当前位置： SCI文献检索 > JOURNAL OF NEUROSCIENCE RESEARCH期刊下所有文献 > Loss of Purkinje cell-associated benzodiazepine receptors spares a high affinity subpopulation: a study with pcd mutant mice.

Loss of Purkinje cell-associated benzodiazepine receptors spares a high affinity subpopulation: a study with pcd mutant mice.

Abstract：

:In order to identify the relative number of benzodiazepine (BZ) receptors in Purkinje and granule cells, the Purkinje cell degeneration (pcd) mutant mouse was used at different ages. In these mice, Purkinje cells have degenerated almost completely by 45-50 days of age. Granule cell loss occurs only later, and is most severe between 180 and 300 days. [3H]Flunitrazepam (FNZ) and [3H]ethyl-carboline-3-carboxylate (beta-CC) were used as ligands. In the 45-50-day-old pcd mice, it was found that there is approximately a 50% decrease in the number of receptors as labeled by [3H]beta-CC or [3H]FNZ, when the binding is expressed as fmol/cerebellum. The binding decreased by approximately 80% in 300-day-old pcd mice (fmol/cerebellum). [3H]FNZ was not displaced by 1 microM RO5-4864, ruling out binding to glial cells. Nonlinear regression analysis of FNZ saturation data provided evidence for two populations of receptors (high and low affinity sites). Only the low-affinity sites were reduced in number at 45 days. [3H]beta-CC saturation data showed, however, only one population of receptors. The total number of receptors (Bmax) was significantly lower for beta-CC than for FNZ in the control mice. It appears that 50% of the total BZ receptors is associated with Purkinje cells. In addition, our data on 300-day-old pcd mutants strongly suggest the existence of granule cell-associated BZ receptors.

journal_name

J Neurosci Res

journal_title

Journal of neuroscience research

authors

Vaccarino FM,Ghetti B,Wade SE,Rea MA,Aprison MH

doi

10.1002/jnr.490090308

subject

Has Abstract

pub_date

1983-01-01 00:00:00

pages

311-23

issue

3

eissn

0360-4012

issn

1097-4547

journal_volume

9

pub_type

杂志文章

相关文献

JOURNAL OF NEUROSCIENCE RESEARCH文献大全
  • Acetylcarnitine induces heme oxygenase in rat astrocytes and protects against oxidative stress: involvement of the transcription factor Nrf2.

    abstract：:Efficient functioning of maintenance and repair processes seem to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, under control of several genes termed vitagenes. These include members of the heat shock protein system,...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.20386

    authors： Calabrese V,Ravagna A,Colombrita C,Scapagnini G,Guagliano E,Calvani M,Butterfield DA,Giuffrida Stella AM

    更新日期：2005-02-15 00:00:00

  • Sodium L-lactate differently affects brain-derived neurothrophic factor, inducible nitric oxide synthase, and heat shock protein 70 kDa production in human astrocytes and SH-SY5Y cultures.

    abstract：:The present study analyzed the in vitro effects induced by sodium L-lactate on human astrocytes and the SH-SY5Y cell line, when added at concentrations of 5, 10, and 25 mmol/liter. Expression of brain-derived neurotrophic factor (BDNF), inducible nitric oxide synthase (iNOS), and heat shock protein 70 kDa (HSP70) was ...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.23154

    authors： Coco M,Caggia S,Musumeci G,Perciavalle V,Graziano AC,Pannuzzo G,Cardile V

    更新日期：2013-02-01 00:00:00

  • NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity.

    abstract：:Cell death in outer hair cells of the mammalian inner ear induced by aminoglycoside antibiotics is mediated by reactive oxygen species (ROS) and can be prevented by antioxidants. The current study investigates the role of the nuclear factor (NF)-kappaB pathway in cell death or survival in adult CBA mice. Kanamycin (70...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.20392

    authors： Jiang H,Sha SH,Schacht J

    更新日期：2005-03-01 00:00:00

  • Detection of increased tissue concentrations of nerve growth factor with an improved extraction procedure.

