Abstract:
:Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis of neural cells induced by glutathione depletion. This finding demonstrates that bcl-2 does not inhibit the cellular death program directly; rather, bcl-2 modulates a cellular process that leads to apoptosis under some conditions but necrosis under others.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Kane DJ,Ord T,Anton R,Bredesen DEdoi
10.1002/jnr.490400216subject
Has Abstractpub_date
1995-02-01 00:00:00pages
269-75issue
2eissn
0360-4012issn
1097-4547journal_volume
40pub_type
杂志文章abstract::To determine whether one or more opioid receptor types might be preferentially involved in gliogenesis, primary mixed glial cultures derived from mouse cerebra were continuously treated with varying concentrations of opioid agonists selective for mu (mu), i.e., DAGO ([D-Ala2, MePhe4, Gly(ol)5]enkephalin), delta (delta...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490290415
更新日期:1991-08-01 00:00:00
abstract::Accumulating evidence indicates an immunosuppressive role for CD4(+)CD25(+) regulatory T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with relapsing-remitting multiple sclerosis (RR-MS) has been reported recently, no information is available so far about Treg function in the pro...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20852
更新日期:2006-06-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22694
更新日期:2011-10-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220212
更新日期:1989-02-01 00:00:00
abstract::A morphogenic role of neurotransmitters during cellular differentiation in vitro has been demonstrated in recent years. Using in situ hybridization, we confirm the presence of the D1 receptor at E16 and show additionally that the transcript is relatively widespread and present in both proliferative and differentiating...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960215)43:4<439::AID-JNR
更新日期:1996-02-15 00:00:00
abstract::The presence of oligodendrocyte precursor cells which cannot be removed from primary cultures by antibody-dependent techniques complicates the interpretation of transplantation experiments designed to examine the potential of astrocytes to influence remyelination (Blakemore et al.; Glia 13:79-91, 1995). In the present...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1997-07-01 00:00:00
abstract::One premise regarding the mechanism of injury-evoked neuroregeneration is that injured cells induce the release of neurotrophic factors to trigger neurogenesis. Extracellular purine nucleotides exert multiple neurotrophic actions in the central nervous system mediated via activation of purinergic receptors. However, w...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21954
更新日期:2009-05-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23211
更新日期:2013-06-01 00:00:00
abstract::Ferritin is the major iron storage protein and accounts for the majority of the iron in the brain. Thus, ferritin is a key component in protecting the brain from iron induced oxidative damage. The high lipid content, high rate of oxidative metabolism, and high iron content combine to make the brain the organ most susc...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490370405
更新日期:1994-03-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.20040
更新日期:2004-04-15 00:00:00
abstract::A Schwann cell line (MSC 80) was established from purified mouse Schwann cell cultures using large doses of serum. MSC 80 cell line is an aneuploid cell line which has a doubling time of 17 hr and has been maintained through more than 110 passages. Most of MSC 80 cells are of bipolar or stellate (3-5 processes) shape....
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320103
更新日期:1992-05-01 00:00:00
abstract::We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320409
更新日期:1992-08-01 00:00:00
abstract::Oligodendrocytes (OLs) show heterogeneous properties that depend on their location in the central nervous system (CNS). In this regard, the investigation of oligodendrocyte precursor cells (OPCs) derived from human pluripotent stem cells (hPSCs) should be reconsidered, particularly in cases of brain-predominant disord...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24413
更新日期:2019-07-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960815)45:4<400::AID-JNR
更新日期:1996-08-15 00:00:00
abstract::Pharmacological characterization of the action of the novel non-N-methyl-D-aspartate (non-NMDA) antagonist AMOA (2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionate) on glutamate receptors was investigated in Xenopus oocytes injected with mouse brain mRNA. AMOA (150 microM) produced a nearly parallel shift ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330305
更新日期:1992-11-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10797
更新日期:2003-12-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10756
更新日期:2003-10-15 00:00:00
abstract::Previous studies from our laboratory suggest that Alzheimer's disease sera contain a repertoire of antibodies to the heavy neurofilament subunit (NF-H) and that a subpopulation of these antibodies bind specifically to epitopes highly enriched in NF-H isolated from the purely cholinergic electromotor neurons of Torpedo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490290409
更新日期:1991-08-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410110
更新日期:1995-05-01 00:00:00
abstract::Protein zero (P0) glycoprotein is the major integral membrane protein of the peripheral nervous system myelin in higher vertebrates. Previous findings indicate the formation of tetrameric assemblies from studies on isolated P0. To determine whether in intact myelin the P0 exists as oligomers, we isolated myelin from s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10167
更新日期:2002-03-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19971015)50:2<202::AID-JNR
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490060111
更新日期:1981-01-01 00:00:00
abstract::Cell transplantation offers a potential new treatment for stroke. Animal studies using models that produce ischemic damage in both the striatum and the frontal cortex have shown beneficial effects when hNT cells (postmitotic immature neurons) were transplanted into the ischemic striatum. In this study, we investigated...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20800
更新日期:2006-05-01 00:00:00
abstract::The analysis of proteins in damaged myelin is crucial to clarify the mechanisms of dysmyelination and demyelination. In the present study, proteomic analysis of myelin using a modified two-dimensional electrophoresis (2-DE) method was carried out to obtain a better understanding of myelin biology. Although standard 2-...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21547
更新日期:2008-03-01 00:00:00
abstract::Growth hormone (GH) appears to play a major role in a reciprocal axis that has been postulated between the thymus and pituitary glands. Our previous studies showed that thymic structure, as well as T-cell proliferation and IL-2 synthesis, could be restored in aged female Wistar-Furth rats by the implantation of GH3 pi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490180118
更新日期:1987-01-01 00:00:00
abstract::Physiological responses to acute stress proceed with the activation of the hypothalamus-pituitary-adrenal gland (HPA) system. Many brain regions are known to modulate the HPA axis activation in stress responses, but the detailed neural circuits and signaling system in the upstream of the HPA axis have to be explored f...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22119
更新日期:2009-10-01 00:00:00
abstract::Preterm birth and associated brain injury are the primary cause of cerebral palsy and developmental disabilities and are among the most serious global health issues that modern society faces. Current therapy for infants suffering from premature brain injury is still mainly supportive, and there are no effective treatm...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24548
更新日期:2020-05-01 00:00:00
abstract::The most visible and, until very recently, the only hypothesis regarding the involvement of microglial cells in Alzheimer's disease (AD) pathogenesis is centered around the notion that activated microglia are neurotoxin-producing immune effector cells actively involved in causing the neurodegeneration that is the caus...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.20093
更新日期:2004-07-01 00:00:00
abstract::The effects of extracellular acidification on the synaptic function and neuronal excitability were investigated on the hippocampal CA1 neurons. A decrease of extracellular pH from 7.4 to 6.7 did not alter either the resting membrane potential or the neuronal membrane input resistance. Extracellularly recorded field ex...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20001101)62:3<403::AID-JNR11>3.0
更新日期:2000-11-01 00:00:00
abstract::Sphingolipidoses are a class of inherited diseases that result from the toxic accumulation of undigested sphingolipids in lysosomes and other cellular membranes. Sphingolipids are particularly enriched in cells of the nervous system, and their excessive accumulation during disease has a significant impact on the nervo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23763
更新日期:2016-11-01 00:00:00