Manipulation of proliferation and differentiation of human bone marrow-derived neural stem cells in vitro and in vivo.

abstract：:A distinct population of white matter progenitor cells (WMPCs), competent but not committed to generate oligodendrocytes, remains ubiquitous in the adult human subcortical white matter. These cells are present in both sexes and into senescence and may constitute as much as 4% of the cells of adult human capsular white...

journal_title：Journal of neuroscience research

authors： Windrem MS,Roy NS,Wang J,Nunes M,Benraiss A,Goodman R,McKhann GM 2nd,Goldman SA

更新日期：2002-09-15 00:00:00

abstract：:Accumulating evidence points to roles for oxidative stress, amyloid beta (Aβ), and mitochondrial dysfunction in the pathogenesis of Alzheimer's disease (AD). In neurons, the base excision repair pathway is the predominant DNA repair (BER) pathway for repairing oxidized base lesions. Apurinic/apyrimidinic endonuclease ...

journal_title：Journal of neuroscience research

authors： Kaur N,Dhiman M,Perez-Polo JR,Mantha AK

更新日期：2015-06-01 00:00:00

abstract：:Iron deficiency and chronic mild carbon monoxide (CO) exposure are nutritional and environmental problems that can be experienced simultaneously. We examined the effects of chronic mild CO exposure and iron availability on auditory development in the rat. We propose that chronic mild CO exposure creates an oxidative s...

journal_title：Journal of neuroscience research

authors： Webber DS,Lopez I,Korsak RA,Hirota S,Acuna D,Edmond J

更新日期：2005-06-01 00:00:00

abstract：:Relationships among different intensities of electroshock treatment (EST), EEG-recordable primary after discharge (PAD), and beta-adrenergic binding in various brain regions were investigated in adult rats. Different intensities of EST (1-2, 6-8, 20-30 mamp) were applied through ear-clip electrodes for 7 consecutive d...

journal_title：Journal of neuroscience research

authors： Perumal AS,Barkai AI

更新日期：1982-01-01 00:00:00

abstract：:Photopic L-type responses were recorded from the soma and the axon terminal of horizontal cells of the catfish (Ictalurus punctatus) retina in eye-cup preparations. The responses were produced by a spot of light with 100-micron diameter (intensity, 10 microW/cm2), which was flashed or steadily illuminated and swept al...

journal_title：Journal of neuroscience research

authors： Hida E,Negishi K,Naka KI

更新日期：1984-01-01 00:00:00

abstract：:Dopaminergic afferents from the mesencephalic areas, such as ventral tegmental area (VTA), synapse with the gamma-aminobutyric acid (GABA)-ergic interneurons in the prefrontal cortex (PFC). Pharmacological and electrophysiological data show that the reinforcement, the dependence-producing properties, as well as the ps...

journal_title：Journal of neuroscience research

authors： Li SP,Park MS,Kim JH,Kim MO

更新日期：2004-12-15 00:00:00

abstract：:There is evidence that zinc may be involved in the pathogenesis of Parkinson's disease by an apoptotic pathway. However, the mechanisms underlying zinc-induced apoptosis are unknown. Previous studies showed that 6-hydroxydopamine (6-OHDA)-enhanced potassium channels are involved in apoptosis of dopaminergic neurons. O...

journal_title：Journal of neuroscience research

authors： Shi L,Song N,Jiang H,Wang J,Ma Z,Xie J

更新日期：2009-02-01 00:00:00

abstract：:Although upregulation of ryanodine receptor (RyR)-1 and -2 is mediated through the activation of dopamine D1 receptors (D1DRs) in the development of psychostimulant-induced place preference, little is known about how such increased expressions of RyRs are negatively regulated. This study investigated negative regulato...

journal_title：Journal of neuroscience research

authors： Kurokawa K,Mizuno K,Ohkuma S

更新日期：2012-08-01 00:00:00

abstract：:Glial cell-line derived neurotrophic factor (GDNF) is the most potent trophic factor for motoneuron survival and neuromuscular junction formation. GDNF is upregulated in injured or denervated skeletal muscle and returns to normal levels following reinnervation. However, the mechanism by which GDNF is regulated in dene...

journal_title：Journal of neuroscience research

authors： Rosa E,Cha J,Bain JR,Fahnestock M

更新日期：2015-03-01 00:00:00

abstract：:The activity levels of pyruvate dehydrogenase, enzymes of the citric acid cycle, aspartate and alanine aminotransferases, and NADP+-isocitrate dehydrogenase were determined in the cerebral cortex, cerebellum, brain stem, corpus striatum, hippocampus, and midbrain regions of normal rats and rats injected with acute and...

