Actin-binding protein, drebrin, accumulates in submembranous regions in parallel with neuronal differentiation.

abstract：:Elk is a member of the eph family of receptor-like tyrosine kinases. Although its function is unknown, elk is postulated to play a role in nervous system development. Using Northern analysis, we examined the developmental regulation of RNAs encoding elk, and several ligands for the eph family of RTKs, the LERKs. Expre...

journal_title：Journal of neuroscience research

authors： Carpenter MK,Shilling H,VandenBos T,Beckmann MP,Cerretti DP,Kott JN,Westrum LE,Davison BL,Fletcher FA

更新日期：1995-10-01 00:00:00

abstract：:Metabolism of amyloid-beta peptide (A beta) is closely associated with the pathology and etiology of Alzheimer's disease (AD). Neprilysin is the only rate-limiting catabolic peptidase proven by means of reverse genetics to participate in A beta metabolism in vivo. The aim of the present study is to assess whether poss...

journal_title：Journal of neuroscience research

authors： Iwata N,Takaki Y,Fukami S,Tsubuki S,Saido TC

更新日期：2002-11-01 00:00:00

abstract：:The cellular constituents of the blood-brain barrier (BBB) must make finely tuned, regulatory responses to maintain microvascular homeostasis. The mechanisms by which this task is accomplished are largely unknown. However, it is thought they involve a series of cross-talk mechanisms among endothelial cells (EC), peric...

journal_title：Journal of neuroscience research

authors： Balabanov R,Beaumont T,Dore-Duffy P

更新日期：1999-03-01 00:00:00

abstract：:Reference genes are often used to normalize expression of data from real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR), and only a validation of their stability during a given experimental paradigm leads to reliable interpretations. The present study was thus designed to validate potentia...

journal_title：Journal of neuroscience research

authors： Pernot F,Dorandeu F,Beaup C,Peinnequin A

更新日期：2010-04-01 00:00:00

abstract：:To study the potential role of Alzheimer precursor protein A4 (APP) and beta-amyloid (A/beta) on aging motor neuron survival, expression of APP, A/beta, and choline acetyltransferase (ChaT) were investigated in aged rats after either distal axotomy or root avulsion injury. Approximately 45% in number of total aged spi...

journal_title：Journal of neuroscience research

authors： Xie Y,Yao Z,Chai H,Wong WM,Wu W

更新日期：2003-08-15 00:00:00

abstract：:Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue-derived mesenchymal stem cells (ADMSCs) were intrave...

journal_title：Journal of neuroscience research

authors： Park D,Yang G,Bae DK,Lee SH,Yang YH,Kyung J,Kim D,Choi EK,Choi KC,Kim SU,Kang SK,Ra JC,Kim YB

更新日期：2013-05-01 00:00:00

abstract：:Immunocytochemical studies indicated that Purkinje cells cultured from chick embryonic cerebellum (embryonic day 8) strongly express a glutamate transporter EAAT2 cloned from human brain (GLT-1 in rat brain). At both 7 days and 14 days in culture, Purkinje neurons accumulated 1 microM [3H]L-glutamate via a potent "hig...

journal_title：Journal of neuroscience research

authors： Meaney JA,Balcar VJ,Rothstein JD,Jeffrey PL

更新日期：1998-12-01 00:00:00

abstract：:Efficient functioning of maintenance and repair processes seem to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, under control of several genes termed vitagenes. These include members of the heat shock protein system,...

journal_title：Journal of neuroscience research

authors： Calabrese V,Ravagna A,Colombrita C,Scapagnini G,Guagliano E,Calvani M,Butterfield DA,Giuffrida Stella AM

更新日期：2005-02-15 00:00:00

abstract：:NRAGE, also denominated as MAGE-D1 or Dlxin-1, is firstly identified as a molecule interacting with NGF low affinity receptor p75NTR. It facilitates cell cycle arrest and NGF-dependent neuronal apoptosis. Here we report that NRAGE is downregulated while p75NTR is upregulated during the process of NGF-induced neuronal ...

journal_title：Journal of neuroscience research

authors： Feng Z,Li K,Liu M,Wen C

更新日期：2010-06-01 00:00:00

abstract：:Dopaminergic afferents from the mesencephalic areas, such as ventral tegmental area (VTA), synapse with the gamma-aminobutyric acid (GABA)-ergic interneurons in the prefrontal cortex (PFC). Pharmacological and electrophysiological data show that the reinforcement, the dependence-producing properties, as well as the ps...

