Rapid assessment of internodal myelin integrity in central nervous system tissue.

abstract：:An increased level of myelin basic protein (MBP) degradation peptide 80-89, representative of myelin breakdown, is detected in myelinating foetal rat brain aggregate cultures supplemented with peritoneal macrophages at a time coinciding with the onset of myelination. During the period of myelination, the proportion of...

journal_title：Journal of neuroscience research

authors： Copelman CA,Diemel LT,Gveric D,Gregson NA,Cuzner ML

更新日期：2001-12-15 00:00:00

abstract：:Music has a long history of healing or mitigating physical and mental illness in the clinical setting. We aimed to test changes in behavioral cognition and serum proteomics in rats undergoing music intervention (MI). The Morris water maze (MWM) was used to evaluate spatial learning and memory in rats. Serum protein ex...

journal_title：Journal of neuroscience research

authors： Xiong X,Han L,Liu S,Miao J,Luo M,Xue M,Wang X,Ni L,Yang J,Huang C

更新日期：2018-10-01 00:00:00

abstract：:Changes in gene expression were examined in the brain of mice treated with a drug of abuse, 3,4-methylenedioxymethamphetamine (MDMA, also called Ecstasy). Frontal cortex and midbrain mRNA, analyzed by differential display polymerase chain reaction (DD-PCR) method, showed an altered expression of several cDNAs, 11 of w...

journal_title：Journal of neuroscience research

authors： Peng W,Simantov R

更新日期：2003-04-15 00:00:00

abstract：:Six different types of spectral responses were recorded from horizontal cells under mesopic conditions in perfused retina, isolated from the dark-adapted mojarra (Eugerres plumieri). They were tentatively termed photopic Lr-, Lg1-, Lg2-, Lb-, and C-type, and scotopic L-type. The Lr-, Lg-, and Lb-type responses showed ...

journal_title：Journal of neuroscience research

authors： Negishi K,Salas R,Parthe V,Drujan BD

更新日期：1988-01-01 00:00:00

abstract：:The Brn-3a transcription factor is critical for survival and differentiation of sensory neurons derived from neural crest cells (NCC). Interaction of Brn-3a with p53 results in differential effects on target gene expression, which profoundly affects fate of neuronal cells. Here we demonstrate colocalization of p53 in ...

journal_title：Journal of neuroscience research

authors： Hudson CD,Podesta J,Henderson D,Latchman DS,Budhram-Mahadeo V

更新日期：2004-12-15 00:00:00

abstract：:Intracranial atherosclerosis (ICAS) is the most common etiology of ischemic stroke with the highest rate of stroke recurrence. Little is currently known of the association of circulating inflammation-regulatory microRNAs (miRNAs) with ICAS. In this review, we briefly discuss that ICAS is characterized as a dynamic and...

journal_title：Journal of neuroscience research

authors： Li J,Li K,Chen X

更新日期：2019-10-01 00:00:00

abstract：:Ferritin is the major iron storage protein and accounts for the majority of the iron in the brain. Thus, ferritin is a key component in protecting the brain from iron induced oxidative damage. The high lipid content, high rate of oxidative metabolism, and high iron content combine to make the brain the organ most susc...

journal_title：Journal of neuroscience research

authors： Connor JR,Boeshore KL,Benkovic SA,Menzies SL

更新日期：1994-03-01 00:00:00

abstract：:Metabotropic glutamate receptors (mGluRs) and calcium receptors (CaR) are closely related G protein-coupled receptors (GPCRs). The similar structural and functional properties of mGluRs and CaRs include conserved amino acid residues involved in glutamate binding in mGluRs and Ca2+ binding in the CaR. Furthermore, rece...

journal_title：Journal of neuroscience research

authors： Francesconi A,Duvoisin RM

更新日期：2004-02-15 00:00:00

abstract：:The role of intracellular proteases (e.g., calpains and caspases) in the pathophysiology of neuronal cell death has been extensively investigated. More recently, accumulating data have suggested that extracellular proteolysis also plays a critical role. The two major systems that modify the extracellular matrix in bra...

journal_title：Journal of neuroscience research

authors： Lo EH,Wang X,Cuzner ML

更新日期：2002-07-01 00:00:00

abstract：:We investigated the possible mechanisms how interferon (IFN)-beta may control T cell infiltration in the CNS in experimental autoimmune encephalomyelitis (EAE). Adoptive transfer (AT) EAE was induced in groups of six female Lewis rats. Animals were treated with 3 x 10(5) units of recombinant rat IFN-beta s.c. once at ...

journal_title：Journal of neuroscience research

authors： Schmidt J,Stürzebecher S,Toyka KV,Gold R

更新日期：2001-07-01 00:00:00

abstract：:Although alterations in adenylate cyclase (AC) activity and somatostatin (SRIF) receptor density have been reported in Alzheimer's disease, the effects of amyloid beta-peptide (Abeta) on these parameters in the hippocampus are unknown. Our aim was to investigate whether the peptide fragment Abeta(25-35) can affect the...

