Astrogliosis in culture: III. Effect of recombinant retrovirus expressing antisense glial fibrillary acidic protein RNA.

abstract：:A mouse monoclonal antibody (5B9), directed against a carbohydrate epitope of human epidermal growth factor receptor (EGFR), recognized an 81-kDalton glycoprotein in buffer-soluble and detergent-solubilized rat brain extracts (BE). The glycoprotein was more abundant in extracts prepared from injured brain than in thos...

journal_title：Journal of neuroscience research

authors： Río C,Pérez-Cerdá F,Matute C,Nieto-Sampedro M

更新日期：1995-04-15 00:00:00

abstract：:The neurotrophins are important for their long-term effects on the survival and differentiation of many types of neurons during development. They also appear to protect mature neurons from injury caused by nutrient or oxygen deprivation. More recently, the neurotrophins have been implicated in such short-term processe...

journal_title：Journal of neuroscience research

authors： Jiang H,Guroff G

更新日期：1997-11-01 00:00:00

abstract：:Gamma-Aminobutyric acid (GABA) is the principal inhibitory neurotransmitter in the brain. A deficiency of GABAergic inhibition mediated via the GABAA receptor complex has for a long time been suspected to be a central factor in epileptogenesis. Status epilepticus is a condition of sustained and prolonged excitation of...

journal_title：Journal of neuroscience research

authors： Karle J,Woldbye DP,Elster L,Diemer NH,Bolwig TG,Olsen RW,Nielsen M

更新日期：1998-12-15 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and disability among young adults and is highly prevalent among recently deployed military personnel. Survivors of TBI often experience cognitive and emotional deficits, suggesting that long-term effects of injury may disrupt neuronal function in critical brain ...

journal_title：Journal of neuroscience research

authors： Klein RC,Acheson SK,Qadri LH,Dawson AA,Rodriguiz RM,Wetsel WC,Moore SD,Laskowitz DT,Dawson HN

更新日期：2016-06-01 00:00:00

abstract：:We have previously shown that Na+, K(+)-ATPase activity in hypothalamus is increased after administration of an acute dose of desipramine, a noradrenaline uptake inhibitor (Viola et al., Cell Molec Neurobiol 9:263-271, 1989). In this report the same treatment (10 mg per kg) was applied to evaluate 3H-ouabain binding i...

journal_title：Journal of neuroscience research

authors： Viola MS,Antonelli MC,Enero MA,Rodríguez de Lores Arnaiz G

更新日期：1997-01-01 00:00:00

abstract：:We investigated whether a learning impairment after a controlled cortical impact (CCI) injury was associated with alterations in molecules involved in synaptic plasticity and learning and memory. Adult male rats with moderate CCI to the left parietal cortex, tested in a Morris water maze (MWM) beginning at postinjury ...

journal_title：Journal of neuroscience research

authors： Griesbach GS,Sutton RL,Hovda DA,Ying Z,Gomez-Pinilla F

更新日期：2009-02-15 00:00:00

abstract：:The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...

journal_title：Journal of neuroscience research

authors： Avale ME,Nemirovsky SI,Raisman-Vozari R,Rubinstein M

更新日期：2004-10-15 00:00:00

abstract：:The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR-alpha agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE), the animal model ...

journal_title：Journal of neuroscience research

authors： Xu J,Storer PD,Chavis JA,Racke MK,Drew PD

更新日期：2005-08-01 00:00:00

abstract：:Direct brain injections of the N-methyl-D-aspartate receptor agonist quinolinic acid (QA) trigger an excitotoxic cascade characterized by rapid neuronal death and glial/immune cell activation. The present study compared the timing of immediate early gene (IEG; c-fos, c-jun, jun-B, and zif/268) induction with the respo...

journal_title：Journal of neuroscience research

authors： Walker PD,Carlock LR

更新日期：1993-12-01 00:00:00

abstract：:The concentration of myelin basic protein (MBP) mRNA in primary cultures of cells dissociated from embryonic mouse cerebra and grown in the presence of varying amounts of thyroid hormone was measured using a 32P-labeled cDNA probe and a dot-blot procedure. The cDNA probe contained 1.85 kilobases of the gene for MBP. T...