    abstract：:Nerve growth factor (NGF) is a protein essential for the survival and normal function of sympathetic neurons. Two-site immunoassays have been developed over the past decade in several laboratories and used to estimate its endogenous concentrations in a variety of effector tissues. However, levels appear restricted to ...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/(SICI)1097-4547(19961201)46:5<581::AID-JNR

    authors： Zettler C,Bridges DC,Zhou XF,Rush RA

    更新日期：1996-12-01 00:00:00

  • Alterations in ciliary neurotrophic factor signaling in rapsyn deficient mice.

    abstract：:Rapsyn is a key molecule involved in the formation of postsynaptic specializations at the neuromuscular junction, in its absence there are both pre- and post-synaptic deficits including failure to cluster acetylcholine receptors. Recently we have documented increases in both nerve-muscle branching and numbers of moton...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.1109

    authors： Bartlett SE,Banks GB,Reynolds AJ,Waters MJ,Hendry IA,Noakes PG

    更新日期：2001-06-15 00:00:00

  • c-Src protein tyrosine kinase activity is required for muscarinic receptor-mediated DNA synthesis and neurogenesis via ERK1/2 and c-AMP-responsive element-binding protein signaling in neural precursor cells.

    abstract：:The G protein-coupled muscarinic acetylcholine receptor (mAChR) isoforms have been identified in neural stem/progenitor (or precursor) cells. In previous studies, activation of these receptors induced elevations in intracellular Ca(2+) signals and mitogen-activated protein (MAP) kinase activity that led to enhanced DN...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.10591

    authors： Zhao WQ,Alkon DL,Ma W

    更新日期：2003-05-01 00:00:00

  • Progesterone increases brain-derived neuroptrophic factor expression and protects against glutamate toxicity in a mitogen-activated protein kinase- and phosphoinositide-3 kinase-dependent manner in cerebral cortical explants.

    abstract：:The higher prevalence and risk for Alzheimer's disease in women relative to men has been partially attributed to the precipitous decline in gonadal hormone levels that occurs in women following the menopause. Although considerable attention has been focused on the consequence of estrogen loss, and thus estrogen's neur...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.21370

    authors： Kaur P,Jodhka PK,Underwood WA,Bowles CA,de Fiebre NC,de Fiebre CM,Singh M

    更新日期：2007-08-15 00:00:00

  • Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion.

    abstract：:The inflammatory response initiated after spinal cord injury (SCI) is characterized by the accumulation of macrophages at the impact site. Monocyte chemoattractant protein-1 (MCP-1) is a strong candidate for mediating chemotaxis of monocytes to the injured nervous system. To help in defining the role of MCP-1 in infla...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.10269

    authors： Ma M,Wei T,Boring L,Charo IF,Ransohoff RM,Jakeman LB

    更新日期：2002-06-15 00:00:00

  • Selective changes in the permeability of the blood-brain barrier after pharmacological or surgical deafferentation.

    abstract：:Unilateral eye removal results in an increased delivery of blood-borne glucose, norepinephrine, choline, and tyrosine, but not of proline, to the denervated optic lobes. Administration of reserpine to chicks increases penetrance of norepinephrine into the brain but not of tyrosine, choline, or proline. Selective alter...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.490010308

    authors： Walker JB,Walker JP,Bondy SC,Purdy J

    更新日期：1975-01-01 00:00:00

  • Enhanced mitochondrial inhibition by 3,4-dihydroxyphenyl-acetaldehyde (DOPAL)-oligomerized α-synuclein.

    abstract：:Oligomeric forms of α-synuclein are believed to cause mitochondrial injury, which may contribute to neurotoxicity in Parkinson's disease (PD). Here oligomers of α-synuclein were prepared using the dopamine metabolite, DOPAL (3,4-dihydroxyphenyl-acetaldehyde), in the presence of guanidinium hydrochloride. Electron micr...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.24513

    authors： Sarafian TA,Yacoub A,Kunz A,Aranki B,Serobyan G,Cohn W,Whitelegge JP,Watson JB

