Purinergic receptor activation evokes neurotrophic factor neuropeptide Y release from neonatal mouse olfactory epithelial slices.

abstract：:During late postnatal development, mice with the autosomal recessive wobbler mutation (wr/wr) develop motoneuron degeneration associated with astrogliosis in the spinal cord. In vitro, primary wobbler astrocytes are also affected, exhibiting abnormal cell-cell contacts. To characterize further the wobbler disease, we ...

journal_title：Journal of neuroscience research

authors： Aït-Ikhlef A,Hantaz-Ambroise D,Henderson CE,Rieger F

更新日期：2000-01-01 00:00:00

abstract：:Ephrins and Eph receptors are a family of molecules that have been implicated in axonal pathfinding. A unique feature of B-class ephrins and Eph receptors is their ability to transmit bidirectional signals in both ephrin- and Eph receptor-expressing cells upon cell-cell contact. These signals can lead to cytoskeletal ...

journal_title：Journal of neuroscience research

authors： Liebl DJ,Morris CJ,Henkemeyer M,Parada LF

更新日期：2003-01-01 00:00:00

abstract：:We here reconsider current theories of neural ensembles in the context of recent discoveries about neuronal dendritic physiology. The key physiological observation is that the dendritic plateau potential produces sustained depolarization of the cell body (amplitude 10-20 mV, duration 200-500 ms). Our central hypothesi...

journal_title：Journal of neuroscience research

authors： Antic SD,Hines M,Lytton WW

更新日期：2018-09-01 00:00:00

abstract：:We have proposed that lactate is a "volume transmitter" in the brain and underpinned this by showing that the lactate receptor, G-protein-coupled receptor 81 (GPR81, also known as HCA1 or HCAR1), which promotes lipid storage in adipocytes, is also active in the mammalian brain. This includes the cerebral neocortex and...

journal_title：Journal of neuroscience research

authors： Morland C,Lauritzen KH,Puchades M,Holm-Hansen S,Andersson K,Gjedde A,Attramadal H,Storm-Mathisen J,Bergersen LH

更新日期：2015-07-01 00:00:00

abstract：:Ischemia elicits a variety of stress responses in neuronal cells, which result in cell death. wld(S) Mice bear a mutation that significantly delays Wallerian degeneration. This mutation also protects all neuronal cells against other types of stresses resulting in cell death, including ischemia. To clarify the types of...

journal_title：Journal of neuroscience research

authors： Tokunaga S,Araki T

更新日期：2012-03-01 00:00:00

abstract：:Noise exposure is one of the most common causes of hearing loss. Recent studies found that noise exposure-induced cochlear damage may change the excitability and tonotopic organization of the central auditory system (CAS). This plasticity was suspected to be related to tinnitus and hyperacusis. However, how cochlear d...

journal_title：Journal of neuroscience research

authors： Niu Y,Kumaraguru A,Wang R,Sun W

更新日期：2013-02-01 00:00:00

abstract：:The activity levels of pyruvate dehydrogenase, enzymes of the citric acid cycle, aspartate and alanine aminotransferases, and NADP+-isocitrate dehydrogenase were determined in the cerebral cortex, cerebellum, brain stem, corpus striatum, hippocampus, and midbrain regions of normal rats and rats injected with acute and...

journal_title：Journal of neuroscience research

authors： Ratnakumari L,Subbalakshmi GY,Murthy CR

更新日期：1985-01-01 00:00:00

abstract：:There are two types of calcium-activated neutral protease (CANP), m-CANP and mu-CANP, following the nomenclature of Suzuki et al to show that each requires mM and microM Ca2+, respectively, for its activation. We found mu-CANP activity in a crude CANP fraction extracted from the peripheral nerve, which degraded the ne...

journal_title：Journal of neuroscience research

authors： Kamakura K,Ishiura S,Suzuki K,Sugita H,Toyokura Y

更新日期：1985-01-01 00:00:00

abstract：:Unilateral eye removal results in an increased delivery of blood-borne glucose, norepinephrine, choline, and tyrosine, but not of proline, to the denervated optic lobes. Administration of reserpine to chicks increases penetrance of norepinephrine into the brain but not of tyrosine, choline, or proline. Selective alter...

journal_title：Journal of neuroscience research

authors： Walker JB,Walker JP,Bondy SC,Purdy J

更新日期：1975-01-01 00:00:00

abstract：:We have recently reported a potent mitogenic stimulation of oligodendroglial (OL) progenitors by the protein kinase C (PKC) activating phorbol ester, i.e., phorbol 12-myristate 13-acetate (PMA) (Bhat NR, J Neurosci Res 22:20-27, 1989). The present study deals with PMA-induced protein phosphorylation reactions in cultu...

