Abstract：
:Ionotropic glutamate receptors, N-methyl-d-aspartate receptors (NMDARs) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs), are densely distributed in the mammalian brain and actively regulate a variety of cellular activities. Expression and function of these receptors are also under a tight regulation by many molecular mechanisms. Protein phosphorylation represents one of the important mechanisms for the posttranslational modulation of these receptors. Constitutive and regulatory phosphorylation occurs at distinct sites (serine, threonine, or tyrosine) on the intracellular C-terminal domain of almost all subunits capable of assembling a functional channel. Several key protein kinases, such as protein kinase A, protein kinase C, Ca(2+)/calmodulin-dependent protein kinases, and tyrosine kinases are involved in the site-specific catalyzation and regulation of NMDAR and AMPAR phosphorylation. Through the phosphorylation mechanism, these protein kinases as well as protein phosphatases control biochemical properties (biosynthesis, delivery, and subunit assembling), subcellular distribution, and interactions of these receptors with various synaptic proteins, which ultimately modify the efficacy and strength of excitatory synapses containing NMDARs and AMPARs and many forms of synaptic plasticity. Emerging evidence shows that psychostimulants (cocaine and amphetamine) are among effective agents that profoundly alter the phosphorylation status of both receptors in striatal neurons in vivo. Thus, psychostimulants may modulate NMDAR and AMPAR function through the phosphorylation mechanism to shape the excitatory synaptic plasticity related to additive properties of drugs of abuse.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Wang JQ,Liu X,Zhang G,Parelkar NK,Arora A,Haines M,Fibuch EE,Mao Ldoi
10.1002/jnr.21050subject
Has Abstractpub_date
2006-12-01 00:00:00pages
1621-9issue
8eissn
0360-4012issn
1097-4547journal_volume
84pub_type
杂志文章,评审abstract：:Traumatic brain injuries (TBIs) pose a massive burden of disease and continue to be a leading cause of morbidity and mortality throughout the world. A major obstacle in developing effective treatments is the lack of comprehensive understanding of the underlying mechanisms that mediate tissue damage and recovery after ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24054
更新日期：2018-04-01 00:00:00
abstract：:The activity levels of pyruvate dehydrogenase, enzymes of the citric acid cycle, aspartate and alanine aminotransferases, and NADP+-isocitrate dehydrogenase were determined in the cerebral cortex, cerebellum, brain stem, corpus striatum, hippocampus, and midbrain regions of normal rats and rats injected with acute and...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490140407
更新日期：1985-01-01 00:00:00
abstract：:Traumatic injury to the adult central nervous system (CNS) results in a rapid response from resident astrocytes, a process often referred to as reactive astrogliosis or glial scarring. The robust formation of the glial scar and its associated extracellular matrix (ECM) molecules have been suggested to interfere with a...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/1097-4547(20010115)63:2<109::AID-JNR1002>3
更新日期：2001-01-15 00:00:00
abstract：:In recent years, several novel types of disorders have been characterized, including what have been termed polyalanine diseases, in which patients have expanded triplet repeats in specific genes, resulting in the translation of aberrantly elongated polyalanine stretches. In this study, we showed that yellow fluorescen...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21619
更新日期：2008-05-15 00:00:00
abstract：:The interaction of bovine white matter proteolipid apoproteins with sodium dodecyl sulfate (SDS) was studied. Equilibrium dialysis binding measurements show that the apoprotein binds approximately 1.5 gm SDS per gram protein at high ionic strength (gamma/2 = 0.17). At low ionic strength (gamma/2 = 0.01) the protein bi...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490060602
更新日期：1981-01-01 00:00:00
abstract：:The Oct-2 transcription factor has a predominantly inhibitory effect on gene expression in neuronal cell lines. This factor and its corresponding mRNA have previously been shown to be elevated in adult rat dorsal root ganglion (DRG) neurons chronically exposed to nerve growth factor (NGF). Here we show that the Oct-2 ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490400205
更新日期：1995-02-01 00:00:00
abstract：:The thrombospondin (TSP) family of extracellular matrix glycoproteins are widely expressed in the developing and adult central nervous system although their function remains poorly defined. We have used cell culture techniques to analyse the expression and function of TSPs in glial cells derived from myelinated region...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/(SICI)1097-4547(19971015)50:2<202::AID-JNR