journal_title：Journal of neuroscience research

authors： Shanker G,Campagnoni AT,Pieringer RA

更新日期：1987-01-01 00:00:00

abstract：:Individuals who regularly shift their sleep timing, like night and/or shift-workers suffer from circadian desynchrony and are at risk of developing cardiometabolic diseases and cancer. Also, shift-work is are suggested to be a risk factor for the development of mood disorders such as the burn out syndrome, anxiety, an...

journal_title：Journal of neuroscience research

authors： Guerrero-Vargas NN,Zárate-Mozo C,Guzmán-Ruiz MA,Cárdenas-Rivera A,Escobar C

更新日期：2021-02-01 00:00:00

abstract：:Four major discoveries on the function of the pedunculopontine nucleus (PPN) have significantly advanced our understanding of the role of arousal in neurodegenerative disorders. The first was the finding that stimulation of the PPN-induced controlled locomotion on a treadmill in decerebrate animals, the second was the...

journal_title：Journal of neuroscience research

authors： Garcia-Rill E

更新日期：2019-12-01 00:00:00

abstract：:The engrailed gene has been identified in Drosophila as an important developmental gene involved in the control of segmentation. Here we describe the embryonic expression of a chicken gene, ChickEn (Darnell et al.: J Cell Biol 103(5):311a, 1986), which contains homology to the Drosophila engrailed gene. Northern blots...

journal_title：Journal of neuroscience research

authors： Gardner CA,Darnell DK,Poole SJ,Ordahl CP,Barald KF

更新日期：1988-10-01 00:00:00

abstract：:Inhibitors of differentiation (Id) play an essential role in the neurogenesis of the central nervous system. However, the expression and function of Id in the development of cochlear sensory epithelial cells have yet to be elucidated. In this study, we demonstrate the Id1 gene was expressed in the rapidly growing otoc...

journal_title：Journal of neuroscience research

authors： Ozeki M,Hamajima Y,Feng L,Ondrey FG,Schlentz E,Lin J

更新日期：2007-02-15 00:00:00

abstract：:NOD-like receptors (NLRs) are critical cytoplasmic pattern-recognition receptors (PRRs) that play an important role in the host innate immune response and immunity homeostasis. There is a growing body of evidence that NLRs are involved in a wide range of inflammatory diseases, including cancer, metabolic diseases, and...

journal_title：Journal of neuroscience research

authors： Kong X,Yuan Z,Cheng J

更新日期：2017-08-01 00:00:00

abstract：:Using subtype-specific Ca-channel blockers, we have characterised the voltage-sensitive Ca2+ currents as well as neurotransmitter release from cultured mouse cerebellar granule cells. The whole cell version of the patch clamp technique was adapted to monitor the isolated Ca-channel currents. The currents were activate...

journal_title：Journal of neuroscience research

authors： Varming T,Christopherson P,Schousboe A,Drejer J

更新日期：1997-04-01 00:00:00

abstract：:Acute intoxication with large ammonia doses leads to activation of NMDA receptors in the brain, resulting in oxidative stress and disturbance of mitochondrial function. Altered mitochondrial function is a crucial step in some mechanisms of cellular apoptosis. This study assesses whether ammonia intoxication in vivo le...

journal_title：Journal of neuroscience research

authors： Kosenko E,Kaminsky Y,Solomadin I,Marov N,Venediktova N,Felipo V,Montoliu C

更新日期：2007-08-15 00:00:00

abstract：:Although gangliosides have been reported to enhance recovery from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced lesions of the substantia nigra, evidence as to whether the administered gangliosides actually reach this or any other site of lesion in the central nervous system (CNS) at which they putativel...

journal_title：Journal of neuroscience research

authors： Saulino MF,Schengrund CL

更新日期：1994-02-15 00:00:00

abstract：:Encephalitogenic T cells from Lewis rats use a restricted T cell receptor (TCR) gene combination, Vbeta8.2 and Valpha2. The oral administration of myelin basic protein (MBP) to Lewis rats prior to encephalitogenic challenge results in a marked inhibition of clinical neurologic signs of encephalitis, reduced central ne...

journal_title：Journal of neuroscience research

authors： Goldman-Brezinski S,Brezinski K,Zhang XM,Gienapp I,Cox K,Heber-Katz E,Whitacre C

更新日期：1998-01-01 00:00:00

abstract：:The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation-reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calcu...