journal_title：Journal of neuroscience research

authors： Bhat NR

更新日期：1991-10-01 00:00:00

abstract：:In this Mini-Review we present a new hypothesis in support of the neurodegenerative theory as a mechanism for the pathogenesis of multiple sclerosis (MS). The pathogenesis of MS results from changes in two distinct CNS compartments. These are the "myelin" and "nonmyelin" compartments. The myelin compartment is where p...

journal_title：Journal of neuroscience research

authors： Mastronardi FG,Moscarello MA

更新日期：2005-05-01 00:00:00

abstract：:The high circulating levels of leptin in neonatal rodents do not seem to be regulating energy balance at this age, but rather may play an important role for brain development. We tested the hypothesis that high neonatal leptin levels modify hippocampal function and production of synaptic proteins with possible long-te...

journal_title：Journal of neuroscience research

authors： Walker CD,Long H,Williams S,Richard D

更新日期：2007-03-01 00:00:00

abstract：:The presence of oligodendrocyte precursor cells which cannot be removed from primary cultures by antibody-dependent techniques complicates the interpretation of transplantation experiments designed to examine the potential of astrocytes to influence remyelination (Blakemore et al.; Glia 13:79-91, 1995). In the present...

journal_title：Journal of neuroscience research

authors： Crang AJ,Blakemore WF

更新日期：1997-07-01 00:00:00

abstract：:The types of cells contacted by growth cones were examined in chick-quail and vice versa chimeras. Simultaneously, the presence of nonspecific cholinesterase (nChE) was monitored in developing peripheral nerves of these embryos. In all the chimeras studied, the growth cones were in contact with both Schwann cell proge...

journal_title：Journal of neuroscience research

authors： Haninec P,Dubový P

更新日期：1992-02-01 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of unknown etiology. Both genetic-susceptibility and environment exposures, including vitamin D deficiency, Epstein-Barr viral and Herpesvirus (HHV-6) infections are strongly implicated in the activation of T cells and MS-pathogenesis. Despite precis...

journal_title：Journal of neuroscience research

authors： Tiwari S,Lapierre J,Ojha CR,Martins K,Parira T,Dutta RK,Caobi A,Garbinski L,Ceyhan Y,Esteban-Lopez M,El-Hage N

更新日期：2018-12-01 00:00:00

abstract：:The ErbB family, ErbB1 (also known as the epidermal growth factor receptor EGFR), ErbB2, ErbB3, and ErbB4 comprise a group of receptor tyrosine kinases that interact with ligands from the epidermal growth factor (EGF) superfamily, subsequently dimerize, catalytically activate each other by cross-phosphorylation, and t...

journal_title：Journal of neuroscience research

authors： Fox IJ,Kornblum HI

更新日期：2005-03-01 00:00:00

abstract：:Microglia, the resident macrophages of the central nervous system, are the primary cells to respond to injury in the brain, both in inflammation, e.g., in multiple sclerosis, and trauma. Chemokines are potential mediators of microglial cell recruitment to sites of injury; thus, the ability of microglia to migrate in r...

journal_title：Journal of neuroscience research

authors： Cross AK,Woodroofe MN

更新日期：1999-01-01 00:00:00

abstract：:The effects of fetal asphyxia on cerebral function and development, involve the transition from fetal to neonatal life. Changes in cerebral glucose metabolism may be an early postnatal indicator of fetal asphyxia. The objective is to develop an experimental lamb model involving the transition from fetal to neonatal li...

journal_title：Journal of neuroscience research

authors： Thorngren-Jerneck K,Ley D,Hellström-Westas L,Hernandez-Andrade E,Lingman G,Ohlsson T,Oskarsson G,Pesonen E,Sandell A,Strand SE,Werner O,Marsal K

更新日期：2001-12-01 00:00:00

abstract：:This investigation explores the central nervous system protein-synthetic responses to hemisection of the spinal cord. Adult male rats hemisected at mid T2 were given intravenous injections of 14C-leucine at 0.7, 30, or 70 days postoperative. Four hours later the T1, T2, T3, and C6 segments of the spinal cord and right...

journal_title：Journal of neuroscience research

authors： Luttge WG,Mannis MJ,Bernstein JJ

更新日期：1975-01-01 00:00:00

abstract：:The incidence of dementia and obstructive sleep apnea (OSA) increases with age. Late-onset Alzheimer's disease (AD) is an irreversible neurodegenerative disease of the elderly characterized by amyloid β (Aβ) plaques and neurofibrillary tangles. The disease involves widespread synaptic loss in the neocortex and the hip...

