Effect of body temperature on chondroitinase ABC's ability to cleave chondroitin sulfate glycosaminoglycans.

abstract：:A rodent model of Parkinson's disease, the 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine treated mouse, was used to determine whether striatal dopamine levels recover following grafting adrenal medulla into the striatum. Four types of grafts were performed: 1) adult mouse adrenal medulla, 2) adult adrenal me...

journal_title：Journal of neuroscience research

authors： Bohn MC,Kanuicki M

更新日期：1990-03-01 00:00:00

abstract：:The presence of acetylcholinesterase has been detected in the thymus of several species both biochemically and histochemically. In this study we have investigated the molecular forms and the level of this enzyme in separate compartments of the murine thymus and in different thymocyte subpopulations. Similar levels of ...

journal_title：Journal of neuroscience research

authors： Rossi A,Vicini E,Scarsella G,Biagioni S

更新日期：1991-06-01 00:00:00

abstract：:Protein zero (P0) glycoprotein is the major integral membrane protein of the peripheral nervous system myelin in higher vertebrates. Previous findings indicate the formation of tetrameric assemblies from studies on isolated P0. To determine whether in intact myelin the P0 exists as oligomers, we isolated myelin from s...

journal_title：Journal of neuroscience research

authors： Thompson AJ,Cronin MS,Kirschner DA

更新日期：2002-03-15 00:00:00

abstract：:CD200, a type I transmembrane glycoprotein, can interact with its receptor CD200R, which plays an inhibitory role in the activation of microglia-the resident macrophages of the central nervous system. In this study, the rat C6 glioma cell line (C6-1) that was previously characterized with high in vivo tumorigenicity w...

journal_title：Journal of neuroscience research

authors： Wang CY,Hsieh YT,Fang KM,Yang CS,Tzeng SF

更新日期：2016-12-01 00:00:00

abstract：:We studied the postischemic alterations of second messenger and receptor systems focusing on the strionigral pathway in order to clarify the mechanism of the delayed neuronal changes in remote areas of the rat brain after transient focal ischemia. Chronological changes of [3H]forskolin and [3H]SCH 23390 binding sites ...

journal_title：Journal of neuroscience research

authors： Nagasawa H,Araki T,Kogure K

更新日期：1992-11-01 00:00:00

abstract：:A series of AMPA [(R,S)-alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid] analogues were evaluated for activity at homomeric, heteromeric, and chimeric rat GluR1(o) and GluR3(o) receptors expressed in Xenopus oocytes, using the two-electrode voltage clamp technique. The formation of heteromeric receptor compl...

journal_title：Journal of neuroscience research

authors： Banke TG,Schousboe A,Pickering DS

更新日期：1997-07-15 00:00:00

abstract：:In 2000, a landmark case report described the concurrent restoration of consciousness and thalamo-frontal connectivity after severe brain injury (Laureys et al., ). Being a single case however, this study could not disambiguate whether the result was specific to the restoration of consciousness per se as opposed to th...

journal_title：Journal of neuroscience research

authors： Crone JS,Bio BJ,Vespa PM,Lutkenhoff ES,Monti MM

更新日期：2018-04-01 00:00:00

abstract：:The expression of gangliosides of the lactosylceramide (LC) and of the gangliotetraosylceramide (GTC) series on the surface of cells from rat embryonic cerebellar tissue was investigated by double-color indirect immunofluorescence. GD3 was assumed to be representative of LC and was detected using a specific monoclonal...

journal_title：Journal of neuroscience research

authors： Gravotta D,Ferreira A,Busciglio J,Caceres A,Landa CA,Maccioni HJ

更新日期：1990-02-01 00:00:00

abstract：:The potassium-induced stimulation of oxygen consumption in brain slices has a threshold value of 15-20 mM potassium, and it reaches its maximum at 35-50 mM. Although this phenomenon now has been known for almost 50 years, its physiological role remains undetermined. One reason for this may be that the high concentrati...

journal_title：Journal of neuroscience research

authors： Hertz L,Kjeldsen CS

更新日期：1985-01-01 00:00:00

abstract：:Corticosteroids, released from the adrenal gland in response to stress, bind to receptors that act as transcription factors to alter gene expression and, subsequently, protein synthesis. Using [(35)S]-methionine-cysteine incorporation to measure protein synthesis in hippocampal slices incubated under ischemic conditio...

journal_title：Journal of neuroscience research

authors： Barr CS,Dokas LA

更新日期：2001-08-15 00:00:00

abstract：:Nicotine has been reported to be neuroprotective in experimental and epidemiological studies. In addition to nicotine, tobacco and cigarette smoke contain cembranoids, which are antagonists of neuronal nicotinic receptors (nAChR). Exposure of hippocampal slices to N-methyl-D-aspartate (NMDA) decreases the population s...