    更新日期：2019-12-01 00:00:00

  • Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival.

    abstract：:Both protein kinase C (PKC) and ceramide play a critical role in cell signaling, but the relationship between PKC and ceramide is unclear. Low concentrations of ceramide were observed to transiently stimulate PKC zeta activity in vitro and in vivo, whereas high doses of ceramide lead to inhibition of PKC zeta. Inhibit...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/(SICI)1097-4547(19990201)55:3<293::AID-JNR

    authors： Wang YM,Seibenhener ML,Vandenplas ML,Wooten MW

    更新日期：1999-02-01 00:00:00

  • Purinergic modulation of neuronal gap junction circuits in the CNS of the leech.

    abstract：:Gap junctions (GJs) are widely distributed in brains across the animal kingdom. To visualize the GJ- coupled networks of two major mechanosensory neurons in the ganglia of medicinal leeches, we injected these cells with the GJ-permeable tracer Neurobiotin. When diffusion time was limited to only 30 min, tracer couplin...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.24599

    authors： Segura OM,Abdulnoor L,Hua VV,Solano MJ,Macagno ER,Baker MW

    更新日期：2020-06-01 00:00:00

  • Phosphorylated cAMP response element-binding protein levels in guinea pig brainstem auditory nuclei after unilateral cochlear ablation.

    abstract：:After left unilateral cochlear ablation (UCA) in young adult guinea pigs, the appearance of plasticities in auditory pathways suggested altered gene expression and modified phenotypic behaviors of auditory neurons. Because phosphorylated cyclic-AMP response element-binding protein (CREB-P) is a transcription factor th...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.20820

    authors： Mo Z,Suneja SK,Potashner SJ

    更新日期：2006-05-15 00:00:00

  • Neuroprotection by hypoxic preconditioning involves upregulation of hypoxia-inducible factor-1 in a prenatal model of acute hypoxia.

    abstract：:The molecular pathways underlying the neuroprotective effects of preconditioning are promising, potentially drugable targets to promote cell survival. However, these pathways are complex and are not yet fully understood. In this study we have established a paradigm of hypoxic preconditioning based on a chick embryo mo...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.22766

    authors： Giusti S,Fiszer de Plazas S

    更新日期：2012-02-01 00:00:00

  • Early postnatal development of rat brain: in vivo diffusion tensor imaging.

    abstract：:Perinatal hypoxia is a major cause of neurodevelopmental deficits. Neuronal migration patterns are particularly sensitive to perinatal hypoxia/ischemia and are associated with the clinical deficits. The rat model of hypoxia/ischemia at P7 mimics that of perinatal injury in humans. Before assessing the effects of postn...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.21607

    authors： Bockhorst KH,Narayana PA,Liu R,Ahobila-Vijjula P,Ramu J,Kamel M,Wosik J,Bockhorst T,Hahn K,Hasan KM,Perez-Polo JR

    更新日期：2008-05-15 00:00:00

  • Hypoglycemia reduces the blood-oxygenation level dependent signal in primary auditory and visual cortex: a functional magnetic resonance imaging study.

    abstract：:Studies of the effects of hypoglycemia on the brain using neurocognitive testing have suggested that mainly complex functions subserved by secondary and tertiary cortex are affected by mild to moderate hypoglycemia and that intensively treated patients with Type I diabetes mellitus (T1DM) may have altered sensitivity ...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.21146

    authors： Driesen NR,Goldberg PA,Anderson AW,Tang L,Flanagan DE,Sherwin RS,Gore JC

    更新日期：2007-02-15 00:00:00

  • Age-changes of brain synapses and synaptic plasticity in response to an enriched environment.

