Inhibition of K+ permeability diminishes alpha 2-adrenoceptor mediated effects on norepinephrine release.

abstract：:The expression of many myelin-specific molecules in Schwann cells is profoundly decreased following denervation. This study examines the early reexpression of myelin protein genes associated with reinnervation. Following sciatic nerve crush, the distal, regenerated nerve was divided into appropriate (2.5 or 5 mm) cons...

journal_title：Journal of neuroscience research

authors： Mitchell LS,Griffiths IR,Morrison S,Barrie JA,Kirkham D,McPhilemy K

更新日期：1990-10-01 00:00:00

abstract：:The phosphorylative neuromodulation of the regulatory subunit of protein kinase type II (R-II) in cytosolic fractions from denervated and sham-operated, contralateral soleus muscles of the rat was evaluated. The denervation-induced increase in the 32P-phosphorylation of R-II is not related to an increased dephosphoryl...

journal_title：Journal of neuroscience research

authors： McLane JA,Squinto SP,Yeoh HC,Held IR

更新日期：1985-01-01 00:00:00

abstract：:The transplantation of dopaminergic (DA) progenitors derived from pluripotent stem cells improves the behavior of Parkinson's disease model animals. However, the survival of DA progenitors is low, and the final yield of DA neurons is only approximately 0.3%-2% the number of transplanted cells. Zonisamide (ZNS) increas...

journal_title：Journal of neuroscience research

authors： Miyawaki Y,Samata B,Kikuchi T,Nishimura K,Takahashi J

更新日期：2020-08-01 00:00:00

abstract：:As it displays progressive hair-cell loss and degeneration of spiral ganglion neurons (SGNs) characterized by early-onset progressive hearing loss (ePHL), DBA/2J is an inbred mouse strain widely used in hearing research. Mouse nerve growth factor (mNGF), as a common exogenous nerve growth factor (NGF), has been studie...

journal_title：Journal of neuroscience research

authors： Wang Q,Zhao H,Zheng T,Wang W,Zhang X,Wang A,Li B,Wang Y,Zheng Q

更新日期：2017-10-01 00:00:00

abstract：:Retinal microglia play an important role as resident immunocompetent and phagocytic cells in the event of injury and disease. Retinal microglia and microglia precursor transplantation show a rescue effect in ischemic retina and retinal degeneration. However, studies of retinal microglia have been hampered by the diffi...

journal_title：Journal of neuroscience research

authors： Jiang XS,Ni YQ,Liu TJ,Zhang M,Jiang R,Xu GZ

更新日期：2014-04-01 00:00:00

abstract：:Sulfoglucuronosyl paragloboside (SGPG) is a member of the sulfated glucuronic acid-containing glycolipid (SGGL) family found primarily in peripheral nerves. These glycolipids contain the HNK-1 carbohydrate epitope and are recognized by monoclonal IgM from patients with chronic demyelinating neuropathy and paraproteine...

journal_title：Journal of neuroscience research

authors： Yamawaki M,Ariga T,Bigbee JW,Ozawa H,Kawashima I,Tai T,Kanda T,Yu RK

更新日期：1996-06-15 00:00:00

abstract：:Oligodendrocyte (OLG) death plays a major role in white matter dysfunction and demyelination following injury to the CNS. Axonal contact, communication, and neuronal activity appear to promote OLG survival and function in cell culture and during development. The application of electrical stimulation to mixed neural cu...

journal_title：Journal of neuroscience research

authors： Gary DS,Malone M,Capestany P,Houdayer T,McDonald JW

更新日期：2012-01-01 00:00:00

abstract：:Despite the large number of growth factors shown to affect dopaminergic cell survival and differentiation in vitro, presently little is known about the role these growth factors play during normal in vivo development of dopaminergic neurons. To address this issue, glia and neurons of both the mesencephalic home region...

journal_title：Journal of neuroscience research

authors： Engele J

更新日期：1998-08-15 00:00:00

abstract：:The existence of endogenous neural progenitor cells (NPCs) in the adult spinal cord (sc) provides the potential for tailored repair therapies after spinal cord injury (SCI). This study investigates the impact of inflammatory mediators on properties of NPC cultures derived from adult rats after SCI. The Infinite Horizo...

journal_title：Journal of neuroscience research

authors： Knerlich-Lukoschus F,Krossa S,Krause J,Mehdorn HM,Scheidig A,Held-Feindt J

更新日期：2015-04-01 00:00:00

abstract：:We have studied the interaction between several growth factors to promote parasympathetic neuronal survival. Neither insulin nor insulin-like growth factor-I (IGF-I) had any effect on the survival of embryonic day 8 chick ciliary neurons in culture. Similarly, the protein kinase C activator phorbol dibutyrate (PdBu) h...

