Abstract:
BACKGROUND:Angiopoietin-like protein 3 (ANGPTL3) is a liver-derived plasma protein that modulates plasma triglyceride clearance, angiogenesis and atherosclerosis in experimental models. So far, no study has examined its role in atherosclerosis in human subjects. We evaluated the possible association between plasma ANGPTL3 level and carotid artery intima-media thickness (CA-IMT) and femoral artery intima-media thickness (FA-IMT) in healthy human subjects. METHODS:The subjects were 381 healthy volunteers. Plasma ANGPTL3 was determined by a specific ELISA. CA-IMT and FA-IMT were measured by high-resolution B-mode ultrasonography. RESULTS:The plasma ANGPTL3 level was 764 +/- 291 ng/ml (mean +/- SD). CA-IMT showed a significant positive correlation with plasma ANGPTL3 and other classical risk factors such as age, blood pressure, and plasma glucose and lipid levels. The positive association between ANGPTL3 and CA-IMT remained significant after adjustment for age, sex, smoking, body mass index, systolic blood pressure, plasma glucose, insulin resistance index, triglyceride, and high-density and low-density lipoprotein cholesterol levels. ANGPTL3 also showed a positive association with FA-IMT independent of these factors. CONCLUSIONS:These results demonstrate for the first time that ANGPTL3 is closely associated with arterial wall thickness in human subjects.
journal_name
J Vasc Resjournal_title
Journal of vascular researchauthors
Hatsuda S,Shoji T,Shinohara K,Kimoto E,Mori K,Fukumoto S,Koyama H,Emoto M,Nishizawa Ydoi
10.1159/000098153subject
Has Abstractpub_date
2007-01-01 00:00:00pages
61-6issue
1eissn
1018-1172issn
1423-0135pii
000098153journal_volume
44pub_type
杂志文章abstract::Organic nitrates act as vasodilators and have long been used for treatment of cardiovascular diseases. However, the therapeutic effect of nitrates is limited by induction of nitrate tolerance which is associated with endothelial dysfunction and enhanced vasoconstriction. Multiple mechanisms cause nitrate tolerance inc...
journal_title:Journal of vascular research
pub_type: 杂志文章
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abstract::Signaling pathways activated by the tachykinin substance P (SP) were investigated in pig coronary artery endothelial cells (PCAECs). Single cells were obtained after enzymatic digestion of coronary arteries. Intracellular Ca2+ ([Ca2+]i) was measured from fura-2 fluorescence while membrane potential or ionic current wa...
journal_title:Journal of vascular research
pub_type: 杂志文章
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abstract:OBJECTIVE:Increased peripheral arterial resistances and decreased maximum vasodilation are characteristic features of chronic hypertension. However, little data are available in the literature regarding the possible alterations in the temporal patterns of vasodilatory responses elicited by various stimuli. DESIGN:This...
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journal_title:Journal of vascular research
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doi:10.1159/000159037
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journal_title:Journal of vascular research
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更新日期:2007-01-01 00:00:00
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journal_title:Journal of vascular research
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journal_title:Journal of vascular research
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journal_title:Journal of vascular research
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journal_title:Journal of vascular research
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journal_title:Journal of vascular research
pub_type: 杂志文章
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journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000025679
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abstract::Coronary bypass vessels, saphenous vein (SV) and internal thoracic artery (ITA), differ in susceptibility to atherosclerosis and medium- to long-term patency. Whereas most ITA remain patent (90% at 10 years), 20% of SV grafts fail in the first year and approximately 45% fail within 10 years. Reasons for these differen...
journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000159245
更新日期:1997-09-01 00:00:00
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journal_title:Journal of vascular research
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更新日期:2004-07-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
doi:10.1159/000449201
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journal_title:Journal of vascular research
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更新日期:2018-01-01 00:00:00
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journal_title:Journal of vascular research
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doi:10.1159/000479873
更新日期:2017-01-01 00:00:00
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journal_title:Journal of vascular research
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doi:10.1159/000076126
更新日期:2004-01-01 00:00:00
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journal_title:Journal of vascular research
pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of vascular research
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doi:10.1159/000159196
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journal_title:Journal of vascular research
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journal_title:Journal of vascular research
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journal_title:Journal of vascular research
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更新日期:2011-01-01 00:00:00
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journal_title:Journal of vascular research
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更新日期:2021-01-27 00:00:00
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