Down-regulation of caveolin-1 in glioma vasculature: modulation by radiotherapy.

abstract：:The widespread expression of circular RNAs (circRNAs) is regarded as a feature of gene expression in highly diverged eukaryotes. Recent studies have shown that circRNAs can act as a miRNA sponge to repress miRNA function, participate in splicing of target genes, translate genes into protein and interact with RNA bindi...

journal_title：Journal of neuroscience research

authors： Zang J,Lu D,Xu A

更新日期：2020-01-01 00:00:00

abstract：:The extracellular matrix surrounds different neuronal compartments in the mature nervous system. In a variety of vertebrates, most brain regions are loaded with a distinct type of extracellular matrix around the somatodendritic part of neurons, termed perineuronal nets. The present study reports that chondrotin sulfat...

journal_title：Journal of neuroscience research

authors： Lendvai D,Morawski M,Brückner G,Négyessy L,Baksa G,Glasz T,Patonay L,Matthews RT,Arendt T,Alpár A

更新日期：2012-02-01 00:00:00

abstract：:Neurotrophic factors regulate the developmental survival and differentiation of specific neuronal populations. Brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) are members of the nerve growth factor (NGF) protein family, also known as the neurotrophins. Insights into the different roles of neurotroph...

journal_title：Journal of neuroscience research

authors： Escandón E,Burton LE,Szönyi E,Nikolics K

更新日期：1993-04-15 00:00:00

abstract：:The non-receptor protein tyrosine kinase Fyn, which is a member of the Src family of kinases, has been shown to be essential for normal myelination and has been suggested to play a role in oligodendrocyte development. However, oligodendrocyte development has not been studied directly in cells lacking Fyn. Additionally...

journal_title：Journal of neuroscience research

authors： Sperber BR,McMorris FA

更新日期：2001-02-15 00:00:00

abstract：:The birth of cells with neurogenic potential in the adult brain is assessed commonly by detection of exogenous S phase markers, such as bromodeoxyuridine (BrdU). Analysis of other phases of the cell cycle, however, can provide insight into how external factors, such as opiates, influence the cycling of newly born cell...

journal_title：Journal of neuroscience research

authors： Mandyam CD,Norris RD,Eisch AJ

更新日期：2004-06-15 00:00:00

abstract：:Ionotropic glutamate receptors, N-methyl-d-aspartate receptors (NMDARs) and alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs), are densely distributed in the mammalian brain and actively regulate a variety of cellular activities. Expression and function of these receptors are also under a tig...

journal_title：Journal of neuroscience research

authors： Wang JQ,Liu X,Zhang G,Parelkar NK,Arora A,Haines M,Fibuch EE,Mao L

更新日期：2006-12-01 00:00:00

abstract：:The use of trimethadione (TMO) as a protector in hyperbaric oxygen toxicity in the conscious rat has been examined in detail. The oxidation-reduction state of pyridine nucleotides was measured simultaneously with the EEG activity from the surface of the brain cortex. From the data obtained, a few parameters were calcu...

journal_title：Journal of neuroscience research

authors： Mayevsky A

更新日期：1975-01-01 00:00:00

abstract：:The transport kinetics of the excitatory sulphur-containing amino acid (SAA) transmitter candidates, L-cysteine sulphinate (L-CSA), L-cysteate (L-CA), L-homocysteine sulphinate (L-HCSA), and L-homocysteate (L-HCA), together with their plasma membrane carrier specificity, was studied in cerebrocortical synaptosome frac...

journal_title：Journal of neuroscience research

authors： Grieve A,Butcher SP,Griffiths R

更新日期：1992-05-01 00:00:00

abstract：:Axotomy of peripheral nerves in neonatal rats induces motoneuron death that can be delayed but not arrested by the application of several neurotrophic factors (NFs) or adenoviral vectors carrying genes for NFs. We tested whether an adenoviral vector carrying the gene for glial cell-line-derived neurotrophic factor (Ad...

journal_title：Journal of neuroscience research

authors： Baumgartner BJ,Shine HD

更新日期：1998-12-15 00:00:00

abstract：:With the use of an antiserum directed against the human smooth muscle-associated protein 8 (SMAP8) fragment SMAP8(98-138), Western blot and immunohistochemical studies revealed SMAP8 expression in the rat brain. A band with a molecular size of about 45 kDa was detected in tissues from the rat hypothalamus and a weaker...

journal_title：Journal of neuroscience research

authors： Brailoiu GC,Dun SL,Mizuo K,Brailoiu E,Yang J,Chang JK,Dun NJ

更新日期：2007-06-01 00:00:00

abstract：:The precise function of APP (Alzheimer's amyloid precursor protein) remains to be fully elucidated, but various lines of evidence suggest that it may be involved in cell adhesion processes. Because APP is a transmembrane glycoprotein, variations in its expression level may have direct bearing on its putative role in c...

