Xeno-free culture for generation of forebrain oligodendrocyte precursor cells from human pluripotent stem cells.

abstract：:Mg2+ATPase and (Na+ + K+)ATPase activities were measured in clonal line NN hamster astroblasts and in clonal lines M1 and N1E-115 mouse neuroblastoma cells after the cells had been subjected to the acute and chronic actions of 100 mM ethanol. Exposure of the astroblasts to ethanol for periods as long as 68 days produc...

journal_title：Journal of neuroscience research

authors： Syapin PJ,Stefanovic V,Mandel P,Noble EP

更新日期：1976-01-01 00:00:00

abstract：:The GTP binding proteins Rhes and AGS1/Dexras1 define a subfamily of the Ras superfamily and have been shown to affect signaling by G-protein-coupled receptors. We tested the effects of both proteins at an early stage of signaling by dopamine receptors, activation of adenylyl cyclase. Rhes decreased dopamine D1 recept...

journal_title：Journal of neuroscience research

authors： Harrison LM,He Y

更新日期：2011-06-01 00:00:00

abstract：:The effects of blinding with or without pineal ablation on brain monoamine levels were studied in male rats. Brain dopamine (DA), norepinephrine (NE), epinephrine (E), and serotonin (5-HT) were measured by radioenzymatic assays. Four weeks following pinealectomy, E levels were significantly enhanced in the frontal cor...

journal_title：Journal of neuroscience research

authors： Niles LP,Brown GM,Mishra RK

更新日期：1983-01-01 00:00:00

abstract：:The incubation of murine thymocytes for 24 hr in the presence of cholinergic agonists induces selective proliferation of PNA- cells as measured by thymidine incorporation. The response of PNA- cells is mediated by the activation of nicotinic receptors. This conclusion is suggested by the inability of the muscarinic ag...

journal_title：Journal of neuroscience research

authors： Rossi A,Tria MA,Baschieri S,Doria G,Frasca D

更新日期：1989-11-01 00:00:00

abstract：:The ligand-activated transcription factor peroxisome proliferator-activated receptor beta (PPARbeta) is present in the brain and is implicated in the regulation of genes with potential roles in neurotoxicity. We sought to examine the role of PPARbeta in neuronal cell death by using the PPARbeta ligand GW0742. Primary ...

journal_title：Journal of neuroscience research

authors： Smith SA,Monteith GR,Robinson JA,Venkata NG,May FJ,Roberts-Thomson SJ

更新日期：2004-07-15 00:00:00

abstract：:We have used adult mouse superior cervical ganglia (SCG) to study the role of mitogen activated protein (MAP) kinase activity during axonal outgrowth in vitro. An initial peak in activity within the first hours of culture was followed by a substantially higher activity after 1 to 2 days, a time when axons were activel...

journal_title：Journal of neuroscience research

authors： Svensson B,Ekström PA

更新日期：1998-05-15 00:00:00

abstract：:F5 was identified originally as an interleukin-2-regulated gene in L2 cells, a murine helper T-lymphocyte clone. In adult mouse, F5 mRNA was expressed at a modest level in lymphoid tissues, at a high level in mature neurons in the nervous system, but not in other tissues. Although the F5 sequence is highly conserved o...

journal_title：Journal of neuroscience research

authors： Arai M,Cohen JA

更新日期：1993-10-15 00:00:00

abstract：:Mannitol, which is a cell-impermeable and nontoxic polyalcohol, has been shown to be a useful tool for reversible opening of the blood-brain barrier (BBB). Despite successful clinical trials, the molecular mechanism of the mannitol-induced changes in cerebral endothelial cells (CECs) are poorly understood. For our exp...

journal_title：Journal of neuroscience research

authors： Farkas A,Szatmári E,Orbók A,Wilhelm I,Wejksza K,Nagyoszi P,Hutamekalin P,Bauer H,Bauer HC,Traweger A,Krizbai IA

更新日期：2005-06-15 00:00:00

abstract：:The properties of neuronal plasma membranes are highly specialized, since they include the receptors by which many hormones, neurotransmitters, drugs, and toxins initiate their actions, as well as the components necessary for receiving synaptic input from a variety of sources and for generating the appropriate pattern...

journal_title：Journal of neuroscience research

authors： Poduslo SE,Chechik T,Filbin MT,Rosenfeld J

更新日期：1986-01-01 00:00:00

abstract：:We reported previously that stem cell factor (SCF) is produced mainly by neurons and that its receptor (c-kitR), encoded by the protooncogene c-kit, is expressed in microglia, suggesting that SCF/c-kitR signaling may be involved in neuron-microglia interactions. We now report that SCF supports microglial survival in c...

