Calcium signalling and autacoid production in endothelial cells are modulated by changes in tyrosine kinase and phosphatase activity.

abstract：:The Cytoscan Model E-II (Cytometrics Inc., Philadelphia, Pa., USA) is a newly developed instrument which functions as an intravital microscope and is small and easily portable. Through the use of orthogonal polarization spectral (OPS) imaging, the Cytoscan Model E-II delivers images of the microcirculation which are c...

journal_title：Journal of vascular research

authors： Harris AG,Sinitsina I,Messmer K

更新日期：2000-11-01 00:00:00

abstract：:Dietary flavonoids are thought to protect against cardiovascular disease. We have studied the effects of bioactive isoflavone metabolites on hyperlipidemia, endothelial dysfunction and the development of atherosclerotic lesions in apolipoprotein E-deficient (apoE(0)) mice fed a Western high-fat diet. Supplementation w...

journal_title：Journal of vascular research

authors： Jiang F,Jones GT,Husband AJ,Dusting GJ

更新日期：2003-05-01 00:00:00

abstract：:In the present study, we investigated the actions of calmodulin (CaM) and CaM-dependent protein kinase II (CaMK-II) on the L-type Ca2+ currents (ICa(L)) of cultured vascular smooth muscle (VSM) cells (A7r5 cell line), using the whole-cell voltage clamp method. The peak IBa (Ca2+ channel using 5 mM Ba2+ as charge carri...

journal_title：Journal of vascular research

authors： Sunagawa M,Yokoshiki H,Seki T,Sperelakis N

更新日期：1998-09-01 00:00:00

abstract：:In response to stimuli, endothelial cells release arachidonic acid, a lipid precursor of various vasoactive substances. We have investigated the relationships between cytosolic Ca2+ movements and arachidonic acid release in human umbilical vein endothelial cells. Histamine, a receptor-dependent agonist, and thapsigarg...

journal_title：Journal of vascular research

authors： Millanvoye-Van Brussel E,David-Dufilho M,Pham TD,Iouzalen L,Aude Devynck M

更新日期：1999-05-01 00:00:00

abstract：:Protein localization in endothelial cells is tightly regulated to create distinct signaling domains within their tight spatial restrictions including luminal membranes, abluminal membranes, and interendothelial junctions, as well as caveolae and calcium signaling domains. Protein localization in endothelial cells is a...

journal_title：Journal of vascular research

authors： Wolpe AG,Ruddiman CA,Hall PJ,Isakson BE

更新日期：2021-01-27 00:00:00

abstract：:We tested the hypothesis that oxidized low-density lipoprotein (oxLDL)-induced inactivation of Akt within endothelial progenitor cells (EPCs) is mediated at the level of phosphoinositide 3-kinase (PI3K), specifically by nitrosylation of the p85 subunit of PI3K, and that this action is critical in provoking oxLDL-induc...

journal_title：Journal of vascular research

authors： Tie G,Yan J,Yang Y,Park BD,Messina JA,Raffai RL,Nowicki PT,Messina LM

更新日期：2010-01-01 00:00:00

abstract：AIM:Vascular remodeling following injury substantially accounts for restenosis and adverse clinical outcomes. In this study, we investigated the role of the giant scaffold protein Ahnak1 in vascular healing after endothelial denudation of the murine femoral artery. METHODS:The spatiotemporal expression pattern of Ahna...

journal_title：Journal of vascular research

authors： Haase N,Rüder C,Haase H,Kamann S,Kouno M,Morano I,Dechend R,Zohlnhöfer D,Haase T

更新日期：2017-01-01 00:00:00

abstract：:Mesenteric endothelial cell function and immunoreactivity for substance P and nitric oxide synthase (NOS) were examined in control rats and rats treated with capsaicin as neonates to destroy primary afferent nerves. Endothelial vasodilator function was examined pharmacologically in the methoxamine raised-tone isolated...

journal_title：Journal of vascular research

authors： Ralevic V,Dikranian K,Burnstock G

更新日期：1995-09-01 00:00:00

abstract：:Fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF) exert their angiogenic activity by interacting with endothelial cells in a distinct manner. In this study, we investigated the morphological features of endothelial cells of the chick embryo chorioallantoic membrane (CAM) microvasculature ...

journal_title：Journal of vascular research

authors： Ribatti D,Nico B,Morbidelli L,Donnini S,Ziche M,Vacca A,Roncali L,Presta M