journal_title：Journal of neuroscience research

authors： Ferchmin PA,Hao J,Perez D,Penzo M,Maldonado HM,Gonzalez MT,Rodriguez AD,de Vellis J

更新日期：2005-12-01 00:00:00

abstract：:The effects of extracellular acidification on the synaptic function and neuronal excitability were investigated on the hippocampal CA1 neurons. A decrease of extracellular pH from 7.4 to 6.7 did not alter either the resting membrane potential or the neuronal membrane input resistance. Extracellularly recorded field ex...

journal_title：Journal of neuroscience research

authors： Hsu KS,Liang YC,Huang CC

更新日期：2000-11-01 00:00:00

abstract：:Embryonic central nervous system neuroepithelial cells are a transient population of cells that give rise to neuronal and glial progenitors. In the E12-E16 embryonic rat spinal neural tube we have identified neuroepithelial cells as radially oriented cells expressing the GD3 ganglioside as recognized by the monoclonal...

journal_title：Journal of neuroscience research

authors： Bannerman PG,Oliver TM,Xu Z,Shieh A,Pleasure DE

更新日期：1996-09-01 00:00:00

abstract：:Plexiform layer synaptic and photoreceptor cell components were investigated in retinas of Royal College of Surgeons (RCS) dystrophic rats transplanted with normal retinal pigment epithelial (RPE) cells by immunocytochemistry using previously characterized monoclonal antibodies. In retinas of normal adult rats and RPE...

journal_title：Journal of neuroscience research

authors： Sheedlo HJ,Li L,Barnstable CJ,Turner JE

更新日期：1993-11-01 00:00:00

abstract：:A previous study demonstrated the release of newly loaded radiolabelled taurine (Tau) from cultured rabbit Müller glia not only following typical cell volume-increasing treatments with high (65 mM) potassium ions or hypotonic media, but also with ammonium chloride (further referred to as ammonia), in a dose-dependent ...

journal_title：Journal of neuroscience research

authors： Faff L,Reichenbach A,Albrecht J

更新日期：1996-10-15 00:00:00

abstract：:Raf kinases are downstream effectors of Ras and upstream activators of the MEK-ERK cascade. Ras and MEK-ERK signaling play roles in learning and memory (L&M) and neural plasticity, but the roles of Raf kinases in L&M and plasticity are unclear. Among Raf isoforms, B-raf is preferentially expressed in the brain. To det...

journal_title：Journal of neuroscience research

authors： Chen AP,Ohno M,Giese KP,Kühn R,Chen RL,Silva AJ

更新日期：2006-01-01 00:00:00

abstract：:Electrical activity shapes development of the nervous system, presumably in part by regulating gene expression. A set of regulatory genes, immediate early genes (IEGs), which are responsive to a number of extrinsic cellular stimuli have been proposed to play a role in coupling such activity to gene expression. Using a...

journal_title：Journal of neuroscience research

authors： Sheng HZ,Fields RD,Nelson PG

更新日期：1993-08-01 00:00:00

abstract：:In contrast to mammals, teleost fish are able to regrow severed long-range projection axons in the central nervous system (CNS), leading to recovery of function. The optic projection in teleost fish is used to study neuron-intrinsic and environmental molecular factors that determine successful axon regrowth and naviga...

journal_title：Journal of neuroscience research

authors： Becker CG,Becker T

更新日期：2007-09-01 00:00:00

abstract：:Chronic alcohol consumption has adverse effects on the central nervous system, affecting some hippocampal and hypothalamic functions. In this study we tempted to demonstrate that some of these modifications could involve impairment of neurotrophic factors. Three experimental groups of male Sprague Dawley rats were stu...

journal_title：Journal of neuroscience research

authors： Tapia-Arancibia L,Rage F,Givalois L,Dingeon P,Arancibia S,Beaugé F

更新日期：2001-01-15 00:00:00

abstract：:We have previously shown that the phorbol ester, TPA, which activates protein kinase C, causes, in PC12 cells, a transcriptional activation of tyrosine hydroxylase (TH), the key enzyme in catecholamine synthesis. The study has now been extended to examine the processes that underlie this transcriptional stimulation an...

journal_title：Journal of neuroscience research

authors： Icard-Liepkalns C,Biguet NF,Vyas S,Robert JJ,Sassone-Corsi P,Mallet J

更新日期：1992-06-01 00:00:00

abstract：:The combination of nerve growth factor (NGF) and phorbol 12-myristate 13-acetate (PMA) rapidly induced the locomotion of PC12 cells by sequentially stimulating lamellar spreading, ruffling with pinocytosis, and polarization by retraction from the substratum. During migration, cells acquired long processes as a result ...

