Target-dependent modulation of neurotransmitter release in cultured Helix neurons involves adhesion molecules.

abstract：:Regulatory factor X4 variant 3 (RFX4_v3) is a recently identified transcription factor specifically expressed in the brain. Gene disruption in mice demonstrated that interruption of a single allele (heterozygous, +/-) prevented formation of the subcommissural organ (SCO), resulting in congenital hydrocephalus, whereas...

journal_title：Journal of neuroscience research

authors： Zhang D,Zeldin DC,Blackshear PJ

更新日期：2007-12-01 00:00:00

abstract：:Contrary to widely held beliefs, the gene encoding proteolipid protein (PLP), the major structural protein of central nervous system myelin, is expressed in Schwann cells and their tumors. Proteolipid mRNA was identified in human acoustic neuromas and in rat and rabbit sciatic nerves using a human PLP cDNA as a probe....

journal_title：Journal of neuroscience research

authors： Puckett C,Hudson L,Ono K,Friedrich V,Benecke J,Dubois-Dalcq M,Lazzarini RA

更新日期：1987-01-01 00:00:00

abstract：:Neural stem cells can be propagated in culture as neurospheres, yielding neurons and glial cells upon differentiation. Although the neurosphere model is widely used, the functional properties of the neurosphere-derived neurons have been only partially characterized, and it is unclear whether repeated passaging alters ...

journal_title：Journal of neuroscience research

authors： Pagani F,Lauro C,Fucile S,Catalano M,Limatola C,Eusebi F,Grassi F

更新日期：2006-06-01 00:00:00

abstract：:Photopic L-type responses were recorded from the soma and the axon terminal of horizontal cells of the catfish (Ictalurus punctatus) retina in eye-cup preparations. The responses were produced by a spot of light with 100-micron diameter (intensity, 10 microW/cm2), which was flashed or steadily illuminated and swept al...

journal_title：Journal of neuroscience research

authors： Hida E,Negishi K,Naka KI

更新日期：1984-01-01 00:00:00

abstract：:The transport kinetics of the excitatory sulphur-containing amino acid (SAA) transmitter candidates, L-cysteine sulphinate (L-CSA), L-cysteate (L-CA), L-homocysteine sulphinate (L-HCSA), and L-homocysteate (L-HCA), together with their plasma membrane carrier specificity, was studied in cerebrocortical synaptosome frac...

journal_title：Journal of neuroscience research

authors： Grieve A,Butcher SP,Griffiths R

更新日期：1992-05-01 00:00:00

abstract：:Brain injury and neuroinflammation are pathophysiologic contributors to acute and chronic neurologic disorders, which are progressive diseases not fully understood. Mammalian metallothioneins I and II (MT-I&II) have significant neuroprotective functions, but the precise mechanisms underlying these effects are still un...

journal_title：Journal of neuroscience research

authors： Penkowa M,Tio L,Giralt M,Quintana A,Molinero A,Atrian S,Vasák M,Hidalgo J

更新日期：2006-05-01 00:00:00

abstract：:Cultured Schwann cells treated with heregulin growth factor require costimulation with a cyclic adenosine monophosphate-elevating agent to produce maximal cell proliferation. Gene chip expression analysis was used to identify genes that are induced or repressed when Schwann cells are treated with heregulin and/or fors...

journal_title：Journal of neuroscience research

authors： Schworer CM,Masker KK,Wood GC,Carey DJ

更新日期：2003-08-15 00:00:00

abstract：:Our previous results support the idea that CREB (cyclic AMP-response element binding protein) may be a mediator of neuroligand and growth factor signals that, coupled to different signal transduction pathways, play different roles at specific stages of oligodendrocyte development. In the early stages, when cells are i...

journal_title：Journal of neuroscience research

authors： Afshari FS,Chu AK,Sato-Bigbee C

更新日期：2001-10-01 00:00:00

abstract：:Gamma-Aminobutyric acid (GABA), the principal inhibitory neurotransmitter of CNS, has been consistently implicated in the pathophysiology of schizophrenia. GABA is synthesized from glutamate by the enzyme glutamic acid decarboxylase (GAD). Two isoforms of GAD have been identified and have been named GAD65 and GAD67 ba...

journal_title：Journal of neuroscience research

authors： Dracheva S,Elhakem SL,McGurk SR,Davis KL,Haroutunian V

更新日期：2004-05-15 00:00:00

abstract：:The Brn-3a transcription factor is critical for survival and differentiation of sensory neurons derived from neural crest cells (NCC). Interaction of Brn-3a with p53 results in differential effects on target gene expression, which profoundly affects fate of neuronal cells. Here we demonstrate colocalization of p53 in ...