更新日期：2001-07-01 00:00:00

abstract：:This study examines the ultrastructural features of diffuse intimal thickenings of human coronary arteries and correlates structural heterogeneity along the radial axis with the distribution and known actions of transforming growth factor beta 1 (TGF-beta 1). Morphometric and immunohistochemical data were collected fr...

journal_title：Journal of vascular research

authors： Merrilees MJ,Beaumont B

更新日期：1993-09-01 00:00:00

abstract：:This work compares the expression of adrenoceptors (ARs) and G-protein-coupled receptor kinase (GRK) 2 (RT-PCR and immunoblotting) and functional responses in conductance (aorta) and resistance vessels (mesenteric resistance arteries; MRA) in two different models of rat hypertension: hypertension induced by chronic tr...

journal_title：Journal of vascular research

authors： Oliver E,Flacco N,Arce C,Ivorra MD,D'Ocon MP,Noguera MA

更新日期：2014-01-01 00:00:00

abstract：:The localization of dopamine receptor subtypes in the rabbit pulmonary circulation was investigated by using combined radioligand binding and light microscope autoradiography techniques. Dopamine D1-like receptors, probably belonging to the dopamine D1 receptor subtype, were demonstrated in sections of rabbit lung usi...

journal_title：Journal of vascular research

authors： Kobayashi Y,Ricci A,Amenta F,Cavallotti C,Hattori K

更新日期：1995-05-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is a principal stimulator of angiogenesis. However, the downstream targets of VEGF in endothelial cells (ECs) are not entirely clarified. Survey of downstream targets of VEGF in human ECs identified a number of genes, including Down syndrome candidate region 1 (DSCR1). Here, w...

journal_title：Journal of vascular research

authors： Iizuka M,Abe M,Shiiba K,Sasaki I,Sato Y

更新日期：2004-07-01 00:00:00

abstract：:The D allele of the insertion (I)/deletion (D) polymorphism in the angiotensin-converting enzyme (ACE) gene and the C allele of the A1166-C polymorphism in the angiotensin II type 1 receptor (AGT1R) gene have been associated with altered vascular structure and with an increased risk of myocardial infarction. The aim o...

journal_title：Journal of vascular research

authors： Steeds RP,Toole LO,Channer KS,Morice AH

更新日期：1999-11-01 00:00:00

abstract：:Mechanical forces generated at the endothelium by fluid shear stress and pulsatile stretch are important in ensuring the continuous release of vasoactive endothelial autacoids. Although the mechanism by which endothelial cells are able to detect and convert these physical stimuli into chemical signals is unclear, this...

journal_title：Journal of vascular research

authors： Busse R,Fleming I

更新日期：1998-03-01 00:00:00

abstract：:Previous studies demonstrated that maintenance of steady-state myogenic tone requires Ca(2+)-dependent myosin phosphorylation. The present studies furthered these observations by examining temporal relationships among Ca(2+), myosin phosphorylation and vessel diameter during acute increases in intraluminal pressure an...

journal_title：Journal of vascular research

authors： Zou H,Ratz PH,Hill MA

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND/AIMS:Endoplasmic reticulum (ER) stress has emerged as a potential mechanism contributing to diabetes and its comorbidities. However, the importance of ER stress in diabetic vascular dysfunction is unclear. The purpose of this study was to examine the effects of the ER stress inhibitor, tauroursodeoxycholic a...

journal_title：Journal of vascular research

authors： Battson ML,Lee DM,Jarrell DK,Hou S,Ecton KE,Phan AB,Gentile CL

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND/AIMS:Dysfunction of endothelial progenitor cell (EPCs) contributes to diabetic vascular disease. We reported that downregulated miR-126 in diabetic patients causes EPC dysfunction. The study was designed to investigate how high glucose (HG) and advanced glycation end products (AGEs) regulate miR-126 expressi...

journal_title：Journal of vascular research

authors： Li Y,Zhou Q,Pei C,Liu B,Li M,Fang L,Sun Y,Li Y,Meng S

更新日期：2016-01-01 00:00:00

abstract：:We examined the growth of the right common carotid artery of young rabbits after ligating the left common carotid artery at 3 weeks of age, a procedure that approximately doubled right carotid blood flows. Flow increased from 0.065 +/-0.003 to 0.096+/-0.009 ml/s within 1 h and, at 15 weeks of age, carotid blood flows ...

journal_title：Journal of vascular research

authors： Di Stefano I,Koopmans DR,Langille BL

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND:The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. METHODS:F...

journal_title：Journal of vascular research

authors： Sponton AC,Silva FH,Araujo HN,Valgas da Silva CP,de Moraes C,Antunes E,Zanesco A,Delbin MA

