Electrical stimulation promotes the survival of oligodendrocytes in mixed cortical cultures.

abstract：:Intact synaptosomes prepared from 28-day-old rat brains were incubated with CMP-N-acetyl-(14C) neuraminic acid in Krebs-Henseleit buffer in an atmosphere of 95% O2: 5% CO2, at 37 degrees C. The activity of CMP-NANA:ganglioside sialosyltransferase using endogenous acceptors was 0.84 pmoles NANA transferred/mg synaptoso...

journal_title：Journal of neuroscience research

authors： Durrie R,Saito M,Rosenberg A

更新日期：1987-01-01 00:00:00

abstract：:In recent years, several novel types of disorders have been characterized, including what have been termed polyalanine diseases, in which patients have expanded triplet repeats in specific genes, resulting in the translation of aberrantly elongated polyalanine stretches. In this study, we showed that yellow fluorescen...

journal_title：Journal of neuroscience research

authors： Toriumi K,Oma Y,Kino Y,Futai E,Sasagawa N,Ishiura S

更新日期：2008-05-15 00:00:00

abstract：:Chondroitinase ABC (Ch'ase ABC) is a bacterial lyase that degrades chondroitin sulfate (CS), dermatan sulfate, and hyaluronan glycosaminoglycans (GAGs). This enzyme has received significant attention as a potential therapy for promoting central nervous system and peripheral nervous system repair based on its degradati...

journal_title：Journal of neuroscience research

authors： Tester NJ,Plaas AH,Howland DR

更新日期：2007-04-01 00:00:00

abstract：:We present here a fast protocol that could be used to obtain highly purified cultures of maximal proliferating adult rat Schwann cells. These adult rat Schwann cells can be transfected in a nonbiological way using the physical transfection method of electroporation. Schwann cells are decisive in recovery of peripheral...

journal_title：Journal of neuroscience research

authors： Mauritz C,Grothe C,Haastert K

更新日期：2004-08-01 00:00:00

abstract：:Laminin mediates neural adhesion and process formation. A possible signal transduction pathway for laminin was investigated in both NG108-15 and PC12 neuronal cells using radiolabeling studies as well as various stimulators and inhibitors of phosphatases and kinases. Using [32P]-ortho-phosphate, laminin caused a decre...

journal_title：Journal of neuroscience research

authors： Weeks BS,DiSalvo J,Kleinman HK

更新日期：1990-11-01 00:00:00

abstract：:Mitochondrial dysfunction has been implicated in cell death in many neurodegenerative diseases. Diminished activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), a key and arguably rate-limiting enzyme of the Krebs cycle, occurs in these disorders and may underlie decreased brain metabolism. The present st...

journal_title：Journal of neuroscience research

authors： Huang HM,Ou HC,Xu H,Chen HL,Fowler C,Gibson GE

更新日期：2003-10-15 00:00:00

abstract：:In order to identify the relative number of benzodiazepine (BZ) receptors in Purkinje and granule cells, the Purkinje cell degeneration (pcd) mutant mouse was used at different ages. In these mice, Purkinje cells have degenerated almost completely by 45-50 days of age. Granule cell loss occurs only later, and is most ...

journal_title：Journal of neuroscience research

authors： Vaccarino FM,Ghetti B,Wade SE,Rea MA,Aprison MH

更新日期：1983-01-01 00:00:00

abstract：:GM1, GD1a, and GT1b inhibit both PDGF-stimulated and serum-stimulated DNA synthesis in Swiss 3T3 cells and the human glioma cell line U-1242 MG in a dose-dependent manner. The ganglioside inhibitory effect is counteracted in a dose-responsive fashion by serum such that ganglioside-induced inhibition is essentially abo...

journal_title：Journal of neuroscience research

authors： Saqr HE,Lee MC,Burkman AM,Yates AJ

更新日期：1995-07-01 00:00:00

abstract：:The molecular pathways underlying the neuroprotective effects of preconditioning are promising, potentially drugable targets to promote cell survival. However, these pathways are complex and are not yet fully understood. In this study we have established a paradigm of hypoxic preconditioning based on a chick embryo mo...

journal_title：Journal of neuroscience research

authors： Giusti S,Fiszer de Plazas S

更新日期：2012-02-01 00:00:00

abstract：:Astrocytes are excitable neural cells that contribute to brain information processing via bidirectional communication with neurons. This involves the release of gliosignaling molecules that affect synapses patterning and activity. Mechanisms mediating the release of these molecules likely consist of non-vesicular and ...

