Dopamine receptors mediate differential morphological effects on cerebral cortical neurons in vitro.

abstract：:Deletion of the tumor suppressor gene p53 has been shown to improve the outcome in experimental models of focal cerebral ischemia and kainate-induced seizures. To evaluate the potential role of p53 in traumatic brain injury, genetically modified mice lacking a functional p53 gene (p53(-/-), n = 9) and their wild-type ...

journal_title：Journal of neuroscience research

authors： Tomasevic G,Raghupathi R,Scherbel U,Wieloch T,McIntosh TK

更新日期：2010-11-15 00:00:00

abstract：:Maternal stress exerts long-lasting psychiatric and somatic on offspring, which persist into adulthood. However, the effect of maternal stress on the postnatal growth of pups has not been widely reported. In this study, we found that maternal immobilization stress (IS) during lactation resulted in low body weight of m...

journal_title：Journal of neuroscience research

authors： Gao P,Ishige A,Murakami Y,Nakata H,Oka J,Munakata K,Yamamoto M,Nishimura K,Watanabe K

更新日期：2011-03-01 00:00:00

abstract：:In cultured Schwann cells, single-channel and whole-cell K+ currents can be activated by depolarizing the membrane to values more negative than -50 mV. In elevated extracellular K+ concentration ([K+]o), however, single-channel activity and whole-cell currents could be recorded at more negative potentials. Thus, the t...

journal_title：Journal of neuroscience research

authors： Verkhratsky A,Hoppe D,Kettenmann H

更新日期：1991-02-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) coactivates a number of transcription factors critical for mitochondrial biogenesis. Previously, we found that the expression of PGC-1alpha is governed by neuronal activity, but the signaling mechanism is poorly understood. The present st...

journal_title：Journal of neuroscience research

authors： Liang HL,Dhar SS,Wong-Riley MT

更新日期：2010-02-15 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) regulates the proliferation and migration of olfactory bulb (OB) interneuron progenitors derived from the subventricular zone (SVZ), but the role of GABA in the differentiation of these progenitors has been largely unexplored. This study examines the role of GABA in the differentiation o...

journal_title：Journal of neuroscience research

authors： Akiba Y,Sasaki H,Huerta PT,Estevez AG,Baker H,Cave JW

更新日期：2009-08-01 00:00:00

abstract：:Cross-linking of alpha-synuclein and Lewy body formation have been implicated in the dopaminergic neuronal cell death observed in Parkinson's disease (PD); the mechanisms responsible, however, are not clear. Reactive oxygen species and advanced glycation end products (AGEs) have been found in the intracellular, alpha-...

journal_title：Journal of neuroscience research

authors： Shaikh S,Nicholson LF

更新日期：2008-07-01 00:00:00

abstract：:The occurrence of type-1 plasminogen activator inhibitor (PAI-1) in human cerebrospinal fluid (CSF) has not previously been reported. As a member of the serpin superfamily of serine protease inhibitors and an acute phase response component, PAI-1 has powerful potential roles in nervous system homeostasis. We have dete...

journal_title：Journal of neuroscience research

authors： Rao JS,Chen M,Festoff BW

更新日期：1993-02-15 00:00:00

abstract：:The normal innervation of structures in mouse foot pads was investigated with immunohistochemistry and confocal microscopy. Nerves were visualized by incubating Zamboni fixed, thick, frozen sections with antibodies to protein gene product 9.5 (PGP 9.5), vasoactive intestinal peptide, substance P, calcitonin gene-relat...

journal_title：Journal of neuroscience research

authors： Navarro X,Verdú E,Wendelscafer-Crabb G,Kennedy WR

更新日期：1995-05-01 00:00:00

abstract：:Apoptosis is a form of cell death historically defined by morphological and biochemical changes that occur in the cell body and nucleus. However, in contrast to nonneuronal cells in which apoptosis has been most intensively studied, neurons exhibit elaborate morphologies with synaptic connections often located at site...

journal_title：Journal of neuroscience research

authors： Mattson MP,Duan W

更新日期：1999-10-01 00:00:00

abstract：:It has been postulated that cellular glutamate is released into the extracellular fluid when the energy supply of the brain is compromised (i.e., anoxia or oxygen/glucose deprivation), and there the amino acid triggers the so-called excitotoxic cascade, causing neuronal death. Several mechanisms for this release have ...