journal_title：Journal of neuroscience research

authors： Li SP,Park MS,Kim JH,Kim MO

更新日期：2004-12-15 00:00:00

abstract：:GM1, GD1a, and GT1b inhibit both PDGF-stimulated and serum-stimulated DNA synthesis in Swiss 3T3 cells and the human glioma cell line U-1242 MG in a dose-dependent manner. The ganglioside inhibitory effect is counteracted in a dose-responsive fashion by serum such that ganglioside-induced inhibition is essentially abo...

journal_title：Journal of neuroscience research

authors： Saqr HE,Lee MC,Burkman AM,Yates AJ

更新日期：1995-07-01 00:00:00

abstract：:Changes in dopamine (DA) D(1), D(2), D(3), and D(4) receptors and serotonin 5-HT(1A) and 5-HT(2A) receptors in rat forebrain regions were autoradiographically quantified after continuous infusion of JL 13 [(5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine fumarate] for 28 days with osmotic minipumps...

journal_title：Journal of neuroscience research

authors： Moran-Gates T,Massari C,Graulich A,Liégeois JF,Tarazi FI

更新日期：2006-08-15 00:00:00

abstract：:The cerebral neocortex is known to modulate asymmetrically certain components of the immune system. It was previously shown that large ablation of the left cortex reduces B and T cell-mediated responses, whereas symmetrical right lesions enhance these responses. We have studied the immunomodulatory role of the brain c...

journal_title：Journal of neuroscience research

authors： Neveu PJ,Barnéoud P,Georgiades O,Vitiello S,Vincendeau P,Le Moal M

更新日期：1989-02-01 00:00:00

abstract：:Pathogenesis of Parkinson's disease and related catecholaminergic neurological disorders is closely associated with changes in the levels of tyrosine hydroxylase (TH). Therefore, investigation of the regulation of the TH gene system should assist in understanding the pathomechanisms involved in these neurological diso...

journal_title：Journal of neuroscience research

authors： Choi EY,Yang JW,Park MS,Sun W,Kim H,Kim SU,Lee MA

更新日期：2012-10-01 00:00:00

abstract：:In previous studies, we have shown that a traumatic lesion to the hippocampus of adult mice induces the transitory expression of TNF alpha and IL-1 alpha by neurons of different brain areas and also by glial cells at the site of injury. The aim of the present study was to establish whether the expression of TNF alpha ...

journal_title：Journal of neuroscience research

authors： Tchélingérian JL,Le Saux F,Jacque C

更新日期：1996-01-01 00:00:00

abstract：:The function of the prion protein is unknown despite suggestions it binds copper. Radioactive copper (Cu(67)) was used to demonstrate that histidine-dependent uptake of copper by cerebellar cells in culture is related to the level of PrP(c) expression. Copper is released by neurones at the synapse. Veratridine-induced...

journal_title：Journal of neuroscience research

authors： Brown DR

更新日期：1999-12-01 00:00:00

abstract：:Vascular smooth muscle (VSM) cells comprise one of the primary targets of the sympathetic nervous system and have been shown to secrete nerve growth factor (NGF). There is increasing evidence that changes in the levels of NGF in the adult may underlie certain pathological conditions. To investigate the potential role ...

journal_title：Journal of neuroscience research

authors： Creedon DJ,Tuttle JB

更新日期：1997-02-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is an extensively studied protein that is evolutionarily conserved and widely distributed in the brain of vertebrates. It acts via its cognate receptors TrkB and p75NTR and plays a central role in the developmental neurogenesis, neuronal survival, proliferation, differentiation...

journal_title：Journal of neuroscience research

authors： Anand SK,Mondal AC

更新日期：2020-05-01 00:00:00

abstract：:It has been postulated that the pathogenesis of Parkinson's disease (PD) is associated with mitochondrial dysfunction. Rotenone, an inhibitor of mitochondrial complex I, provides models of PD both in vivo and in vitro. We investigated the neuroprotective effect of D-beta-hydroxybutyrate (bHB), a ketone body, against r...

journal_title：Journal of neuroscience research

authors： Imamura K,Takeshima T,Kashiwaya Y,Nakaso K,Nakashima K

更新日期：2006-11-01 00:00:00

abstract：:One premise regarding the mechanism of injury-evoked neuroregeneration is that injured cells induce the release of neurotrophic factors to trigger neurogenesis. Extracellular purine nucleotides exert multiple neurotrophic actions in the central nervous system mediated via activation of purinergic receptors. However, w...