journal_title：Journal of neuroscience research

authors： Hudson CD,Podesta J,Henderson D,Latchman DS,Budhram-Mahadeo V

更新日期：2004-12-15 00:00:00

abstract：:Currently, presymtomatic hematopoietic stem and progenitor cell transplantation (HSPCT) is the only therapeutic modality that alleviates Krabbe's disease (KD)-induced central nervous system damage. However, all HSPCT-treated patients exhibit severe deterioration in peripheral nervous system function characterized by m...

journal_title：Journal of neuroscience research

authors： Hu P,Li Y,Nikolaishvili-Feinberg N,Scesa G,Bi Y,Pan D,Moore D,Bongarzone ER,Sands MS,Miller R,Kafri T

更新日期：2016-11-01 00:00:00

abstract：:Four brain-specific, DNase I hypersensitive sites (HSS) have been mapped to the 5' flanking region of the mouse 68-kDa neurofilament gene. These sites are contained within a 1.7-kb sequence that confers neuronal specificity of expression of this gene in transgenic mice. To identify DNA sequences that might be involved...

journal_title：Journal of neuroscience research

authors： Ivanov TR,Brown IR

更新日期：1992-06-01 00:00:00

abstract：:Essential to understanding the roles proteins and structural elements play at the synapse is to understand the development, remodeling and reinnervation of peripheral neuromuscular junctions. It has, however, been a challenging task to label and visualize neuromuscular junctions. In this paper we demonstrate how adeno...

journal_title：Journal of neuroscience research

authors： Jacob JM,Zhou Q,Liu Y

更新日期：2000-07-01 00:00:00

abstract：:Neurotransmitter transporters are involved in termination of the synaptic neurotransmission and they also play a key role in neuroregulation and brain development. In this report, we describe the developmental distribution of the y-aminobutyric acid transporter GAT3 which transports gamma-aminobutyric acid (GABA) and ...

journal_title：Journal of neuroscience research

authors： Jursky F,Nelson N

更新日期：1999-02-01 00:00:00

abstract：:Treatment of chromaffin cells with nitric oxide (NO) donors (SNP and SNAP) and peroxynitrite produces a time- and dose-dependent necrotic and apoptotic cell death. Necrotic cell death was characterized by both an increase in lactate dehydrogenase and ATP release and changes in nuclei and cell morphology (as seen with ...

journal_title：Journal of neuroscience research

authors： Vicente S,Pérez-Rodríguez R,Oliván AM,Martínez Palacián A,González MP,Oset-Gasque MJ

更新日期：2006-07-01 00:00:00

abstract：:The rate and direction of neurite growth have been shown in a number of studies to be determined by the distribution of adhesive sites on the growth cone. Recent evidence showing that the application of extrinsic electric fields can redistribute membrane molecules and alter both the rate and direction of neurite growt...

journal_title：Journal of neuroscience research

authors： Freeman JA,Manis PB,Snipes GJ,Mayes BN,Samson PC,Wikswo JP Jr,Freeman DB

更新日期：1985-01-01 00:00:00

abstract：:Zinc ion elevation contributes to acute excitotoxic brain injury and correlates with the severity of dementia in chronic neurodegenerative diseases. Downstream control of zinc-triggered signals is believed to be an efficient countermeasure. In the current study, we examined whether the flavonoid luteolin (Lu) could pr...

journal_title：Journal of neuroscience research

authors： Zhou F,Qu L,Lv K,Chen H,Liu J,Liu X,Li Y,Sun X

更新日期：2011-11-01 00:00:00

abstract：:Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...

journal_title：Journal of neuroscience research

authors： Zeng Z,Yuan X,Liu G,Zeng X,Zeng X,Ng H,Chen H,Jiang T,Akasaki Y,Kessey K,Black KL,Yu JS

更新日期：2007-02-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) infection in its human host often results in progressive dementia and encephalopathy in adults and children, respectively. The mechanisms underlying virus-induced neurocognitive dysfunction are not fully understood. However, several studies strongly suggest that secretory vi...

journal_title：Journal of neuroscience research

authors： Dong J,Xiong H

更新日期：2006-02-15 00:00:00

abstract：:Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much pe...

journal_title：Journal of neuroscience research

authors： Lee SM,Lee JW,Song YS,Hwang DY,Kim YK,Nam SY,Kim DJ,Yun YW,Yoon DY,Hong JT