journal_title：Journal of neuroscience research

authors： Burgos-Ramos E,Hervás-Aguilar A,Puebla-Jiménez L,Boyano-Adánez MC,Arilla-Ferreiro E

更新日期：2007-02-01 00:00:00

abstract：:The chronic constriction injury (CCI) of the sciatic nerve is a nerve injury-based model of neuropathic pain (NP). Comorbidities of NP such as depression, anxiety, and cognitive deficits are associated with a functional reorganization of the medial prefrontal cortex (mPFC). Here, we have employed an adapted model of C...

journal_title：Journal of neuroscience research

authors： Medeiros P,de Freitas RL,Boccella S,Iannotta M,Belardo C,Mazzitelli M,Romano R,De Gregorio D,Coimbra NC,Palazzo E,Maione S

更新日期：2020-02-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) plays an important role in the differentiation, development, and survival of neural stem cells. In this study, we analyzed its effects on the stimulation of human umbilical cord blood-derived mesenchymal stem cells in terms of their potential to differentiate into neuron-like c...

journal_title：Journal of neuroscience research

authors： Lim JY,Park SI,Oh JH,Kim SM,Jeong CH,Jun JA,Lee KS,Oh W,Lee JK,Jeun SS

更新日期：2008-08-01 00:00:00

abstract：:Both the adenosine analogue 2-chloro-adenosine (2-CA) and the reducing sugar deoxy-D-ribose (dRib) induce apoptosis of astroglial cells in rat brain primary cultures (Abbracchio et al.: Biochem Biophys Res Commun 213:908-915, 1995). The present study was undertaken to elucidate by both morphological and cytofluorimetr...

journal_title：Journal of neuroscience research

authors： Ceruti S,Barbieri D,Veronese E,Cattabeni F,Cossarizza A,Giammarioli AM,Malorni W,Franceschi C,Abbracchio MP

更新日期：1997-02-15 00:00:00

abstract：:We have investigated the involvement of c-Jun in cell death induced by exposure of primary cultures of murine cerebellar granule cells to the glutamate receptor agonist kainate (KA) and evaluated its possible use as a marker for apoptosis. Using cerebellar granule cell neurones from postnatal day 7 mice, we found that...

journal_title：Journal of neuroscience research

authors： Cheung NS,Carroll FY,Larm JA,Beart PM,Giardina SF

更新日期：1998-04-01 00:00:00

abstract：:Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...

journal_title：Journal of neuroscience research

authors： Zeng Z,Yuan X,Liu G,Zeng X,Zeng X,Ng H,Chen H,Jiang T,Akasaki Y,Kessey K,Black KL,Yu JS

更新日期：2007-02-01 00:00:00

abstract：:Ca(2+) and synaptotagmin (a Ca(2+)-binding protein that regulates axolemmal fusion of synaptic vesicles) play essential roles in the repair of axolemmal damage in invertebrate giant axons. We now report that neurites of a rat pheochromocytoma (PC12) cell line transected and maintained in a serum medium form a dye barr...

journal_title：Journal of neuroscience research

authors： Detrait ER,Yoo S,Eddleman CS,Fukuda M,Bittner GD,Fishman HM

更新日期：2000-11-15 00:00:00

abstract：:Previously we reported the amplification of the peripheral myelin protein 22 (PMP22) gene in cell lines of human osteogenic and glioma tumors. PMP22 normally is expressed at high levels in Schwann cells of the peripheral nervous system and is suggested to function as a structural protein of the myelin sheath. One of t...

journal_title：Journal of neuroscience research

authors： Hühne K,Park O,Liehr T,Rautenstrauss B

更新日期：1999-12-01 00:00:00

abstract：:5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria. We have demonstrated recently that 5-hydroxyoxindole is an endogenous compound in blood and tissues of mammals, including humans. To date, 5-hydroxyoxindole's role...

journal_title：Journal of neuroscience research

authors： Crumeyrolle-Arias M,Tournaire MC,Rabot S,Malpaux B,Thiéry JC

更新日期：2008-01-01 00:00:00

abstract：:Light microscopic anterograde tracing studies indicate that neurons in the central nucleus of the amygdala (CNA) project to a region of the dorsal pontine tegmentum ventral to the superior cerebellar peduncle which contains noradrenergic dendrites of the nucleus locus coeruleus (LC). However, it has not been establish...

journal_title：Journal of neuroscience research

authors： Van Bockstaele EJ,Chan J,Pickel VM

更新日期：1996-08-01 00:00:00

abstract：:Raf kinases are downstream effectors of Ras and upstream activators of the MEK-ERK cascade. Ras and MEK-ERK signaling play roles in learning and memory (L&M) and neural plasticity, but the roles of Raf kinases in L&M and plasticity are unclear. Among Raf isoforms, B-raf is preferentially expressed in the brain. To det...

