Protein kinase C mechanism enhances vascular muscle relaxation by the Ca2+ antagonist, Ro 40-5967.

abstract：BACKGROUND:Angiopoietin-like protein 3 (ANGPTL3) is a liver-derived plasma protein that modulates plasma triglyceride clearance, angiogenesis and atherosclerosis in experimental models. So far, no study has examined its role in atherosclerosis in human subjects. We evaluated the possible association between plasma ANGP...

journal_title：Journal of vascular research

authors： Hatsuda S,Shoji T,Shinohara K,Kimoto E,Mori K,Fukumoto S,Koyama H,Emoto M,Nishizawa Y

更新日期：2007-01-01 00:00:00

abstract：:The novel endothelial cell tyrosine kinase receptors, Tie1 and Tie2, are essential for vascular development and remodeling in the embryo but little is known regarding the regulation of their expression and their role in the maintenance and repair of the adult vascular system. We examined the expression of Tie1 and Tie...

journal_title：Journal of vascular research

authors： Fujikawa K,Presman E,Isner JM,Varticovski L

更新日期：1999-07-01 00:00:00

abstract：:A radioligand binding assay and autoradiographic localisation of P2X-purinoceptors were carried out in several different blood vessels from rat, guinea-pig and rabbit by using [3H]alpha,beta-methylene ATP ([3H]alpha,beta-MeATP) as the radioligand. The radioligand binding assay on rabbit ear artery showed that the bind...

journal_title：Journal of vascular research

authors： Bo X,Burnstock G

更新日期：1993-03-01 00:00:00

abstract：:We investigated the possible interference of smooth muscle cells with monocyte response to LDL as well as with their adhesion and transmigration in a coculture of porcine endothelial and smooth muscle cells. Lysophosphatidylcholine (LPC), a component of oxidized LDL (oxLDL), stimulated the adhesion of THP-1 cells to e...

journal_title：Journal of vascular research

authors： Kinard F,Jaworski K,Sergent-Engelen T,Goldstein D,Van Veldhoven PP,Holvoet P,Trouet A,Schneider YJ,Remacle C

更新日期：2001-09-01 00:00:00

abstract：:The release of cytokines and chemokines from activated immune-competent cells plays a crucial role in determining the pathology of the atherogenic progress. We investigated the effect of bacterial lipopolysaccharide (LPS) on cytokine/chemokine expression in carotid lesions and normal renal arteries. The lesions or ren...

journal_title：Journal of vascular research

authors： Jatta K,Wågsäter D,Norgren L,Stenberg B,Sirsjö A

更新日期：2005-05-01 00:00:00

abstract：:Fibroblast growth factor-2 (FGF2) and vascular endothelial growth factor (VEGF) exert their angiogenic activity by interacting with endothelial cells in a distinct manner. In this study, we investigated the morphological features of endothelial cells of the chick embryo chorioallantoic membrane (CAM) microvasculature ...

journal_title：Journal of vascular research

authors： Ribatti D,Nico B,Morbidelli L,Donnini S,Ziche M,Vacca A,Roncali L,Presta M

更新日期：2001-07-01 00:00:00

abstract：:Proper development of the vascular system as one of the earliest and most critical steps during vertebrate embryogenesis is ensured by the exact spatial and temporal control of gene expression in cells forming the vessel network. Whereas the regulation of vascular system development is well elucidated on the level of ...

journal_title：Journal of vascular research

authors： Bruderer M,Alini M,Stoddart MJ

更新日期：2013-01-01 00:00:00

abstract：:Topical application of elastase to induce arterial aneurysm formation is an emerging murine model of vascular disease. In the context of aortic abdominal aneurysm (AAA), angiotensin II infusion and porcine pancreatic elastase perfusion models are commonly used today. This study, therefore, compares matrix remodeling, ...

journal_title：Journal of vascular research

authors： Busch A,Holm A,Wagner N,Ergün S,Rosenfeld M,Otto C,Baur J,Kellersmann R,Lorenz U

更新日期：2016-01-01 00:00:00

abstract：AIM:Transglutaminase 2 (TG2) is important for the deposition and stability of the extracellular matrix via effects on cross-linking of matrix proteins and transforming growth factor beta (TGFbeta) activity. The purpose of this study was to investigate the effect of TG2 deficiency on the composi- tion of atherosclerotic...

journal_title：Journal of vascular research

authors： Van Herck JL,Schrijvers DM,De Meyer GR,Martinet W,Van Hove CE,Bult H,Vrints CJ,Herman AG

