy J,Caidahl K,Nyström T,Hedin U,Razuvaev A

更新日期：2015-01-01 00:00:00

abstract：:The novel endothelial cell tyrosine kinase receptors, Tie1 and Tie2, are essential for vascular development and remodeling in the embryo but little is known regarding the regulation of their expression and their role in the maintenance and repair of the adult vascular system. We examined the expression of Tie1 and Tie...

journal_title：Journal of vascular research

authors： Fujikawa K,Presman E,Isner JM,Varticovski L

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Infusion of exogenous vascular endothelial growth factor (VEGF) into adult brain at doses above 60 ng/day induces dramatic angiogenesis accompanied by vascular leak and inflammation. Blood vessels formed by this treatment are dilated and tortuous, exhibiting a pathological morphology. Pathological VEGF-induc...

journal_title：Journal of vascular research

authors： Kasselman LJ,Kintner J,Sideris A,Pasnikowski E,Krellman JW,Shah S,Rudge JS,Yancopoulos GD,Wiegand SJ,Croll SD

更新日期：2007-01-01 00:00:00