journal_title：Journal of neuroscience research

authors： Kanekar S,Jia C,Hegg CC

更新日期：2009-05-01 00:00:00

abstract：:Fetal low brain oxygenation may be an outcome of maternal complications during pregnancy and is associated with increased risk of cerebral palsy and periventricular leukomalacia in newborns. One treatment used for prevention of fetal brain damage is maternal treatment with MgSO(4). Although this treatment is indicated...

journal_title：Journal of neuroscience research

authors： Golan H,Kashtuzki I,Hallak M,Sorokin Y,Huleihel M

更新日期：2004-11-01 00:00:00

abstract：:Thymocyte differentiation antigen-1 (Thy-1) is a cell surface glycoprotein found on T cells and neurons and is involved in cell-to-cell interactions. In addition, Thy-1 knockouts (KO) are a potential mouse model of restless legs syndrome (RLS) based on clinical observations and the role of dopamine in the disease. In ...

journal_title：Journal of neuroscience research

authors： Carkaci-Salli N,Battula S,Wang X,Connor JR,Vrana KE

更新日期：2012-08-01 00:00:00

abstract：:The secretory capabilities of the serotonergic neuron C1 of cerebral ganglion of Helix pomatia were markedly reduced when it was cultured in contact with the wrong target neuron, C3. When the neuron B2, one of its physiological targets, was micromanipulated within the network made of intermingled neurites originating ...

journal_title：Journal of neuroscience research

authors： Ghirardi M,Naretto G,Fiumara F,Vitiello F,Montarolo PG

更新日期：2001-07-15 00:00:00

abstract：:Sensory axons do not regenerate into or within the spinal cord because of the presence of the axon regeneration inhibitor chondroitin sulfate proteoglycan (CSPG) on activated astrocytes. In the peripheral nervous system, CSPG associated with denervated Schwann cells retards axon regeneration, but regeneration occurs b...

journal_title：Journal of neuroscience research

authors： Kuffler DP,Sosa IJ,Reyes O

更新日期：2009-10-01 00:00:00

abstract：:Neuron-glia interactions at paranodal junctions play important roles in action potential propagation. Among their many functions, they contribute to the passive electrical properties of myelinated nerve fibers and actively regulate the polarized distribution of ion channels along axons. Despite their importance, relat...

journal_title：Journal of neuroscience research

authors： Ogawa Y,Rasband MN

更新日期：2009-11-15 00:00:00

abstract：:The expression of the immunoglobulin superfamily member myelin-associated glycoprotein (MAG) and the extracellular matrix glycoprotein tenascin-R (TN-R) by oligodendrocytes overlaps in time and space. The two molecules can be neurite outgrowth-inhibitory or -promoting depending on the neuronal cell type and the enviro...

journal_title：Journal of neuroscience research

authors： Yang H,Xiao ZC,Becker B,Hillenbrand R,Rougon G,Schachner M

更新日期：1999-03-15 00:00:00

abstract：:Mouse sciatic nerves were transected and 3 hr to 16 days later proximal segments were removed and homogenized. Supernatants of these segments or of normal sciatic nerves were added to Schwann cells maintained in Dulbecco's modified Eagle's medium (DMEM) + 15% fetal calf serum (FCS). After 6 days, Schwann cells were so...

journal_title：Journal of neuroscience research

authors： Zhang QL,Lin PX,Chang Y,Webster HD

更新日期：1994-04-01 00:00:00

abstract：:Nuclear inclusions formed by proteins with expanded polyglutamine tracts are found in several neurodegenerative diseases. The effect of nuclear inclusions formed by these disease proteins on the functional organization of the nucleus is only partially understood. In particular, it is not known whether polyglutamine di...

journal_title：Journal of neuroscience research

authors： Sun J,Xu H,Negi S,Subramony SH,Hebert MD

更新日期：2007-08-15 00:00:00

abstract：:To investigate the function of the dipeptide carnosine in the olfactory system, alterations of carnosine in the primary olfactory nerve after unilateral naris closure or olfactory bulb semilesion were studied by means of immunocytochemistry. After unilateral naris closure, carnosine staining showed no alteration, but ...

journal_title：Journal of neuroscience research

authors： Sakai M,Nagatsu I

更新日期：1993-04-15 00:00:00

abstract：:The inward-rectifier K(+) channel Kir4.1 is responsible for maintaining cochlear homeostasis and restoring neural excitability. The large-conductance calcium-activated K(+) channel (BK(Ca)) plays a key role in phase locking signals in the mammalian inner ear. To evaluate the influence of mitochondrial dysfunction on t...

journal_title：Journal of neuroscience research

authors： Zou J,Zhang Y,Yin S,Wu H,Pyykkö I

更新日期：2009-01-01 00:00:00