journal_title：Journal of neuroscience research

authors： Mayevsky A

更新日期：1975-01-01 00:00:00

abstract：:This study was undertaken in order to establish the presence of pluripotential neuroblasts in the developing chick CNS. This has been suggested by our previous observations that expression of emerging neuronal phenotypes in the chick embryo CNS is affected by exposure to neurotrophic substances (i.e., GHRH, SRIF, NGF,...

journal_title：Journal of neuroscience research

authors： Kentroti S,Vernadakis A

更新日期：1995-08-01 00:00:00

abstract：:Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis...

journal_title：Journal of neuroscience research

authors： Kane DJ,Ord T,Anton R,Bredesen DE

更新日期：1995-02-01 00:00:00

abstract：:Axotomy is a powerful stimulus of axon growth and plastic changes. We investigated the potential role of BDNF/trkB signaling in the sprouting of dopaminergic nigral axons in response to axotomy of the medial forebrain bundle. Tyrosine hydroxylase immunohistochemistry revealed the existence of sprouting mechanisms in t...

journal_title：Journal of neuroscience research

authors： García Navia JT,Burguillos MA,Ramón-Cueto A,Machado A,Cano J,Venero JL

更新日期：2008-07-01 00:00:00

abstract：:T cell receptor (TCR) transgenic mice have been used extensively to study T cell development in vivo. Such studies have demonstrated high levels of expression of the TCR transgenes. Although a number of human T cell receptors appear to play a role in the development of autoimmune diseases, in vitro studies have proven...

journal_title：Journal of neuroscience research

authors： Baker AM,Wang Y,Richert JR

更新日期：1996-08-15 00:00:00

abstract：:Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme activity that degrades neuromodulatory fatty acid amides, including oleamide and anandamide. A single 2.5-kb FAAH mRNA is distributed throughout the rat CNS and accumulates progressively between embryonic day 14 and postnatal day 10, remains high until postn...

journal_title：Journal of neuroscience research

authors： Thomas EA,Cravatt BF,Danielson PE,Gilula NB,Sutcliffe JG

更新日期：1997-12-15 00:00:00

abstract：:Inhibitory luminopsins (iLMO2) integrate opto- and chemo-genetic approaches and allow for cell-type specific inhibition of neuronal activity. When exposed to a Renilla luciferase substrate, Coelenterazine (CTZ), iLMO2 generates bioluminescence-mediated activation of its amino-terminal halorhodopsin, resulting in neuro...

journal_title：Journal of neuroscience research

authors： Jaiswal PB,Tung JK,Gross RE,English AW

更新日期：2020-03-01 00:00:00

abstract：:We studied the electrophysiological, hemodynamic, and cytomorphological consequences of microhemorrhagic brain injury induced by a nanoscale iron injection. Of particular interest were the etiology, development, and treatment of epilepsy associated with this injury. We developed an animal model of chronic epilepsy usi...

journal_title：Journal of neuroscience research

authors： Jo A,Heo C,Schwartz TH,Suh M

更新日期：2014-03-01 00:00:00

abstract：:The blood-brain barrier (BBB) refers to the network of microvessels that selectively restricts the passage of substances between the circulation and the central nervous system (CNS). This microvascular network is comprised of arterioles, capillaries and venules, yet the respective contribution of each of these to the ...

journal_title：Journal of neuroscience research

authors： Macdonald JA,Murugesan N,Pachter JS

更新日期：2010-05-15 00:00:00

abstract：:Previous studies have demonstrated variability in the phenotype of rat C6 glioma cells. In the present study, we compared morphology, growth rate, and beta-adrenergic regulation of gene expression in early (P39-47) and late (P55-90) passage C6 cells. Morphological changes were observed in five independently derived, l...

journal_title：Journal of neuroscience research

authors： Gubits RM,Yu H,Casey G,Munell F,Vitek MP

更新日期：1992-10-01 00:00:00

abstract：:Neurotransmitter transporters are involved in termination of the synaptic neurotransmission and they also play a key role in neuroregulation and brain development. In this report, we describe the developmental distribution of the y-aminobutyric acid transporter GAT3 which transports gamma-aminobutyric acid (GABA) and ...

journal_title：Journal of neuroscience research

authors： Jursky F,Nelson N

更新日期：1999-02-01 00:00:00