更新日期：1997-10-15 00:00:00
abstract：:Plexiform layer synaptic and photoreceptor cell components were investigated in retinas of Royal College of Surgeons (RCS) dystrophic rats transplanted with normal retinal pigment epithelial (RPE) cells by immunocytochemistry using previously characterized monoclonal antibodies. In retinas of normal adult rats and RPE...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490360408
更新日期：1993-11-01 00:00:00
abstract：:A frontal pole cDNA library from monkey (Macaca mulatta) brain was screened to identify mRNAs that are expressed more in frontal pole as compared to primary visual cortex. Three cDNA clones, whose greater expression was confirmed by Northern blot analysis, were identified as cytochrome oxidase (COX) subunits I, II, an...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490320313
更新日期：1992-07-01 00:00:00
abstract：:Statins are potent cholesterol biosynthesis inhibitors that exert protective effects in humans and in experimental models of stroke. The mechanisms involved in these protective actions are not completely understood. This study evaluates whether atorvastatin (ATV) treatment affects the GluN1 and GluN2B subunits of the ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23426
更新日期：2014-11-01 00:00:00
abstract：:Neural stem cells (NSCs) have great potential as a therapeutic tool for the repair of a number of CNS disorders. NSCs can either be isolated from embryonic and adult brain tissue or be induced from both mouse and human ES cells. These cells proliferate in vitro through many passages without losing their multipotential...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.10240
更新日期：2002-06-01 00:00:00
abstract：:We have observed significantly lower kinetic parameters (KM and Vmax) for methionine adenosyltransferase activity in erythrocytes obtained from early onset schizophrenics when compared to samples from normal subjects. These differences are apparently not due to differences in S-adenosylmethionine (SAM) utilization. Th...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490080113
更新日期：1982-01-01 00:00:00
abstract：:Fast-scan cyclic voltammetry (FSCV) is an established method for measuring dopamine (DA) levels in the brain in real time. However, it is difficult to discriminate DA from other monoamines such as serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE). We report a novel DA-specific biosensor consisting of a car...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24193
更新日期：2018-05-01 00:00:00
abstract：:Trophic factors, such as the neurotrophins, CNTF, and GDNF, represent unique families of proteins that are essential for the development of the vertebrate nervous system. Surprisingly, there is little evidence to date that these proteins exist in Drosophila melanogaster and Caenorhabditis elegans, even though other po...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：
更新日期：2000-02-01 00:00:00
abstract：:The distribution of phosphofructokinase (PFK) in gray and white matter regions of the rat nervous system was evaluated. Determinations of PFK activity revealed that cell body enriched regions (sensorimotor cortex) had a significantly higher level of activity than axonal regions (sciatic nerve, dorsal roots, and optic ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490210105
更新日期：1988-09-01 00:00:00
abstract：:Protein kinase C (PKC) and its potential role in myelin gene expression were investigated in primary cultured rat oligodendrocytes. The major myelin genes were expressed in a developmentally coordinated manner in cultured oligodendrocytes. PKC activity in these cells was similarly regulated with differential expressio...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490340509
更新日期：1993-04-01 00:00:00
abstract：:The pathogenic processing of the amyloid precursor protein (APP) into beta-amyloid peptides, which give rise to beta-amyloid plaques in the brains of Alzheimer's disease patients, requires the enzymatic activity of the beta-site APP-cleaving enzyme 1 (BACE1). We report the cloning and sequence of a 1.5-kb DNA fragment...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10639
更新日期：2003-07-01 00:00:00
abstract：:Programmed cell death involving gene regulation and de novo protein synthesis is a major component of both normal development and a number of disease conditions. Hence, knowledge of its mechanisms, especially transcription factors, that regulate expression of the genes involved in neurodegenerative disorders is of gre...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21469
更新日期：2008-01-01 00:00:00
