Abstract:
:Chronic alcohol consumption has adverse effects on the central nervous system, affecting some hippocampal and hypothalamic functions. In this study we tempted to demonstrate that some of these modifications could involve impairment of neurotrophic factors. Three experimental groups of male Sprague Dawley rats were studied: one control group, one chronically treated with alcohol vapor according to a well-established model that induces behavioral dependence, and a third group treated similarly but killed 12 hr after alcohol withdrawal. In all groups, changes in brain-derived neurotrophic factor mRNA expression occurring in the hippocampus and supraoptic nucleus were first analyzed by reverse transcription-polymerase chain reaction and then by in situ hybridization. In parallel, we used ribonuclease protection assay to measure mRNA levels encoding trkB in the two central nervous system regions. We showed that chronic alcohol intoxication decreases brain-derived neurotrophic factor mRNA expression in discrete regions of the rat hippocampus (CA1 region and dentate gyrus) and in the supraoptic nucleus of the hypothalamus. We also showed a global up-regulation of trkB mRNA expression encoding the high-affinity brain-derived neurotrophic factor receptor (TrkB), after applying the same treatment. Following 12 hr of alcohol withdrawal, a significant increase in BDNF mRNA expression was observed in the dentate gyrus and CA3 region of hippocampus and in the hypothalamic supraoptic nucleus. These findings suggest that chronic alcohol intake may modify hippocampal and hypothalamic neuronal functions through modifications in growth factors and its receptors.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Tapia-Arancibia L,Rage F,Givalois L,Dingeon P,Arancibia S,Beaugé Fdoi
10.1002/1097-4547(20010115)63:2<200::AID-JNR1012>3keywords:
subject
Has Abstractpub_date
2001-01-15 00:00:00pages
200-8issue
2eissn
0360-4012issn
1097-4547pii
10.1002/1097-4547(20010115)63:2<200::AID-JNR1012>3journal_volume
63pub_type
杂志文章abstract::Muscle spindles are sensory receptors composed of specialized muscle fibers, known as intrafusal muscle fibers, along with the endings of sensory neuron axons that innervate these muscle fibers. Formation of muscle spindles requires neuregulin1 (NRG1), which is released by sensory axons, activating ErbB receptors in m...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23293
更新日期:2014-02-01 00:00:00
abstract::Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra-hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various degenerative and ischemic CNS diseases like...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24049
更新日期:2017-10-01 00:00:00
abstract::The birth of cells with neurogenic potential in the adult brain is assessed commonly by detection of exogenous S phase markers, such as bromodeoxyuridine (BrdU). Analysis of other phases of the cell cycle, however, can provide insight into how external factors, such as opiates, influence the cycling of newly born cell...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20090
更新日期:2004-06-15 00:00:00
abstract::Nerve growth factor (NGF) is a homodimer that binds to two distinct receptor types, TrkA and p75, to support survival and differentiation of neurons. The high-affinity binding on the cell surface is believed to involve a heteroreceptor complex, but its exact nature is unclear. We developed a heterodimer (heteromutein)...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23116
更新日期:2012-12-01 00:00:00
abstract::Oligodendrocytes (OLs) and the myelin produced by them are enriched in two glycosphingolipids, galactosylceramide (GalC) and its sulfated form, cerebroside sulfate (CBS). We showed earlier that these two glycolipids in opposed liposomal membranes or in methanol solution can adhere to each other. Here we have examined ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1217
更新日期:2001-10-15 00:00:00
abstract::Fibroblast growth factor 2 (FGF2) exhibits pleiotropic functions during embryogenesis. In neural development, both pro- and antineurogenic activities of FGF2 have been described in the differentiation of neuronal progenitors into postmitotic neurons. We used cultured neural stem cells (NSCs) derived from rat embryonic...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20627
更新日期:2005-10-15 00:00:00
abstract::Membrane compaction and adhesion at the major dense line (cytoplasmic apposition) of myelin, particularly in the central nervous system (CNS), is typically attributed to myelin basic protein (MBP). To explore the role of MBP in myelin membrane adhesion, we attempted to reconstitute the major dense line of myelin from ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000215)59:4<513::AID-JNR
更新日期:2000-02-15 00:00:00
