Chronic morphine induces premature mitosis of proliferating cells in the adult mouse subgranular zone.

abstract：:Antiglycolipid IgM antibodies are known to induce formation of "wide spaced" or "expanded" myelin, a distinctive form of dysmyelination characterized by a repeat period approximately two or three times normal, which is seen also in diseases, including multiple sclerosis. To determine whether an antibody directed again...

journal_title：Journal of neuroscience research

authors： Rosenbluth J,Schiff R

更新日期：2009-03-01 00:00:00

abstract：:Molecular mechanisms which underlie the heat shock response have commonly been analyzed using tissue culture systems, with less investigation of the intact mammal. In tissue culture, a temperature elevation of 5 degrees C is required to activate mammalian heat shock transcription factor 1 (HSF1) to the DNA-binding for...

journal_title：Journal of neuroscience research

authors： Brown IR,Rush SJ

更新日期：1996-04-01 00:00:00

abstract：:Glial cell line-derived neurotrophic factor (GDNF) has been shown to be a preferentially selective neurotrophic factor for dopamine (DA) neurons. In the present study, we have examined the distribution of GDNF mRNA expression in several major DA-containing cell body and terminal areas and the regulation of GDNF mRNA e...

journal_title：Journal of neuroscience research

authors： Tang YP,Ma YL,Chao CC,Chen KY,Lee EH

更新日期：1998-09-01 00:00:00

abstract：:Recently we demonstrated that a member of the neuregulin-1 (NRG-1) family of growth factors is a mitogen and survival factor for olfactory ensheathing cells (OECs). OECs are specialized glial cells within the olfactory system that are believed to play a role in the continual nerve re-growth of this tissue. OECs share ...

journal_title：Journal of neuroscience research

authors： Thompson RJ,Roberts B,Alexander CL,Williams SK,Barnett SC

更新日期：2000-07-15 00:00:00

abstract：:Zinc is an endogenous N-methyl-D-aspartate (NMDA) receptor blocker. It is possible that zinc-mediated modification of hippocampal CA1 long-term potentiation (LTP) is linked to the expression of NMDA receptor subunits, which varies with postnatal development. In the present study, the effect of ZnCl(2) and CaEDTA, a me...

journal_title：Journal of neuroscience research

authors： Takeda A,Itagaki K,Ando M,Oku N

更新日期：2012-03-01 00:00:00

abstract：:We studied the effects of electrical stimulation of the inferior alveolar nerve (IAN) on cardiovascular responses in cats. There was statistical correlation between cardiovascular response and prestimulus mean arterial blood pressure (MABP) and heart rate (HR). A trigeminal depressor response (TDR) was induced when th...

journal_title：Journal of neuroscience research

authors： Ohshita N,Nakajo N,Takemura M

更新日期：2004-06-15 00:00:00

abstract：:A mouse monoclonal antibody (5B9), directed against a carbohydrate epitope of human epidermal growth factor receptor (EGFR), recognized an 81-kDalton glycoprotein in buffer-soluble and detergent-solubilized rat brain extracts (BE). The glycoprotein was more abundant in extracts prepared from injured brain than in thos...

journal_title：Journal of neuroscience research

authors： Río C,Pérez-Cerdá F,Matute C,Nieto-Sampedro M

更新日期：1995-04-15 00:00:00

abstract：:Neuronal cell differentiation alterations induced by mutant presenilin 2 (PS2) were investigated in transgenic mice expressing wild-type or mutant-type PS2. Progressive increases in differentiation and marker protein expression were found in neuronal cells expressing wild-type PS2, whereas these processes were much pe...

journal_title：Journal of neuroscience research

authors： Lee SM,Lee JW,Song YS,Hwang DY,Kim YK,Nam SY,Kim DJ,Yun YW,Yoon DY,Hong JT

更新日期：2005-11-15 00:00:00

abstract：:We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of ...

journal_title：Journal of neuroscience research

authors： Martin D,Schoenen J,Delrée P,Gilson V,Rogister B,Leprince P,Stevenaert A,Moonen G

更新日期：1992-08-01 00:00:00

abstract：:We report a study of the characterization of voltage-activated potassium (K+) currents in retinal ON bipolar cells in zebrafish. At single-channels levels, the open probability of the K+ channels increased when the membrane potential was increased. The maximal open proportion was 0.76+/-0.05 under our testing conditio...

journal_title：Journal of neuroscience research

authors： Yu CJ,Li L

更新日期：2005-11-01 00:00:00

abstract：:Our previous work indicated that in E14 embryonic rat spinal cord cultures ciliary neuronotrophic factor (CNTF) exerted (1) a survival-promoting effect on motor neurons and on a large population of unidentified neurons, and (2) a regulatory role on the expression of ChAT and low affinity NGF receptor (LNGFR) in a popu...