journal_title：Journal of neuroscience research

authors： Daulatzai MA

更新日期：2015-12-01 00:00:00

abstract：:Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vasospasm remain poorl...

journal_title：Journal of neuroscience research

authors： Kolias AG,Sen J,Belli A

更新日期：2009-01-01 00:00:00

abstract：:Intrinsic mechanisms that guide damaged axons to regenerate following spinal cord injury remain poorly understood. Manipulation of posttranslational modifications of key proteins in mature neurons could reinvigorate growth machinery after injury. One such modification is acetylation, a reversible process controlled by...

journal_title：Journal of neuroscience research

authors： Lin S,Nazif K,Smith A,Baas PW,Smith GM

更新日期：2015-08-01 00:00:00

abstract：:In the embryonic and postnatal rat retina a cell surface antigen that is detected by monoclonal antibody JONES is distributed in a dorsoventral gradient. Biochemical analysis has determined that the antigen is a modified ganglioside, 9-O-acetyl GD3. In the present study, the distributions of 9-O-acetyl GD3 and its pos...

journal_title：Journal of neuroscience research

authors： Sparrow JR,Barnstable CJ

更新日期：1988-10-01 00:00:00

abstract：:The localization of voltage-gated calcium channel (VGCC) alpha(1) subunits in cultured GABAergic mouse cortical neurons was examined by immunocytochemical methods. Ca(v)1.2 and Ca(v)1.3 subunits of L-type VGCCs were found in cell bodies and dendrites of GABA-immunopositive neurons. Likewise, the Ca(v)2.3 subunit of R-...

journal_title：Journal of neuroscience research

authors： Timmermann DB,Westenbroek RE,Schousboe A,Catterall WA

更新日期：2002-01-01 00:00:00

abstract：:The immunohistochemical distribution of microtubule-associated protein 2 (MAP2), being normally restricted to nerve cell bodies and dendrites, became altered in rat dorsal root ganglia and spinal cord neurons in cultures infected with rhesus rotavirus. MAP2 appeared in axons of both sources of neurons as displayed wit...

journal_title：Journal of neuroscience research

authors： Weclewicz K,Svensson L,Billger M,Holmberg K,Wallin M,Kristensson K

更新日期：1993-10-01 00:00:00

abstract：:We used intracellular recording to investigate the functional interaction between protein kinase C (PKC) and protein kinase A (PKA) signal transduction cascades in the control of transmitter release in the neuromuscular synapses from adult rats. Our results indicate that: 1) PKA and PKC are independently involved in a...

journal_title：Journal of neuroscience research

authors： Santafé MM,Garcia N,Lanuza MA,Tomàs M,Tomàs J

更新日期：2009-02-15 00:00:00

abstract：:The striatum plays an important role in learning, selecting, and executing actions. As a major input hub of the basal ganglia, it receives and processes a diverse array of signals related to sensory, motor, and cognitive information. Aberrant neural activity in this area is implicated in a wide variety of neurological...

journal_title：Journal of neuroscience research

authors： Lee K,Masmanidis SC

更新日期：2019-12-01 00:00:00

abstract：:GM1, GD1a, and GT1b inhibit both PDGF-stimulated and serum-stimulated DNA synthesis in Swiss 3T3 cells and the human glioma cell line U-1242 MG in a dose-dependent manner. The ganglioside inhibitory effect is counteracted in a dose-responsive fashion by serum such that ganglioside-induced inhibition is essentially abo...

journal_title：Journal of neuroscience research

authors： Saqr HE,Lee MC,Burkman AM,Yates AJ

更新日期：1995-07-01 00:00:00

abstract：:Studies of the effects of hypoglycemia on the brain using neurocognitive testing have suggested that mainly complex functions subserved by secondary and tertiary cortex are affected by mild to moderate hypoglycemia and that intensively treated patients with Type I diabetes mellitus (T1DM) may have altered sensitivity ...

journal_title：Journal of neuroscience research

authors： Driesen NR,Goldberg PA,Anderson AW,Tang L,Flanagan DE,Sherwin RS,Gore JC

更新日期：2007-02-15 00:00:00

abstract：:Scatchard analysis of saturation isotherms of [125I]-iodopindolol was used to characterize beta-adrenoceptor density (Bmax) and affinity constant (Kd) in female and male hamster Harderian glands. Single-point experiments were also completed in intact females, intact males, and castrated or superior cervical ganglionec...

journal_title：Journal of neuroscience research

authors： Pangerl A,Pangerl B,Buzzell GR,Jones DJ,Reiter RJ

更新日期：1989-04-01 00:00:00