更新日期：2010-01-01 00:00:00

abstract：:Pituitary adenylate cyclase-activating peptide (PACAP; 1-38 and 1-27) and vasoactive intestinal peptide (VIP) are related neuropeptides of the secretin/glucagon family. Overlapping signaling through G-protein-coupled receptors mediates their vasomotor activity. We previously showed that PACAP deficiency (PACAP-KO) shi...

journal_title：Journal of vascular research

authors： Ivic I,Solymar M,Fulop BD,Hashimoto H,Toth G,Tamas A,Juhasz T,Koller A,Reglodi D

更新日期：2017-01-01 00:00:00

abstract：:Although the content of histamine in myocardial tissue is high, its contribution to the regulation of coronary blood flow has not been clearly defined. The aim of the present study was to investigate whether or not nitric oxide (NO), an important modulator of coronary vascular tone, is involved in histamine-induced co...

journal_title：Journal of vascular research

authors： Kelm M,Feelisch M,Krebber T,Motz W,Strauer BE

更新日期：1993-05-01 00:00:00

abstract：:The localization of dopamine receptor subtypes in the rabbit pulmonary circulation was investigated by using combined radioligand binding and light microscope autoradiography techniques. Dopamine D1-like receptors, probably belonging to the dopamine D1 receptor subtype, were demonstrated in sections of rabbit lung usi...

journal_title：Journal of vascular research

authors： Kobayashi Y,Ricci A,Amenta F,Cavallotti C,Hattori K

更新日期：1995-05-01 00:00:00

abstract：:Previous studies have demonstrated endothelial and smooth muscle hyperplasia occur during arterial luminal expansion associated with elevation of arterial wall shear rates. The current study investigated whether remodeling induced by elevated wall shear would ultimately result in a vessel with intimal and medial cell ...

journal_title：Journal of vascular research

authors： Fath SW,Burkhart HM,Miller SC,Dalsing MC,Unthank JL

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Lipoxin A4 (LXA4) is a biologically active product generated from arachidonic acid by lipoxygenase action. The production of lipoxins is enhanced by aspirin through acetylation of cyclooxygenase-2, via a mechanism known as 'aspirin-triggered lipoxin'. LXA4 has both anti-inflammatory and proinflammatory actio...

journal_title：Journal of vascular research

authors： Wenceslau CF,McCarthy CG,Szasz T,Webb RC

更新日期：2014-01-01 00:00:00

abstract：:The circadian clock is rhythmically expressed in blood vessels, but the interaction between the circadian clock and disturbed blood flow remains unclear. We examined the relationships between BMAL1 and CLOCK and 2 regulators of endothelial function, AKT1 and endothelial nitric oxide synthase (eNOS), in vascular region...

journal_title：Journal of vascular research

authors： Shang X,Pati P,Anea CB,Fulton DJ,Rudic RD

更新日期：2016-01-01 00:00:00

abstract：:There is evidence suggesting that fluid shear stress activates phospholipid turnover in endothelial cells, but it is not clear which phospholipids are involved in the transduction of the flow signal. Cultured human umbilical-vein endothelial cells were prelabeled with [14C]-arachidonic acid and subjected to laminar sh...

journal_title：Journal of vascular research

authors： Bhagyalakshmi A,Berthiaume F,Reich KM,Frangos JA

更新日期：1992-11-01 00:00:00

abstract：:The pH has marked effects on the blood flow in several vascular beds but the underlying mechanisms remain incompletely understood. It is still not agreed, for example, whether it is the fall in extracellular pH or intracellular pH that is responsible for changes in tone resulting from hypercapnic acidosis. The issue h...

journal_title：Journal of vascular research

authors： Aalkjaer C,Poston L

更新日期：1996-09-01 00:00:00

abstract：:The assembly of the vessel wall from its cellular and extracellular matrix components is a critical process in the development and maturation of the cardiovascular system. However, fundamental questions concerning the origin of vessel wall cells and the mechanisms that regulate their development and differentiation re...

journal_title：Journal of vascular research

authors： Hungerford JE,Little CD

更新日期：1999-01-01 00:00:00

abstract：:The aim of this study was to use periarterial manipulation to produce an atheroma-like neo-intima in rabbits and study resting blood flow and vascular responsiveness in vivo. One common carotid artery was enclosed in a silastic collar to induce a neo-intima similar to that of human early atherosclerosis, and carotid b...

journal_title：Journal of vascular research

authors： Arthur JF,Dusting GJ,Woodman OL

更新日期：1994-07-01 00:00:00

abstract：BACKGROUND:Transfer of molecular signals from veins to adjacent arteries is an established mechanism of vascular communication in the uterine circulation, which ultimately depends on venous permeability. This study tests the hypotheses that: (1) uterine veins are permeable to intravenous solutes, using a 3-kDa dextran ...