journal_title：Journal of neuroscience research

authors： Ratnakumari L,Subbalakshmi GY,Murthy CR

更新日期：1985-01-01 00:00:00

abstract：:Mouse sciatic nerves were transected and 3 hr to 16 days later proximal segments were removed and homogenized. Supernatants of these segments or of normal sciatic nerves were added to Schwann cells maintained in Dulbecco's modified Eagle's medium (DMEM) + 15% fetal calf serum (FCS). After 6 days, Schwann cells were so...

journal_title：Journal of neuroscience research

authors： Zhang QL,Lin PX,Chang Y,Webster HD

更新日期：1994-04-01 00:00:00

abstract：:Neurodevelopmental disorders (NDDs) such as intellectual disability and autism spectrum disorder consistently show a male bias in prevalence, but it remains unclear why males and females are affected with different frequency. While many behavioral studies of transgenic NDD models have focused only on males, the requir...

journal_title：Journal of neuroscience research

authors： Mossa A,Manzini MC

更新日期：2021-01-01 00:00:00

abstract：:T cell receptor (TCR) transgenic mice have been used extensively to study T cell development in vivo. Such studies have demonstrated high levels of expression of the TCR transgenes. Although a number of human T cell receptors appear to play a role in the development of autoimmune diseases, in vitro studies have proven...

journal_title：Journal of neuroscience research

authors： Baker AM,Wang Y,Richert JR

更新日期：1996-08-15 00:00:00

abstract：:Green fluorescent protein (GFP) transgenic zebrafish technology has been employed to directly visualize and analyze dynamic developmental processes, such as cell migration and morphogenesis. Stable transgenic zebrafish that express GFP in oligodendrocytes can be a valuable tool to visualize complex myelination process...

journal_title：Journal of neuroscience research

authors： Yoshida M,Macklin WB

更新日期：2005-07-01 00:00:00

abstract：:Rapsyn is a key molecule involved in the formation of postsynaptic specializations at the neuromuscular junction, in its absence there are both pre- and post-synaptic deficits including failure to cluster acetylcholine receptors. Recently we have documented increases in both nerve-muscle branching and numbers of moton...

journal_title：Journal of neuroscience research

authors： Bartlett SE,Banks GB,Reynolds AJ,Waters MJ,Hendry IA,Noakes PG

更新日期：2001-06-15 00:00:00

abstract：:In order to quantify the changes that occur in the cholinergic central nervous system with aging, we have compared acetylcholine (Ach) formation in brain cortex slice preparations from 2-year-old aged CBF-1 mouse brains and compared the findings with those in 2-4-month-old young adult mouse brain slices. Incorporation...

journal_title：Journal of neuroscience research

authors： Saito M,Kindel G,Karczmar AG,Rosenberg A

更新日期：1986-01-01 00:00:00

abstract：:Identification of behavioral loci through complex trait mapping remains a widely employed approach but suffers from poor gene localization and low replicability. Genome-tagged mice (GTMs) are overlapping sets of congenic strains spanning the whole genome and offer the possibilities of superior mapping power and reprod...

journal_title：Journal of neuroscience research

authors： Liu D,Singh RP,Khan AH,Bhavsar K,Lusis AJ,Davis RC,Smith DJ

更新日期：2003-11-15 00:00:00

abstract：:A morphogenic role of neurotransmitters during cellular differentiation in vitro has been demonstrated in recent years. Using in situ hybridization, we confirm the presence of the D1 receptor at E16 and show additionally that the transcript is relatively widespread and present in both proliferative and differentiating...

journal_title：Journal of neuroscience research

authors： Reinoso BS,Undie AS,Levitt P

更新日期：1996-02-15 00:00:00

abstract：:Alterations in the 5-HT2A receptor gene expression in the prefrontal cortex have been suggested to play a role in the pathophysiology and pharmacotherapy of schizophrenia. This study measured mRNA encoding 5-HT2A receptor in the left superior frontal gyrus from chronic elderly schizophrenics (n = 21) with varying neur...

journal_title：Journal of neuroscience research

authors： Hernandez I,Sokolov BP

更新日期：2000-01-15 00:00:00

abstract：:Acoustic overstimulation causes apoptotic cell death in the cochlea. This death process is mediated, in part, by the mitochondrial signaling pathway involving Bcl-2 family proteins. Myeloid cell leukemia sequence 1 (Mcl-l) is an antiapoptotic member of the Bcl-2 family. Its involvement in noise-induced hair cell death...

journal_title：Journal of neuroscience research

authors： Hu BH,Cai Q

更新日期：2010-06-01 00:00:00

abstract：:Alpha2-adrenergic receptors control norepinephrine (NE) release and tumor necrosis factor-alpha (TNF) production from neurons. TNF regulates NE release, depending on alpha2-adrenergic receptor functioning. The relationship between TNF production in the brain and alpha2-adrenergic receptor activation could have profoun...

