Abstract:
:Parkinson's disease (PD) is the most common movement disorder associated with the elderly which, other than symptomatic therapies, has no effective treatment or preventive measures. Sirtuins and their pharmacological activators/inhibitors have been associated with a range of neuroprotective effects, and a large body of work on sirtuins' influence on PD pathology has accumulated over the past decade. Here, evidence for sirtuins' activities as modifiers of PD pathology and how the mammalian sirtuin paralogues may have conflicting impacts on PD pathogenesis and disease progression is reviewed. The possible cellular and molecular mechanisms underlying sirtuin activities in PD are discussed in the light of current knowledge with reference to autophagy, mitochondrial homeostasis, and microtubule dynamics. © 2016 Wiley Periodicals, Inc.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Tang BLdoi
10.1002/jnr.23806subject
Has Abstractpub_date
2017-04-01 00:00:00pages
930-942issue
4eissn
0360-4012issn
1097-4547journal_volume
95pub_type
杂志文章,评审abstract::Recent experiments have shown that Arg, Lys, and Leu can be incorporated posttranslationally into proteins of regenerating sciatic nerves of rats. The present experiments investigate a mixture of 15 radioactive amino acids to determine if additional amino acids can be conjugated posttranslationally to proteins of rege...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250407
更新日期:1990-04-01 00:00:00
abstract::This essay discusses the directional movements of metazoan tissue cells generally, with special emphasis on neurons, in an attempt to show that the directional movements of all share fundamental similarities. ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.490130102
更新日期:1985-01-01 00:00:00
abstract::To scale up human neural stem/progenitor cell (NSPC) cultures for clinical use, we need to know how long these cells can live ex vivo without losing their ability to proliferate and differentiate; thus, a convenient method is needed to estimate the proliferative activity of human NSPCs grown in neurosphere cultures, a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10377
更新日期:2002-09-15 00:00:00
abstract::The gene mutated in the mouse open brain (opb) phenotype antagonizes sonic hedgehog-mediated signaling and encodes a small GTPase of the Rab family, Rab23. To date, the brain expression profile and exact mechanism of function of the Rab23 protein has remained unknown. Specific antibodies generated against Rab23 showed...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20788
更新日期:2006-05-01 00:00:00
abstract::In a number of pathological states of the brain, the activation of the inducible nitric oxide synthase (iNOS) plays a major role. Interleukin (IL)-1beta is believed to be an essential factor in the induction of iNOS. However, little is known about the cascade of events culminating in iNOS expression in vivo. To identi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1999-08-01 00:00:00
abstract::Human T-cell lymphotropic virus type I (HTLV-I) may infect up to 10% of peripheral blood T cells in patients with HTLV-I myelopathy. To examine the impact of HTLV-I infection on the abilities of T cells to present and respond to peptide antigen, we HTLV-I infected and subcloned a myelin basic protein peptide 84-102 (M...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960915)45:6<786::AID-JNR
更新日期:1996-09-15 00:00:00
abstract::Although the expression of hepatocyte growth factor (HGF) and its receptor, proto-oncogene c-met, has been demonstrated in the central nervous system (CNS), the function of HGF in the CNS was not fully understood. In the present studies, we determined the effects of HGF on neuronal development in neocortical explant a...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960301)43:5<554::AID-JNR
更新日期:1996-03-01 00:00:00
abstract::The distribution of phosphofructokinase (PFK) in gray and white matter regions of the rat nervous system was evaluated. Determinations of PFK activity revealed that cell body enriched regions (sensorimotor cortex) had a significantly higher level of activity than axonal regions (sciatic nerve, dorsal roots, and optic ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490210105
更新日期:1988-09-01 00:00:00
abstract::The molecular pathways underlying the neuroprotective effects of preconditioning are promising, potentially drugable targets to promote cell survival. However, these pathways are complex and are not yet fully understood. In this study we have established a paradigm of hypoxic preconditioning based on a chick embryo mo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22766
更新日期:2012-02-01 00:00:00
abstract::The cerebral neocortex is known to modulate asymmetrically certain components of the immune system. It was previously shown that large ablation of the left cortex reduces B and T cell-mediated responses, whereas symmetrical right lesions enhance these responses. We have studied the immunomodulatory role of the brain c...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490220212
更新日期:1989-02-01 00:00:00
abstract::Noise exposure is one of the most common causes of hearing loss. Recent studies found that noise exposure-induced cochlear damage may change the excitability and tonotopic organization of the central auditory system (CAS). This plasticity was suspected to be related to tinnitus and hyperacusis. However, how cochlear d...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23152
更新日期:2013-02-01 00:00:00
abstract::The neural cell adhesion molecule (NCAM) plays a key role in neural development, regeneration, and synaptic plasticity. The crystal structure of a fragment of NCAM comprising the three N-terminal immunoglobulin (Ig)-like modules indicates that the first and second Ig modules bind to each other, thereby presumably medi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22380
更新日期:2010-08-01 00:00:00
abstract::An aminopeptidase purified to homogeneity from cytosol of rat brain cleaved dynorphins having 5-17 residues and selected proenkephalins at the Tyr-Gly bond only to release Tyr and the desTyr fragments. The enzyme protein consisted of a single polypeptide chain of Mr 103,000 and was inhibited by puromycin, bestatin, an...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490110311
更新日期:1984-01-01 00:00:00
abstract::Factor Xa (FXa) plays a critical role in the coagulation cascade by generation of thrombin. During focal ischemia thrombin levels increase in the brain tissue and cause neural damage. This study examined the hypothesis that administration of the FXa inhibitor, apixaban, following focal ischemic stroke may have therape...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24253
