Mice lacking adenylyl cyclase-5 cope badly with repeated restraint stress.

abstract：:Oligodendrocytes (OLs) show heterogeneous properties that depend on their location in the central nervous system (CNS). In this regard, the investigation of oligodendrocyte precursor cells (OPCs) derived from human pluripotent stem cells (hPSCs) should be reconsidered, particularly in cases of brain-predominant disord...

journal_title：Journal of neuroscience research

authors： Hermanto Y,Maki T,Takagi Y,Miyamoto S,Takahashi J

更新日期：2019-07-01 00:00:00

abstract：:Functional MRI (fMRI) on spinal cord-injured rodents at 4 and 8 weeks post injury (PI) is described. The paradigm for fMRI, based on electrical stimulation of rat paws, was automated using an in-house designed microprocessor-based controller that was interfaced to a stimulator. The MR images were spatially normalized ...

journal_title：Journal of neuroscience research

authors： Ramu J,Bockhorst KH,Mogatadakala KV,Narayana PA

更新日期：2006-11-01 00:00:00

abstract：:Early studies of murine experimental autoimmune encephalomyelitis (EAE) induced with myelin basic protein (MBP) divide various mouse strains into either "susceptible" or "resistant" phenotypes. Resistance is defined as lack of encephalitogenic responses after active immunization or adoptive transfer. It is now becomin...

journal_title：Journal of neuroscience research

authors： Shaw MK,Kim C,Hao HW,Chen F,Tse HY

更新日期：1996-09-15 00:00:00

abstract：:The cellular localization of calpain is important in understanding the roles that calpain may play in physiological function. We, therefore, examined calpain expression, activity, and immunofluorescent localization in primary cultures of rat oligodendrocytes. The mRNA expression of m-calpain was 64.8% (P = 0.0033) and...

journal_title：Journal of neuroscience research

authors： Ray SK,Neuberger TJ,Deadwyler G,Wilford G,DeVries GH,Banik NL

更新日期：2002-11-15 00:00:00

abstract：:The role of the NT-3 has been implicated in the survival of progenitor oligodendrocytes in culture. The object of this study was to investigate the expression of the TrkC receptor and its responsiveness in glial cells. We report the expression of two TrkC receptor isoforms in rat primary oligodendrocyte cultures, a gl...

journal_title：Journal of neuroscience research

authors： Kumar S,de Vellis J

更新日期：1996-06-01 00:00:00

abstract：:Calpain, an intracellular cysteine protease, has been widely reported to be involved in neuronal cell death. The purpose of this study is to investigate the role of calpain activation in axonal damage-induced retinal ganglion cell (RGC) death. Twelve-week-old male calpstatin (an endogenous calpain inhibitor) knockout ...

journal_title：Journal of neuroscience research

authors： Ryu M,Yasuda M,Shi D,Shanab AY,Watanabe R,Himori N,Omodaka K,Yokoyama Y,Takano J,Saido T,Nakazawa T

更新日期：2012-04-01 00:00:00

abstract：:Neurons in culture rely on the supply of exogenous cysteine for their glutathione synthesis. After application of cysteine to neuron-rich primary cultures, the glutathione content was doubled after a 4-hr incubation. The dipeptide cysteinylglycine (CysGly) was able to substitute for cysteine as exogenous glutathione p...

journal_title：Journal of neuroscience research

authors： Dringen R,Gutterer JM,Gros C,Hirrlinger J

更新日期：2001-12-01 00:00:00

abstract：:GM1, GD1a, and GT1b inhibit both PDGF-stimulated and serum-stimulated DNA synthesis in Swiss 3T3 cells and the human glioma cell line U-1242 MG in a dose-dependent manner. The ganglioside inhibitory effect is counteracted in a dose-responsive fashion by serum such that ganglioside-induced inhibition is essentially abo...

journal_title：Journal of neuroscience research

authors： Saqr HE,Lee MC,Burkman AM,Yates AJ

更新日期：1995-07-01 00:00:00

abstract：:Tau microtubule-associated proteins are believed to play a role in regulation of the growth of neuronal processes. In order to study the function of tau protein in vivo, we examined the inhibition of tau expression in PC12 cells by exposing the cells to tau antisense oligodeoxynucleotides. A specific retraction of neu...

journal_title：Journal of neuroscience research

authors： Hanemaaijer R,Ginzburg I

更新日期：1991-09-01 00:00:00

abstract：:The inherited deficiency of galactosylceramide beta-galactosidase (E.C. 3.2.1.46: galactocerebrosidase) activity results in globoid cell leukodystrophy in humans (Krabbe disease) and in mice (twitcher mutant). To determine whether Krabbe patients' cells complement twitcher cells to produce, in hybrid combination, grea...