journal_title：Journal of neuroscience research

authors： Rebelo S,Henriques AG,da Cruz e Silva EF,da Cruz e Silva OA

更新日期：2004-05-01 00:00:00

abstract：:Cerebrospinal fluid was collected from the lateral ventricles and cisternal space from beagle dogs under light pentobarbital anesthesia. Homovanillic acid (HVA), 5-hydroxyindoleacetic acid (5-HIAA), and 3-methoxy-4-hydroxyphenylglyco-sulfate (MOPEG-SO4) levels in the liquor taken from these two regions were evaluated,...

journal_title：Journal of neuroscience research

authors： Bareggi SR,Stabenau JR,Shaskan EG,Becker RE,Roberts M

更新日期：1975-01-01 00:00:00

abstract：:Soluble oligomeric aggregates of the amyloid-beta (A beta) peptide are believed to be the most neurotoxic A beta species affecting the brain in Alzheimer disease (AD), a terminal neurodegenerative disorder involving severe cognitive decline underscored by initial synaptic dysfunction and later extensive neuronal death...

journal_title：Journal of neuroscience research

authors： Dineley KT,Kayed R,Neugebauer V,Fu Y,Zhang W,Reese LC,Taglialatela G

更新日期：2010-10-01 00:00:00

abstract：:The present study examined the effects of high-altitude exposure on the pineal gland, the main source of production of melatonin. It was surmised that hypoxia experienced at high altitude, caused by decreased oxygen tension in the ambient air, might lead to some structural alterations in the pineal gland and, hence, a...

journal_title：Journal of neuroscience research

authors： Kaur C,Srinivasan KN,Singh J,Peng CM,Ling EA

更新日期：2002-02-15 00:00:00

abstract：:The gene mutated in the mouse open brain (opb) phenotype antagonizes sonic hedgehog-mediated signaling and encodes a small GTPase of the Rab family, Rab23. To date, the brain expression profile and exact mechanism of function of the Rab23 protein has remained unknown. Specific antibodies generated against Rab23 showed...

journal_title：Journal of neuroscience research

authors： Guo A,Wang T,Ng EL,Aulia S,Chong KH,Teng FY,Wang Y,Tang BL

更新日期：2006-05-01 00:00:00

abstract：:CADASIL is a cerebrovascular disease caused by mutations in the NOTCH3 gene. Most mutations result in a gain or loss of cysteine residue in one of the 34 epidermal growth factor-like repeats in the extracellular domain of the Notch3 protein, thus sparing the number of cysteine residues. To date, more than 130 differen...

journal_title：Journal of neuroscience research

authors： Ungaro C,Mazzei R,Conforti FL,Sprovieri T,Servillo P,Liguori M,Citrigno L,Gabriele AL,Magariello A,Patitucci A,Muglia M,Quattrone A

更新日期：2009-04-01 00:00:00

abstract：:Neurotrophins may have a neuroprotective role and are probably involved in the control of axonal sprouting and synaptic plasticity. An antibody raised against a pro-sequence of nerve growth factor (NGF) was tested. In control undisturbed rats, a strong immunoreactivity was detected in scattered cells in and around the...

journal_title：Journal of neuroscience research

authors： Humpel C,Ebendal T,Cao Y,Olson L

更新日期：1993-07-01 00:00:00

abstract：:Reference genes are often used to normalize expression of data from real-time quantitative reverse transcription-polymerase chain reaction (RT-qPCR), and only a validation of their stability during a given experimental paradigm leads to reliable interpretations. The present study was thus designed to validate potentia...

journal_title：Journal of neuroscience research

authors： Pernot F,Dorandeu F,Beaup C,Peinnequin A

更新日期：2010-04-01 00:00:00

abstract：:The cytokines ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF) signal through a receptor complex formed between two transmembrane proteins, gp130 and LIFRbeta. In addition, CNTF also uses a ligand-binding component which is anchored to the cell membrane. In the case of cardiotrophin-1 (CT-1), LI...

journal_title：Journal of neuroscience research

authors： Arce V,Garces A,de Bovis B,Filippi P,Henderson C,Pettmann B,deLapeyrière O

更新日期：1999-01-01 00:00:00

abstract：:Functional MRI (fMRI) on spinal cord-injured rodents at 4 and 8 weeks post injury (PI) is described. The paradigm for fMRI, based on electrical stimulation of rat paws, was automated using an in-house designed microprocessor-based controller that was interfaced to a stimulator. The MR images were spatially normalized ...