journal_title：Journal of neuroscience research

authors： Jorgačevski J,Potokar M,Kreft M,Guček A,Mothet JP,Zorec R

更新日期：2017-11-01 00:00:00

abstract：:We investigated the ability of human bone marrow stromal cell (hBMSC) treatment to reduce axonal loss in experimental autoimmune encephalomyelitis (EAE) mice. EAE was induced in SJL/J mice by injection with proteolipid protein (PLP). Mice were injected intravenously with hBMSCs or PBS on the day of clinical onset, and...

journal_title：Journal of neuroscience research

authors： Zhang J,Li Y,Lu M,Cui Y,Chen J,Noffsinger L,Elias SB,Chopp M

更新日期：2006-08-15 00:00:00

abstract：:Physiological responses to acute stress proceed with the activation of the hypothalamus-pituitary-adrenal gland (HPA) system. Many brain regions are known to modulate the HPA axis activation in stress responses, but the detailed neural circuits and signaling system in the upstream of the HPA axis have to be explored f...

journal_title：Journal of neuroscience research

authors： Kim KS,Han PL

更新日期：2009-10-01 00:00:00

abstract：:Our aim has been to investigate the ability of the rat brain to retain its level of neurotransmitter release over life. We have investigated the neurotransmitter release from the rat brain synaptosomes prelabeled with 3H-DA, 3H-NA, or 3H-5HT, and perfused with Krebs-Ringer medium alone (basal release) or containing a ...

journal_title：Journal of neuroscience research

authors： Cerrito F,Aloisi G,Arminio P

更新日期：1993-02-15 00:00:00

abstract：:Inhibitory luminopsins (iLMO2) integrate opto- and chemo-genetic approaches and allow for cell-type specific inhibition of neuronal activity. When exposed to a Renilla luciferase substrate, Coelenterazine (CTZ), iLMO2 generates bioluminescence-mediated activation of its amino-terminal halorhodopsin, resulting in neuro...

journal_title：Journal of neuroscience research

authors： Jaiswal PB,Tung JK,Gross RE,English AW

更新日期：2020-03-01 00:00:00

abstract：:Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vasospasm remain poorl...

journal_title：Journal of neuroscience research

authors： Kolias AG,Sen J,Belli A

更新日期：2009-01-01 00:00:00

abstract：:Peroxides are generated continuously in cells that consume oxygen. Among the different peroxides, hydrogen peroxide is the molecule that is formed in highest quantities. In addition, organic hydroperoxides are synthesized as products of cellular metabolism. Generation and disposal of peroxides is a very important proc...

journal_title：Journal of neuroscience research

authors： Dringen R,Pawlowski PG,Hirrlinger J

更新日期：2005-01-01 00:00:00

abstract：:Nitric oxide (NO) is produced by the enzyme nitric oxide synthase (NOS) and has been implicated in inter- and intracellular communication in the nervous system. The present study was undertaken to assess the effects of sodium nitroprusside (SNP) and hydroxylamine (HOA), NO donors, on a dopamine (DA)-induced K+ current...

journal_title：Journal of neuroscience research

authors： Sawada M,Ichinose M,Stefano GB

更新日期：1997-11-01 00:00:00

abstract：:Although increased neurogenesis has been described in rodent models of focal traumatic brain injury (TBI), the neurogenic response occurring after diffuse TBI uncomplicated by focal injury has not been examined to date, despite the pervasiveness of this distinct type of brain injury in the TBI patient population. Here...

journal_title：Journal of neuroscience research

authors： Bye N,Carron S,Han X,Agyapomaa D,Ng SY,Yan E,Rosenfeld JV,Morganti-Kossmann MC

更新日期：2011-07-01 00:00:00

abstract：:The hippocampus is an important brain region involved in memory and learning. Brain-derived neurotrophic factor (BDNF), tyrosine kinase receptor B (TrkB), and phospho-p44/p42 mitogen-activated protein kinase (MAPK) are known to contribute to hippocampal memory/learning. The present study aimed to clarify the effects o...

journal_title：Journal of neuroscience research

authors： Ogawa T,Okihara H,Kokai S,Abe Y,Karin Harumi UK,Makiguchi M,Kato C,Yabushita T,Michikawa M,Ono T

更新日期：2018-06-01 00:00:00

abstract：:Growth hormone (GH) appears to play a major role in a reciprocal axis that has been postulated between the thymus and pituitary glands. Our previous studies showed that thymic structure, as well as T-cell proliferation and IL-2 synthesis, could be restored in aged female Wistar-Furth rats by the implantation of GH3 pi...

journal_title：Journal of neuroscience research

authors： Davila DR,Brief S,Simon J,Hammer RE,Brinster RL,Kelley KW

更新日期：1987-01-01 00:00:00

abstract：:Inhibitors of differentiation (Id) play an essential role in the neurogenesis of the central nervous system. However, the expression and function of Id in the development of cochlear sensory epithelial cells have yet to be elucidated. In this study, we demonstrate the Id1 gene was expressed in the rapidly growing otoc...

