Abstract:
:Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much perturbed in mutant-type PS2 with elevated ryanodine-receptor (RyR) expression and intracellular calcium levels. Moreover, dantrolene, a blocker of RyR reduced the PS2 mutation-induced interference of cell differentiation and calcium release, but caffeine, an activator of RyR, exacerbated PS2 mutation-induced interference with cell differentiation. Our results indicate that mutant PS2 inhibits normal neuronal cell differentiation and that RyR-mediated calcium overrelease may be a significant factor.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Lee SM,Lee JW,Song YS,Hwang DY,Kim YK,Nam SY,Kim DJ,Yun YW,Yoon DY,Hong JTdoi
10.1002/jnr.20655keywords:
subject
Has Abstractpub_date
2005-11-15 00:00:00pages
542-50issue
4eissn
0360-4012issn
1097-4547journal_volume
82pub_type
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