journal_title：Journal of neuroscience research

authors： Reynolds JL,Ignatowski TA,Spengler RN

更新日期：2005-03-15 00:00:00

abstract：:Calpain, an intracellular cysteine protease, has been widely reported to be involved in neuronal cell death. The purpose of this study is to investigate the role of calpain activation in axonal damage-induced retinal ganglion cell (RGC) death. Twelve-week-old male calpstatin (an endogenous calpain inhibitor) knockout ...

journal_title：Journal of neuroscience research

authors： Ryu M,Yasuda M,Shi D,Shanab AY,Watanabe R,Himori N,Omodaka K,Yokoyama Y,Takano J,Saido T,Nakazawa T

更新日期：2012-04-01 00:00:00

abstract：:We studied the effects of electrical stimulation of the inferior alveolar nerve (IAN) on cardiovascular responses in cats. There was statistical correlation between cardiovascular response and prestimulus mean arterial blood pressure (MABP) and heart rate (HR). A trigeminal depressor response (TDR) was induced when th...

journal_title：Journal of neuroscience research

authors： Ohshita N,Nakajo N,Takemura M

更新日期：2004-06-15 00:00:00

abstract：:Post-translational modification of neural cell adhesion molecule (NCAM) with alpha2,8-linked polysialic acid, which regulates homophilic adhesion and/or signal transduction events, is crucial to synaptic plasticity in the developing and adult brain. Evidence from in vitro models has implicated polysialylation in the r...

journal_title：Journal of neuroscience research

authors： Gallagher HC,Odumeru OA,Regan CM

更新日期：2000-09-15 00:00:00

abstract：:Lead is putatively regarded as an environmental neurotoxicant. Long-term low-level lead exposure causes cognitive deficits, but the mechanism remains to be elucidated. In the present study, the excitatory effects of low-level lead exposure on action potential (AP) firing of pyramidal neurons in CA1 region of rat hippo...

journal_title：Journal of neuroscience research

authors： Yan D,Xiao C,Ma FL,Wang L,Luo YY,Liu J,Wang HL,Chen JT,Ruan DY

更新日期：2008-12-01 00:00:00

abstract：:The distribution of phosphofructokinase (PFK) in gray and white matter regions of the rat nervous system was evaluated. Determinations of PFK activity revealed that cell body enriched regions (sensorimotor cortex) had a significantly higher level of activity than axonal regions (sciatic nerve, dorsal roots, and optic ...

journal_title：Journal of neuroscience research

authors： Oblinger MM,Foe LG,Kwiatkowska D,Kemp RG

更新日期：1988-09-01 00:00:00

abstract：:Functional MRI (fMRI) on spinal cord-injured rodents at 4 and 8 weeks post injury (PI) is described. The paradigm for fMRI, based on electrical stimulation of rat paws, was automated using an in-house designed microprocessor-based controller that was interfaced to a stimulator. The MR images were spatially normalized ...

journal_title：Journal of neuroscience research

authors： Ramu J,Bockhorst KH,Mogatadakala KV,Narayana PA

更新日期：2006-11-01 00:00:00

abstract：:Gangliosides, sialic acid-containing glycosphingolipids, are ubiquitously expressed in all eukaryotic cells and are localized primarily in the plasma membrane. For a rat pheochromocytoma cell line, PC12, which has been used frequently as a model for investigating events leading to neuronal differentiation, it is gener...

journal_title：Journal of neuroscience research

authors： Yanagisawa M,Ariga T,Yu RK

更新日期：2006-11-01 00:00:00

abstract：:A growing body of evidence suggests that neurotrophins (NTs) play a critical role in synaptic plasticity and other activity dependent processes in the CNS. Release of these growth factors by neurons and neuroendocrine cells was recently shown to occur via the regulated secretory pathway, representing a possible mechan...

journal_title：Journal of neuroscience research

authors： Möller JC,Krüttgen A,Heymach JV Jr,Ghori N,Shooter EM

更新日期：1998-02-15 00:00:00

abstract：:The actions of endogenous opioids and nociceptin/orphanin FQ are mediated by four homologous G protein-coupled receptors that constitute the opioid receptor family. However, little is known about opioid systems in cyclostomes (living jawless fish) and how opioid systems might have evolved from invertebrates. Here, we ...

journal_title：Journal of neuroscience research

authors： Huang AY,Taylor AMW,Ghogha A,Pribadi M,Wang Q,Kim TSJ,Cahill CM,Coppola G,Evans CJ

更新日期：2020-08-23 00:00:00