journal_title：Journal of neuroscience research

authors： Crouch MF,Hendry IA

更新日期：1991-01-01 00:00:00

abstract：:Previously we reported results of an incubation experiment with neurofilaments that supported the existence of a mu-type of Ca2+-activated neutral protease in the rat peripheral nerve; it was active with microM order Ca2+ (mu-CANP). This time, we partially purified the mu-CANP from a crude CANP fraction of rat periphe...

journal_title：Journal of neuroscience research

authors： Kamakura K,Ishiura S,Sugita H

更新日期：1986-01-01 00:00:00

abstract：:The exposure of SY5Y neuroblastoma cells to high concentrations of glucose, fructose, or galactose is an experimental model commonly used for in vitro evaluation of typical neuronal alterations observed in diabetes mellitus. In the present study, we observed that 2 weeks of exposure to high carbohydrate concentrations...

journal_title：Journal of neuroscience research

authors： Di Giulio AM,Lesma E,Germani E,Gorio A

更新日期：1999-09-01 00:00:00

abstract：:Increased serum level of homocysteine, a sulfur-containing amino acid, is considered a risk factor in vascular disorders and in dementias. The effect of homocysteine and metabolically related compounds on brain production of kynurenic acid (KYNA), an endogenous antagonist of glutamate ionotropic receptors, was studied...

journal_title：Journal of neuroscience research

authors： Luchowska E,Luchowski P,Paczek R,Ziembowicz A,Kocki T,Turski WA,Wielosz M,Lazarewicz J,Urbanska EM

更新日期：2005-02-01 00:00:00

abstract：:The properties of neuronal plasma membranes are highly specialized, since they include the receptors by which many hormones, neurotransmitters, drugs, and toxins initiate their actions, as well as the components necessary for receiving synaptic input from a variety of sources and for generating the appropriate pattern...

journal_title：Journal of neuroscience research

authors： Poduslo SE,Chechik T,Filbin MT,Rosenfeld J

更新日期：1986-01-01 00:00:00

abstract：:Most previous studies on spinal cord injury (SCI) have used rodent models. Direct extrapolation of the results obtained in rodents to clinical cases is difficult, however, because of neurofunctional and anatomic differences between rodents and primates. In the present study, the development of histopathologic changes ...

journal_title：Journal of neuroscience research

authors： Iwanami A,Yamane J,Katoh H,Nakamura M,Momoshima S,Ishii H,Tanioka Y,Tamaoki N,Nomura T,Toyama Y,Okano H

更新日期：2005-04-15 00:00:00

abstract：:Mice heterozygously deficient in the major myelin component P0 are an established model of an inherited neuropathy and show signs of myelin degeneration in motor nerves. Unlike the case in patients, the sensory nerves are only mildly affected in the mouse mutants and do not show features indicative of myelin degenerat...

journal_title：Journal of neuroscience research

authors： Samsam M,Frei R,Marziniak M,Martini R,Sommer C

更新日期：2002-01-15 00:00:00

abstract：:The dentate gyrus is selectively reduced in size in the insulin-like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of...

journal_title：Journal of neuroscience research

authors： Cheng CM,Cohen M,Tseng V,Bondy CA

更新日期：2001-05-15 00:00:00

abstract：:The amygdala contributes to the generation and propagation of epileptiform activity in temporal lobe epilepsy (TLE). Ictal symptoms such as fear, dreamy states (déjà vu, memory flashbacks, experiential hallucinations), epigastric auras, or sympathetic outflow with cardiovascular changes are often linked to a seizure f...

journal_title：Journal of neuroscience research

authors： Yilmazer-Hanke D,O'Loughlin E,McDermott K

更新日期：2016-06-01 00:00:00

abstract：:Zinc ion elevation contributes to acute excitotoxic brain injury and correlates with the severity of dementia in chronic neurodegenerative diseases. Downstream control of zinc-triggered signals is believed to be an efficient countermeasure. In the current study, we examined whether the flavonoid luteolin (Lu) could pr...

journal_title：Journal of neuroscience research

authors： Zhou F,Qu L,Lv K,Chen H,Liu J,Liu X,Li Y,Sun X

更新日期：2011-11-01 00:00:00

abstract：:Pathogenesis of Parkinson's disease and related catecholaminergic neurological disorders is closely associated with changes in the levels of tyrosine hydroxylase (TH). Therefore, investigation of the regulation of the TH gene system should assist in understanding the pathomechanisms involved in these neurological diso...