journal_title：Journal of neuroscience research

authors： Martín ME,Muñoz FM,Dickinson DA,Forman HJ,Martín del Río R,Salinas M,Fando JL

更新日期：2005-10-01 00:00:00

abstract：:Leptin is a potent AMP kinase (AMPK) inhibitor that induces neuroprotection, neurogenesis, and angiogenesis when administered immediately after stroke. To dissociate these effects, we explored the effects of delayed administration of leptin, at 10 days after stroke onset, on neurogenesis and angiogenesis after stroke....

journal_title：Journal of neuroscience research

authors： Avraham Y,Dayan M,Lassri V,Vorobiev L,Davidi N,Chernoguz D,Berry E,Leker RR

更新日期：2013-02-01 00:00:00

abstract：:Peroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important proc...

journal_title：Journal of neuroscience research

authors： Dringen R,Pawlowski PG,Hirrlinger J

更新日期：2005-01-01 00:00:00

abstract：:Our previous work indicated that in E14 embryonic rat spinal cord cultures ciliary neuronotrophic factor (CNTF) exerted (1) a survival-promoting effect on motor neurons and on a large population of unidentified neurons, and (2) a regulatory role on the expression of ChAT and low affinity NGF receptor (LNGFR) in a popu...

journal_title：Journal of neuroscience research

authors： Magal E,Burnham P,Varon S

更新日期：1991-11-01 00:00:00

abstract：:Calcium/calmodulin-dependent serine kinase (CASK), a causative gene in X-linked mental retardation, carries out multiple functions in neurons, including vesicle trafficking of ion channels, synapse formation, and gene transcription. From a yeast two-hybrid screen, Krüppel-like zinc finger protein B cell lymphoma/COUP-...

journal_title：Journal of neuroscience research

authors： Kuo TY,Hong CJ,Chien HL,Hsueh YP

更新日期：2010-08-15 00:00:00

abstract：:Although gangliosides have been reported to enhance recovery from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced lesions of the substantia nigra, evidence as to whether the administered gangliosides actually reach this or any other site of lesion in the central nervous system (CNS) at which they putativel...

journal_title：Journal of neuroscience research

authors： Saulino MF,Schengrund CL

更新日期：1994-02-15 00:00:00

abstract：:The citric acid cycle forms a major metabolic hub and as such it is involved in many disease states involving energetic imbalance. In spite of the fact that it is being branded as a "cycle", during hypoxia, when the electron transport chain does not oxidize reducing equivalents, segments of this metabolic pathway rema...

journal_title：Journal of neuroscience research

authors： Chinopoulos C

更新日期：2013-08-01 00:00:00

abstract：:Oligodendrocytes have a high rate of synthetic activity and produce vast amounts of myelin. The membrane production requires specific sorting and transport processes and structural support. In culture, oligodendrocytes extend flat membranous sheets containing an extensive cytoskeletal network of microtubules (MTs) and...

journal_title：Journal of neuroscience research

authors： Richter-Landsberg C

更新日期：2000-01-01 00:00:00

abstract：:Parkinson's disease (PD) is the most common movement disorder associated with the elderly which, other than symptomatic therapies, has no effective treatment or preventive measures. Sirtuins and their pharmacological activators/inhibitors have been associated with a range of neuroprotective effects, and a large body o...

journal_title：Journal of neuroscience research

authors： Tang BL

更新日期：2017-04-01 00:00:00

abstract：:We reported previously that stem cell factor (SCF) is produced mainly by neurons and that its receptor (c-kitR), encoded by the protooncogene c-kit, is expressed in microglia, suggesting that SCF/c-kitR signaling may be involved in neuron-microglia interactions. We now report that SCF supports microglial survival in c...

journal_title：Journal of neuroscience research

authors： Zhang SC,Fedoroff S

更新日期：1998-07-01 00:00:00

abstract：:CD9 is a tetra-membrane-spanning glycoprotein involved in cell adhesion, migration, and proliferation in both the immune and the immature nervous system. In this study, CD9 expression was detected in myelin of mouse brain, starting at postnatal day 16. The amount of CD9 protein continuously increased with age and pers...

journal_title：Journal of neuroscience research

authors： Kagawa T,Mekada E,Shishido Y,Ikenaka K

更新日期：1997-10-15 00:00:00

abstract：:Chondroitinase ABC (Ch'ase ABC) is a bacterial lyase that degrades chondroitin sulfate (CS), dermatan sulfate, and hyaluronan glycosaminoglycans (GAGs). This enzyme has received significant attention as a potential therapy for promoting central nervous system and peripheral nervous system repair based on its degradati...