journal_title：Journal of neuroscience research

authors： Magal E,Burnham P,Varon S

更新日期：1991-11-01 00:00:00

abstract：:Thymocyte differentiation antigen-1 (Thy-1) is a cell surface glycoprotein found on T cells and neurons and is involved in cell-to-cell interactions. In addition, Thy-1 knockouts (KO) are a potential mouse model of restless legs syndrome (RLS) based on clinical observations and the role of dopamine in the disease. In ...

journal_title：Journal of neuroscience research

authors： Carkaci-Salli N,Battula S,Wang X,Connor JR,Vrana KE

更新日期：2012-08-01 00:00:00

abstract：:Axonal injury is often characterized by axonal transport defects and abnormal accumulation of intra-axonal components. Nitric oxide (NO) has a key role in mediating inflammatory axonopathy in many neurodegenerative diseases, but little is known about how nitrosative/oxidative stress affects axonal transport or whether...

journal_title：Journal of neuroscience research

authors： Redondo J,Hares K,Wilkins A,Scolding N,Kemp K

更新日期：2015-06-01 00:00:00

abstract：:It is suggested that masticatory dysfunction affects the central nervous system; however, the underlying mechanism remains unknown. Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are known to play important roles in memory and learning. In this study, we examined the effects of mastication on memory,...

journal_title：Journal of neuroscience research

authors： Okihara H,Ito J,Kokai S,Ishida T,Hiranuma M,Kato C,Yabushita T,Ishida K,Ono T,Michikawa M

更新日期：2014-08-01 00:00:00

abstract：:The cutaneous electroreceptor "tuberous organs" of the lateral line system of Eigenmannia virescens were studied at light and electron microscopic levels with immunohistochemical and autoradiographic techniques after sectioning of the posterior branch of the lateral line nerve. After deafferentation total degeneration...

journal_title：Journal of neuroscience research

authors： Bensouilah M,Denizot JP

更新日期：1994-12-01 00:00:00

abstract：:An angiotensin 2 type 1 receptor blocker, olmesartan, and a calcium channel blocker, azelnidipine, possess not only an antihypertensive effect but also an antioxidative effect and other beneficial effects. In the present study, we examined the efficacy of olmesartan and azelnidipine monotherapy (2 mg/kg or 10 mg/kg ea...

journal_title：Journal of neuroscience research

authors： Omote Y,Deguchi K,Kono S,Liu W,Kurata T,Hishikawa N,Yamashita T,Ikeda Y,Abe K

更新日期：2014-10-01 00:00:00

abstract：:In the present study we report self-assembly of individual neurofilament (NF) triplet proteins (70K, 150K, and 200K daltons) isolated by anion exchange chromatography from bovine spinal cord. Formation of smooth 10-nm filaments by both NF 150K and NF 70K is shown. Optimal conditions for NK 150K filament formation were...

journal_title：Journal of neuroscience research

authors： Gardner EE,Dahl D,Bignami A

更新日期：1984-01-01 00:00:00

abstract：:The objective of this study was to compare cerebrospinal fluid (CSF) levels of the light subtype of the neurofilament proteins (NFL), tau, and beta-amyloid42 (Abeta42) in individuals with moderate or severe white matter changes (WMC) and in those with mild or no WMC. Twenty-two patients with Alzheimer's disease (AD), ...

journal_title：Journal of neuroscience research

authors： Sjögren M,Blomberg M,Jonsson M,Wahlund LO,Edman A,Lind K,Rosengren L,Blennow K,Wallin A

更新日期：2001-11-01 00:00:00

abstract：:The first synapse in the olfactory pathway mediates a significant transfer of information given the restricted association of specific olfactory receptor neurons with specific glomeruli in the olfactory bulb. To understand better how this connection is made and what the functional capacities of the participating cells...

journal_title：Journal of neuroscience research

authors： Josephson EM,Yilma S,Vodyanoy V,Morrison EE

更新日期：2004-03-01 00:00:00

abstract：:Microarray analyses demonstrated that a variety of genes was affected by treatment of cerebellar granule cell neurons with the neurotrophic factor pigment epithelium-derived factor (PEDF). The genes for neurotrophins, glial cell-derived neurotrophic factor (GDNF), and their receptors were regulated differentially in i...