journal_title：Journal of neuroscience research

authors： Skiba MC,Lyerla TA,Konola JT,Raghavan S

更新日期：1990-12-01 00:00:00

abstract：:Rapsyn is a key molecule involved in the formation of postsynaptic specializations at the neuromuscular junction, in its absence there are both pre- and post-synaptic deficits including failure to cluster acetylcholine receptors. Recently we have documented increases in both nerve-muscle branching and numbers of moton...

journal_title：Journal of neuroscience research

authors： Bartlett SE,Banks GB,Reynolds AJ,Waters MJ,Hendry IA,Noakes PG

更新日期：2001-06-15 00:00:00

abstract：:Quantitative evaluation of gamma-aminobutyric acid immunoreactivity (GABA-IR) in the hindlimb representation of the rat somatosensory cortex after 14 days of exposure to hypergravity (hyper-G) was conducted by using computer-assisted image processing. The area of GABA-IR axosomatic terminals apposed to pyramidal cells...

journal_title：Journal of neuroscience research

authors： D'Amelio F,Wu LC,Fox RA,Daunton NG,Corcoran ML,Polyakov I

更新日期：1998-07-15 00:00:00

abstract：:Unilateral eye removal results in an increased delivery of blood-borne glucose, norepinephrine, choline, and tyrosine, but not of proline, to the denervated optic lobes. Administration of reserpine to chicks increases penetrance of norepinephrine into the brain but not of tyrosine, choline, or proline. Selective alter...

journal_title：Journal of neuroscience research

authors： Walker JB,Walker JP,Bondy SC,Purdy J

更新日期：1975-01-01 00:00:00

abstract：:The brain is both central in orchestrating the response to stress, and, a very sensitive target when such response is not controlled. In fact, stress has long been associated with the onset and/or exacerbation of several neuropsychiatric disorders such as anxiety, depression, and drug addiction. The hippocampus is a k...

journal_title：Journal of neuroscience research

authors： Alviña K,Jodeiri Farshbaf M,Mondal AK

更新日期：2021-01-01 00:00:00

abstract：:Neuronal progenitors in the adult hippocampus continually proliferate and differentiate to the neuronal lineage, and ischemic insult promotes hippocampal neurogenesis. However, newborn neurons show a progressive reduction in numbers during the initial few weeks, therefore, enhanced survival of newborn neurons seems to...

journal_title：Journal of neuroscience research

authors： Sasaki T,Kitagawa K,Yagita Y,Sugiura S,Omura-Matsuoka E,Tanaka S,Matsushita K,Okano H,Tsujimoto Y,Hori M

更新日期：2006-11-01 00:00:00

abstract：:The purpose of this study was to determine how oligodendrocytes die following Fas receptor activation. An immortalized human oligodendrocyte hybrid line (MO3.13) was challenged with Fas ligand (FasL), and cell death was assessed by flow cytometry and DNA gel electrophoresis. Caspase activation was determined by either...

journal_title：Journal of neuroscience research

authors： Li W,Maeda Y,Ming X,Cook S,Chapin J,Husar W,Dowling P

更新日期：2002-07-15 00:00:00

abstract：:Motor neurons (MNs) are designated as alpha/gamma and fast/slow based on their target sites and the types of muscle fibers innervated; however, few molecular markers that distinguish between these subtypes are available. Here we report that osteopontin (OPN) is a selective marker of alpha MNs in the mouse spinal cord....

journal_title：Journal of neuroscience research

authors： Misawa H,Hara M,Tanabe S,Niikura M,Moriwaki Y,Okuda T

更新日期：2012-04-01 00:00:00

abstract：:The prenatal and early postnatal stages represent a critical time window for human brain development. Interestingly, this window partly overlaps with the maturation of the intestinal flora (microbiota) that play a critical role in the bidirectional communication between the central and the enteric nervous systems (mic...

journal_title：Journal of neuroscience research

authors： Eltokhi A,Janmaat IE,Genedi M,Haarman BCM,Sommer IEC

更新日期：2020-07-01 00:00:00

abstract：:Cultured Schwann cells treated with heregulin growth factor require costimulation with a cyclic adenosine monophosphate-elevating agent to produce maximal cell proliferation. Gene chip expression analysis was used to identify genes that are induced or repressed when Schwann cells are treated with heregulin and/or fors...