journal_title：Journal of neuroscience research

authors： Tester NJ,Plaas AH,Howland DR

更新日期：2007-04-01 00:00:00

abstract：:Netrin-1 regulates axon extension during embryonic development and is expressed by neurons and myelinating oligodendrocytes in the adult CNS. To investigate the potential role of netrin-1 after spinal cord injury, we examined the expression of netrin-1 and netrin receptors after sagittal myelotomy in adult rats. This ...

journal_title：Journal of neuroscience research

authors： Manitt C,Wang D,Kennedy TE,Howland DR

更新日期：2006-12-01 00:00:00

abstract：:The expression of gangliosides of the lactosylceramide (LC) and of the gangliotetraosylceramide (GTC) series on the surface of cells from rat embryonic cerebellar tissue was investigated by double-color indirect immunofluorescence. GD3 was assumed to be representative of LC and was detected using a specific monoclonal...

journal_title：Journal of neuroscience research

authors： Gravotta D,Ferreira A,Busciglio J,Caceres A,Landa CA,Maccioni HJ

更新日期：1990-02-01 00:00:00

abstract：:The analysis of proteins in damaged myelin is crucial to clarify the mechanisms of dysmyelination and demyelination. In the present study, proteomic analysis of myelin using a modified two-dimensional electrophoresis (2-DE) method was carried out to obtain a better understanding of myelin biology. Although standard 2-...

journal_title：Journal of neuroscience research

authors： Yamaguchi Y,Miyagi Y,Baba H

更新日期：2008-03-01 00:00:00

abstract：:Retinal microglia play an important role as resident immunocompetent and phagocytic cells in the event of injury and disease. Retinal microglia and microglia precursor transplantation show a rescue effect in ischemic retina and retinal degeneration. However, studies of retinal microglia have been hampered by the diffi...

journal_title：Journal of neuroscience research

authors： Jiang XS,Ni YQ,Liu TJ,Zhang M,Jiang R,Xu GZ

更新日期：2014-04-01 00:00:00

abstract：:To investigate the function of the dipeptide carnosine in the olfactory system, alterations of carnosine in the primary olfactory nerve after unilateral naris closure or olfactory bulb semilesion were studied by means of immunocytochemistry. After unilateral naris closure, carnosine staining showed no alteration, but ...

journal_title：Journal of neuroscience research

authors： Sakai M,Nagatsu I

更新日期：1993-04-15 00:00:00

abstract：:The present study examined the effects of high-altitude exposure on the pineal gland, the main source of production of melatonin. It was surmised that hypoxia experienced at high altitude, caused by decreased oxygen tension in the ambient air, might lead to some structural alterations in the pineal gland and, hence, a...

journal_title：Journal of neuroscience research

authors： Kaur C,Srinivasan KN,Singh J,Peng CM,Ling EA

更新日期：2002-02-15 00:00:00

abstract：:Sky (also known as "Tyro3" and "Rse") is a member of the Axl/Sky/Mer receptor tyrosine kinase family and has two immunoglobulin-like repeats and two fibronectin type III-like repeats in the extracellular domain. Gas6 is a ligand for all members of the Axl family, each of which (Axl, Sky, and c-Mer) has different affin...

journal_title：Journal of neuroscience research

authors： Funakoshi H,Yonemasu T,Nakano T,Matumoto K,Nakamura T

更新日期：2002-04-15 00:00:00

abstract：:The concentration of myelin basic protein (MBP) mRNA in primary cultures of cells dissociated from embryonic mouse cerebra and grown in the presence of varying amounts of thyroid hormone was measured using a 32P-labeled cDNA probe and a dot-blot procedure. The cDNA probe contained 1.85 kilobases of the gene for MBP. T...

journal_title：Journal of neuroscience research

authors： Shanker G,Campagnoni AT,Pieringer RA

更新日期：1987-01-01 00:00:00

abstract：:Molecular and behavioral timekeeping is regulated by the circadian system which includes the brain's suprachiasmatic nucleus (SCN) that translates environmental light information into neuronal and endocrine signals aligning peripheral tissue rhythms to the time of day. Despite the critical role of circadian rhythms in...

journal_title：Journal of neuroscience research

authors： Yaw AM,Duong TV,Nguyen D,Hoffmann HM

更新日期：2021-01-01 00:00:00