Phosphorylative neuromodulation of the regulatory subunit of cyclic AMP-dependent protein kinase type II in skeletal muscle.

abstract：:A distinct population of white matter progenitor cells (WMPCs), competent but not committed to generate oligodendrocytes, remains ubiquitous in the adult human subcortical white matter. These cells are present in both sexes and into senescence and may constitute as much as 4% of the cells of adult human capsular white...

journal_title：Journal of neuroscience research

authors： Windrem MS,Roy NS,Wang J,Nunes M,Benraiss A,Goodman R,McKhann GM 2nd,Goldman SA

更新日期：2002-09-15 00:00:00

abstract：:The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR-alpha agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE), the animal model ...

journal_title：Journal of neuroscience research

authors： Xu J,Storer PD,Chavis JA,Racke MK,Drew PD

更新日期：2005-08-01 00:00:00

abstract：:The possibility that neuron-astrocyte communication may be responsible for glutamate (Glu)-stimulated cGMP formation even in relatively homogeneous primary cultures of mouse cerebellar granule cells (7 days in vitro) was investigated. Pharmacological analysis using selective excitatory amino acid (EAA) receptor antago...

journal_title：Journal of neuroscience research

authors： Malcolm C,Grieve A,Ritchie L,Schousboe A,Griffiths R

更新日期：1996-07-15 00:00:00

abstract：:Maternal stress exerts long-lasting psychiatric and somatic on offspring, which persist into adulthood. However, the effect of maternal stress on the postnatal growth of pups has not been widely reported. In this study, we found that maternal immobilization stress (IS) during lactation resulted in low body weight of m...

journal_title：Journal of neuroscience research

authors： Gao P,Ishige A,Murakami Y,Nakata H,Oka J,Munakata K,Yamamoto M,Nishimura K,Watanabe K

更新日期：2011-03-01 00:00:00

abstract：:Both protein kinase C (PKC) and ceramide play a critical role in cell signaling, but the relationship between PKC and ceramide is unclear. Low concentrations of ceramide were observed to transiently stimulate PKC zeta activity in vitro and in vivo, whereas high doses of ceramide lead to inhibition of PKC zeta. Inhibit...

journal_title：Journal of neuroscience research

authors： Wang YM,Seibenhener ML,Vandenplas ML,Wooten MW

更新日期：1999-02-01 00:00:00

abstract：:Previous histochemical studies of iron in the brain demonstrated iron enrichment in oligodendrocytes, but the iron-enriched oligodendrocytes had a spatially restricted distribution that excluded major white matter tracts. In this study we used techniques designed to permeabilize tissue, combined with iron histochemist...

journal_title：Journal of neuroscience research

authors： LeVine SM,Macklin WB

更新日期：1990-08-01 00:00:00

abstract：:Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into the mouse Htt gene, whereas in the Q140s, mouse exon 1 H...

journal_title：Journal of neuroscience research

authors： Franich NR,Hickey MA,Zhu C,Osborne GF,Ali N,Chu T,Bove NH,Lemesre V,Lerner RP,Zeitlin SO,Howland D,Neueder A,Landles C,Bates GP,Chesselet MF

更新日期：2019-12-01 00:00:00

abstract：:The olfactory ensheathing cell (OEC) is a unique glial cell able to support neurite outgrowth in the CNS throughout life. The OEC has been described as having both Schwann cell-like and astrocyte-like characteristics. The purpose of this study was to compare gap junctional communication and connexin (Cx) expression in...

journal_title：Journal of neuroscience research

authors： Barnett SC,Thompson RJ,Lakatos A,Pitts J

更新日期：2001-09-15 00:00:00

abstract：:Parkinson's disease (PD) is a movement disorder characterized by a progressive loss of nigrostriatal dopaminergic neurons. Microglia activation and neuroinflammation have been associated with the pathogenesis of PD. Indeed, cytokines have been proposed as candidates that mediate the apoptotic cell death of dopaminergi...

journal_title：Journal of neuroscience research

authors： Bureau G,Longpré F,Martinoli MG

更新日期：2008-02-01 00:00:00

abstract：:Microtubule-associated protein (MAP)1B-heterozygous (MAP1B+/-) mice are deficient in the expression of MAP1B in the hippocampus, cerebellum, and olfactory cortex. Although MAP1B+/- mice showed half the normal levels of MAP1B protein, they had no measurable amounts of phosphorylated MAP1B. High-frequency theta burst st...

