Abstract:
:Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra-hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various degenerative and ischemic CNS diseases like Alzheimer's, multiple sclerosis, cerebral ischemia, and hemorrhage in a dose dependent manner. Additionally, the association of thrombin with various malignancies has recently become evident. Thrombin facilitates the interaction between tumor cells with platelets, endothelial cells, and the adhesion to matrix proteins in various tumor types. Consequently, thrombin enables tumor cell seeding and metastasis, resulting in increased tumor cell growth and angiogenesis. Despite the exceptional position of thrombin in the CNS, its involvement in brain tumor course and development has so far been largely neglected. Over the last decade, several studies found a detrimental effect of thrombin in the most devastating of all primary brain tumors, glioblastomas (GBM). This review highlights the current knowledge on the involvement of thrombin in the pathophysiology and clinical course of GBMs. © 2017 Wiley Periodicals, Inc.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Krenzlin H,Lorenz V,Alessandri Bdoi
10.1002/jnr.24049subject
Has Abstractpub_date
2017-10-01 00:00:00pages
2080-2085issue
10eissn
0360-4012issn
1097-4547journal_volume
95pub_type
杂志文章,评审abstract::Heat shock proteins (HSPs) are stress-responsive proteins that serve as important molecules contributing to cellular "protein triage." We and others have reported an increase of selected HSPs in multiple sclerosis (MS) lesions. However, the exact expression pattern of HSP family genes in MS is not known. The aim of ou...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23079
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abstract::The periglomerular cells (PG) of the olfactory bulb (OB) are involved in the primary processing and the refinement of sensory information from the olfactory epithelium. The neurochemical composition of these neurons has been studied in depth in many species, and over the last decades such studies have focused mainly o...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22521
更新日期:2011-01-01 00:00:00
abstract::Traditionally, the sources of guidance cues for dendritic outgrowth are mainly associated with external bodies (A) rather than with the same neuron from which dendrites originate (B). To quantify the relationship between factors A and B as determinants of the adult dendritic shape, the morphology of 83 intracellularly...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10475
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abstract::Changes in dopamine (DA) D(1), D(2), D(3), and D(4) receptors and serotonin 5-HT(1A) and 5-HT(2A) receptors in rat forebrain regions were autoradiographically quantified after continuous infusion of JL 13 [(5-(4-methylpiperazin-1-yl)-8-chloro-pyrido[2,3-b][1,5]benzoxazepine fumarate] for 28 days with osmotic minipumps...
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journal_title:Journal of neuroscience research
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abstract::Toll-like receptors (TLRs) play a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules as well as endogenous signals. In addition, TLR expression within nonimmune cells has been recognized as as modulator of cell behavior. In this study we have addressed the question of wh...
journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:2019-06-01 00:00:00
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490310211
更新日期:1992-02-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(sici)1097-4547(19970801)49:3<389::aid-jnr
更新日期:1997-08-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10203
更新日期:2002-05-01 00:00:00
abstract::Convergent lines of evidence have recently highlighted β3-adrenoreceptors (ARs) as a potentially critical target in the regulation of nervous and behavioral functions, including memory consolidation, anxiety, and depression. Nevertheless, the role of β3-ARs in the cerebellum has been never investigated. To address thi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24712
更新日期:2020-11-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.21325
更新日期:2007-08-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490310206
更新日期:1992-02-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
doi:10.1002/jnr.24374
更新日期:2019-08-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300127
更新日期:1991-09-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960415)44:2<124::AID-JNR
更新日期:1996-04-15 00:00:00
abstract::Perinatal hypoxic-ischemic (HI)-related brain injury is an important cause of morbidity and long-standing disability in newborns. The only currently approved therapeutic strategy available to reduce brain injury in the newborn is hypothermia. Therapeutic hypothermia can only be used to treat HI encephalopathy in full-...
journal_title:Journal of neuroscience research
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更新日期:2020-07-01 00:00:00
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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更新日期:2004-10-15 00:00:00
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journal_title:Journal of neuroscience research
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更新日期:2003-07-15 00:00:00
abstract::Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than ma...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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更新日期:2017-01-02 00:00:00
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journal_title:Journal of neuroscience research
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abstract::Although gangliosides have been reported to enhance recovery from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced lesions of the substantia nigra, evidence as to whether the administered gangliosides actually reach this or any other site of lesion in the central nervous system (CNS) at which they putativel...
journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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journal_title:Journal of neuroscience research
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更新日期:2006-02-01 00:00:00