journal_title：Journal of vascular research

authors： Celia G,Osol G

更新日期：2005-01-01 00:00:00

abstract：:Regulation of [Ca2+]i and modulation of the [Ca2+]i sensitivity of myosin phosphorylation in smooth muscles may involve phosphorylation of one or more proteins on tyrosine residues. We tested this hypothesis by measuring tyrosine phosphorylation of proteins extracted from swine carotid artery and separated by SDS gel ...

journal_title：Journal of vascular research

authors： Rembold CM,Weaver BA

更新日期：1997-01-01 00:00:00

abstract：:In the present study, we investigated the actions of calmodulin (CaM) and CaM-dependent protein kinase II (CaMK-II) on the L-type Ca2+ currents (ICa(L)) of cultured vascular smooth muscle (VSM) cells (A7r5 cell line), using the whole-cell voltage clamp method. The peak IBa (Ca2+ channel using 5 mM Ba2+ as charge carri...

journal_title：Journal of vascular research

authors： Sunagawa M,Yokoshiki H,Seki T,Sperelakis N

更新日期：1998-09-01 00:00:00

abstract：:Organic nitrates act as vasodilators and have long been used for treatment of cardiovascular diseases. However, the therapeutic effect of nitrates is limited by induction of nitrate tolerance which is associated with endothelial dysfunction and enhanced vasoconstriction. Multiple mechanisms cause nitrate tolerance inc...

journal_title：Journal of vascular research

authors： Pi X,Yan C,Kim D,Chen J,Berk BC

更新日期：2002-07-01 00:00:00

abstract：:This study examines the ultrastructural features of diffuse intimal thickenings of human coronary arteries and correlates structural heterogeneity along the radial axis with the distribution and known actions of transforming growth factor beta 1 (TGF-beta 1). Morphometric and immunohistochemical data were collected fr...

journal_title：Journal of vascular research

authors： Merrilees MJ,Beaumont B

更新日期：1993-09-01 00:00:00

abstract：BACKGROUND/AIMS:The endothelium has been recognized as a key component in the regulation of blood vessels. We designed a simple procedure to separate endothelial and smooth muscle RNA from rat aorta and mesenteric artery and used this method to establish the distribution of Na(+)/K(+)-ATPase alpha-subunit isoforms (NaK...

journal_title：Journal of vascular research

authors： Krenek P,Hamaide MC,Morel N,Wibo M

更新日期：2006-01-01 00:00:00

abstract：:The effect of shear stress at the endothelium in the attenuation of the noradrenaline-induced constriction of the femoral vascular bed perfused at a constant blood flow was investigated in 16 anesthetized cats. It is known that the adrenergic vasoconstriction of the femoral vascular bed is considerably greater at a co...

journal_title：Journal of vascular research

authors： Kartamyshev SP,Balashov SA,Melkumyants AM

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:Elevated plasma homocysteine (Hcy) is a risk factor for coronary disease. The objective of this study was to investigate whether Hcy either alone or in high glucose conditions induces endothelin-1 (ET-1) synthesis via the production of reactive oxygen species (ROS). METHODS:Bovine aortic endothelial cells w...

journal_title：Journal of vascular research

authors： Sethi AS,Lees DM,Douthwaite JA,Dawnay AB,Corder R

更新日期：2006-01-01 00:00:00

abstract：:Vascular restenosis is one of the major concerns for the management of coronary artery disease using therapeutic vascular procedures. Treatments with thrombin-specific inhibitors, hirudin or hirulog-1, reduced ischemic events in coronary artery disease patients. Early started and prolonged infusions of these thrombin ...

journal_title：Journal of vascular research

authors： Xue M,Ren S,Welch S,Shen GX

更新日期：2001-03-01 00:00:00

abstract：:The Notch4 signaling pathway of endothelial progenitor cells (EPCs) may play a crucial role in Kawasaki disease (KD). We investigated the proliferation, adhesion, migration, angiogenesis, and expression levels of Notch4, recombination signal-binding protein-Jκ (RBP-Jκ), P-selectin, and vascular cell adhesion molecule-...

journal_title：Journal of vascular research

authors： Wang H,Xia Y,Fu S,Wang W,Xie C,Zhang Y,Gong F

更新日期：2016-01-01 00:00:00

abstract：:It has been well established that wall shear stress is an important determinant of endothelial cell function and gene expression as well as of its structure. There is increasing evidence that low wall shear stress, as present in artery bifurcations opposite to the flow divider where atherosclerotic lesions preferentia...

journal_title：Journal of vascular research

authors： Reneman RS,Arts T,Hoeks AP

更新日期：2006-01-01 00:00:00