Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase.

abstract：:Neural precursor cells, including neural stem and progenitor cells, in the subventricular zone (SVZ) are the main targets for cytomegalovirus (CMV) infection in developing brains. The neural precursor cells in the SVZ of the adult brain have been reported to respond by proliferating after infusion with epidermal growt...

journal_title：Journal of neuroscience research

authors： Han GP,Li L,Kosugi I,Kawasaki H,Tsuchida T,Miura K,Tsutsui Y

更新日期：2007-10-01 00:00:00

abstract：:Toll-like receptors (TLRs) play a key role in controlling innate immune responses to a wide variety of pathogen-associated molecules as well as endogenous signals. In addition, TLR expression within nonimmune cells has been recognized as as modulator of cell behavior. In this study we have addressed the question of wh...

journal_title：Journal of neuroscience research

authors： Bsibsi M,Nomden A,van Noort JM,Baron W

更新日期：2012-02-01 00:00:00

abstract：:In this report, we address the molecular mechanisms that regulate axonal growth by focusing on the gene for one of the major axonal cytoskeletal proteins, T alpha1 alpha-tubulin. During the developmental growth of sympathetic neurons, transcription of a beta-galactosidase transgene driven by the T alpha1 promoter (T a...

journal_title：Journal of neuroscience research

authors： Wu W,Gloster A,Miller FD

更新日期：1997-06-01 00:00:00

abstract：:Neurodevelopmental disorders (NDDs) such as intellectual disability and autism spectrum disorder consistently show a male bias in prevalence, but it remains unclear why males and females are affected with different frequency. While many behavioral studies of transgenic NDD models have focused only on males, the requir...

journal_title：Journal of neuroscience research

authors： Mossa A,Manzini MC

更新日期：2021-01-01 00:00:00

abstract：:Metabolic abnormalities found in epileptogenic tissue provide considerable evidence of brain hypometabolism, while major risk factors for acquired epilepsy all share brain hypometabolism as one common outcome, suggesting that a breakdown of brain energy homeostasis may actually precede epileptogenesis. However, a caus...

journal_title：Journal of neuroscience research

authors： Samokhina E,Popova I,Malkov A,Ivanov AI,Papadia D,Osypov A,Molchanov M,Paskevich S,Fisahn A,Zilberter M,Zilberter Y

更新日期：2017-11-01 00:00:00

abstract：:The present study examined trophic activities in normal and injured brain which affect the survival and growth of central neurons in culture. Adult rats received bilateral lesions through the angular bundle, severing projections between the entorhinal cortex and the hippocampus. Ten days later, extracts were prepared ...

journal_title：Journal of neuroscience research

authors： Gibbs RB,Needels DL,Yu J,Cotman CW

更新日期：1987-01-01 00:00:00

abstract：:Catecholamine-producing cell types are generated from specified neuronal lineages during vertebrate development. The catecholaminergic phenotype is also expressed transiently in some cell types in non-catecholaminergic tissues, including the sensory ganglia, enteric ganglia, and ventral portions of the neural tube dur...

journal_title：Journal of neuroscience research

authors： Matsushita N,Kobayashi K,Miyazaki J,Kobayashi K

更新日期：2004-10-01 00:00:00

abstract：:Microtubule-associated protein (MAP)1B-heterozygous (MAP1B+/-) mice are deficient in the expression of MAP1B in the hippocampus, cerebellum, and olfactory cortex. Although MAP1B+/- mice showed half the normal levels of MAP1B protein, they had no measurable amounts of phosphorylated MAP1B. High-frequency theta burst st...

journal_title：Journal of neuroscience research

authors： Zervas M,Opitz T,Edelmann W,Wainer B,Kucherlapati R,Stanton PK

更新日期：2005-10-01 00:00:00

abstract：:Mannitol, which is a cell-impermeable and nontoxic polyalcohol, has been shown to be a useful tool for reversible opening of the blood-brain barrier (BBB). Despite successful clinical trials, the molecular mechanism of the mannitol-induced changes in cerebral endothelial cells (CECs) are poorly understood. For our exp...

journal_title：Journal of neuroscience research

authors： Farkas A,Szatmári E,Orbók A,Wilhelm I,Wejksza K,Nagyoszi P,Hutamekalin P,Bauer H,Bauer HC,Traweger A,Krizbai IA

更新日期：2005-06-15 00:00:00

abstract：:Cerebral vasospasm is a potentially incapacitating or lethal complication in patients with aneurysmal subarachnoid hemorrhage (SAH). The development of effective preventative and therapeutic interventions has been largely hindered by the fact that the underlying pathogenic mechanisms of cerebral vasospasm remain poorl...

