Abstract:
:We have observed significantly lower kinetic parameters (KM and Vmax) for methionine adenosyltransferase activity in erythrocytes obtained from early onset schizophrenics when compared to samples from normal subjects. These differences are apparently not due to differences in S-adenosylmethionine (SAM) utilization. These results offer an explanation for the conflicting reports of previous investigators and support the concept that undermethylation may characterize some forms of schizophrenia. Methylation is involved in multiple aspects of metabolism and although similar differences in the MAT enzyme in the brain have not been reported, such a deficit could have profound effects on the nervous system. Decreased availability of SAM could decrease catecholamine metabolism or rates of phospholipid methylation.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Kelsoe JR Jr,Tolbert LC,Crews EL,Smythies JRdoi
10.1002/jnr.490080113subject
Has Abstractpub_date
1982-01-01 00:00:00pages
99-103issue
1eissn
0360-4012issn
1097-4547journal_volume
8pub_type
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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doi:10.1002/jnr.490090308
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journal_title:Journal of neuroscience research
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更新日期:2004-10-15 00:00:00
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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doi:10.1002/jnr.490220404
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490070108
更新日期:1982-01-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Journal of neuroscience research
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doi:10.1002/jnr.20109
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:2005-10-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1999-09-15 00:00:00