Endothelial modulation of ouabain-induced contraction and sodium pump activity in aortas of normotensive Wistar-Kyoto and spontaneously hypertensive rats.

abstract：:In the present study, we investigated the actions of calmodulin (CaM) and CaM-dependent protein kinase II (CaMK-II) on the L-type Ca2+ currents (ICa(L)) of cultured vascular smooth muscle (VSM) cells (A7r5 cell line), using the whole-cell voltage clamp method. The peak IBa (Ca2+ channel using 5 mM Ba2+ as charge carri...

journal_title：Journal of vascular research

authors： Sunagawa M,Yokoshiki H,Seki T,Sperelakis N

更新日期：1998-09-01 00:00:00

abstract：:Increased vascular disease occurs with low albumin (human serum albumin, HSA), possibly reflecting specific inhibition of endothelial apoptosis reported for tissue culture. Despite the reported specificity for endothelial protection by HSA, the high but physiological concentrations needed appear more consistent with n...

journal_title：Journal of vascular research

authors： Bolitho C,Bayl P,Hou JY,Lynch G,Hassel AJ,Wall AJ,Zoellner H

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:We have developed an in vitro model by organ culture of rat mesenteric arteries to imitate vascular smooth muscle cell (VSMC) receptor changes in cardiovascular disease. By using this model, alteration of VSMC thromboxane A(2) (TP) receptors was studied. METHODS AND RESULTS:After organ culture of the arteri...

journal_title：Journal of vascular research

authors： Zhang W,Zhang Y,Edvinsson L,Xu CB

更新日期：2009-01-01 00:00:00

abstract：:Conduit arteries of hypertensive rats are thicker and stiffer than those of normotensive controls. The possible role played by collagen type I and II subtypes in the mechanism of arterial stiffness remains unknown. The carotid and aortic arterial wall of rats of Japanese (Wistar-Kyoto and spontaneously hypertensive ra...

journal_title：Journal of vascular research

authors： Chamiot Clerc P,Renaud JF,Blacher J,Legrand M,Samuel JL,Levy BI,Sassard J,Safar ME

更新日期：1999-03-01 00:00:00

abstract：:Migration of vascular smooth muscle cells (SMCs) leading to neointimal hyperplasia is an early and cardinal feature of atherogenesis. Migration of rat aortic SMCs from an upper chamber towards a lower one has been studied in a microchemotaxis (Boyden) chamber. Spontaneous migration of SMCs was practically prevented by...

journal_title：Journal of vascular research

authors： Gorog P,Kovacs IB

更新日期：1998-05-01 00:00:00

abstract：:The localization of dopamine receptor subtypes in the rabbit pulmonary circulation was investigated by using combined radioligand binding and light microscope autoradiography techniques. Dopamine D1-like receptors, probably belonging to the dopamine D1 receptor subtype, were demonstrated in sections of rabbit lung usi...

journal_title：Journal of vascular research

authors： Kobayashi Y,Ricci A,Amenta F,Cavallotti C,Hattori K

更新日期：1995-05-01 00:00:00

abstract：:The aim of this study was to use periarterial manipulation to produce an atheroma-like neo-intima in rabbits and study resting blood flow and vascular responsiveness in vivo. One common carotid artery was enclosed in a silastic collar to induce a neo-intima similar to that of human early atherosclerosis, and carotid b...

journal_title：Journal of vascular research

authors： Arthur JF,Dusting GJ,Woodman OL

更新日期：1994-07-01 00:00:00

abstract：:Vascular restenosis is one of the major concerns for the management of coronary artery disease using therapeutic vascular procedures. Treatments with thrombin-specific inhibitors, hirudin or hirulog-1, reduced ischemic events in coronary artery disease patients. Early started and prolonged infusions of these thrombin ...

journal_title：Journal of vascular research

authors： Xue M,Ren S,Welch S,Shen GX

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND/AIMS:Dysfunction of endothelial progenitor cell (EPCs) contributes to diabetic vascular disease. We reported that downregulated miR-126 in diabetic patients causes EPC dysfunction. The study was designed to investigate how high glucose (HG) and advanced glycation end products (AGEs) regulate miR-126 expressi...

journal_title：Journal of vascular research

authors： Li Y,Zhou Q,Pei C,Liu B,Li M,Fang L,Sun Y,Li Y,Meng S

更新日期：2016-01-01 00:00:00

abstract：:Atherosclerosis underlies late occlusion of human saphenous vein (HSV) coronary artery bypass grafts. Monocyte infiltration is implicated, but its mechanisms are unclear given that HSV normally expresses the ICAM-1 but not the VCAM-1 adhesion molecule. To define the mechanisms underlying monocyte adhesion, samples of ...