更新日期：2017-01-01 00:00:00

abstract：:The novel endothelial cell tyrosine kinase receptors, Tie1 and Tie2, are essential for vascular development and remodeling in the embryo but little is known regarding the regulation of their expression and their role in the maintenance and repair of the adult vascular system. We examined the expression of Tie1 and Tie...

journal_title：Journal of vascular research

authors： Fujikawa K,Presman E,Isner JM,Varticovski L

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVES:Extracellular nucleotide release at the site of arterial injury mediates the proliferation and migration of vascular smooth muscle cells. Our aim was to investigate the role of the P2Y2 nucleotide receptor (P2Y2R) in neointimal hyperplasia. Approach and Results: Vascular injury was induced by the implantatio...

journal_title：Journal of vascular research

authors： Agca Y,Qian S,Agca C,Seye CI

更新日期：2016-01-01 00:00:00

abstract：:Therapies aimed at manipulating the microcirculation require the ability to control angiogenesis, defined as the sprouting of new capillaries from existing vessels. Blocking angiogenesis would be beneficial in many pathologies (e.g. cancer, retinopathies and rheumatoid arthritis). In others (e.g. myocardial infarction...

journal_title：Journal of vascular research

authors： Stapor PC,Sweat RS,Dashti DC,Betancourt AM,Murfee WL

更新日期：2014-01-01 00:00:00

abstract：:Migration of vascular smooth muscle cells (SMCs) leading to neointimal hyperplasia is an early and cardinal feature of atherogenesis. Migration of rat aortic SMCs from an upper chamber towards a lower one has been studied in a microchemotaxis (Boyden) chamber. Spontaneous migration of SMCs was practically prevented by...

journal_title：Journal of vascular research

authors： Gorog P,Kovacs IB

更新日期：1998-05-01 00:00:00

abstract：:Neointima formation participates in the pathophysiology of atherosclerosis and restenosis. Proliferation and migration of vascular smooth muscle cells (VSMC) are initial responses to vascular injury. The aim of the present study was to assess the effect of gliotoxin, an inhibitor of nuclear factor (NF)-kappaB, on migr...

journal_title：Journal of vascular research

authors： Pozo M,Izquierdo MC,de Nicolás R,Egido J,Ortiz A,González-Cabrero J

更新日期：2009-01-01 00:00:00

abstract：:This study was designed to establish the in vitro pharmacological responses of rat middle cerebral arteries (MCA), and also their susceptibility to overnight cold storage at 4 degrees C. MCAs were harvested from rats and pharmacological responses were studied using a Mulvany myograph. Responses to prostaglandin F2 alp...

journal_title：Journal of vascular research

authors： Laing RJ,Jakubowski J,Morice AH

更新日期：1995-07-01 00:00:00

abstract：:Coronary bypass vessels, saphenous vein (SV) and internal thoracic artery (ITA), differ in susceptibility to atherosclerosis and medium- to long-term patency. Whereas most ITA remain patent (90% at 10 years), 20% of SV grafts fail in the first year and approximately 45% fail within 10 years. Reasons for these differen...

journal_title：Journal of vascular research

authors： Scott L,Kerr A,Haydock D,Merrilees M

更新日期：1997-09-01 00:00:00

abstract：:The circadian clock is rhythmically expressed in blood vessels, but the interaction between the circadian clock and disturbed blood flow remains unclear. We examined the relationships between BMAL1 and CLOCK and 2 regulators of endothelial function, AKT1 and endothelial nitric oxide synthase (eNOS), in vascular region...

journal_title：Journal of vascular research

authors： Shang X,Pati P,Anea CB,Fulton DJ,Rudic RD

更新日期：2016-01-01 00:00:00

abstract：:Although the content of histamine in myocardial tissue is high, its contribution to the regulation of coronary blood flow has not been clearly defined. The aim of the present study was to investigate whether or not nitric oxide (NO), an important modulator of coronary vascular tone, is involved in histamine-induced co...

journal_title：Journal of vascular research

authors： Kelm M,Feelisch M,Krebber T,Motz W,Strauer BE

更新日期：1993-05-01 00:00:00

abstract：BACKGROUND:Transfer of molecular signals from veins to adjacent arteries is an established mechanism of vascular communication in the uterine circulation, which ultimately depends on venous permeability. This study tests the hypotheses that: (1) uterine veins are permeable to intravenous solutes, using a 3-kDa dextran ...

journal_title：Journal of vascular research

authors： Celia G,Osol G

更新日期：2005-01-01 00:00:00