Modulation of microtubule dynamics by the microtubule-associated protein 1a.

abstract：:Although increased neurogenesis has been described in rodent models of focal traumatic brain injury (TBI), the neurogenic response occurring after diffuse TBI uncomplicated by focal injury has not been examined to date, despite the pervasiveness of this distinct type of brain injury in the TBI patient population. Here...

journal_title：Journal of neuroscience research

authors： Bye N,Carron S,Han X,Agyapomaa D,Ng SY,Yan E,Rosenfeld JV,Morganti-Kossmann MC

更新日期：2011-07-01 00:00:00

abstract：:The balance of bone morphogenic protein (BMP), transforming growth factor-β (TGFβ)/activin/nodal, and Wnt signals regulates the early lineage segregation of human embryonic stem cells (ESCs). Here we demonstrate that a combination of small-molecule inhibitors of BMP (Dorsomorphin) and TGFβ/activin/nodal (SB431542) sig...

journal_title：Journal of neuroscience research

authors： Morizane A,Doi D,Kikuchi T,Nishimura K,Takahashi J

更新日期：2011-02-01 00:00:00

abstract：:Using a canine model of classical late-infantile neuronal ceroid lipofuscinosis (CLN2 disease), a study was conducted to evaluate the potential pharmacological activity of recombinant human tripeptidyl peptidase-1 (rhTPP1) enzyme replacement therapy administered directly to the cerebrospinal fluid (CSF). CLN2 disease ...

journal_title：Journal of neuroscience research

authors： Katz ML,Coates JR,Sibigtroth CM,Taylor JD,Carpentier M,Young WM,Wininger FA,Kennedy D,Vuillemenot BR,O'Neill CA

更新日期：2014-11-01 00:00:00

abstract：:Molecular and behavioral timekeeping is regulated by the circadian system which includes the brain's suprachiasmatic nucleus (SCN) that translates environmental light information into neuronal and endocrine signals aligning peripheral tissue rhythms to the time of day. Despite the critical role of circadian rhythms in...

journal_title：Journal of neuroscience research

authors： Yaw AM,Duong TV,Nguyen D,Hoffmann HM

更新日期：2021-01-01 00:00:00

abstract：:To promote neurite elongation, nerve growth cones must adhere to other surfaces. A complex of integral membrane glycoproteins mediates cell binding to the extracellular glycoproteins fibronectin and laminin (Horwitz et al., J Cell Biol 101:2134-2144, 1985). The receptor complex, named integrin, binds to fibronectin by...

journal_title：Journal of neuroscience research

authors： Letourneau PC,Pech IV,Rogers SL,Palm SL,McCarthy JB,Furcht LT

更新日期：1988-10-01 00:00:00

abstract：:Both IgCAMs and the actin cytoskeleton play critical roles in neuronal growth cone motility and guidance. However, it is unclear how IgCAM receptors transduce signals from the plasma membrane to induce actin remodeling. Previous studies have shown that local clustering and immobilization of apCAM, the Aplysia homolog ...

journal_title：Journal of neuroscience research

authors： Decourt B,Munnamalai V,Lee AC,Sanchez L,Suter DM

更新日期：2009-04-01 00:00:00

abstract：:We have used adult mouse superior cervical ganglia (SCG) to study the role of mitogen activated protein (MAP) kinase activity during axonal outgrowth in vitro. An initial peak in activity within the first hours of culture was followed by a substantially higher activity after 1 to 2 days, a time when axons were activel...

journal_title：Journal of neuroscience research

authors： Svensson B,Ekström PA

更新日期：1998-05-15 00:00:00

abstract：:Astrocytes purified from the neonatal rat brain were cultured for up to 3 weeks prior to being treated with agents that can induce reactive changes in astrocytes. These agents included dibutyryl cAMP, interleukin-1 beta, and macrophage conditioned media. After treating astrocytes for 3 days, the agents were removed an...

journal_title：Journal of neuroscience research

authors： Miller C,Tsatas O,David S

更新日期：1994-05-01 00:00:00

abstract：:Adult neurogenesis is influenced by blood-borne factors. In this context, greater or lesser vascular permeability along neurogenic niches would expose differentially neural stem cells (NSCs), transit amplifying cells (TACs), and neuroblasts to such factors. Here we evaluate endothelial cell morphology and vascular per...

journal_title：Journal of neuroscience research

authors： Colín-Castelán D,Ramírez-Santos J,Gutiérrez-Ospina G

更新日期：2016-02-01 00:00:00

abstract：:Astroglial cells play an important role in maintaining neuronal function in the adult and in the developing nervous system. Ethanol exposure induces profound alterations in the astrogliogenesis process, affecting important cell functions, including intracellular protein trafficking. Because the actin cytoskeleton play...

