Abstract:
:We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of compression or the volume of saline used to inflate the balloon. The locomotor deficit of animals with various degrees of injury has been assessed at increasing delays after trauma. The parameters generating transient or definitive deficits of varying intensity were defined. Some injured animals underwent nuclear magnetic resonance imaging. Detailed histopathological studies demonstrated that the extent of the spinal lesion was significantly correlated with the physical parameters of compression and with the severity of the behavioral deficit.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Martin D,Schoenen J,Delrée P,Gilson V,Rogister B,Leprince P,Stevenaert A,Moonen Gdoi
10.1002/jnr.490320409keywords:
subject
Has Abstractpub_date
1992-08-01 00:00:00pages
539-50issue
4eissn
0360-4012issn
1097-4547journal_volume
32pub_type
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490240408
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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更新日期:1993-03-01 00:00:00
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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journal_title:Journal of neuroscience research
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