journal_title：Journal of neuroscience research

authors： Zervas M,Opitz T,Edelmann W,Wainer B,Kucherlapati R,Stanton PK

更新日期：2005-10-01 00:00:00

abstract：:The distribution of phosphofructokinase (PFK) in gray and white matter regions of the rat nervous system was evaluated. Determinations of PFK activity revealed that cell body enriched regions (sensorimotor cortex) had a significantly higher level of activity than axonal regions (sciatic nerve, dorsal roots, and optic ...

journal_title：Journal of neuroscience research

authors： Oblinger MM,Foe LG,Kwiatkowska D,Kemp RG

更新日期：1988-09-01 00:00:00

abstract：:As a neurotransmitter and neuromodulator, serotonin (5-HT) influences neuronal outgrowth in the nervous systems of several species. In PC12 cells, 5-HT is known to have neuritogenic effects, although the signal transduction pathway responsible for these effects is not understood. In this study, we hypothesized that a ...

journal_title：Journal of neuroscience research

authors： Homma K,Kitamura Y,Ogawa H,Oka K

更新日期：2006-08-01 00:00:00

abstract：:An aminopeptidase purified to homogeneity from cytosol of rat brain cleaved dynorphins having 5-17 residues and selected proenkephalins at the Tyr-Gly bond only to release Tyr and the desTyr fragments. The enzyme protein consisted of a single polypeptide chain of Mr 103,000 and was inhibited by puromycin, bestatin, an...

journal_title：Journal of neuroscience research

authors： Berg MJ,Marks N

更新日期：1984-01-01 00:00:00

abstract：:High levels of the proto-oncogene product, pp60c-src, have been found in developing and adult neural tissues as well as in certain fully mature cells of the hematopoietic lineage, e.g., platelets and myelomonocytes. Adrenal medullary chromaffin cells exhibit characteristics of both types of cells, i.e., they are deriv...

journal_title：Journal of neuroscience research

authors： Oddie KM,Litz JS,Balserak JC,Payne DM,Creutz CE,Parsons SJ

更新日期：1989-09-01 00:00:00

abstract：:The N-methyl-D-aspartate receptor (NMDAR) is a major neurotransmitter receptor in the central nervous system (CNS), with functional roles in learning, memory, and sensation. Several mechanisms potentiate NMDARs, and NMDAR hyperexcitability plays pathophysiological roles in many conditions, such as neurodegenerative di...

journal_title：Journal of neuroscience research

authors： Mattar PA,Holmes KD,Dekaban GA

更新日期：2003-12-01 00:00:00

abstract：:The expression of gangliosides of the lactosylceramide (LC) and of the gangliotetraosylceramide (GTC) series on the surface of cells from rat embryonic cerebellar tissue was investigated by double-color indirect immunofluorescence. GD3 was assumed to be representative of LC and was detected using a specific monoclonal...

journal_title：Journal of neuroscience research

authors： Gravotta D,Ferreira A,Busciglio J,Caceres A,Landa CA,Maccioni HJ

更新日期：1990-02-01 00:00:00

abstract：:Cell death has been described as either apoptotic, in which the cell actively participates, or necrotic, in which the cell is felt to be passive. The proto-oncogene bcl-2 has been shown to inhibit apoptosis in some hematopoietic and neural cells, by an unknown mechanism. We demonstrate that bcl-2 inhibits the necrosis...

journal_title：Journal of neuroscience research

authors： Kane DJ,Ord T,Anton R,Bredesen DE

更新日期：1995-02-01 00:00:00

abstract：:The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...

journal_title：Journal of neuroscience research

authors： Yeh YY

更新日期：1988-03-01 00:00:00

abstract：:Several recently discovered lines of evidence support the involvement of myelin basic protein (BP)-specific T cells in multiple sclerosis (MS). To identify potentially relevant immunodominant T cell epitopes, human BP (Hu-BP)-reactive T cell lines were selected from MS and normal donors and tested for reactivity to cl...

journal_title：Journal of neuroscience research

authors： Chou YK,Henderikx P,Vainiene M,Whitham R,Bourdette D,Chou CH,Hashim G,Offner H,Vandenbark AA

更新日期：1991-02-01 00:00:00

abstract：:Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men,...