journal_title：Journal of neuroscience research

authors： Guasch RM,Tomas M,Miñambres R,Valles S,Renau-Piqueras J,Guerri C

更新日期：2003-05-15 00:00:00

abstract：:The non-receptor protein tyrosine kinase Fyn, which is a member of the Src family of kinases, has been shown to be essential for normal myelination and has been suggested to play a role in oligodendrocyte development. However, oligodendrocyte development has not been studied directly in cells lacking Fyn. Additionally...

journal_title：Journal of neuroscience research

authors： Sperber BR,McMorris FA

更新日期：2001-02-15 00:00:00

abstract：:Autonomic neuropathy in several neurodegenerative disorders results from disturbance in physiological functions of different cell types in the central and peripheral nervous systems. For a clearer understanding of the etiology and pathogenesis of the autonomic disorders it is necessary to create animal models in which...

journal_title：Journal of neuroscience research

authors： Sawada H,Nishii K,Suzuki T,Hasegawa K,Hata T,Nagatsu I,Kreitman RJ,Pastan I,Nagatsu T,Kobayashi K

更新日期：1998-01-15 00:00:00

abstract：:In previous studies, we have shown that a traumatic lesion to the hippocampus of adult mice induces the transitory expression of TNF alpha and IL-1 alpha by neurons of different brain areas and also by glial cells at the site of injury. The aim of the present study was to establish whether the expression of TNF alpha ...

journal_title：Journal of neuroscience research

authors： Tchélingérian JL,Le Saux F,Jacque C

更新日期：1996-01-01 00:00:00

abstract：:We investigated by (13)C nuclear magnetic resonance (NMR) the mechanisms underlying Li(+) effects on glutamatergic and GABAergic neurotransmission systems in the adult rat brain and in primary cultures of cortical neurons and astrocytes during the metabolism of (1-(13)C) glucose or (2-(13)C) acetate. Adult male rats r...

journal_title：Journal of neuroscience research

authors： Fonseca CP,Sierra A,Geraldes CF,Cerdán S,Castro MM

更新日期：2009-03-01 00:00:00

abstract：:Monitoring pathology/regeneration in experimental models of de-/remyelination requires an accurate measure not only of functional changes but also of the amount of myelin. We tested whether X-ray diffraction (XRD), which measures periodicity in unfixed myelin, can assess the structural integrity of myelin in fixed tis...

journal_title：Journal of neuroscience research

authors： Kirschner DA,Avila RL,Gamez Sazo RE,Luoma A,Enzmann GU,Agrawal D,Inouye H,Bunge MB,Kocsis J,Peters A,Whittemore SR

更新日期：2010-03-01 00:00:00

abstract：:Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of unknown etiology. Both genetic-susceptibility and environment exposures, including vitamin D deficiency, Epstein-Barr viral and Herpesvirus (HHV-6) infections are strongly implicated in the activation of T cells and MS-pathogenesis. Despite precis...

journal_title：Journal of neuroscience research

authors： Tiwari S,Lapierre J,Ojha CR,Martins K,Parira T,Dutta RK,Caobi A,Garbinski L,Ceyhan Y,Esteban-Lopez M,El-Hage N

更新日期：2018-12-01 00:00:00

abstract：:Previous studies on the NG2 chondroitin sulfate proteoglycan have shown that NG2 is expressed on A2B5-positive O2A progenitor cells, which are known to respond to platelet-derived growth factor (PDGF). In the accompanying paper (Nishiyama et al.; J Neurosci Res 43:299-314, 1996) we show that on O2A progenitors in the ...

journal_title：Journal of neuroscience research

authors： Nishiyama A,Lin XH,Giese N,Heldin CH,Stallcup WB

更新日期：1996-02-01 00:00:00

abstract：:Cultured Schwann cells treated with heregulin growth factor require costimulation with a cyclic adenosine monophosphate-elevating agent to produce maximal cell proliferation. Gene chip expression analysis was used to identify genes that are induced or repressed when Schwann cells are treated with heregulin and/or fors...

journal_title：Journal of neuroscience research

authors： Schworer CM,Masker KK,Wood GC,Carey DJ

更新日期：2003-08-15 00:00:00

abstract：:Heme oxygenase-1 (HO1) catalyzes oxidation of the heme molecule in concert with NADPH-cytochrome P450 reductase following the specific cleavage of heme into carbon monoxide, iron, and biliverdin, which is rapidly metabolized to bilirubin. HO1 is a stress-inducible protein that protects cells against oxidative injury, ...

journal_title：Journal of neuroscience research

authors： Kitamura Y,Ishida Y,Takata K,Mizutani H,Kakimura J,Inden M,Nakata J,Taniguchi T,Tsukahara T,Akaike A,Shimohama S