    abstract：:Numerical synaptic density and synaptic vesicle density in rat frontal cortex were examined by electron microscopy as a function of age. The density of axospinous synapses, a major population of synapses, was found to peak at age 1 month, and to gradually decrease with aging. The synaptic vesicle density in axospinous...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/(SICI)1097-4547(19990501)56:3<307::AID-JNR

    authors： Nakamura H,Kobayashi S,Ohashi Y,Ando S

    更新日期：1999-05-01 00:00:00

  • Transcriptional profiling of microdissected areas of active multiple sclerosis lesions reveals activation of heat shock protein genes.

    abstract：:Heat shock proteins (HSPs) are stress-responsive proteins that serve as important molecules contributing to cellular "protein triage." We and others have reported an increase of selected HSPs in multiple sclerosis (MS) lesions. However, the exact expression pattern of HSP family genes in MS is not known. The aim of ou...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.23079

    authors： Mycko MP,Brosnan CF,Raine CS,Fendler W,Selmaj KW

    更新日期：2012-10-01 00:00:00

  • Regional-specific regulation of BDNF and trkB correlates with nigral dopaminergic cell sprouting following unilateral nigrostriatal axotomy.

    abstract：:Axotomy is a powerful stimulus of axon growth and plastic changes. We investigated the potential role of BDNF/trkB signaling in the sprouting of dopaminergic nigral axons in response to axotomy of the medial forebrain bundle. Tyrosine hydroxylase immunohistochemistry revealed the existence of sprouting mechanisms in t...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.21654

    authors： García Navia JT,Burguillos MA,Ramón-Cueto A,Machado A,Cano J,Venero JL

    更新日期：2008-07-01 00:00:00

  • Actions of the neurotrophins on calcium uptake.

    abstract：:The neurotrophins are important for their long-term effects on the survival and differentiation of many types of neurons during development. They also appear to protect mature neurons from injury caused by nutrient or oxygen deprivation. More recently, the neurotrophins have been implicated in such short-term processe...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章,评审

    doi：10.1002/(SICI)1097-4547(19971101)50:3<355::AID-JNR

    authors： Jiang H,Guroff G

    更新日期：1997-11-01 00:00:00

  • Glutamate transport in cultures from developing avian cerebellum: presence of GLT-1 immunoreactivity in Purkinje neurons.

    abstract：:Immunocytochemical studies indicated that Purkinje cells cultured from chick embryonic cerebellum (embryonic day 8) strongly express a glutamate transporter EAAT2 cloned from human brain (GLT-1 in rat brain). At both 7 days and 14 days in culture, Purkinje neurons accumulated 1 microM [3H]L-glutamate via a potent "hig...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/(SICI)1097-4547(19981201)54:5<595::AID-JNR

    authors： Meaney JA,Balcar VJ,Rothstein JD,Jeffrey PL

    更新日期：1998-12-01 00:00:00

  • Neurotransmitter phenotype plasticity in cultured dissociated adult rat dorsal root ganglia: an immunocytochemical study.

    abstract：:Culturing sympathetic ganglion neurons in vitro may modify phenotypic expression of some neurotransmitters. For dorsal root ganglia (DRG), contradictory results have been reported; most studies have used immature material. We have therefore performed a detailed immunocytochemical analysis of the transmitter content of...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.490220414

    authors： Schoenen J,Delree P,Leprince P,Moonen G

    更新日期：1989-04-01 00:00:00

  • Cx29 and Cx32, two connexins expressed by myelinating glia, do not interact and are functionally distinct.

    abstract：:In rodents, oligodendrocytes and myelinating Schwann cells express connexin32 (Cx32) and Cx29, which have different localizations in the two cell types. We show here that, in contrast to Cx32, Cx29 does not form gap junction plaques or functional gap junctions in transfected cells. Furthermore, when expressed together...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.21561

    authors： Ahn M,Lee J,Gustafsson A,Enriquez A,Lancaster E,Sul JY,Haydon PG,Paul DL,Huang Y,Abrams CK,Scherer SS