journal_title：Journal of neuroscience research

authors： Schworer CM,Masker KK,Wood GC,Carey DJ

更新日期：2003-08-15 00:00:00

abstract：:Heat shock protein 60 (HSP60) and HSP10 are mitochondrial chaperonin proteins and are responsible for the folding of newly imported proteins and 13 polypeptides encoded by mitochondrial DNA. The expressions of HSP60 and HSP10 are regulated simultaneously because these genes are localized head to head on chromosome, se...

journal_title：Journal of neuroscience research

authors： Kim SW,Lee JK

更新日期：2007-05-01 00:00:00

abstract：:Monoamine oxidase B (MAO-B) is well known as a therapeutic target for Parkinson's disease (PD). MAO-B inhibitors retain antiparkinsonism abilities to improve motor function and prevent neuronal loss by decreasing dopamine metabolism and oxidative stress in the brain. From the study to find novel antiparkinsonism drugs...

journal_title：Journal of neuroscience research

authors： Chung JY,Lee JW,Ryu CH,Min HK,Yoon YJ,Lim MJ,Park CH

更新日期：2015-08-01 00:00:00

abstract：:Previous studies from our laboratory suggest that Alzheimer's disease sera contain a repertoire of antibodies to the heavy neurofilament subunit (NF-H) and that a subpopulation of these antibodies bind specifically to epitopes highly enriched in NF-H isolated from the purely cholinergic electromotor neurons of Torpedo...

journal_title：Journal of neuroscience research

authors： Faigon M,Hadas E,Alroy G,Chapman J,Auerbach JM,Michaelson DM

更新日期：1991-08-01 00:00:00

abstract：:Cross-linking of alpha-synuclein and Lewy body formation have been implicated in the dopaminergic neuronal cell death observed in Parkinson's disease (PD); the mechanisms responsible, however, are not clear. Reactive oxygen species and advanced glycation end products (AGEs) have been found in the intracellular, alpha-...

journal_title：Journal of neuroscience research

authors： Shaikh S,Nicholson LF

更新日期：2008-07-01 00:00:00

abstract：:Traditionally, the sources of guidance cues for dendritic outgrowth are mainly associated with external bodies (A) rather than with the same neuron from which dendrites originate (B). To quantify the relationship between factors A and B as determinants of the adult dendritic shape, the morphology of 83 intracellularly...

journal_title：Journal of neuroscience research

authors： Samsonovich AV,Ascoli GA

更新日期：2003-01-15 00:00:00

abstract：:Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vasospasm remain poorl...

journal_title：Journal of neuroscience research

authors： Kolias AG,Sen J,Belli A

更新日期：2009-01-01 00:00:00

abstract：:After hemisection of the spinal cord in rats, alterations in amino acid incorporation into protein have been observed in brain and spinal cord. Proteins mediating these changes have been studied in the present experiment. Male, Long-Evans hooded rats were given either a laminectomy and dura incision (sham) at spinal s...

journal_title：Journal of neuroscience research

authors： Wells MR

更新日期：1980-01-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection in its human host often results in progressive dementia and encephalopathy in adults and children, respectively. The mechanisms underlying virus-induced neurocognitive dysfunction are not fully understood. However, several studies strongly suggest that secretory vi...

journal_title：Journal of neuroscience research

authors： Dong J,Xiong H

更新日期：2006-02-15 00:00:00

abstract：:In this study, we examined the neuroprotective effect of standardized Bacopa monniera extract (BME: BESEB CDRI-08) against the D-galactose (D-gal)-induced brain aging in rats. Experimental groups were subjected to contextual-associative learning task. We found that the administration of BME in the D-gal-treated group ...

journal_title：Journal of neuroscience research

authors： Prisila Dulcy C,Singh HK,Preethi J,Rajan KE

更新日期：2012-10-01 00:00:00

abstract：:The development of cells of the oligodendroglial lineage, from immature progenitor to myelinating cells, occurs largely in a neuronal environment, yet little is known about specific interactions between these 2 cell types. We have tested the effects of medium conditioned by cultures of rat cerebral cortical neurons (C...

journal_title：Journal of neuroscience research

authors： Hardy R,Reynolds R

更新日期：1993-04-01 00:00:00

abstract：:We previously demonstrated that a synthetic retinoic acid receptor agonist, Am80, attenuated intracerebral hemorrhage (ICH)-induced neuropathological changes and neurological dysfunction. Because inflammatory events are among the prominent features of ICH pathology that are affected by Am80, this study investigated th...

journal_title：Journal of neuroscience research

authors： Matsushita H,Hijioka M,Ishibashi H,Anan J,Kurauchi Y,Hisatsune A,Seki T,Shudo K,Katsuki H

更新日期：2014-08-01 00:00:00