journal_title：Journal of neuroscience research

authors： Ramu J,Bockhorst KH,Mogatadakala KV,Narayana PA

更新日期：2006-11-01 00:00:00

abstract：:Tumor necrosis factor-alpha (TNF-alpha) has attracted the greatest attention as a major factor in experimental autoimmune encephalomyelitis (EAE) pathogenesis. We compared rats undergoing EAE with manipulated but healthy animals by examining TNF-alpha gene expression in cells recovered from the brain. We used reverse ...

journal_title：Journal of neuroscience research

authors： Sun D,Hu X,Shah R,Zhang L,Coleclough C

更新日期：1996-08-15 00:00:00

abstract：:Glial fibrillary acidic protein (GFAP) is the major constituent of glial filaments and is restricted within the CNS to astrocytes. As with other classes of intermediate filament proteins, the regulation of GFAP expression is poorly understood. Utilizing highly purified cultures of astrocytes and a chemically defined (...

journal_title：Journal of neuroscience research

authors： Morrison RS,De Vellis J,Lee YL,Bradshaw RA,Eng LF

更新日期：1985-01-01 00:00:00

abstract：:Living organotypic cocultures of rat thalamic and cortical explants were used to examine the effects of blocking action potential activity on the morphological development of axons in the mammalian neocortex. Studies in vivo have suggested that blocking sodium channel-dependent activity influences the growth character...

journal_title：Journal of neuroscience research

authors： Wilkemeyer MF,Angelides KJ

更新日期：1996-03-15 00:00:00

abstract：:Transplanting neural stem cells (NSC) to the damaged brain has been regarded as a potential treatment for neurodegenerative diseases such as Alzheimer's disease (AD), a condition characterized by memory loss. We hypothesized that transplantation of NSC into the hippocampal regions of APP + PS1 transgenic (Tg) mice, a ...

journal_title：Journal of neuroscience research

authors： Zhang W,Wang GM,Wang PJ,Zhang Q,Sha SH

更新日期：2014-02-01 00:00:00

abstract：:Remyelination of the central nervous system in multiple sclerosis patients is often incomplete. Remyelination depends on normal oligodendrogenesis and the differentiation of oligodendrocyte precursor cells (OPC) into mature oligodendrocytes (OL). Inhibitor of DNA binding (ID), a transcription factor, is thought to inh...

journal_title：Journal of neuroscience research

authors： Chen XS,Zhang YH,Cai QY,Yao ZX

更新日期：2012-05-01 00:00:00

abstract：:Astrocyte activation is an important feature in many disorders of the central nervous system, including chronic pain conditions. Activation of astrocytes is characterized by a change in morphology, including hypertrophy and increased size of processes, proliferation, and an increased production of proinflammatory medi...

journal_title：Journal of neuroscience research

authors： Norsted Gregory E,Delaney A,Abdelmoaty S,Bas DB,Codeluppi S,Wigerblad G,Svensson CI

更新日期：2013-02-01 00:00:00

abstract：:We used cDNA arrays to investigate molecular aspects of the differentiation of an immortalized line of oligodendroglial progenitors, and of immunopan-purified primary cultures of oligodendroglial progenitors, to immature oligodendroglia. Developmental regulation of the proteolipid and 2-hydroxyacylsphingosine 1-galact...

journal_title：Journal of neuroscience research

authors： Scarlato M,Beesley J,Pleasure D

更新日期：2000-02-01 00:00:00

abstract：:Neural stem cells reside in defined areas of the adult mammalian brain, including the dentate gyrus of the hippocampus. Rat neural stem/progenitor cells (NSPCs) isolated from this region retain their multipotency in vitro and in vivo after grafting into the adult brain. Recent studies have shown that endogenous or gra...

journal_title：Journal of neuroscience research

authors： Faijerson J,Tinsley RB,Apricó K,Thorsell A,Nodin C,Nilsson M,Blomstrand F,Eriksson PS

更新日期：2006-11-15 00:00:00

abstract：:Dorsal root ganglia (DRG) neurons connect the spinal cord and uterine cervix, and are activated at parturition with subsequent stimulation of secondary neurons in the spinal dorsal horn and autonomic areas. Neuropeptide neurotransmitters and receptors have been studied in these areas, but amino acid transmitters, e.g....

journal_title：Journal of neuroscience research

authors： Ghosh C,Storey-Workley M,Usip S,Hafemeister J,Miller KE,Papka RE

更新日期：2007-05-01 00:00:00

abstract：:Microarray analyses demonstrated that a variety of genes was affected by treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor (PEDF). The genes for neurotrophins, glial cell-derived neurotrophic factor (GDNF), and their receptors were regulated differentially in i...

journal_title：Journal of neuroscience research

authors： Yabe T,Herbert JT,Takanohashi A,Schwartz JP

更新日期：2004-09-01 00:00:00