abstract：:We investigated the possible mechanisms how interferon (IFN)-beta may control T cell infiltration in the CNS in experimental autoimmune encephalomyelitis (EAE). Adoptive transfer (AT) EAE was induced in groups of six female Lewis rats. Animals were treated with 3 x 10(5) units of recombinant rat IFN-beta s.c. once at ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1128
更新日期：2001-07-01 00:00:00
abstract：:Oligodendrocytes (OLs) and the myelin produced by them are enriched in two glycosphingolipids, galactosylceramide (GalC) and its sulfated form, cerebroside sulfate (CBS). We showed earlier that these two glycolipids in opposed liposomal membranes or in methanol solution can adhere to each other. Here we have examined ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.1217
更新日期：2001-10-15 00:00:00
abstract：:Noradrenalin (NA) regulates the expression of arginine-vasopressin (AVP) and oxytocin (OT) by magnocellular neurons in the supraoptic nucleus (SON) of the hypothamalus. Nitric oxide (NO) may be one of the factors involved in the NA signaling pathway regulating AVP and OT expression. To test this possibility, we used a...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.21394
更新日期：2007-10-01 00:00:00
abstract：:Nerve growth factor (NGF) has been purified from the guinea pig prostate using a modification of the Bocchini-Angeletti method for isolating 2.5S NGF from mouse submaxillary glands. As with the mouse preparation, guinea pig prostate NGF appears to migrate as a high molecular weight entity at physiological pH. Followin...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490060403
更新日期：1981-01-01 00:00:00
abstract：:gammadelta T cells represent a small subpopulation of T cells expressing a restricted repertoire of T-cell receptors and, unlike alphabeta T cells, function more as cells of the innate immune system. These cells are found in skin and mucosal sites as well as secondary lymphoid tissues and frequently act as first line ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章,评审
doi：10.1002/jnr.22176
更新日期：2010-01-01 00:00:00
abstract：:Previous studies have shown that the mechanical wounding of 3-week-old cultured rat astrocytes results in cell proliferation and hypertrophy resembling astrocyte responses to a brain injury in vivo. We now report the effects of basic fibroblast growth factor (bFGF) and an anti-bFGF antibody on astrocyte morphology, pr...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490400310
更新日期：1995-02-15 00:00:00
abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q140s, mouse exon 1 H...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.24493
更新日期：2019-12-01 00:00:00
abstract：:Neural expression of constitutive hsc70 mRNA and hyperthermia-inducible hsp70 mRNA is examined using radioactive and non-radioactive in situ hybridization procedures. A strong induction of hsp70 mRNA was noted in cell populations in cerebellar layers and in the brainstem which demonstrated expression of mRNA encoding ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490410506
更新日期：1995-08-01 00:00:00
abstract：:An increased level of myelin basic protein (MBP) degradation peptide 80-89, representative of myelin breakdown, is detected in myelinating foetal rat brain aggregate cultures supplemented with peritoneal macrophages at a time coinciding with the onset of myelination. During the period of myelination, the proportion of...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.10026
更新日期：2001-12-15 00:00:00
abstract：:Cytoskeletal structures under the cell membrane carry out pivotal roles in the maintenance and remodeling of the cell structures. Reforming of the cytoskeletal networks after partial extraction of membrane components could be a good clue to identify molecular components pertaining the interaction of cytoskeleton with ...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.20555
更新日期：2005-07-15 00:00:00
abstract：:Primary cultures of cerebral glia derived from neonatal rat brain were utilized to determine 1) the developmental changes of dolichol-linked oligosaccharide and N-linked glycoprotein biosyntheses, 2) the enzymatic correlates of these developmental changes, and 3) the temporal relations between the biosyntheses of doli...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.490200409
更新日期：1988-08-01 00:00:00
abstract：:The multifactorial nature of traumatic brain injury (TBI), especially the complex secondary tissue injury involving intertwined networks of molecular pathways that mediate cellular behavior, has confounded attempts to elucidate the pathology underlying the progression of TBI. Here, systems biology strategies are explo...
journal_title：Journal of neuroscience research
pub_type： 杂志文章
doi：10.1002/jnr.23503
更新日期：2015-02-01 00:00:00