journal_title：Journal of neuroscience research

authors： Kolias AG,Sen J,Belli A

更新日期：2009-01-01 00:00:00

abstract：:In a military setting, traumatic brain injury (TBI) is frequently caused by blast waves that can trigger a series of neuronal biochemical changes. Although many animal models have been used to study the effects of primary blast waves, elucidating the mechanisms of damage in a whole-animal model is extremely complex. I...

journal_title：Journal of neuroscience research

authors： Zander NE,Piehler T,Boggs ME,Banton R,Benjamin R

更新日期：2015-09-01 00:00:00

abstract：:The minimal requirements for the regeneration of optic nerve fibers in vitro were established in a serum-free retinal explant preparation. This serum-free preparation was developed as a prerequisite for testing the growth-promoting activity of tissue extracts prepared from the primary target of regenerating fibers. Ex...

journal_title：Journal of neuroscience research

authors： Johnson JE,Turner JE

更新日期：1982-01-01 00:00:00

abstract：:Glutamate, the major excitatory neurotransmitter, induces a signal from the membrane to the nucleus that regulates gene expression. The gene encoding the chick kainate binding protein undergoes a glutamate-dependent transcriptional regulation via an activator protein-1 site within its promoter region. To characterize ...

journal_title：Journal of neuroscience research

authors： Aguirre A,López-Bayghen E,Ortega A

更新日期：2002-10-01 00:00:00

abstract：:Localization of acetylcholine receptors (AChRs) to the postsynaptic region of muscle is mediated in part by transcriptional mechanisms, because the genes encoding AChR subunits are transcribed selectively in synaptic myofiber nuclei. Neuregulin-1 (NRG-1) is a synaptic signal and induces transcription of AChRs in muscl...

journal_title：Journal of neuroscience research

authors： Herndon CA,Fromm L

更新日期：2008-04-01 00:00:00

abstract：:A frontal pole cDNA library from monkey (Macaca mulatta) brain was screened to identify mRNAs that are expressed more in frontal pole as compared to primary visual cortex. Three cDNA clones, whose greater expression was confirmed by Northern blot analysis, were identified as cytochrome oxidase (COX) subunits I, II, an...

journal_title：Journal of neuroscience research

authors： Chandrasekaran K,Stoll J,Giordano T,Atack JR,Matocha MF,Brady DR,Rapoport SI

更新日期：1992-07-01 00:00:00

abstract：:The central nervous system (CNS) is considered a nonpermissive environment for axonal regeneration because of the presence of myelin and associated repulsive molecules. However, neural cells transplanted to the CNS preferably migrate and extend their fibers in white matter areas. We previously showed that white matter...

journal_title：Journal of neuroscience research

authors： Fang Z,Forslund N,Takenaga K,Lukanidin E,Kozlova EN

更新日期：2006-03-01 00:00:00

abstract：:Using morphological, immunocytochemical, and functional parameters we have previously shown that highly purified adult rat microglial cells undergo a process of "activation" when cultured in a serum-containing medium in the absence of added proinflammatory substances or other factors (Slepko and Levi: Glia 16:241-246,...

journal_title：Journal of neuroscience research

authors： Slepko N,Minghetti L,Polazzi E,Nicolini A,Levi G

更新日期：1997-08-01 00:00:00

abstract：:Several neurological diseases involve focal injury of specific brain structures. Poisons of the electron transport chain complexes (ETCC) can also produce selective injury of brain structures when given systemically and have been implicated in the development of neurological disease. Why ETCC poisons damage particular...

journal_title：Journal of neuroscience research

authors： Fern R

更新日期：2003-03-15 00:00:00

abstract：:Ischemic stroke is a leading cause of death and disability in the United States. It is known that males and females respond differently to stroke. Depending on age, the incidence, prevalence, mortality rate, and disability outcome of stroke differ between the sexes. Females generally have strokes at older ages than ma...

journal_title：Journal of neuroscience research

authors： Dotson AL,Offner H

更新日期：2017-01-02 00:00:00

abstract：:The cellular constituents of the blood-brain barrier (BBB) must make finely tuned, regulatory responses to maintain microvascular homeostasis. The mechanisms by which this task is accomplished are largely unknown. However, it is thought they involve a series of cross-talk mechanisms among endothelial cells (EC), peric...

