Age- and concentration-dependent neuroprotection and toxicity by TNF in cortical neurons from beta-amyloid.

abstract：:gammadelta T cells represent a small subpopulation of T cells expressing a restricted repertoire of T-cell receptors and, unlike alphabeta T cells, function more as cells of the innate immune system. These cells are found in skin and mucosal sites as well as secondary lymphoid tissues and frequently act as first line ...

journal_title：Journal of neuroscience research

authors： Wohler JE,Smith SS,Barnum SR

更新日期：2010-01-01 00:00:00

abstract：:The human immunodeficiency virus type 1 (HIV-1) glycoprotein gp120 causes neuronal cell death; however, the molecular mechanisms of the neurotoxic effect remain largely unresolved. It has been suggested that gp120 evokes cell death by inducing the release of neurotoxins, including glutamate. The objective of this work...

journal_title：Journal of neuroscience research

authors： Bachis A,Mocchetti I

更新日期：2004-01-01 00:00:00

abstract：:Astrocytes are excitable neural cells that contribute to brain information processing via bidirectional communication with neurons. This involves the release of gliosignaling molecules that affect synapses patterning and activity. Mechanisms mediating the release of these molecules likely consist of non-vesicular and ...

journal_title：Journal of neuroscience research

authors： Jorgačevski J,Potokar M,Kreft M,Guček A,Mothet JP,Zorec R

更新日期：2017-11-01 00:00:00

abstract：:Adhesion responses triggered by integrin-class matrix receptors have been implicated in the synaptic reorganization events necessary for certain types of neuronal plasticity. Hippocampal slice cultures were used to test whether the related structural transformations elicited by NMDA receptor stimulation are regulated ...

journal_title：Journal of neuroscience research

authors： Bahr BA

更新日期：2000-03-15 00:00:00

abstract：:To identify and characterize the lineage potential of rat neural retina progenitor cells (NRPCs) in vitro and engrafted into rats with retinal degeneration, NRPCs were isolated from neural retinas of embryonic day 17 Long Evans rats and cultured in serum-free or serum-containing media with fibroblast growth factor 2 a...

journal_title：Journal of neuroscience research

authors： Yang P,Seiler MJ,Aramant RB,Whittemore SR

更新日期：2002-08-15 00:00:00

abstract：:The objective of the present investigation was to answer the following question: Does the visual cortex affect the neuronal firing of retinal ganglion cells in the rat? To test this hypothesis, the visual cortex was inactivated by a reversible cryoblockade. Action potentials of a ganglion cell were recorded from its a...

journal_title：Journal of neuroscience research

authors： Molotchnikoff S,Tremblay F

更新日期：1983-01-01 00:00:00

abstract：:The extension of filopodia from growth cones of regenerating neurites from rat superior cervical ganglion neurons in tissue culture was studied. Cultures were grown on a thin layer of fibrous collagen and maintained in a medium containing serum and nerve growth factor. Time-lapse cinematography and computer-assisted m...

journal_title：Journal of neuroscience research

authors： Argiro V,Bunge MB,Johnson MI

更新日期：1985-01-01 00:00:00

abstract：:Green fluorescent protein (GFP) transgenic zebrafish technology has been employed to directly visualize and analyze dynamic developmental processes, such as cell migration and morphogenesis. Stable transgenic zebrafish that express GFP in oligodendrocytes can be a valuable tool to visualize complex myelination process...

journal_title：Journal of neuroscience research

authors： Yoshida M,Macklin WB

更新日期：2005-07-01 00:00:00

abstract：:A distinct population of white matter progenitor cells (WMPCs), competent but not committed to generate oligodendrocytes, remains ubiquitous in the adult human subcortical white matter. These cells are present in both sexes and into senescence and may constitute as much as 4% of the cells of adult human capsular white...

journal_title：Journal of neuroscience research

authors： Windrem MS,Roy NS,Wang J,Nunes M,Benraiss A,Goodman R,McKhann GM 2nd,Goldman SA

更新日期：2002-09-15 00:00:00

abstract：:Injury to the central nervous system (CNS) either from trauma or due to demyelinating/degenerating diseases results in a typical response of astrocytes, termed astrogliosis. This reaction is characterized by astrocyte proliferation, extensive hypertrophy of nuclei, cell body, and cytoplasmic processes and an increase ...