journal_title：Journal of vascular research

authors： Crook MF,Southgate KM,Newby AC

更新日期：2002-05-01 00:00:00

abstract：:We tested the hypothesis that oxidized low-density lipoprotein (oxLDL)-induced inactivation of Akt within endothelial progenitor cells (EPCs) is mediated at the level of phosphoinositide 3-kinase (PI3K), specifically by nitrosylation of the p85 subunit of PI3K, and that this action is critical in provoking oxLDL-induc...

journal_title：Journal of vascular research

authors： Tie G,Yan J,Yang Y,Park BD,Messina JA,Raffai RL,Nowicki PT,Messina LM

更新日期：2010-01-01 00:00:00

abstract：AIMS:Percutaneous coronary intervention is routinely performed to treat occlusive coronary artery disease. Coronary perforation is a potential complication and can be treated with a stent graft. Current stent grafts are associated with high restenosis rates. We tested the safety and feasibility of biodegradable stent g...

journal_title：Journal of vascular research

authors： Taavitsainen J,Tarvainen S,Kuivanen A,Mangiardi EK,Guelcher M,Martin J,Mathur A,Hytönen JP,Ylä-Herttuala S

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND/AIMS:Endothelial colony-forming cells (ECFCs) have the potential to be used in regenerative medicine. Dysfunction of ECFCs is correlated with the onset of cardiovascular disorders, especially coronary artery disease (CAD). Binding of vascular endothelial growth factor A (VEGFA) to vascular endothelial growth...

journal_title：Journal of vascular research

authors： Su SH,Wu CH,Chiu YL,Chang SJ,Lo HH,Liao KH,Tsai CF,Tsai TN,Lin CH,Cheng SM,Cheng CC,Wang HW

更新日期：2017-01-01 00:00:00

abstract：:The Notch4 signaling pathway of endothelial progenitor cells (EPCs) may play a crucial role in Kawasaki disease (KD). We investigated the proliferation, adhesion, migration, angiogenesis, and expression levels of Notch4, recombination signal-binding protein-Jκ (RBP-Jκ), P-selectin, and vascular cell adhesion molecule-...

journal_title：Journal of vascular research

authors： Wang H,Xia Y,Fu S,Wang W,Xie C,Zhang Y,Gong F

更新日期：2016-01-01 00:00:00

abstract：:The Ig-like cell adhesion molecule ICAM-3 is mainly expressed on human leukocytes and is involved in cell-cell interactions. Its expression on endothelium is observed during disorders such as Crohn's disease and in solid tumors. We found low but detectable expression of ICAM-3 on VE-cadherin-expressing cells from prim...

journal_title：Journal of vascular research

authors： van Buul JD,Mul FP,van der Schoot CE,Hordijk PL

更新日期：2004-01-01 00:00:00

abstract：:We investigated the possible interference of smooth muscle cells with monocyte response to LDL as well as with their adhesion and transmigration in a coculture of porcine endothelial and smooth muscle cells. Lysophosphatidylcholine (LPC), a component of oxidized LDL (oxLDL), stimulated the adhesion of THP-1 cells to e...

journal_title：Journal of vascular research

authors： Kinard F,Jaworski K,Sergent-Engelen T,Goldstein D,Van Veldhoven PP,Holvoet P,Trouet A,Schneider YJ,Remacle C

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Controversial reports on prolactin receptors (PRL-R), the long and short form, on endothelial cells (EC) may be explained by the choice of EC derived from the micro- and macrovascular bed of either endocrine and non-endocrine organs. METHODS:We studied here PRL-R expression in organs [bovine corpus luteum (...

journal_title：Journal of vascular research

authors： Ricken AM,Traenkner A,Merkwitz C,Hummitzsch K,Grosche J,Spanel-Borowski K

更新日期：2007-01-01 00:00:00

abstract：:The assembly of the vessel wall from its cellular and extracellular matrix components is a critical process in the development and maturation of the cardiovascular system. However, fundamental questions concerning the origin of vessel wall cells and the mechanisms that regulate their development and differentiation re...

journal_title：Journal of vascular research

authors： Hungerford JE,Little CD

更新日期：1999-01-01 00:00:00

abstract：:In this study we aimed to investigate whether the therapeutic efficacy of anisodamine in the treatment of bacteraemic shock could--at least in part--be brought about by its direct interference with the lipopolysaccharide (LPS)-induced activation of endothelial cells. Thus, we investigated the effect of anisodamine on ...

journal_title：Journal of vascular research

authors： Ruan QR,Zhang WJ,Hufnagl P,Kaun C,Binder BR,Wojta J

更新日期：2001-01-01 00:00:00

abstract：:The circadian clock is rhythmically expressed in blood vessels, but the interaction between the circadian clock and disturbed blood flow remains unclear. We examined the relationships between BMAL1 and CLOCK and 2 regulators of endothelial function, AKT1 and endothelial nitric oxide synthase (eNOS), in vascular region...