journal_title：Journal of neuroscience research

authors： Altun-Gultekin ZF,Wagner JA

更新日期：1996-05-15 00:00:00

abstract：:In this Mini-Review we present a new hypothesis in support of the neurodegenerative theory as a mechanism for the pathogenesis of multiple sclerosis (MS). The pathogenesis of MS results from changes in two distinct CNS compartments. These are the "myelin" and "nonmyelin" compartments. The myelin compartment is where p...

journal_title：Journal of neuroscience research

authors： Mastronardi FG,Moscarello MA

更新日期：2005-05-01 00:00:00

abstract：:Intracranial atherosclerosis (ICAS) is the most common etiology of ischemic stroke with the highest rate of stroke recurrence. Little is currently known of the association of circulating inflammation-regulatory microRNAs (miRNAs) with ICAS. In this review, we briefly discuss that ICAS is characterized as a dynamic and...

journal_title：Journal of neuroscience research

authors： Li J,Li K,Chen X

更新日期：2019-10-01 00:00:00

abstract：:The effects of KCl-treatment on the survival and proliferation of NE-4C self-renewing neural progenitor cells were investigated during early phases of in vitro induced neurogenesis. NE-4C cells, derived from the anterior brain vesicles of embryonic mouse (E9), divided continuously under non-inducing conditions, but ac...

journal_title：Journal of neuroscience research

authors： Herberth B,Pataki A,Jelitai M,Schlett K,Deák F,Spät A,Madarász E

更新日期：2002-03-01 00:00:00

abstract：:We recently reported that a new monoclonal antibody, 4F2, which labels oligodendroglial lineage cells, recognizes a DEAD-box RNA helicase Ddx54 and that Ddx54 binds to myelin basic protein (MBP) in brain and cultured oligodendrocytes. To elucidate the biological function of Ddx54, we generated a recombinant adenovirus...

journal_title：Journal of neuroscience research

authors： Zhan R,Yamamoto M,Ueki T,Yoshioka N,Tanaka K,Morisaki H,Seiwa C,Yamamoto Y,Kawano H,Tsuruo Y,Watanabe K,Asou H,Aiso S

更新日期：2013-03-01 00:00:00

abstract：:Primary brain tumors, particularly glioblastomas (GB), remain a challenge for oncology. An element of the malignant brain tumors' aggressive behavior is the fact that GB are among the most densely vascularized tumors. To determine some of the molecular regulations occuring at the brain tumor endothelium level during t...

journal_title：Journal of neuroscience research

authors： Régina A,Jodoin J,Khoueir P,Rolland Y,Berthelet F,Moumdjian R,Fenart L,Cecchelli R,Demeule M,Béliveau R

更新日期：2004-01-15 00:00:00

abstract：:Detergent-resistant lipid microdomains (Rafts) were isolated from human oligodendroglioma (HOG), human neuroblastoma (LA-N-5), and immortalized dorsal root ganglion (F-11) cell lines by sucrose-density gradient ultracentrifugation and shown to be enriched in cholesterol, sphingomyelin, and ceramide. [(3)H]palmitate la...

journal_title：Journal of neuroscience research

authors： Kilkus J,Goswami R,Testai FD,Dawson G

更新日期：2003-04-01 00:00:00

abstract：:Recent data indicate that molecular mimicry may play a role in the pathogenesis of human-T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an immune-mediated disease of the central nervous system (CNS). Specifically, HAM/TSP patients developed antibodies that cross-reac...

journal_title：Journal of neuroscience research

authors： Kalume F,Lee SM,Morcos Y,Callaway JC,Levin MC

更新日期：2004-07-01 00:00:00

abstract：:Sympathetic noradrenergic nerve fibers, stained with antiserum for tyrosine hydroxylase (TH), richly innervate the splenic white pulp. These fibers distribute with the vascular and trabecular systems, and associate mainly with the central artery and its branches, the periarteriolar lymphatic sheath (PALS), the margina...

journal_title：Journal of neuroscience research

authors： Felten DL,Ackerman KD,Wiegand SJ,Felten SY

更新日期：1987-01-01 00:00:00

abstract：:Progressive "dying back" neurodegenerative diseases are debilitating due to loss of connectivity after nerve terminal and axonal withdrawal, which impairs peripheral nerve function and leads ultimately to neuronal cell death. The mutant mouse (Wallerian degeneration slow; Wld(s)) provides an accessible model system to...

journal_title：Journal of neuroscience research

authors： Parson SH,Ribchester RR,Davie N,Gandhi NP,Malik RQ,Gillingwater TH,Thomson D

更新日期：2004-04-01 00:00:00