journal_title：Journal of neuroscience research

authors： Chen AP,Ohno M,Giese KP,Kühn R,Chen RL,Silva AJ

更新日期：2006-01-01 00:00:00

abstract：:The tissue- and cell-specific expression of three neutral glycosphingolipids, gangliotetraosylceramide (GA1), gangliopentaosylceramide (GalNAc-GA1), and the novel 3-O-acetyl-sphingosine-series glycolipid (FMC-5), were examined with monospecific polyclonal antibodies. Immunohistochemical studies of rodent brain cross-s...

journal_title：Journal of neuroscience research

authors： Dasgupta S,Bhat NR,Spicer SS,Hogan EL,Furuya S,Hirabayashi Y

更新日期：2007-10-01 00:00:00

abstract：:The extracellular matrix surrounds different neuronal compartments in the mature nervous system. In a variety of vertebrates, most brain regions are loaded with a distinct type of extracellular matrix around the somatodendritic part of neurons, termed perineuronal nets. The present study reports that chondrotin sulfat...

journal_title：Journal of neuroscience research

authors： Lendvai D,Morawski M,Brückner G,Négyessy L,Baksa G,Glasz T,Patonay L,Matthews RT,Arendt T,Alpár A

更新日期：2012-02-01 00:00:00

abstract：:It was previously reported that a monoclonal antibody to beta-amyloid precursor protein (mab22C11; Boehringer Mannheim, Indianapolis, IN) labels an intermediate filament-associated protein (beta APP-IFAP) in cultured human skin fibroblasts (Dooley et al.: J Neurosci Res 33:60-67, 1992). The time course of its expressi...

journal_title：Journal of neuroscience research

authors： Durham HD,Minotti S,Dooley NP,Nalbantoglu J

更新日期：1994-08-15 00:00:00

abstract：:The cholinergic neurons of the basal forebrain (CNBF) are the major source of cholinergic innervation of the cortex and hippocampus. In Alzheimer's disease and aged brain, there are severe losses of cholinergic neurons in the nucleus basalis of Meynert, leading to a reduction of cortical cholinergic activity which cor...

journal_title：Journal of neuroscience research

authors： Wörtwein G,Yu J,Toliver-Kinsky T,Perez-Polo JR

更新日期：1998-05-01 00:00:00

abstract：:The neuron-glia cell adhesion molecule (Ng-CAM) mediates neuron-neuron adhesion by a homophilic mechanism and neuron-astrocyte adhesion by a heterophilic mechanism. The protein is expressed on neurons and Schwann cells but not on astrocytes. It is most prevalent during development on cell bodies of migrating neurons a...

journal_title：Journal of neuroscience research

authors： Grumet M

更新日期：1992-01-01 00:00:00

abstract：:Cognitive decline in Parkinson's disease (PD) is a common sequela of the disorder that has a large impact on patient well-being. Its physiological etiology, however, remains elusive. Our study used graph theory analysis to investigate the large-scale topological patterns of the extrastriatal dopamine D2 receptor netwo...

journal_title：Journal of neuroscience research

authors： Mihaescu AS,Kim J,Masellis M,Graff-Guerrero A,Cho SS,Christopher L,Valli M,Díez-Cirarda M,Koshimori Y,Strafella AP

更新日期：2020-12-03 00:00:00

abstract：:Biology of GnRH neurons is critically dependent on extracellular Ca(2+) (Ca(2+) (o)). We evaluated differences in gene expression patterns with low and high Ca(2+) (o) in an immortalized GnRH neuron line, GT1-7 cells. Mouse global oligonucleotide microarray was used to evaluate transcriptional differences among the ge...

journal_title：Journal of neuroscience research

authors： Bandyopadhyay S,Jeong KH,Hansen JT,Vassilev PM,Brown EM,Chattopadhyay N

更新日期：2007-03-01 00:00:00

abstract：:Dopaminergic afferents from the mesencephalic areas, such as ventral tegmental area (VTA), synapse with the gamma-aminobutyric acid (GABA)-ergic interneurons in the prefrontal cortex (PFC). Pharmacological and electrophysiological data show that the reinforcement, the dependence-producing properties, as well as the ps...

journal_title：Journal of neuroscience research

authors： Li SP,Park MS,Kim JH,Kim MO

更新日期：2004-12-15 00:00:00

abstract：:Green fluorescent protein (GFP) transgenic zebrafish technology has been employed to directly visualize and analyze dynamic developmental processes, such as cell migration and morphogenesis. Stable transgenic zebrafish that express GFP in oligodendrocytes can be a valuable tool to visualize complex myelination process...

journal_title：Journal of neuroscience research

authors： Yoshida M,Macklin WB

更新日期：2005-07-01 00:00:00