Abstract:
:Fatty acid amide hydrolase (FAAH) is a membrane-bound enzyme activity that degrades neuromodulatory fatty acid amides, including oleamide and anandamide. A single 2.5-kb FAAH mRNA is distributed throughout the rat CNS and accumulates progressively between embryonic day 14 and postnatal day 10, remains high until postnatal day 30, then decreases into adulthood. FAAH enzymatic activity, as measured in dissected brain regions, was well correlated with the distribution of its messenger RNA. In situ hybridization revealed profound distribution of FAAH mRNA in neuronal cells throughout the CNS. The most prominent signals were detected in the neocortex, hippocampal formation, amygdala, and cerebellum. The FAAH distribution in the CNS suggests that degradation of neuromodulatory fatty acid amides at their sites of action influences their effects on sleep, euphoria, and analgesia.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Thomas EA,Cravatt BF,Danielson PE,Gilula NB,Sutcliffe JGdoi
10.1002/(SICI)1097-4547(19971215)50:6<1047::AID-JNsubject
Has Abstractpub_date
1997-12-15 00:00:00pages
1047-52issue
6eissn
0360-4012issn
1097-4547pii
10.1002/(SICI)1097-4547(19971215)50:6<1047::AID-JNjournal_volume
50pub_type
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