Abstract:
:Dissociated neurons from the neural tube containing the trigeminal motor nucleus from early chick embryos were cultured on laminin or collagen-polyornithine substrates, with and without nerve growth factor (NGF). Control cultures were grown in similar conditions with cytochrome-C. It was found that neuronal survival was not affected by NGF or cytochrome-C, but it was enhanced by laminin. The expression of neuritic processes, however, was significantly enhanced in the presence of NGF on both laminin and collagen-polyornithine surfaces, with the greatest number of neurons producing processes seen in the laminin-plus-NGF group. The length of processes was similarly enhanced by laminin and by NGF. Cytochrome-C did not influence any of these measures. The results indicate that while laminin potentiates the NGF effect on these early neuronal populations, NGF in conjunction with other substrata can have similar, though less dramatic, effects. These results, together with prior evidence of NGF receptors and specific NGF retrograde transport, suggest that this growth factor may play a significant role in the normal ontogeny of early motoneuron populations.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Heaton MBdoi
10.1002/jnr.490220404subject
Has Abstractpub_date
1989-04-01 00:00:00pages
390-6issue
4eissn
0360-4012issn
1097-4547journal_volume
22pub_type
杂志文章abstract::The cellular localization of calpain is important in understanding the roles that calpain may play in physiological function. We, therefore, examined calpain expression, activity, and immunofluorescent localization in primary cultures of rat oligodendrocytes. The mRNA expression of m-calpain was 64.8% (P = 0.0033) and...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10414
更新日期:2002-11-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10397
更新日期:2002-09-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:2010-12-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10116
更新日期:2002-02-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23350
更新日期:2014-05-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1999-09-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10765
更新日期:2003-11-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490410113
更新日期:1995-05-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:1997-11-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200114
更新日期:1988-05-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20001001)62:1<84::AID-JNR9>3.0.C
更新日期:2000-10-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490310206
更新日期:1992-02-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270102
更新日期:1990-09-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21858
更新日期:2009-02-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/1097-4547(20000715)61:2<172::AID-JNR8>3.0.
更新日期:2000-07-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490070403
更新日期:1982-01-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980615)52:6<709::AID-JNR
更新日期:1998-06-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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更新日期:2000-10-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:2010-09-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24235
更新日期:2018-07-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490390408
更新日期:1994-11-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21937
更新日期:2009-04-01 00:00:00
abstract::The male preponderance in autism prevalence has brought together the disparate topics of sex/gender and autism research. Two directions of neuroimaging studies on the relationships between sex/gender and autism may inform male-specific risk mechanisms and female-specific protective mechanisms of autism. First, we revi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.23948
更新日期:2017-01-02 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490010513
更新日期:1975-01-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490390604
更新日期:1994-12-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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更新日期:2009-11-15 00:00:00
abstract::Apoptosis and neuronal atrophy are commonly seen in patients infected with the human immunodeficiency virus type 1 (HIV-1) in the late phase of infection. The HIV-1 envelope glycoprotein gp120 has been suggested to be a causal agent of neuronal loss. Therefore, blocking gp120 neurotoxicity may be an effective way to r...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20780
更新日期:2006-04-01 00:00:00