journal_title：Journal of neuroscience research

authors： Ghirnikar RS,Yu AC,Eng LF

更新日期：1994-07-01 00:00:00

abstract：:Biology of GnRH neurons is critically dependent on extracellular Ca(2+) (Ca(2+) (o)). We evaluated differences in gene expression patterns with low and high Ca(2+) (o) in an immortalized GnRH neuron line, GT1-7 cells. Mouse global oligonucleotide microarray was used to evaluate transcriptional differences among the ge...

journal_title：Journal of neuroscience research

authors： Bandyopadhyay S,Jeong KH,Hansen JT,Vassilev PM,Brown EM,Chattopadhyay N

更新日期：2007-03-01 00:00:00

abstract：:Previous studies have shown that PC12 cells overexpressing beta/A4 amyloid peptide display altered morphology characterized by pronounced membrane ruffling and extensive intercellular appositions. Having observed other cell types in which these features accompany increased connexin43 (Cx43) production and gap junction...

journal_title：Journal of neuroscience research

authors： Nagy JI,Hossain MZ,Hertzberg EL,Marotta CA

更新日期：1996-04-15 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is an inflammatory demyelinating disease with similarities to multiple sclerosis that requires the activation of auto reactive T cells that infiltrate the central nervous system. In previous studies we have shown that intraperitoneal administration of synaptosomal antige...

journal_title：Journal of neuroscience research

authors： Scerbo MJ,Rupil LL,Bibolini MJ,Roth GA,Monferran CG

更新日期：2009-08-01 00:00:00

abstract：:Cyclin-dependent kinase 5 (cdk5), in contrast to other members of the cyclin-dependent kinase family, is not activated by cyclins but instead is activated by complexing with neuron-specific activator molecules (p35, p39, and p67). The most effective activator of cdk5 both in vitro and in vivo is p35. We have taken a k...

journal_title：Journal of neuroscience research

authors： Amin ND,Albers W,Pant HC

更新日期：2002-02-01 00:00:00

abstract：:Following the identification of the nociceptin/orphanin FQ (N/OFQ) peptide (NOP) as an endogenous ligand for the NOP receptor, ample evidence has revealed unique functional profiles of the N/OFQ-NOP receptor system. NOP receptors are expressed in key neural substrates involved in pain and reward modulation. In nonhuma...

journal_title：Journal of neuroscience research

authors： Kiguchi N,Ding H,Ko MC

更新日期：2020-04-07 00:00:00

abstract：:The concentration of myelin basic protein (MBP) mRNA in primary cultures of cells dissociated from embryonic mouse cerebra and grown in the presence of varying amounts of thyroid hormone was measured using a 32P-labeled cDNA probe and a dot-blot procedure. The cDNA probe contained 1.85 kilobases of the gene for MBP. T...

journal_title：Journal of neuroscience research

authors： Shanker G,Campagnoni AT,Pieringer RA

更新日期：1987-01-01 00:00:00

abstract：:The dentate gyrus is selectively reduced in size in the insulin-like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of...

journal_title：Journal of neuroscience research

authors： Cheng CM,Cohen M,Tseng V,Bondy CA

更新日期：2001-05-15 00:00:00

abstract：:Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system with an autoimmune attack on the components of the myelin sheath and axons. The etiology of the disease remains largely unknown, but it is commonly acknowledged that the development of MS probably results from the interacti...

journal_title：Journal of neuroscience research

authors： Cheng Y,Sun L,Xie Z,Fan X,Cao Q,Han J,Zhu J,Jin T

更新日期：2017-10-01 00:00:00

abstract：:Little is known about the structural neural substrates that may contribute to sex differences in risk-taking propensity (RTP). A close association between risk-seeking behavior and the emotional-regulation network led us to hypothesize that the sex differences in RTP would be associated with sex differences in brain m...

journal_title：Journal of neuroscience research

authors： Bajaj S,Killgore WDS

更新日期：2020-02-01 00:00:00

abstract：:Chronic alcohol consumption has adverse effects on the central nervous system, affecting some hippocampal and hypothalamic functions. In this study we tempted to demonstrate that some of these modifications could involve impairment of neurotrophic factors. Three experimental groups of male Sprague Dawley rats were stu...