journal_title：Journal of neuroscience research

authors： Yabe T,Herbert JT,Takanohashi A,Schwartz JP

更新日期：2004-09-01 00:00:00

abstract：:The ability of altered environmental conditions to modulate some properties of synaptosomes has been studied. Incubation conditions used included the presence of methyl mercury or an organochlorine insecticide: chlordecone. Other adverse chemical conditions during incubation were the absence of calcium salts from the ...

journal_title：Journal of neuroscience research

authors： Bondy SC,McKee M

更新日期：1990-02-01 00:00:00

abstract：:The localization of voltage-gated calcium channel (VGCC) alpha(1) subunits in cultured GABAergic mouse cortical neurons was examined by immunocytochemical methods. Ca(v)1.2 and Ca(v)1.3 subunits of L-type VGCCs were found in cell bodies and dendrites of GABA-immunopositive neurons. Likewise, the Ca(v)2.3 subunit of R-...

journal_title：Journal of neuroscience research

authors： Timmermann DB,Westenbroek RE,Schousboe A,Catterall WA

更新日期：2002-01-01 00:00:00

abstract：:Experimental allergic encephalomyelitis (EAE), an animal model for multiple sclerosis (MS), is a demyelinating autoimmune disease of the central nervous system (CNS). The proinflammatory cytokine TNF alpha, as an endogenous mediator of inflammation, plays an important role in the pathogenesis of EAE disease. In this s...

journal_title：Journal of neuroscience research

authors： Villarroya H,Marie Y,Ouallet JC,Le Saux F,Tchélingérian JL,Baumann N

更新日期：1997-09-01 00:00:00

abstract：:A coordinated up-regulation in the expression of all three neurofilament (NF) proteins occurs during postnatal development in the rat (Schlaepfer and Bruce, J Neurosci Res [in press], 1990a). In the present study, sciatic nerves were transected in neonatal rats in order to determine the effects of axotomy on the postn...

journal_title：Journal of neuroscience research

authors： Schwartz ML,Shneidman PS,Bruce J,Schlaepfer WW

更新日期：1990-10-01 00:00:00

abstract：:The role of the NT-3 has been implicated in the survival of progenitor oligodendrocytes in culture. The object of this study was to investigate the expression of the TrkC receptor and its responsiveness in glial cells. We report the expression of two TrkC receptor isoforms in rat primary oligodendrocyte cultures, a gl...

journal_title：Journal of neuroscience research

authors： Kumar S,de Vellis J

更新日期：1996-06-01 00:00:00

abstract：:Destruction of the ventromedial hypothalamic nuclei (VMN) in the weanling rat without injury to the median eminence results in a series of somatic, endocrine, and metabolic changes that are characterized by normal food and water intake but decreased linear growth, normal body weight but increased carcass fat and reduc...

journal_title：Journal of neuroscience research

authors： Bernardis LL,Goldman JK

更新日期：1976-01-01 00:00:00

abstract：:Studies of the effects of hypoglycemia on the brain using neurocognitive testing have suggested that mainly complex functions subserved by secondary and tertiary cortex are affected by mild to moderate hypoglycemia and that intensively treated patients with Type I diabetes mellitus (T1DM) may have altered sensitivity ...

journal_title：Journal of neuroscience research

authors： Driesen NR,Goldberg PA,Anderson AW,Tang L,Flanagan DE,Sherwin RS,Gore JC

更新日期：2007-02-15 00:00:00

abstract：:Culturing sympathetic ganglion neurons in vitro may modify phenotypic expression of some neurotransmitters. For dorsal root ganglia (DRG), contradictory results have been reported; most studies have used immature material. We have therefore performed a detailed immunocytochemical analysis of the transmitter content of...

journal_title：Journal of neuroscience research

authors： Schoenen J,Delree P,Leprince P,Moonen G

更新日期：1989-04-01 00:00:00

abstract：:After hemisection of the spinal cord in rats, alterations in amino acid incorporation into protein have been observed in brain and spinal cord. Proteins mediating these changes have been studied in the present experiment. Male, Long-Evans hooded rats were given either a laminectomy and dura incision (sham) at spinal s...

journal_title：Journal of neuroscience research

authors： Wells MR

更新日期：1980-01-01 00:00:00

abstract：:Neuronal ceroid lipofuscinoses (NCLs) are a group of hereditary childhood diseases characterized mainly by lipopigment accumulation and a multisystemic pattern of symptoms including mental retardation, seizures, motor impairment, and blindness. The mnd mouse, carrying a mutation in the Cln8 gene, has been proposed as ...

journal_title：Journal of neuroscience research

authors： Bigini P,Milanese M,Gardoni F,Longhi A,Bonifacino T,Barbera S,Fumagalli E,Di Luca M,Mennini T,Bonanno G

更新日期：2012-06-01 00:00:00