Abstract：
:Dietary flavonoids are thought to protect against cardiovascular disease. We have studied the effects of bioactive isoflavone metabolites on hyperlipidemia, endothelial dysfunction and the development of atherosclerotic lesions in apolipoprotein E-deficient (apoE(0)) mice fed a Western high-fat diet. Supplementation with dihydrodaidzein (DiD), dehydroequol (DeE) (both 25 mg kg(-1) x day(-1)) and their combination (D/D; 12.5 mg kg(-1) x day(-1) for each) for 24 weeks reduced plasma high-density lipoprotein (HDL) and non-HDL cholesterol. D/D also reduced the triglyceride level. In the abdominal aorta of apoE(0) mice, these compounds significantly increased endothelial nitric oxide (NO)-mediated vasorelaxations induced by acetylcholine, but had a minor effect on relaxations induced by the NO donor S-nitroso-N-acetylpenicillamine. Isoflavone treatment for 24 weeks had no effect on the total area of atherosclerotic plaques in the whole aorta, but DeE reduced the plaque thickness in the aortic arch by 29%, although this did not reach statistical significance. The endothelial dysfunction in apoE(0) mice is associated with hyperlipidemia and increased vascular oxidative stress measured as increased superoxide production. Both isoflavones have superoxide-scavenging activities in vitro. We suggest that chronic supplementation with bioactive isoflavone metabolites may protect endothelial NO function in apoE(0) mice, through both lipid-lowering and antioxidant actions.
journal_name
J Vasc Resjournal_title
Journal of vascular researchauthors
Jiang F,Jones GT,Husband AJ,Dusting GJdoi
10.1159/000071891keywords:
subject
Has Abstractpub_date
2003-05-01 00:00:00pages
276-84issue
3eissn
1018-1172issn
1423-0135pii
71891journal_volume
40pub_type
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journal_title：Journal of vascular research
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更新日期：1993-07-01 00:00:00
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更新日期：2004-11-01 00:00:00
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更新日期：2000-09-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000159134
更新日期：1996-01-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000381097
更新日期：2015-01-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章
doi：10.1159/000505454
更新日期：2020-01-01 00:00:00
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journal_title：Journal of vascular research
pub_type： 杂志文章,评审
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更新日期：1998-03-01 00:00:00
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pub_type： 杂志文章
doi：10.1159/000159150
更新日期：1996-05-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2014-01-01 00:00:00
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journal_title：Journal of vascular research
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更新日期：2013-01-01 00:00:00
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更新日期：1998-07-01 00:00:00
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更新日期：1995-01-01 00:00:00
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journal_title：Journal of vascular research
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更新日期：1998-11-01 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2021-01-27 00:00:00
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更新日期：2011-01-01 00:00:00
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