更新日期：2005-11-15 00:00:00

abstract：:Protein zero (P0) glycoprotein is the major integral membrane protein of the peripheral nervous system myelin in higher vertebrates. Previous findings indicate the formation of tetrameric assemblies from studies on isolated P0. To determine whether in intact myelin the P0 exists as oligomers, we isolated myelin from s...

journal_title：Journal of neuroscience research

authors： Thompson AJ,Cronin MS,Kirschner DA

更新日期：2002-03-15 00:00:00

abstract：:Accumulation of beta-amyloid protein (Abeta) in the brain is a hallmark of Alzheimer's disease (AD), and Abeta-mediated pathogenesis could result from increased production of Abeta or insufficient Abeta clearance by microglia, astrocytes, or the vascular system. Cell-surface receptors, such as scavenger receptors, mig...

journal_title：Journal of neuroscience research

authors： Nakamura K,Ohya W,Funakoshi H,Sakaguchi G,Kato A,Takeda M,Kudo T,Nakamura T

更新日期：2006-09-01 00:00:00

abstract：:The dentate gyrus is selectively reduced in size in the insulin-like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of...

journal_title：Journal of neuroscience research

authors： Cheng CM,Cohen M,Tseng V,Bondy CA

更新日期：2001-05-15 00:00:00

abstract：:This study was undertaken in order to establish the presence of pluripotential neuroblasts in the developing chick CNS. This has been suggested by our previous observations that expression of emerging neuronal phenotypes in the chick embryo CNS is affected by exposure to neurotrophic substances (i.e., GHRH, SRIF, NGF,...

journal_title：Journal of neuroscience research

authors： Kentroti S,Vernadakis A

更新日期：1995-08-01 00:00:00

abstract：:Ex vivo gene therapy is emerging as a promising approach for the treatment of neurodegenerative diseases and central nervous system (CNS) trauma. We have shown previously that human adult astrocytes can be expanded in vitro and can express various therapeutic transgenes (Ridet et al. [1999] Hum. Gene Ther. 10:271-280;...

journal_title：Journal of neuroscience research

authors： Ridet JL,Sarkis C,Serguera C,Zennou V,Charneau P,Mallet J

更新日期：2003-06-15 00:00:00

abstract：:It has been postulated that the pathogenesis of Parkinson's disease (PD) is associated with mitochondrial dysfunction. Rotenone, an inhibitor of mitochondrial complex I, provides models of PD both in vivo and in vitro. We investigated the neuroprotective effect of D-beta-hydroxybutyrate (bHB), a ketone body, against r...

journal_title：Journal of neuroscience research

authors： Imamura K,Takeshima T,Kashiwaya Y,Nakaso K,Nakashima K

更新日期：2006-11-01 00:00:00

abstract：:SH-SY5Y cells differentiate into neuronal-like cells and express marker proteins like growth-associated protein (GAP-43) and neuropeptide tyrosine when treated with a low concentration (16 nM) of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in the presence of growth factors or serum. Both control and d...

journal_title：Journal of neuroscience research

authors： Parrow V,Fagerström S,Meyerson G,Nånberg E,Påhlman S

更新日期：1995-08-15 00:00:00

abstract：:Nitric oxide (NO) is produced by the enzyme nitric oxide synthase (NOS) and has been implicated in inter- and intracellular communication in the nervous system. The present study was undertaken to assess the effects of sodium nitroprusside (SNP) and hydroxylamine (HOA), NO donors, on a dopamine (DA)-induced K+ current...

journal_title：Journal of neuroscience research

authors： Sawada M,Ichinose M,Stefano GB

更新日期：1997-11-01 00:00:00

abstract：:In order to identify the relative number of benzodiazepine (BZ) receptors in Purkinje and granule cells, the Purkinje cell degeneration (pcd) mutant mouse was used at different ages. In these mice, Purkinje cells have degenerated almost completely by 45-50 days of age. Granule cell loss occurs only later, and is most ...

journal_title：Journal of neuroscience research

authors： Vaccarino FM,Ghetti B,Wade SE,Rea MA,Aprison MH

更新日期：1983-01-01 00:00:00

abstract：:We have studied the effect of induced glial fibrillary acidic protein (GFAP) on motility, cell morphology, and proliferation of two originally GFAP-negative human glioma cell lines. Glioma cell lines U-1242 MG and U-251 MG sp subclone 3A were transfected with a vector system that allows for an inducible GFAP expressio...

journal_title：Journal of neuroscience research

authors： Elobeid A,Bongcam-Rudloff E,Westermark B,Nistér M

更新日期：2000-04-15 00:00:00