journal_title：Journal of vascular research

authors： Shang X,Pati P,Anea CB,Fulton DJ,Rudic RD

更新日期：2016-01-01 00:00:00

abstract：:Intima-media thickening (IMT) of the carotid artery, a form of vascular remodeling, correlates well with coronary artery disease risk in humans. Vascular remodeling in response to blood flow is a complex process that critically involves altered cell matrix interactions. To gain insight into these events, we performed ...

journal_title：Journal of vascular research

authors： Korshunov VA,Solomatina MA,Plekhanova OS,Parfyonova YV,Tkachuk VA,Berk BC

更新日期：2004-11-01 00:00:00

abstract：OBJECTIVE:Increased peripheral arterial resistances and decreased maximum vasodilation are characteristic features of chronic hypertension. However, little data are available in the literature regarding the possible alterations in the temporal patterns of vasodilatory responses elicited by various stimuli. DESIGN:This...

journal_title：Journal of vascular research

authors： Bertoldi D,Parzy E,Fromes Y,Wary C,Leroy-Willig A,Carlier PG

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. METHODS:F...

journal_title：Journal of vascular research

authors： Sponton AC,Silva FH,Araujo HN,Valgas da Silva CP,de Moraes C,Antunes E,Zanesco A,Delbin MA

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Low birth weight (LBW) is associated with increased risk of type 2 diabetes and cardiovascular disease. We studied endothelial function and insulin sensitivity in young men with LBW (n = 22) and controls (n = 22). METHODS:Insulin sensitivity and endothelial function was studied with venous occlusion plethys...

journal_title：Journal of vascular research

authors： Sonne MP,Højbjerre L,Alibegovic AC,Vaag A,Stallknecht B,Dela F

更新日期：2010-01-01 00:00:00

abstract：:During the early stage of angiogenesis, neovascular sprouts are composed primarily of endothelial cells. As they mature, microvessels acquire a coating of mural cells, which are critical for the development and maintenance of a functional vasculature. Though growth factor regulation of mural cell recruitment has been ...

journal_title：Journal of vascular research

authors： Zhu WH,Han J,Nicosia RF

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:It is well known that inflammation plays key roles in the development of atherosclerosis and that the transplantation of bone marrow mononuclear cells (BMMNCs) can suppress inflammation in rodent models of ischemic diseases. Here, we explored whether transplantation of autologous BMMNCs could prevent the prog...

journal_title：Journal of vascular research

authors： Cui K,Wang M,Yu L,Ren X,Cui H,Yu XF,Hou S,Fu C,Wang J

更新日期：2016-01-01 00:00:00

abstract：:Previous studies demonstrated that maintenance of steady-state myogenic tone requires Ca(2+)-dependent myosin phosphorylation. The present studies furthered these observations by examining temporal relationships among Ca(2+), myosin phosphorylation and vessel diameter during acute increases in intraluminal pressure an...

journal_title：Journal of vascular research

authors： Zou H,Ratz PH,Hill MA

更新日期：2000-11-01 00:00:00

abstract：PURPOSE:Exercise elicits early adaptation of coronary vessels enabling the coronary circulation to respond adequately to higher flow demands. We hypothesized that short-term daily exercise induces biomechanical and functional remodeling of the coronary resistance arteries related to pressure. METHODS:Male rats were su...

journal_title：Journal of vascular research

authors： Szekeres M,Nádasy GL,Dörnyei G,Szénási A,Koller A

更新日期：2018-01-01 00:00:00

abstract：AIM:Transglutaminase 2 (TG2) is important for the deposition and stability of the extracellular matrix via effects on cross-linking of matrix proteins and transforming growth factor beta (TGFbeta) activity. The purpose of this study was to investigate the effect of TG2 deficiency on the composi- tion of atherosclerotic...

journal_title：Journal of vascular research

authors： Van Herck JL,Schrijvers DM,De Meyer GR,Martinet W,Van Hove CE,Bult H,Vrints CJ,Herman AG

更新日期：2010-01-01 00:00:00

abstract：:The effect of insulin on the vasoconstriction induced by norepinephrine is presently controversial. Therefore, the aims of our study were: (1) to evaluate the effect of low- and high-dose insulin on the concentration-response curve to norepinephrine in small resistance arteries of spontaneously hypertensive rats (SHR)...

journal_title：Journal of vascular research

authors： Rizzoni D,Porteri E,Piccoli A,Castellano M,Pasini G,Guelfi D,Muiesan ML,Rosei EA

更新日期：1999-09-01 00:00:00