Abstract:
:Contrary to widely held beliefs, the gene encoding proteolipid protein (PLP), the major structural protein of central nervous system myelin, is expressed in Schwann cells and their tumors. Proteolipid mRNA was identified in human acoustic neuromas and in rat and rabbit sciatic nerves using a human PLP cDNA as a probe. Proteolipid protein itself was shown to be present in human and rat sciatic nerve Schwann cells by immunofluorescence microscopy and by Western blot analysis using antisera raised to a synthetic PLP polypeptide. Although easily detected in the Schwann cell body, PLP was not detected in the peripheral myelin itself, suggesting that the PLP is preferentially excluded from this portion of the Schwann cell membrane.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Puckett C,Hudson L,Ono K,Friedrich V,Benecke J,Dubois-Dalcq M,Lazzarini RAdoi
10.1002/jnr.490180402subject
Has Abstractpub_date
1987-01-01 00:00:00pages
511-8issue
4eissn
0360-4012issn
1097-4547journal_volume
18pub_type
杂志文章abstract::Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than ma...
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pub_type: 杂志文章
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journal_title:Journal of neuroscience research
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更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章
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doi:10.1002/1097-4547(20000715)61:2<172::AID-JNR8>3.0.
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