journal_title：Journal of neuroscience research

authors： Tapia-Arancibia L,Rage F,Givalois L,Dingeon P,Arancibia S,Beaugé F

更新日期：2001-01-15 00:00:00

abstract：:Target ablation by olfactory bulbectomy synchronizes the degenerative cell death of olfactory receptor neurons (ORNs), infiltration of macrophages, and proliferation of progenitor cells, leading to neurogenesis, ORN replacement, and regeneration of the sensory epithelium. Although macrophages participate in the degene...

journal_title：Journal of neuroscience research

authors： Getchell TV,Subhedar NK,Shah DS,Hackley G,Partin JV,Sen G,Getchell ML

更新日期：2002-12-15 00:00:00

abstract：:Previous studies have shown that treating rat cortical neurons in primary culture with apolipoprotein E (apoE) peptide increased cytoplasmic Ca2+ by 2 mechanisms: 1) an influx of extracellular Ca2+ resulting from the activation of a cell surface Ca2+ channel; and 2) release of Ca2+ from internal Ca2+ stores via a G-pr...

journal_title：Journal of neuroscience research

authors： Wang X,Luebbe P,Gruenstein E,Zemlan F

更新日期：1998-03-01 00:00:00

abstract：:Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much pe...

journal_title：Journal of neuroscience research

authors： Lee SM,Lee JW,Song YS,Hwang DY,Kim YK,Nam SY,Kim DJ,Yun YW,Yoon DY,Hong JT

更新日期：2005-11-15 00:00:00

abstract：:To further our understanding of the functions of the major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP), and other myelin proteins, such as 2'3'-cyclic nucleotide 3'-phosphodiesterase (CNP) and myelin-associated glycoprotein (MAG), bovine brain myelin was extracted with Triton X-100, and p...

journal_title：Journal of neuroscience research

authors： Arvanitis DN,Yang W,Boggs JM

更新日期：2002-10-01 00:00:00

abstract：:The precise function of APP (Alzheimer's amyloid precursor protein) remains to be fully elucidated, but various lines of evidence suggest that it may be involved in cell adhesion processes. Because APP is a transmembrane glycoprotein, variations in its expression level may have direct bearing on its putative role in c...

journal_title：Journal of neuroscience research

authors： Rebelo S,Henriques AG,da Cruz e Silva EF,da Cruz e Silva OA

更新日期：2004-05-01 00:00:00

abstract：:The periglomerular cells (PG) of the olfactory bulb (OB) are involved in the primary processing and the refinement of sensory information from the olfactory epithelium. The neurochemical composition of these neurons has been studied in depth in many species, and over the last decades such studies have focused mainly o...

journal_title：Journal of neuroscience research

authors： Baltanás FC,Curto GG,Gómez C,Díaz D,Murias AR,Crespo C,Erdelyi F,Szabó G,Alonso JR,Weruaga E

更新日期：2011-01-01 00:00:00

abstract：:Both protein kinase C (PKC) and ceramide play a critical role in cell signaling, but the relationship between PKC and ceramide is unclear. Low concentrations of ceramide were observed to transiently stimulate PKC zeta activity in vitro and in vivo, whereas high doses of ceramide lead to inhibition of PKC zeta. Inhibit...

journal_title：Journal of neuroscience research

authors： Wang YM,Seibenhener ML,Vandenplas ML,Wooten MW

更新日期：1999-02-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is well known to play a critical role in cognition. Its role in mood disorders, including post stroke depression (PSD), is also recognized with more evidence surfacing. In patients with PSD, their serum BNDF level is lower than in those without depression. Furthermore, antidepr...

journal_title：Journal of neuroscience research

authors： Zhang E,Liao P

更新日期：2020-03-01 00:00:00

abstract：:Microarray analyses demonstrated that a variety of genes was affected by treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor (PEDF). The genes for neurotrophins, glial cell-derived neurotrophic factor (GDNF), and their receptors were regulated differentially in i...

journal_title：Journal of neuroscience research

authors： Yabe T,Herbert JT,Takanohashi A,Schwartz JP

更新日期：2004-09-01 00:00:00

abstract：:We investigated the possible mechanisms how interferon (IFN)-beta may control T cell infiltration in the CNS in experimental autoimmune encephalomyelitis (EAE). Adoptive transfer (AT) EAE was induced in groups of six female Lewis rats. Animals were treated with 3 x 10(5) units of recombinant rat IFN-beta s.c. once at ...

journal_title：Journal of neuroscience research

authors： Schmidt J,Stürzebecher S,Toyka KV,Gold R

更新日期：2001-07-01 00:00:00