更新日期:2018-08-01 00:00:00
abstract::Recombinant adeno-associated viral (AAV)-mediated therapeutic gene transfer to dorsal root ganglia (DRG) is an effective and safe tool for treating chronic pain. However, AAV with various constitutively active promoters leads to transgene expression predominantly to neurons, while glial cells are refractory to AAV tra...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24183
更新日期:2018-03-01 00:00:00
abstract::Rapsyn is a key molecule involved in the formation of postsynaptic specializations at the neuromuscular junction, in its absence there are both pre- and post-synaptic deficits including failure to cluster acetylcholine receptors. Recently we have documented increases in both nerve-muscle branching and numbers of moton...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1109
更新日期:2001-06-15 00:00:00
abstract::Neural expression of constitutive hsc70 mRNA and hyperthermia-inducible hsp70 mRNA is examined using radioactive and non-radioactive in situ hybridization procedures. A strong induction of hsp70 mRNA was noted in cell populations in cerebellar layers and in the brainstem which demonstrated expression of mRNA encoding ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410506
更新日期:1995-08-01 00:00:00
abstract::Brain zinc homeostasis is strictly controlled under healthy conditions, indicating the importance of zinc for physiological function in the brain. A part of zinc in the brain exists in the synaptic vesicles, is released from a subclass of glutamatergic neurons (i.e., zincergic neurons), and serves as a signal factor (...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23385
更新日期:2014-07-01 00:00:00
abstract::The cellular localization of calpain is important in understanding the roles that calpain may play in physiological function. We, therefore, examined calpain expression, activity, and immunofluorescent localization in primary cultures of rat oligodendrocytes. The mRNA expression of m-calpain was 64.8% (P = 0.0033) and...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10414
更新日期:2002-11-15 00:00:00
abstract::Adenosine signalling has an important role in cochlear protection from oxidative stress. In most tissues, intracellular adenosine kinase (ADK) is the primary route of adenosine metabolism and the key regulator of intracellular and extracellular adenosine levels. The present study provides the first evidence for ADK di...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22421
更新日期:2010-09-01 00:00:00
abstract::Changes in gene expression were examined in the brain of mice treated with a drug of abuse, 3,4-methylenedioxymethamphetamine (MDMA, also called Ecstasy). Frontal cortex and midbrain mRNA, analyzed by differential display polymerase chain reaction (DD-PCR) method, showed an altered expression of several cDNAs, 11 of w...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10571
更新日期:2003-04-15 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, has been implicated in the pathogenesis of several disorders and injuries in the central nervous system (CNS). Unlike IGF-I, which promotes CNS growth, TNF-alpha causes brain growth retardation and neural damage. Recently TNF-alpha has been shown to ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10512
更新日期:2003-03-01 00:00:00
abstract::Autonomic neuropathy in several neurodegenerative disorders results from disturbance in physiological functions of different cell types in the central and peripheral nervous systems. For a clearer understanding of the etiology and pathogenesis of the autonomic disorders it is necessary to create animal models in which...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980115)51:2<162::AID-JNR
更新日期:1998-01-15 00:00:00
abstract::We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis. The study has now been extended to examine the processes that underlie this transcriptional stimulation an...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320219
更新日期:1992-06-01 00:00:00
abstract::We have shown that ethanol exposure during embryogenesis affects a variety of parameters of neuronal growth. In this study we examined the direct effects of ethanol exposure on developing neuroblasts in culture. Neuroblast-enriched cultures derived from 3-day-old whole chick embryos were grown in the presence of ethan...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300305
更新日期:1991-11-01 00:00:00
abstract::Drebrins are developmentally regulated actin-binding proteins. In this study, we analyzed subcellular distribution of drebrin E in neuroblastoma cells (SH-SY5Y) in culture, especially in terms of its relationship to actin filaments. In undifferentiated cells, drebrin E was scattered as flocculus small dots along the s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490380205
更新日期:1994-06-01 00:00:00
abstract::Few diseases in clinical medicine cause as much diagnostic consternation as central nervous system (CNS) vasculitis because of its varying modes of presentation and frequently overlapping clinical and pathological features. There are no pathognomonic clinical or laboratory findings. The purpose of the present retrospe...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10180
更新日期:2002-03-15 00:00:00
abstract::Membrane compaction and adhesion at the major dense line (cytoplasmic apposition) of myelin, particularly in the central nervous system (CNS), is typically attributed to myelin basic protein (MBP). To explore the role of MBP in myelin membrane adhesion, we attempted to reconstitute the major dense line of myelin from ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000215)59:4<513::AID-JNR
更新日期:2000-02-15 00:00:00
abstract::L-deprenyl protects neurons in a number of in vivo and in vitro models and it has been postulated that it ameliorates some neurodegenerative disorders. Superoxide dismutase (SOD) is one of the enzymes responsible for the inactivation of oxygen free radicals, and one of the mechanisms of the effect of L-deprenyl is tho...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980715)53:2<235::AID-JNR
更新日期:1998-07-15 00:00:00
abstract::Recent data indicate that molecular mimicry may play a role in the pathogenesis of human-T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an immune-mediated disease of the central nervous system (CNS). Specifically, HAM/TSP patients developed antibodies that cross-reac...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20137
更新日期:2004-07-01 00:00:00