Abstract:
:Zinc concentration and (65)Zn uptake in the brain of rats fed zinc-deficient diet for 12 weeks were examined, based on a previous finding of the impairment of learning behavior by the zinc deprivation. Zinc concentrations in the brain, except for the hippocampal formation, did not decrease significantly in zinc-deficient rats, whereas zinc concentration in the liver of the zinc-deficient rats was approximately half that of control rats. When zinc-deficient rats were subjected to brain autoradiography with (65)Zn, (65)Zn concentration in any brain region of zinc-deficient rats was significantly higher than in control rats 6 days after injection of (65)ZnCl(2). The increase rate of (65)Zn concentration in the brain by the zinc deprivation was approximately 150%, and was similar to those in the liver and serum, suggesting that dietary zinc deprivation may cause a scarcity of zinc in the brain, in addition to the peripheral tissues such as the liver. These results indicate that the adult brain is responsive to dietary zinc deprivation. In the brain of zinc-deficient rats, the increase rate of (65)Zn concentration in the hippocampal formation seemed to be low compared to those in other brain regions. The hippocampal formation may be the most responsive to dietary zinc deprivation in the adult brain. The present finding demonstrates that zinc homeostasis in the brain is altered by chronically dietary zinc deprivation.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Takeda A,Minami A,Takefuta S,Tochigi M,Oku Ndoi
10.1002/1097-4547(20010301)63:5<447::AID-JNR1040>3keywords:
subject
Has Abstractpub_date
2001-03-01 00:00:00pages
447-52issue
5eissn
0360-4012issn
1097-4547pii
10.1002/1097-4547(20010301)63:5<447::AID-JNR1040>3journal_volume
63pub_type
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