Abstract:
:An increased level of myelin basic protein (MBP) degradation peptide 80-89, representative of myelin breakdown, is detected in myelinating foetal rat brain aggregate cultures supplemented with peritoneal macrophages at a time coinciding with the onset of myelination. During the period of myelination, the proportion of activated macrophages/microglia in the aggregates decreases, accompanied by a reduction in the content of MBP degradation products. During the recovery period following a demyelinating episode, the rate of MBP synthesis in antibody-treated standard aggregates was greater than in their medium controls. However, the rate of MBP accumulation was not as efficient in macrophage-enriched aggregates and was associated with persistently raised MBP peptide levels. Thus, as occurs in multiple sclerosis lesions, attempts at remyelination appear to be counterbalanced by macrophage-mediated demyelination, with the continued presence of degraded myelin rendering a local environment that is not fully conducive to remyelination.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Copelman CA,Diemel LT,Gveric D,Gregson NA,Cuzner MLdoi
10.1002/jnr.10026keywords:
subject
Has Abstractpub_date
2001-12-15 00:00:00pages
1173-8issue
6eissn
0360-4012issn
1097-4547pii
10.1002/jnr.10026journal_volume
66pub_type
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