abstract::Recent evidence has demonstrated that neural stem cells (NSC) can be expanded from a variety of sources, including embryos, fetuses, and adult bone marrow and brain tissue. We have previously reported the generation of adult rat bone marrow-derived cellular spheres that are morphologically and phenotypically similar t...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21131
更新日期:2007-02-01 00:00:00
abstract::Time-to-contact (TTC) perception refers to the ability of an observer to estimate the remaining time before an object reaches a point in the environment, and is of crucial importance in daily life. Noninvasive correlational approaches have identified several brain areas sensitive to TTC information. Here we report the...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24740
更新日期:2021-02-01 00:00:00
abstract::The properties of neuronal plasma membranes are highly specialized, since they include the receptors by which many hormones, neurotransmitters, drugs, and toxins initiate their actions, as well as the components necessary for receiving synaptic input from a variety of sources and for generating the appropriate pattern...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490150412
更新日期:1986-01-01 00:00:00
abstract::The hypoxia-responsive cytokine erythropoietin (EPO) provides neuroprotective effects in the damaged brain during ischemic events and neurodegenerative diseases. The purpose of the present study is to evaluate the EPO/EPO receptor (EPOR) endogenous system between astrocyte and oligodendrocyte precursor cell (OPC) unde...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22702
更新日期:2011-10-01 00:00:00
abstract::The presence of glycosaminoglycans (GAG) has been histochemically demonstrated in the CNS of various mammalian species. They have been related with some nerve functions as neurotransmitters storage and synaptic transmission. In the present paper, the histochemical properties of nerve cell cytoplasmic GAG were studied ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490110103
更新日期:1984-01-01 00:00:00
abstract::Previous studies have demonstrated variability in the phenotype of rat C6 glioma cells. In the present study, we compared morphology, growth rate, and beta-adrenergic regulation of gene expression in early (P39-47) and late (P55-90) passage C6 cells. Morphological changes were observed in five independently derived, l...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490330213
更新日期:1992-10-01 00:00:00
abstract::Manganese (Mn) is an essential metal and plays an important role in the brain. To evaluate Mn uptake into the brain during development and aging, 54Mn concentrations in the brain of rats aged from 5 days to 95 weeks were measured after injection of 54MnCl2. 54Mn concentration in the brain of 5-day-old rats was the hig...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990401)56:1<93::AID-JNR1
更新日期:1999-04-01 00:00:00
abstract::Even though ischemic stroke is among the leading causes of death worldwide, the pathogenic mechanisms underlying ischemia reperfusion (I/R) brain injury remain unclear. Gasdermin D (GSDMD), as an important factor of pyroptotic death execution downstream of caspase-11 (noncanonical inflammasome) and caspase-1 (canonica...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24385
更新日期:2019-06-01 00:00:00
abstract::Chondroitinase ABC (Ch'ase ABC) is a bacterial lyase that degrades chondroitin sulfate (CS), dermatan sulfate, and hyaluronan glycosaminoglycans (GAGs). This enzyme has received significant attention as a potential therapy for promoting central nervous system and peripheral nervous system repair based on its degradati...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21199
更新日期:2007-04-01 00:00:00
abstract::Protein zero (P0) glycoprotein is the major integral membrane protein of the peripheral nervous system myelin in higher vertebrates. Previous findings indicate the formation of tetrameric assemblies from studies on isolated P0. To determine whether in intact myelin the P0 exists as oligomers, we isolated myelin from s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10167
更新日期:2002-03-15 00:00:00
abstract::Structural microtubule-associated proteins (MAPs) interact with microtubules to regulate the various dynamic stages of microtubules. The purpose of this study was to measure the impact of myc-tagged MAP1a fragments on microtubule dynamic phases in vivo. Cells from an epithelial kidney cell line (LLCPK1) that had been ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21920
更新日期:2009-04-01 00:00:00
abstract::The mammalian genome contains both constitutively expressed and heat-shock-inducible members of the hsp70 gene family. Riboprobes derived from members of these two classes of heat shock genes were utilized in Northern blot studies to analyze brain mRNA isolated from control rabbits and rats and from animals subjected ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250103