journal_title：Journal of neuroscience research

authors： Zhang SC,Fedoroff S

更新日期：1998-07-01 00:00:00

abstract：:We have previously shown that myelin-associated glycoprotein (MAG) inhibits neurite growth from a neuronal cell line. In this study we show that 60% of axonal growth cones of postnatal day 1 hippocampal neurons collapsed when they encountered polystyrene beads coated with recombinant MAG (rMAG). Such collapse was not ...

journal_title：Journal of neuroscience research

authors： Li M,Shibata A,Li C,Braun PE,McKerracher L,Roder J,Kater SB,David S

更新日期：1996-11-15 00:00:00

abstract：:Identification of behavioral loci through complex trait mapping remains a widely employed approach but suffers from poor gene localization and low replicability. Genome-tagged mice (GTMs) are overlapping sets of congenic strains spanning the whole genome and offer the possibilities of superior mapping power and reprod...

journal_title：Journal of neuroscience research

authors： Liu D,Singh RP,Khan AH,Bhavsar K,Lusis AJ,Davis RC,Smith DJ

更新日期：2003-11-15 00:00:00

abstract：:Little is known about the structural neural substrates that may contribute to sex differences in risk-taking propensity (RTP). A close association between risk-seeking behavior and the emotional-regulation network led us to hypothesize that the sex differences in RTP would be associated with sex differences in brain m...

journal_title：Journal of neuroscience research

authors： Bajaj S,Killgore WDS

更新日期：2020-02-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is well known to play a critical role in cognition. Its role in mood disorders, including post stroke depression (PSD), is also recognized with more evidence surfacing. In patients with PSD, their serum BNDF level is lower than in those without depression. Furthermore, antidepr...

journal_title：Journal of neuroscience research

authors： Zhang E,Liao P

更新日期：2020-03-01 00:00:00

abstract：:Fast oscillations at approximately 200 Hz, termed ripples, occur in the hippocampus and cortex of several species, including humans, and are thought to play a role in physiological (e.g., sensory information processing or memory consolidation) and pathological (e.g., seizures) processes. Blocking gamma-aminobutyric ac...

journal_title：Journal of neuroscience research

authors： D'Antuono M,de Guzman P,Kano T,Avoli M

更新日期：2005-04-01 00:00:00

abstract：:Peroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important proc...

journal_title：Journal of neuroscience research

authors： Dringen R,Pawlowski PG,Hirrlinger J

更新日期：2005-01-01 00:00:00

abstract：:We have studied the effect of induced glial fibrillary acidic protein (GFAP) on motility, cell morphology, and proliferation of two originally GFAP-negative human glioma cell lines. Glioma cell lines U-1242 MG and U-251 MG sp subclone 3A were transfected with a vector system that allows for an inducible GFAP expressio...

journal_title：Journal of neuroscience research

authors： Elobeid A,Bongcam-Rudloff E,Westermark B,Nistér M

更新日期：2000-04-15 00:00:00

abstract：:We have developed tendon chitosan tubes having the ability to bind peptides covalently, and the effectiveness of laminin peptides coupled to these tubular wall on nerve regeneration was examined in vivo. Bridge graft implantation (15 mm) into the sciatic nerve of SD rats was carried out using chitosan tubes having a t...

journal_title：Journal of neuroscience research

authors： Suzuki M,Itoh S,Yamaguchi I,Takakuda K,Kobayashi H,Shinomiya K,Tanaka J

更新日期：2003-06-01 00:00:00

abstract：:Hemin, the oxidized form of heme, is released from hemoglobin after CNS hemorrhage and may contribute to injury to surrounding tissue. The heme oxygenase (HO) enzymes catalyze the breakdown of hemin to biliverdin, carbon monoxide, and ferric iron. Although HO-2, the isoform expressed predominantly in neurons, accelera...

journal_title：Journal of neuroscience research

authors： Chen-Roetling J,Benvenisti-Zarom L,Regan RF

更新日期：2005-12-15 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q140s, mouse exon 1 H...

journal_title：Journal of neuroscience research

authors： Franich NR,Hickey MA,Zhu C,Osborne GF,Ali N,Chu T,Bove NH,Lemesre V,Lerner RP,Zeitlin SO,Howland D,Neueder A,Landles C,Bates GP,Chesselet MF

更新日期：2019-12-01 00:00:00

abstract：:Embryonic central nervous system neuroepithelial cells are a transient population of cells that give rise to neuronal and glial progenitors. In the E12-E16 embryonic rat spinal neural tube we have identified neuroepithelial cells as radially oriented cells expressing the GD3 ganglioside as recognized by the monoclonal...

