Endothelial modulation of ouabain-induced contraction and sodium pump activity in aortas of normotensive Wistar-Kyoto and spontaneously hypertensive rats.

abstract：:Chemokines play an important role in the process of leukocyte recruitment and activation at sites of inflammation. Until recently, the actions of chemokines and the expression of their receptors have only been described on different leukocyte populations. However, increasing evidence has suggested that non-haematopoie...

journal_title：Journal of vascular research

authors： Murdoch C,Finn A

更新日期：2000-01-01 00:00:00

abstract：:In segments of rabbit basilar artery (BA) platelet-activating factor (PAF) initiated a concentration-dependent transitory contraction which was unaffected by indomethacin or nordihydroguaiaretic acid (NDGA). N omega-nitro-L-arginine (NLA) did not change the magnitude of PAF-induced contraction, but in the presence of ...

journal_title：Journal of vascular research

authors： Akopov SE,Sercombe R,Seylaz J

更新日期：1995-01-01 00:00:00

abstract：:This study utilised catecholamine fluorescence histochemistry, multiple-labelling immunohistochemistry and retrograde axonal transport to determine the distribution and neuropeptide content of sympathetic neurons innervating veins in the dorsal skin of the guinea pig pinna. There was a dense plexus of sympathetic axon...

journal_title：Journal of vascular research

authors： Morris JL

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:It has been reported that smoking is one of the strongest positive risk factors for abdominal aortic aneurysms (AAAs). Although many studies have been directed to decipher the effect of smoking on AAA, its effect on macrophage activation has not yet been explored. OBJECTIVES:We have reported the importance ...

journal_title：Journal of vascular research

authors： Igari K,Kelly MJ,Yamanouchi D

更新日期：2019-01-01 00:00:00

abstract：INTRODUCTION:This study aimed to investigate whether epigallocatechin-3-gallate (EGCG) shows antioxidant activity against angiotensin II (Ang II)-induced human umbilical vein endothelial cell (HUVEC) apoptosis. MATERIALS AND METHODS:The viability of HUVECs was revealed by MTT and LDH assay. The cell apoptosis was dete...

journal_title：Journal of vascular research

authors： Zhou X,Liang L,Zhao Y,Zhang H

更新日期：2017-01-01 00:00:00

abstract：:Cx40-deficient mice (Cx40-/-) are hypertensive due to increased renin secretion. We evaluated the renal expression of neuronal nitric oxide synthase (nNOS) and cyclooxygenases COX-1 and COX-2, three macula densa enzymes. The levels of nNOS were increased in kidneys of Cx40-/- mice, as well as in those of wild-type (WT...

journal_title：Journal of vascular research

authors： Krattinger N,Alonso F,Capponi A,Mazzolai L,Nicod P,Meda P,Haefliger JA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:We have developed an in vitro model by organ culture of rat mesenteric arteries to imitate vascular smooth muscle cell (VSMC) receptor changes in cardiovascular disease. By using this model, alteration of VSMC thromboxane A(2) (TP) receptors was studied. METHODS AND RESULTS:After organ culture of the arteri...

journal_title：Journal of vascular research

authors： Zhang W,Zhang Y,Edvinsson L,Xu CB

更新日期：2009-01-01 00:00:00

abstract：:The pathophysiology of Raynaud's phenomenon (RP) remains an enigma. Whatever theories proposed, the final event leading to the clinical symptoms is the occlusion of digital vessels. However, the possibility that the upstream large arterial vessels contribute to vasopasm has never been investigated. We used a high reso...

journal_title：Journal of vascular research

authors： Mourad JJ,Priollet P,Girerd X,Safar M,Lazareth I,Laurent S

更新日期：1997-07-01 00:00:00

abstract：:The effect of shear stress at the endothelium in the attenuation of the noradrenaline-induced constriction of the femoral vascular bed perfused at a constant blood flow was investigated in 16 anesthetized cats. It is known that the adrenergic vasoconstriction of the femoral vascular bed is considerably greater at a co...

journal_title：Journal of vascular research

authors： Kartamyshev SP,Balashov SA,Melkumyants AM

更新日期：2007-01-01 00:00:00

abstract：:Ruptured atherosclerotic plaques, lined with activated platelets, constitute an attractive target for magnetic resonance imaging (MRI). This study evaluated whether microparticles of iron oxide (MPIO) targeting ligand-induced binding sites (LIBS) on the activated conformation of glycoprotein IIb/IIIa could be used to ...

journal_title：Journal of vascular research

authors： von zur Muhlen C,Peter K,Ali ZA,Schneider JE,McAteer MA,Neubauer S,Channon KM,Bode C,Choudhury RP