更新日期:1990-01-01 00:00:00
abstract::Neurons in culture rely on the supply of exogenous cysteine for their glutathione synthesis. After application of cysteine to neuron-rich primary cultures, the glutathione content was doubled after a 4-hr incubation. The dipeptide cysteinylglycine (CysGly) was able to substitute for cysteine as exogenous glutathione p...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10042
更新日期:2001-12-01 00:00:00
abstract::In offspring, an adequate maternal diet is important for neurodevelopment. One mechanism by which maternal diet impacts neurodevelopment is through its dynamic role in the development of the gut microbiota. Communication between the gut, and its associated microbiota, and the brain is facilitated by the vagus nerve, i...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24605
更新日期:2021-01-01 00:00:00
abstract::The striatum plays an important role in learning, selecting, and executing actions. As a major input hub of the basal ganglia, it receives and processes a diverse array of signals related to sensory, motor, and cognitive information. Aberrant neural activity in this area is implicated in a wide variety of neurological...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24519
更新日期:2019-12-01 00:00:00
abstract::Apolipoprotein E (apo-E), a protein involved in lipid metabolism and cholesterol transport, has been found to be up-regulated in CNS injury and is associated with Alzheimer's disease in humans. In this study, we show that apo-E is also up-regulated after complete spinal cord transection in the C57BL/6 mouse. In the un...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10482
更新日期:2003-02-01 00:00:00
abstract::Experiments were conducted with the aid of intracellular microelectrodes to study physiological properties of neuropile glial cells in the central nervous system of the medicinal leech. The results showed significant contributions of both K+ and Cl- ions to the membrane potential. The transmitter substance 5-hydroxytr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490070108
更新日期:1982-01-01 00:00:00
abstract::The pathogenic processing of the amyloid precursor protein (APP) into beta-amyloid peptides, which give rise to beta-amyloid plaques in the brains of Alzheimer's disease patients, requires the enzymatic activity of the beta-site APP-cleaving enzyme 1 (BACE1). We report the cloning and sequence of a 1.5-kb DNA fragment...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10639
更新日期:2003-07-01 00:00:00
abstract::Currently antidepressants take several weeks to be effective, which is one of the main reasons why patients with depression quit therapy. In the present study, we examine the acute and subacute effects of soluble epoxide hydolase (sEH) inhibitor (sEHI), a compound shown to have antidepressant effects, on mice. We foun...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24080
更新日期:2017-12-01 00:00:00
abstract::Increasing evidence has shown that β-amyloid (Aβ) induces hyperphosphorylation of tau and contributes to Aβ toxicity. Recently, tau hyperphosphorylation by glycogen synthase kinase-3β (GSK-3β) activation has been emphasized as one of the pathogenic mechanisms of Alzheimer's disease (AD). The phosphoinositide 3 kinase ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22563
更新日期:2011-03-01 00:00:00
abstract::Accumulating evidence indicates an immunosuppressive role for CD4(+)CD25(+) regulatory T cells (Tregs) in autoimmune diseases. Although an impaired Treg function in patients with relapsing-remitting multiple sclerosis (RR-MS) has been reported recently, no information is available so far about Treg function in the pro...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20852
更新日期:2006-06-01 00:00:00
abstract::Dopamine has been implicated as a potential mediating factor in a variety of neurodegenerative disorders. Dopamine can be oxidized to form a reactive dopamine quinone that can covalently modify cellular macromolecules including protein and DNA. This oxidation can be enhanced through various enzymes including tyrosinas...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19981201)54:5<691::AID-JNR
更新日期:1998-12-01 00:00:00
abstract::Uptake of 2-deoxy-D-glucose (2-DG) has been studied in synaptosomes from the Long-Evans rat. Although there are some differences, the results are generally similar to those reported for Sprague--Dawley rats. Both D-glucose and 2-DG are taken up by the same carrier, since D-glucose was found to inhibit uptake of 2-DG. ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490040207
更新日期:1979-01-01 00:00:00