journal_title：Journal of neuroscience research

authors： Ozeki M,Hamajima Y,Feng L,Ondrey FG,Schlentz E,Lin J

更新日期：2007-02-15 00:00:00

abstract：:Previous studies have shown that the mechanical wounding of 3-week-old cultured rat astrocytes results in cell proliferation and hypertrophy resembling astrocyte responses to a brain injury in vivo. We now report the effects of basic fibroblast growth factor (bFGF) and an anti-bFGF antibody on astrocyte morphology, pr...

journal_title：Journal of neuroscience research

authors： Hou YJ,Yu AC,Garcia JM,Aotaki-Keen A,Lee YL,Eng LF,Hjelmeland LJ,Menon VK

更新日期：1995-02-15 00:00:00

abstract：:The ED1 monoclonal antibody recognizes an antigen in lysosomal membranes of phagocytes. The expression of this antigen in cells increases during phagocytic activity. Here we describe the expression of ED1-immunoreactivity during the various stages of both acute (monophasic) and chronic relapsing experimental autoimmun...

journal_title：Journal of neuroscience research

authors： Bauer J,Sminia T,Wouterlood FG,Dijkstra CD

更新日期：1994-07-01 00:00:00

abstract：:Astrocytomas are the most common brain tumors arising in the CNS and account for 65% of all primary brain tumors. Astrocytes have been shown to have the highest predisposition to malignant transformation compared to any other CNS cell type. The majority of astrocytomas are histologically malignant neoplasm. Previous s...

journal_title：Journal of neuroscience research

authors： Lal PG,Ghirnikar RS,Eng LF

更新日期：1996-05-01 00:00:00

abstract：:Pigment epithelium-derived factor (PEDF) is a neurotrophic protein synthesized and secreted by retinal pigment epithelial (RPE) cells in early embryogenesis and has been shown to be present in the extracellular matrix between the RPE cells and the neural retina. It induces neuronal differentiation and promotes surviva...

journal_title：Journal of neuroscience research

authors： Cao W,Tombran-Tink J,Chen W,Mrazek D,Elias R,McGinnis JF

更新日期：1999-09-15 00:00:00

abstract：:Disturbances in neuronal calcium homeostasis have been implicated in a variety of neuropathological conditions, including cerebral ischemia, hypoglycemia, and epilepsy, and possibly constitute part of the cell death process associated with chronic neurodegenerative disorders. We investigated if endoplasmic reticulum (...

journal_title：Journal of neuroscience research

authors： Hernández-Fonseca K,Massieu L

更新日期：2005-10-15 00:00:00

abstract：:Oligodendrocyte responses in vitro to platelet-derived growth factor (PDGF) include proliferation, survival, migration, and changes in cell morphology and molecular expression. Studies of mixed glial cultures established that astrocytes secrete PDGF; thus astrocytes are considered to be key regulators of oligodendrocy...

journal_title：Journal of neuroscience research

authors： Ellison JA,Scully SA,de Vellis J

更新日期：1996-07-01 00:00:00

abstract：:It has been postulated that the pathogenesis of Parkinson's disease (PD) is associated with mitochondrial dysfunction. Rotenone, an inhibitor of mitochondrial complex I, provides models of PD both in vivo and in vitro. We investigated the neuroprotective effect of D-beta-hydroxybutyrate (bHB), a ketone body, against r...

journal_title：Journal of neuroscience research

authors： Imamura K,Takeshima T,Kashiwaya Y,Nakaso K,Nakashima K

更新日期：2006-11-01 00:00:00

abstract：:Interleukin-1 receptor antagonist (IL-1ra), a true antagonist of the interleukin-1 (IL-1) receptors, is released by activated macrophages and binds specifically to the IL-1 receptors without triggering IL-1 effects. Following peripheral nerve axotomy, activated macrophages release IL-1, which induces the expression of...

journal_title：Journal of neuroscience research

authors： Guénard V,Dinarello CA,Weston PJ,Aebischer P

更新日期：1991-07-01 00:00:00

abstract：:The cytokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) signal through a receptor complex formed between two transmembrane proteins, gp130 and LIFRbeta. In addition, CNTF also uses a ligand-binding component which is anchored to the cell membrane. In the case of cardiotrophin-1 (CT-1), LI...

journal_title：Journal of neuroscience research

authors： Arce V,Garces A,de Bovis B,Filippi P,Henderson C,Pettmann B,deLapeyrière O

更新日期：1999-01-01 00:00:00