更新日期：2009-01-01 00:00:00

abstract：:We tested the hypothesis that oxidized low-density lipoprotein (oxLDL)-induced inactivation of Akt within endothelial progenitor cells (EPCs) is mediated at the level of phosphoinositide 3-kinase (PI3K), specifically by nitrosylation of the p85 subunit of PI3K, and that this action is critical in provoking oxLDL-induc...

journal_title：Journal of vascular research

authors： Tie G,Yan J,Yang Y,Park BD,Messina JA,Raffai RL,Nowicki PT,Messina LM

更新日期：2010-01-01 00:00:00

abstract：:Neointima formation participates in the pathophysiology of atherosclerosis and restenosis. Proliferation and migration of vascular smooth muscle cells (VSMC) are initial responses to vascular injury. The aim of the present study was to assess the effect of gliotoxin, an inhibitor of nuclear factor (NF)-kappaB, on migr...

journal_title：Journal of vascular research

authors： Pozo M,Izquierdo MC,de Nicolás R,Egido J,Ortiz A,González-Cabrero J

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Extracellular matrix deposition is the main factor inducing stenotic lesions in arterial grafts. Lysyl oxidases (LOX) play a key role in stabilizing collagen and elastin. OBJECTIVE:To examine the repair response to arterial allografts in terms of LOX expression and collagen/elastin deposition using LOX inhi...

journal_title：Journal of vascular research

authors： Rodríguez M,Pascual G,Cifuentes A,Perez-Köhler B,Bellón JM,Buján J

更新日期：2011-01-01 00:00:00

abstract：AIMS:We investigated the role of superoxide O(2)(-) during the initiation of vascular endothelial growth factor (VEGF)- and placental growth factor (PlGF)-mediated signal transduction in bone marrow-derived endothelial cells. METHODS:BMhTERT cells were treated with VEGF or PlGF in the presence or absence of antioxidan...

journal_title：Journal of vascular research

authors： Dhar-Mascareno M,Mascareno E,Golde DW

更新日期：2009-01-01 00:00:00

abstract：:The purpose of this study was to determine the contribution of long-chain fatty acids relative to other mitochondrial substrates in active vascular smooth muscle (VSM). Hog carotid arteries were isometrically contracted in physiological saline solution containing 0.71 mM U-(13)C-oleic acid (bound to albumin at a ratio...

journal_title：Journal of vascular research

authors： Allen TJ,Hardin CD

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:Lipoxin A4 (LXA4) is a biologically active product generated from arachidonic acid by lipoxygenase action. The production of lipoxins is enhanced by aspirin through acetylation of cyclooxygenase-2, via a mechanism known as 'aspirin-triggered lipoxin'. LXA4 has both anti-inflammatory and proinflammatory actio...

journal_title：Journal of vascular research

authors： Wenceslau CF,McCarthy CG,Szasz T,Webb RC

更新日期：2014-01-01 00:00:00

abstract：:We evaluated the effects of a simulated workday of prolonged sitting on blood pressure (BP) and pulse wave velocity (PWV) and examined whether posture (seated vs. supine) affected responses. Participants (n = 25) were adults, with overweight/obesity and elevated BP, and performed seated desk work for 7.5 h. BP and PWV...

journal_title：Journal of vascular research

authors： Alansare AB,Kowalsky RJ,Jones MA,Perdomo SJ,Stoner L,Gibbs BB

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Vasomotion consists in cyclic oscillations of the arterial diameter induced by the synchronized activity of the smooth muscle cells. So far, contradictory results have emerged in the literature about the role of the endothelium in the onset and maintenance of vasomotion. Here our aim is to understan...

journal_title：Journal of vascular research

authors： Seppey D,Sauser R,Koenigsberger M,Bény JL,Meister JJ

更新日期：2008-01-01 00:00:00

abstract：:The Ig-like cell adhesion molecule ICAM-3 is mainly expressed on human leukocytes and is involved in cell-cell interactions. Its expression on endothelium is observed during disorders such as Crohn's disease and in solid tumors. We found low but detectable expression of ICAM-3 on VE-cadherin-expressing cells from prim...

journal_title：Journal of vascular research

authors： van Buul JD,Mul FP,van der Schoot CE,Hordijk PL

更新日期：2004-01-01 00:00:00

abstract：:In response to stimuli, endothelial cells release arachidonic acid, a lipid precursor of various vasoactive substances. We have investigated the relationships between cytosolic Ca2+ movements and arachidonic acid release in human umbilical vein endothelial cells. Histamine, a receptor-dependent agonist, and thapsigarg...

journal_title：Journal of vascular research

authors： Millanvoye-Van Brussel E,David-Dufilho M,Pham TD,Iouzalen L,Aude Devynck M