journal_title：Journal of neuroscience research

authors： Choi EY,Yang JW,Park MS,Sun W,Kim H,Kim SU,Lee MA

更新日期：2012-10-01 00:00:00

abstract：:The neuronal intermediate filaments include not only the neurofilament triplet proteins but also peripherin and alpha-internexin. To determine whether neurite outgrowth is enhanced by alpha-internexin, the cDNA of rat alpha-internexin tagged with enhanced green fluorescent protein (EGFP) was transfected into a rat adr...

journal_title：Journal of neuroscience research

authors： Chien CL,Liu TC,Ho CL,Lu KS

更新日期：2005-06-01 00:00:00

abstract：:The effects of cations on the spontaneous and potassium-stimulated taurine release from mouse cerebral cortex slices were assessed with an emphasis on the as yet unestablished calcium dependence of the stimulated release. Spontaneous and stimulated GABA release was analyzed for comparison. A depolarizing concentration...

journal_title：Journal of neuroscience research

authors： Oja SS,Kontro P

更新日期：1987-01-01 00:00:00

abstract：:We investigated whether certain hydrophobic dipeptides, Leu-Ile, Leu-Pro, and Pro-Ile, which partially resemble the site on FK506 that binds to immunophilin, could stimulate glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) synthesis in cultured neurons and found only Leu-...

journal_title：Journal of neuroscience research

authors： Nitta A,Nishioka H,Fukumitsu H,Furukawa Y,Sugiura H,Shen L,Furukawa S

更新日期：2004-10-15 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha), a proinflammatory cytokine, has been implicated in the pathogenesis of several disorders and injuries in the central nervous system (CNS). Unlike IGF-I, which promotes CNS growth, TNF-alpha causes brain growth retardation and neural damage. Recently TNF-alpha has been shown to ...

journal_title：Journal of neuroscience research

authors： Ye P,Price W,Kassiotis G,Kollias G,D'Ercole AJ

更新日期：2003-03-01 00:00:00

abstract：:Production of hydrogen peroxide as a by-product of the breakdown of catecholamines by the enzyme monoamine oxidase (MAO) has been hypothesized to contribute to the increased proclivity of dopaminergic neurons for oxidative injury. We established clonal dopaminergic PC12 cell lines which have elevated MAO activity leve...

journal_title：Journal of neuroscience research

authors： Wei Q,Yeung M,Jurma OP,Andersen JK

更新日期：1996-12-15 00:00:00

abstract：:Netrin-1 regulates axon extension during embryonic development and is expressed by neurons and myelinating oligodendrocytes in the adult CNS. To investigate the potential role of netrin-1 after spinal cord injury, we examined the expression of netrin-1 and netrin receptors after sagittal myelotomy in adult rats. This ...

journal_title：Journal of neuroscience research

authors： Manitt C,Wang D,Kennedy TE,Howland DR

更新日期：2006-12-01 00:00:00

abstract：:Neuronal ceroid lipofuscinoses (NCLs) are a group of hereditary childhood diseases characterized mainly by lipopigment accumulation and a multisystemic pattern of symptoms including mental retardation, seizures, motor impairment, and blindness. The mnd mouse, carrying a mutation in the Cln8 gene, has been proposed as ...

journal_title：Journal of neuroscience research

authors： Bigini P,Milanese M,Gardoni F,Longhi A,Bonifacino T,Barbera S,Fumagalli E,Di Luca M,Mennini T,Bonanno G

更新日期：2012-06-01 00:00:00

abstract：:Peroxisome proliferator-activated receptor gamma coactivator 1alpha (PGC-1alpha) coactivates a number of transcription factors critical for mitochondrial biogenesis. Previously, we found that the expression of PGC-1alpha is governed by neuronal activity, but the signaling mechanism is poorly understood. The present st...

journal_title：Journal of neuroscience research

authors： Liang HL,Dhar SS,Wong-Riley MT

更新日期：2010-02-15 00:00:00

abstract：:Epidural hematoma (EDH) is a type of life-threatening traumatic brain injury. Little is known about the extent to which EDH may cause neural damage and regenerative response in the cerebral cortex. Here we attempted to explore these issues by using guinea pigs as an experimental model. Unilateral EDH was induced by in...

journal_title：Journal of neuroscience research

authors： Pan A,Li M,Gao JY,Xue ZQ,Li Z,Yuan XY,Luo DW,Luo XG,Yan XX

更新日期：2013-02-01 00:00:00

abstract：:We have investigated the involvement of c-Jun in cell death induced by exposure of primary cultures of murine cerebellar granule cells to the glutamate receptor agonist kainate (KA) and evaluated its possible use as a marker for apoptosis. Using cerebellar granule cell neurones from postnatal day 7 mice, we found that...

journal_title：Journal of neuroscience research

authors： Cheung NS,Carroll FY,Larm JA,Beart PM,Giardina SF

更新日期：1998-04-01 00:00:00