Abstract:
:We reported previously that stem cell factor (SCF) is produced mainly by neurons and that its receptor (c-kitR), encoded by the protooncogene c-kit, is expressed in microglia, suggesting that SCF/c-kitR signaling may be involved in neuron-microglia interactions. We now report that SCF supports microglial survival in cultures, maintains them in process-bearing morphology, and inhibits microglial proliferation induced by colony stimulating factor-1. SCF potentiates microglial expression of the mRNAs of nerve growth factor, brain-derived neurotrophic factor and ciliary neurotrophic factor, and downregulates microglial expression of the inflammation-associated cytokines, tumor necrosis factor-a (TNF-alpha), and interleukin-1beta (IL-1beta). SCF potentiates lipopolysaccharide-stimulated, but attenuates interferon-gamma TFNalpha mediated expression of the mRNAs of IL-1beta and TNF-alpha. The SCF-induced expression of neurotrophin mRNAs is enhanced by the addition of lipopolysaccharide (LPS) but is reduced by IFNgamma. The interactions between SCF and LPS or IFNgamma in the regulation of inflammation-associated cytokine gene expression are accompanied by the differential regulation of c-kitR in microglia. These observations suggest that SCF/c-kitR signaling modulates microglial activity.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Zhang SC,Fedoroff Sdoi
10.1002/(SICI)1097-4547(19980701)53:1<29::AID-JNR4subject
Has Abstractpub_date
1998-07-01 00:00:00pages
29-37issue
1eissn
0360-4012issn
1097-4547pii
10.1002/(SICI)1097-4547(19980701)53:1<29::AID-JNR4journal_volume
53pub_type
杂志文章abstract::Unilateral eye removal results in an increased delivery of blood-borne glucose, norepinephrine, choline, and tyrosine, but not of proline, to the denervated optic lobes. Administration of reserpine to chicks increases penetrance of norepinephrine into the brain but not of tyrosine, choline, or proline. Selective alter...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490010308
更新日期:1975-01-01 00:00:00
abstract::Mitochondria are power organelles generating biochemical energy, ATP, in the cell. Mitochondria play a variety of roles, including integrating extracellular signals and executing critical intracellular events, such as neuronal cell survival and death. Increasing evidence suggests that a cross-talk mechanism between mi...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490080113
更新日期:1982-01-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490010513
更新日期:1975-01-01 00:00:00
abstract::Transient global ischemia causes delayed white matter injury to the brain with oligodendrocyte (OLG) death and myelin breakdown. There is increasing evidence that hypoxia may be involved in several diseases of the white matter, including multiple sclerosis, vascular dementia, and ischemia. Matrix metalloproteinases (M...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22257
更新日期:2010-03-01 00:00:00
abstract::Direct brain injections of the N-methyl-D-aspartate receptor agonist quinolinic acid (QA) trigger an excitotoxic cascade characterized by rapid neuronal death and glial/immune cell activation. The present study compared the timing of immediate early gene (IEG; c-fos, c-jun, jun-B, and zif/268) induction with the respo...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490360511
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abstract::Although reactive oxygen species (ROS) have been implicated in ischemic preconditioning (IPC)-induced neuronal protection, several key questions concerning ROS remain to be elucidated. The purpose of this study is to obtain direct evidence for the formation of specific ROS species generated by IPC, and to determine th...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20402
更新日期:2005-03-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490420103
更新日期:1995-09-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22720
更新日期:2011-11-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22650
更新日期:2011-12-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490320313
更新日期:1992-07-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10303
更新日期:2002-08-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23666
更新日期:2015-12-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250312
更新日期:1990-03-01 00:00:00
abstract::Human T-cell lymphotropic virus type I (HTLV-I) may infect up to 10% of peripheral blood T cells in patients with HTLV-I myelopathy. To examine the impact of HTLV-I infection on the abilities of T cells to present and respond to peptide antigen, we HTLV-I infected and subcloned a myelin basic protein peptide 84-102 (M...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19960915)45:6<786::AID-JNR
更新日期:1996-09-15 00:00:00
abstract::Precursor cells of the adult mouse subventricular zone (SVZ) are mobilized and recruited by a lysolecithin (LPC)-induced demyelination of the corpus callosum. Because age decreases the proliferation of the SVZ neural precursors as well as the potential for myelin repair of the adult central nervous system, we have com...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10411
更新日期:2002-09-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10668
更新日期:2003-08-01 00:00:00
abstract::Structural microtubule-associated proteins (MAPs) interact with microtubules to regulate the various dynamic stages of microtubules. The purpose of this study was to measure the impact of myc-tagged MAP1a fragments on microtubule dynamic phases in vivo. Cells from an epithelial kidney cell line (LLCPK1) that had been ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21920
更新日期:2009-04-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22475
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300111
更新日期:1991-09-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980115)51:2<268::AID-JNR
更新日期:1998-01-15 00:00:00
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journal_title:Journal of neuroscience research
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更新日期:2002-10-15 00:00:00
abstract::Oligomeric forms of α-synuclein are believed to cause mitochondrial injury, which may contribute to neurotoxicity in Parkinson's disease (PD). Here oligomers of α-synuclein were prepared using the dopamine metabolite, DOPAL (3,4-dihydroxyphenyl-acetaldehyde), in the presence of guanidinium hydrochloride. Electron micr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24513
更新日期:2019-12-01 00:00:00
abstract::Here we assess the potential functional role of increased aquaporin 9 (APQ9) in astrocytes. Increased AQP9 expression was achieved in primary astrocyte cultures by transfection of a plasmid-containing green fluorescent protein fused to either wild-type or mutated human AQP9. Increased AQP9 expression and phosphorylati...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.24061
更新日期:2018-02-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21967
更新日期:2009-05-15 00:00:00
abstract::We describe here the presence of ubiquitin and its conjugation system in the rat retina. Retinal homogenates and supernatants conjugate [125I]human ubiquitin with either endogenous or exogenous proteins. The conjugating activity is relatively stable over time, requires ATP, and has a pH optimum of approximately 8. The...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300220
更新日期:1991-10-01 00:00:00
abstract::Recent studies suggest that heterotypic cell-cell interactions influence gliogenesis in the developing rat central nervous system. CNS neuron-derived factors have been hypothesized to exist, and several have been identified and partially characterized which affect the number of oligodendrocytes in vitro. In order to s...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490200303
更新日期:1988-07-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490300305
更新日期:1991-11-01 00:00:00
abstract::The brain acid-soluble protein BASP1 (CAP-23, NAP-22) belongs to the family of growth-associated proteins, which also includes GAP-43, a protein recently shown to regulate neural cell adhesion molecule (NCAM)-mediated neurite outgrowth. Here, the effects of BASP1 overexpression were investigated in PC12E2 cells and pr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21678
更新日期:2008-08-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.23638
更新日期:2015-12-01 00:00:00