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Safety concerns associated with drug-eluting stents have spurred interest in alternative vessel therapeutics following angioplasty. Microbubble contrast agents have been shown to increase gene transfection in vivo in the presence of ultrasound. OBJECTIVES/METHODS:The purpose of this study was to determine w...

journal_title：Journal of vascular research

authors： Phillips LC,Klibanov AL,Bowles DK,Ragosta M,Hossack JA,Wamhoff BR

更新日期：2010-01-01 00:00:00

abstract：:The purpose of the present study was to develop a rapid, reproducible method of nonviral gene transfer to the intact vasculature. Male Sprague-Dawley rats were anesthetized, a midline abdominal incision was made and segmental branches of the superior mesenteric artery were dissected free of surrounding mesentery. A sp...

journal_title：Journal of vascular research

authors： Martin JB,Young JL,Benoit JN,Dean DA

更新日期：2000-09-01 00:00:00

abstract：UNLABELLED:Diabetic patients have an increased risk of restenosis and late stent thrombosis after angioplasty, i.e. complications that are related to a defective re-endothelialization. Exendin-4, a stable glucagon-like peptide (GLP)-1 receptor agonist, has been suggested to influence the formation of intimal hyperplasi...

journal_title：Journal of vascular research

authors： Eriksson L,Saxelin R,Röhl S,Roy J,Caidahl K,Nyström T,Hedin U,Razuvaev A

更新日期：2015-01-01 00:00:00

abstract：:The mechanosensitive nonselective cation channel (NSC(MS)) is a key player in vascular myogenic contraction. The functional channel density and pressure sensitivity of NSC(MS) in vascular myocytes were compared between pulmonary and systemic arteries (coronary, mesenteric and cerebral arteries) in the rabbit. In cell-...

journal_title：Journal of vascular research

authors： Park KS,Lee HA,Earm KH,Ko JH,Earm YE,Kim SJ

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVES:Extracellular nucleotide release at the site of arterial injury mediates the proliferation and migration of vascular smooth muscle cells. Our aim was to investigate the role of the P2Y2 nucleotide receptor (P2Y2R) in neointimal hyperplasia. Approach and Results: Vascular injury was induced by the implantatio...

journal_title：Journal of vascular research

authors： Agca Y,Qian S,Agca C,Seye CI

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Angiopoietin-like protein 3 (ANGPTL3) is a liver-derived plasma protein that modulates plasma triglyceride clearance, angiogenesis and atherosclerosis in experimental models. So far, no study has examined its role in atherosclerosis in human subjects. We evaluated the possible association between plasma ANGP...

journal_title：Journal of vascular research

authors： Hatsuda S,Shoji T,Shinohara K,Kimoto E,Mori K,Fukumoto S,Koyama H,Emoto M,Nishizawa Y

更新日期：2007-01-01 00:00:00

abstract：:Intima-media thickening (IMT) of the carotid artery, a form of vascular remodeling, correlates well with coronary artery disease risk in humans. Vascular remodeling in response to blood flow is a complex process that critically involves altered cell matrix interactions. To gain insight into these events, we performed ...

journal_title：Journal of vascular research

authors： Korshunov VA,Solomatina MA,Plekhanova OS,Parfyonova YV,Tkachuk VA,Berk BC

更新日期：2004-11-01 00:00:00

abstract：:Actions of the novel Ca2+ antagonist, Ro 40-5967, which displays unusual efficacy against endothelin (ET)-induced contractions, were studied in isolated vascular muscle cells (VMCs) using the fluorescent protein kinase C (PKC) indicator, BODIPY 12 alpha-phorbol ester 13 beta-acetate (PBA-BODIPY). High-sensitivity (pho...

journal_title：Journal of vascular research

authors： Hermsmeyer K,Miyagawa K

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND:Hypoxia results in pulmonary hypertension and vascular remodeling due to induction of pulmonary artery cell proliferation. Besides pulmonary artery smooth muscle cells, pulmonary artery endothelial cells (PAECs) are also involved in the development of pulmonary hypertension, but the effect of hypoxia on PAEC...

journal_title：Journal of vascular research

authors： Yu L,Hales CA

更新日期：2011-01-01 00:00:00

abstract：:The role of leukocytes (WBCs) and platelets (PLTs) in the pulmonary circulation may be important in the development of monocrotaline (MCT)-induced pulmonary hypertension in rats. We investigated the suppressive effects of long-term prostaglandin E(1) (PGE(1)) aerosol on the changes in WBCs and PLTs in the peripheral b...

journal_title：Journal of vascular research

authors： Kato S,Kishiro I,Sugimura H,Machida S,Fuse D,Kaneko N

更新日期：2002-01-01 00:00:00