journal_title：Journal of neuroscience research

authors： Balabanov R,Beaumont T,Dore-Duffy P

更新日期：1999-03-01 00:00:00

abstract：:Enriched populations of human microglial cells were isolated from mixed cell cultures prepared from embryonic human telencephalon tissues. Human microglial cells exhibited cell type-specific antigens for macrophage-microglia lineage cells including CD11b (Mac-1), CD68, B7-2 (CD86), HLA-ABC, HLA-DR and ricinus communis...

journal_title：Journal of neuroscience research

authors： Lee YB,Nagai A,Kim SU

更新日期：2002-07-01 00:00:00

abstract：:Cultures of dissociated hypothalamic cells taken from rat fetuses of 19 days of gestation were studied using time-lapse recording and sequential microphotography from 1 to 5 days in vitro (DIV) and at 7 and 21 DIV. Cultures were seeded with cells taken from fetuses grouped by sex or sexually mixed; experimental cultur...

journal_title：Journal of neuroscience research

authors： Díaz H,Lorenzo A,Carrer HF,Cáceres A

更新日期：1992-10-01 00:00:00

abstract：:α-Synuclein (α-syn) is the major component of pathological inclusions characteristic of several neurodegenerative disorders, such as Parkinson's disease. The major posttranslational modification of α-syn is phosphorylation at S129, and previous studies estimate that approximately 90% of α-syn in proteinaceous, patholo...

journal_title：Journal of neuroscience research

authors： Waxman EA,Giasson BI

更新日期：2011-02-01 00:00:00

abstract：:In many regions of the rat central nervous system, oligodendrocytes develop from migratory A2B5+ precursor cells. In the rat spinal cord, during early embryonic development the capacity for oligodendrogenesis appears to be restricted to ventral regions of the spinal cord, while cultures of postnatal rat spinal cord co...

journal_title：Journal of neuroscience research

authors： Fok-Seang J,Miller RH

更新日期：1994-02-01 00:00:00

abstract：:Damage to the lateral nucleus of the septum in the rat resulted in atypical learning to a previously meaningless stimulus. Nonreinforced preexposure to a stimulus normally makes more difficult subsequent use of that stimulus for learning. The effect of this preexposure on learning is termed latent inhibition and was d...

journal_title：Journal of neuroscience research

authors： Toga AW,Burton HA

更新日期：1979-01-01 00:00:00

abstract：:We have investigated the involvement of c-Jun in cell death induced by exposure of primary cultures of murine cerebellar granule cells to the glutamate receptor agonist kainate (KA) and evaluated its possible use as a marker for apoptosis. Using cerebellar granule cell neurones from postnatal day 7 mice, we found that...

journal_title：Journal of neuroscience research

authors： Cheung NS,Carroll FY,Larm JA,Beart PM,Giardina SF

更新日期：1998-04-01 00:00:00

abstract：:The twitcher mouse is well known as a naturally occurring authentic mouse model of human globoid cell leukodystrophy (GLD; Krabbe disease) due to genetic deficiency of lysosomal galactosylceramidase. The twitcher mice used most commonly are on the C57BL/6J background. We generated twitcher mice that were on the mixed ...

journal_title：Journal of neuroscience research

authors： Tominaga K,Matsuda J,Kido M,Naito E,Yokota I,Toida K,Ishimura K,Suzuki K,Kuroda Y

更新日期：2004-08-15 00:00:00

abstract：:Programmed cell death involving gene regulation and de novo protein synthesis is a major component of both normal development and a number of disease conditions. Hence, knowledge of its mechanisms, especially transcription factors, that regulate expression of the genes involved in neurodegenerative disorders is of gre...

journal_title：Journal of neuroscience research

authors： Mioduszewska B,Jaworski J,Szklarczyk AW,Klejman A,Kaczmarek L

更新日期：2008-01-01 00:00:00

abstract：:Rho-GTPase has been implicated in the apoptosis of many cell types, including neurons, but the mechanism by which it acts is not fully understood. Here, we investigate the roles of Rho and ROCK in apoptosis during transplantation of embryonic stem cell-derived neural precursor cells. We find that dissociation of neura...

journal_title：Journal of neuroscience research

authors： Koyanagi M,Takahashi J,Arakawa Y,Doi D,Fukuda H,Hayashi H,Narumiya S,Hashimoto N

更新日期：2008-02-01 00:00:00

abstract：:Macroautophagy is an evolutionally conserved membrane trafficking pathway that delivers intracellular materials to lysosomes for degradation and recycling. Rab7, as a member of the Rab GTPase superfamily, has a unique role in the regulation of macroautophagy, especially in modulating autophagy flux. The functional sta...

journal_title：Journal of neuroscience research

authors： Wen H,Zhan L,Chen S,Long L,Xu E

更新日期：2017-10-01 00:00:00