journal_title：Journal of neuroscience research

authors： Bannerman PG,Oliver TM,Xu Z,Shieh A,Pleasure DE

更新日期：1996-09-01 00:00:00

abstract：:A novel approach was developed to raise a panel of monoclonal antibodies (mAb) against brain antigens using Xenopus oocytes as immunological vectors. Xenopus oocytes were injected to express proteins encoded by brain-derived mRNA extracted from rat cerebral cortex. A crude membrane preparation from mRNA-injected oocyt...

journal_title：Journal of neuroscience research

authors： Matute C,Tigyi GJ,Miledi R

更新日期：1991-05-01 00:00:00

abstract：:In contrast to its known anti-apoptotic activity in sympathetic neurons, immortal neuronal cell lines, and primary cultured immature neurons of the central nervous system (CNS), the role of Bcl-2 in CNS neurons in the adult brain is poorly understood. In the present study, we examined effects of overexpression of Bcl-...

journal_title：Journal of neuroscience research

authors： Wang HD,Fukuda T,Suzuki T,Hashimoto K,Liou SY,Momoi T,Kosaka T,Yamamoto K,Nakanishi H

更新日期：1999-07-01 00:00:00

abstract：:Oligodendrocyte responses in vitro to platelet-derived growth factor (PDGF) include proliferation, survival, migration, and changes in cell morphology and molecular expression. Studies of mixed glial cultures established that astrocytes secrete PDGF; thus astrocytes are considered to be key regulators of oligodendrocy...

journal_title：Journal of neuroscience research

authors： Ellison JA,Scully SA,de Vellis J

更新日期：1996-07-01 00:00:00

abstract：:NOD-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in a wide range of inflammatory diseases, including cancer, metabolic diseases, and...

journal_title：Journal of neuroscience research

authors： Kong X,Yuan Z,Cheng J

更新日期：2017-08-01 00:00:00

abstract：:In the present work, we analyzed whether endogenous and/or transplanted bone marrow mononuclear cells (BMMC) migrate spontaneously to the crushed sciatic nerve and whether they transdifferentiate into Schwann cells (SC) in order to help repair the damaged tissue. We also studied both the immunohistochemical evolution ...

journal_title：Journal of neuroscience research

authors： Usach V,Goitia B,Lavalle L,Martinez Vivot R,Setton-Avruj P

更新日期：2011-08-01 00:00:00

abstract：:Nonmotor symptoms of cognitive and affective nature are present in premotor and motor stages of Parkinson's disease (PD). Neurogenesis, the generation of new neurons, persists throughout the mammalian life span in the hippocampal dentate gyrus. Adult hippocampal neurogenesis may be severely affected in the course of P...

journal_title：Journal of neuroscience research

authors： Schlachetzki JC,Grimm T,Schlachetzki Z,Ben Abdallah NM,Ettle B,Vöhringer P,Ferger B,Winner B,Nuber S,Winkler J

更新日期：2016-01-01 00:00:00

abstract：:Biology of GnRH neurons is critically dependent on extracellular Ca(2+) (Ca(2+) (o)). We evaluated differences in gene expression patterns with low and high Ca(2+) (o) in an immortalized GnRH neuron line, GT1-7 cells. Mouse global oligonucleotide microarray was used to evaluate transcriptional differences among the ge...

journal_title：Journal of neuroscience research

authors： Bandyopadhyay S,Jeong KH,Hansen JT,Vassilev PM,Brown EM,Chattopadhyay N

更新日期：2007-03-01 00:00:00

abstract：:Anoxia during delivery is a complication that can disturb infant brain development leading to various types of neurological disorders. Our studies have shown that increased body temperature of newborn rats of both sexes intensifies the postanoxic oxidative stress and prevents triggering the endogenous adaptive respons...

journal_title：Journal of neuroscience research

authors： Kletkiewicz H,Maliszewska J,Jaworski K,Jermacz Ł,Smoliński DJ,Rogalska J

更新日期：2019-10-01 00:00:00

abstract：:This study tested the hypothesis that sensitivity to the Ca(2+) -induced loss of mitochondrial membrane potential (ΔΨ(m)) and the sensitivity of the loss of ΔΨ to mitochondrial permeability transition pore (PTP) inhibitors are different for neurons and astrocytes. Primary cultures of rat cortical neurons and astrocyte...

journal_title：Journal of neuroscience research

authors： Kahraman S,Bambrick LL,Fiskum G

更新日期：2011-12-01 00:00:00