更新日期：2003-02-15 00:00:00

abstract：:Pinealocytes of various mammalian species contain abundant synaptic-like microvesicles (SLMVs) which are considered the endocrine equivalent of neuronal synaptic vesicles. Although the pinealocytes may thus be a suitable cellular model for experimental in vitro studies of SLMVs, nothing is known about the presence of ...

journal_title：Journal of neuroscience research

authors： Redecker P,Pabst H,Gebert A,Steinlechner S

更新日期：1997-03-01 00:00:00

abstract：:The effect of neonatal hyperthyroidism produced by injection of tri-iodothyronine (T3) on myelination and on the microperoxisomal population of the brain was studied in young rats. Data on the lipid composition of myelin show that myelinogenesis starts earlier in treated animals. In coincidence with the early appearan...

journal_title：Journal of neuroscience research

authors： Adamo AM,Aloise PA,Soto EF,Pasquini JM

更新日期：1990-03-01 00:00:00

abstract：:Muscle spindles are sensory receptors composed of specialized muscle fibers, known as intrafusal muscle fibers, along with the endings of sensory neuron axons that innervate these muscle fibers. Formation of muscle spindles requires neuregulin1 (NRG1), which is released by sensory axons, activating ErbB receptors in m...

journal_title：Journal of neuroscience research

authors： Herndon CA,Ankenbruck N,Fromm L

更新日期：2014-02-01 00:00:00

abstract：:Acrylamide (ACR) is an environmental toxicant and prototypic tool for studying mechanisms of peripheral neuropathies. Reductions in fast anterograde axonal transport (faAXT) are thought to be a critical step leading to axonal degeneration. Kinesin and microtubules (MT) were evaluated as molecular sites of action using...

journal_title：Journal of neuroscience research

authors： Sickles DW,Brady ST,Testino A,Friedman MA,Wrenn RW

更新日期：1996-10-01 00:00:00

abstract：:The molecular mechanisms by which extracellular guidance cues regulate axonal morphology are not fully understood. Recent findings suggest that increased activity of the protein kinase Akt promotes dendritic branching and elongation in hippocampal neurons. We tested whether expression of constitutively active Akt (CA-...

journal_title：Journal of neuroscience research

authors： Grider MH,Park D,Spencer DM,Shine HD

更新日期：2009-11-01 00:00:00

abstract：:Substance P (SP) acts as an immunoregulator by binding to specific functional cell surface receptors on a subpopulation of human T-helper lymphocytes. Receptors with similar properties have also been characterized on the human IM-9 B-lymphoblast cell line. Four distinct proteins of molecular weight (MW) 33,000, 58,000...

journal_title：Journal of neuroscience research

authors： McGillis JP,Organist ML,Scriven KH,Payan DG

更新日期：1987-01-01 00:00:00

abstract：:Efficient functioning of maintenance and repair processes seem to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, under control of several genes termed vitagenes. These include members of the heat shock protein system,...

journal_title：Journal of neuroscience research

authors： Calabrese V,Ravagna A,Colombrita C,Scapagnini G,Guagliano E,Calvani M,Butterfield DA,Giuffrida Stella AM

更新日期：2005-02-15 00:00:00

abstract：:We report a study of the characterization of voltage-activated potassium (K+) currents in retinal ON bipolar cells in zebrafish. At single-channels levels, the open probability of the K+ channels increased when the membrane potential was increased. The maximal open proportion was 0.76+/-0.05 under our testing conditio...

journal_title：Journal of neuroscience research

authors： Yu CJ,Li L

更新日期：2005-11-01 00:00:00

abstract：:The neural cell adhesion molecule L1 is a multidomain protein that plays important roles in cell adhesion, migration, and neurite outgrowth. It can interact with itself by a self-binding, i.e., homophilic adhesion mechanism (Kadmon et al.: J Cell Biol 110: 193-208, 1990a). To determine the domains of L1 involved in ho...

journal_title：Journal of neuroscience research

authors： Holm J,Appel F,Schachner M

更新日期：1995-09-01 00:00:00

abstract：:The five major antioxidant enzymes, glutathione, and in vivo or in vitro stimulated (Fe(++)-ascorbate) peroxidation were similar in old and young Rana perezi frogs. Long-term (2.5 months) treatment with aminotriazole strongly decreased cerebral catalase (CAT) activity and increased in vivo but not in vitro peroxidatio...

journal_title：Journal of neuroscience research

authors： Barja de Quiroga G,Pérez-Campo R,López-Torres M

更新日期：1990-07-01 00:00:00

abstract：:In eukaryotes, mitochondria are critical for cellular bioenergetics and mediating apoptosis. The transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) is an important regulator of mitochondrial biogenesis and function. However, the role of PGC-1alpha in neuronal a...

journal_title：Journal of neuroscience research

authors： Liang J,Yang Y,Zhu X,Wang X,Chen R

更新日期：2010-07-01 00:00:00