    更新日期：2008-04-01 00:00:00

  • Sprouting inducing activity of human sera: low capacity in sera from patients with cranial polyneuropathy.

    abstract：:Cranial idiopathic acute peripheral facial nerve paralysis (Bell palsy) has been used as a model disease in the present study mainly to investigate trophic capacity of serum components. The ability to induce sprouting from chick embryo dorsal root ganglia was used as the bioassay for trophic activity. Sera from normal...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.490090411

    authors： Aviel A,Schwartz M

    更新日期：1983-01-01 00:00:00

  • Pathogenesis of cerebral vasospasm following aneurysmal subarachnoid hemorrhage: putative mechanisms and novel approaches.

    abstract：:Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vasospasm remain poorl...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章,评审

    doi：10.1002/jnr.21823

    authors： Kolias AG,Sen J,Belli A

    更新日期：2009-01-01 00:00:00

  • Xeno-free culture for generation of forebrain oligodendrocyte precursor cells from human pluripotent stem cells.

    abstract：:Oligodendrocytes (OLs) show heterogeneous properties that depend on their location in the central nervous system (CNS). In this regard, the investigation of oligodendrocyte precursor cells (OPCs) derived from human pluripotent stem cells (hPSCs) should be reconsidered, particularly in cases of brain-predominant disord...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.24413

    authors： Hermanto Y,Maki T,Takagi Y,Miyamoto S,Takahashi J

    更新日期：2019-07-01 00:00:00

  • Comparison of the agonist binding site of homomeric, heteromeric, and chimeric GluR1(o) and GluR3(o) AMPA receptors.

    abstract：:A series of AMPA [(R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid] analogues were evaluated for activity at homomeric, heteromeric, and chimeric rat GluR1(o) and GluR3(o) receptors expressed in Xenopus oocytes, using the two-electrode voltage clamp technique. The formation of heteromeric receptor compl...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/(sici)1097-4547(19970715)49:2<176::aid-jnr

    authors： Banke TG,Schousboe A,Pickering DS

    更新日期：1997-07-15 00:00:00

  • Glial fibrillary acidic protein immunohistochemistry of spinal cord astrocytes after induction of ischemia or anoxia in culture.

    abstract：:The effects of ischemia (removal of oxygen and glucose for 4 h) and anoxia (removal of oxygen alone) on astrocytes were studied in dissociated cultures of E14 spinal cord containing both neurons and astrocytes. In addition, a group of cultures was treated with a low Na+, low Ca2+, and high K+ medium during the 4-h isc...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.490170212

    authors： Goldberg WJ,Connor JR,Bernstein JJ

    更新日期：1987-01-01 00:00:00

  • Cobalt-dependent potentiation of net inward current density in Helix aspersa neurons.

    abstract：:A low concentration of transition metal ions Co2+ and Ni2+ increases the inward current density in neurons from the land snail Helix aspersa. The currents were measured using a single electrode voltage-clamp/internal perfusion method under conditions in which the external Na+ was replaced by Tris+, the predominant ext...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.490280411

    authors： Kim YK,Woodruff ML

    更新日期：1991-04-01 00:00:00

  • Xenopus oocytes as immunological vectors to produce monoclonal antibodies to rat brain antigens.

    abstract：:A novel approach was developed to raise a panel of monoclonal antibodies (mAb) against brain antigens using Xenopus oocytes as immunological vectors. Xenopus oocytes were injected to express proteins encoded by brain-derived mRNA extracted from rat cerebral cortex. A crude membrane preparation from mRNA-injected oocyt...

    journal_title：Journal of neuroscience research

    pub_type： 杂志文章

    doi：10.1002/jnr.490290109

    authors： Matute C,Tigyi GJ,Miledi R

    更新日期：1991-05-01 00:00:00