journal_title：Journal of neuroscience research

authors： Spychala MS,Honarpisheh P,McCullough LD

更新日期：2017-01-02 00:00:00

abstract：:An early and essential step in the formation of functional neuronal circuits is the establishment of cell polarity, a process involving the morphological and functional differentiation of the axon (axonogenesis). We now report that treatment of cultured embryonic hippocampal neurons with ethidium bromide (EtBr; an age...

journal_title：Journal of neuroscience research

authors： Mattson MP,Partin J

更新日期：1999-04-01 00:00:00

abstract：:Photopic L-type responses were recorded from the soma and the axon terminal of horizontal cells of the catfish (Ictalurus punctatus) retina in eye-cup preparations. The responses were produced by a spot of light with 100-micron diameter (intensity, 10 microW/cm2), which was flashed or steadily illuminated and swept al...

journal_title：Journal of neuroscience research

authors： Hida E,Negishi K,Naka KI

更新日期：1984-01-01 00:00:00

abstract：:Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...

journal_title：Journal of neuroscience research

authors： Humpel C,Ebendal T,Cao Y,Olson L

更新日期：1993-07-01 00:00:00

abstract：:Lentiviral vectors are used widely to direct efficient gene transfer in vivo. We examined cell-specific expression in adult murine white matter after stereotaxic microinjection of four lentiviral constructs. We synthesized vesicular stomatitis virus glycoprotein (VSV-G) pseudotyped lentiviruses with combinations of tw...

journal_title：Journal of neuroscience research

authors： McIver SR,Lee CS,Lee JM,Green SH,Sands MS,Snider BJ,Goldberg MP

更新日期：2005-11-01 00:00:00

abstract：:Glycolysis was blocked in the hippocampus of the otherwise unaffected rabbit by perfusion of a previously implanted thin dialysis tube with a medium containing 0.1 mM iodoacetate. The perfusate from the dialysis tube was analyzed for free amino acids with liquid chromatographic separation of ortophthaldialdehyde deriv...

journal_title：Journal of neuroscience research

authors： Sandberg M,Nyström B,Hamberger A

更新日期：1985-01-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) regulates the proliferation and migration of olfactory bulb (OB) interneuron progenitors derived from the subventricular zone (SVZ), but the role of GABA in the differentiation of these progenitors has been largely unexplored. This study examines the role of GABA in the differentiation o...

journal_title：Journal of neuroscience research

authors： Akiba Y,Sasaki H,Huerta PT,Estevez AG,Baker H,Cave JW

更新日期：2009-08-01 00:00:00

abstract：:Brain metabolism increases during stimulation, but this increase does not affect all energy metabolism equally. Briefly after stimulation, there is a local increase in cerebral blood flow and in glucose uptake, but a smaller increase in oxygen uptake. This indicates that temporarily the rate of glycolysis is faster th...

journal_title：Journal of neuroscience research

authors： Díaz-García CM,Yellen G

更新日期：2019-08-01 00:00:00

abstract：:Plexiform layer synaptic and photoreceptor cell components were investigated in retinas of Royal College of Surgeons (RCS) dystrophic rats transplanted with normal retinal pigment epithelial (RPE) cells by immunocytochemistry using previously characterized monoclonal antibodies. In retinas of normal adult rats and RPE...

journal_title：Journal of neuroscience research

authors： Sheedlo HJ,Li L,Barnstable CJ,Turner JE

更新日期：1993-11-01 00:00:00

abstract：:Our previous work indicated that in E14 embryonic rat spinal cord cultures ciliary neuronotrophic factor (CNTF) exerted (1) a survival-promoting effect on motor neurons and on a large population of unidentified neurons, and (2) a regulatory role on the expression of ChAT and low affinity NGF receptor (LNGFR) in a popu...

journal_title：Journal of neuroscience research

authors： Magal E,Burnham P,Varon S

更新日期：1991-11-01 00:00:00

abstract：:The thyroid hormones triiodothyronine (T3) and L-thyroxine appear to enhance regeneration in the peripheral and central nervous system (CNS). The following experiments examine possible metabolic substrates for the action of T3 on the adult rat CNS after spinal hemisection. The protein incorporation of (3H)lysine after...

journal_title：Journal of neuroscience research

authors： Wells MR,Lofton SA,Bernstein JJ

更新日期：1981-01-01 00:00:00