Selective changes in the permeability of the blood-brain barrier after pharmacological or surgical deafferentation.

abstract：:Gap junctions (GJs) are widely distributed in brains across the animal kingdom. To visualize the GJ- coupled networks of two major mechanosensory neurons in the ganglia of medicinal leeches, we injected these cells with the GJ-permeable tracer Neurobiotin. When diffusion time was limited to only 30 min, tracer couplin...

journal_title：Journal of neuroscience research

authors： Segura OM,Abdulnoor L,Hua VV,Solano MJ,Macagno ER,Baker MW

更新日期：2020-06-01 00:00:00

abstract：:The growth and differentiation of neural precursor cells in the central nervous system (CNS) are regulated by their response to polypeptide growth factors which interact with specific transmembrane receptor tyrosine kinases (RTKs). We demonstrate that rat oligodendrocyte-type 2 astrocyte (O-2A) glial progenitor cells,...

journal_title：Journal of neuroscience research

authors： Ida JA Jr,Dubois-Dalcq M,McKinnon RD

更新日期：1993-12-01 00:00:00

abstract：:Iron deficiency and chronic mild carbon monoxide (CO) exposure are nutritional and environmental problems that can be experienced simultaneously. We examined the effects of chronic mild CO exposure and iron availability on auditory development in the rat. We propose that chronic mild CO exposure creates an oxidative s...

journal_title：Journal of neuroscience research

authors： Webber DS,Lopez I,Korsak RA,Hirota S,Acuna D,Edmond J

更新日期：2005-06-01 00:00:00

abstract：:Restless Legs Syndrome (RLS) is a disorder of sensation with a prevalence of around 2-5% of the population. Relevant to understanding the possible pathophysiological mechanism is the fact that RLS is extremely responsive to dopaminergic agents. A second issue is that iron deficiency states may precipitate RLS in as mu...

journal_title：Journal of neuroscience research

authors： Earley CJ,Allen RP,Beard JL,Connor JR

更新日期：2000-12-01 00:00:00

abstract：:Localization of acetylcholine receptors (AChRs) to the postsynaptic region of muscle is mediated in part by transcriptional mechanisms, because the genes encoding AChR subunits are transcribed selectively in synaptic myofiber nuclei. Neuregulin-1 (NRG-1) is a synaptic signal and induces transcription of AChRs in muscl...

journal_title：Journal of neuroscience research

authors： Herndon CA,Fromm L

更新日期：2008-04-01 00:00:00

abstract：:Pyruvate carboxylation was studied in cerebellar astrocytes and granule neurons. The cells were incubated in medium containing [U-(13)C]glucose (2.5 mM) and [U-(13)C]lactate (1 mM) and varying amounts of 3-nitropropionic acid (3-NPA) plus/minus aspartate. 3-NPA alone clearly stopped tricarboxylic acid (TCA) cycle acti...

journal_title：Journal of neuroscience research

authors： Waagepetersen HS,Qu H,Schousboe A,Sonnewald U

更新日期：2001-12-01 00:00:00

abstract：:Neuropathic pain is a debilitating chronic pain and represents a major clinical challenge. The molecular and cellular mechanisms underlying its development and maintenance are not fully understood but involve abnormal excitability in the dorsal horn of the spinal cord. A growing body of evidence has shown that this ab...

journal_title：Journal of neuroscience research

authors： Tsuda M

更新日期：2017-06-01 00:00:00

abstract：:It has been postulated that the pathogenesis of Parkinson's disease (PD) is associated with mitochondrial dysfunction. Rotenone, an inhibitor of mitochondrial complex I, provides models of PD both in vivo and in vitro. We investigated the neuroprotective effect of D-beta-hydroxybutyrate (bHB), a ketone body, against r...

journal_title：Journal of neuroscience research

authors： Imamura K,Takeshima T,Kashiwaya Y,Nakaso K,Nakashima K

更新日期：2006-11-01 00:00:00

abstract：:Previously, we reported the presence of multiple neurotransmitters in subclones of SN6, a septal cholinergic hybrid cell line. To obtain information concerning the functionality of these transmitters, we measured transmitter contents, activities of transmitter-producing enzymes, and the effect of serum-free culture me...

journal_title：Journal of neuroscience research

authors： Gallyas F Jr,Satoh J,Endoh M,Kunishita T,Tabira T

更新日期：1995-12-15 00:00:00

abstract：:Axonal injury is often characterized by axonal transport defects and abnormal accumulation of intra-axonal components. Nitric oxide (NO) has a key role in mediating inflammatory axonopathy in many neurodegenerative diseases, but little is known about how nitrosative/oxidative stress affects axonal transport or whether...

journal_title：Journal of neuroscience research

authors： Redondo J,Hares K,Wilkins A,Scolding N,Kemp K

更新日期：2015-06-01 00:00:00

abstract：:Efficient functioning of maintenance and repair processes seem to be crucial for both survival and physical quality of life. This is accomplished by a complex network of the so-called longevity assurance processes, under control of several genes termed vitagenes. These include members of the heat shock protein system,...

journal_title：Journal of neuroscience research

authors： Calabrese V,Ravagna A,Colombrita C,Scapagnini G,Guagliano E,Calvani M,Butterfield DA,Giuffrida Stella AM

更新日期：2005-02-15 00:00:00

abstract：:Metabolic abnormalities found in epileptogenic tissue provide considerable evidence of brain hypometabolism, while major risk factors for acquired epilepsy all share brain hypometabolism as one common outcome, suggesting that a breakdown of brain energy homeostasis may actually precede epileptogenesis. However, a caus...

journal_title：Journal of neuroscience research

authors： Samokhina E,Popova I,Malkov A,Ivanov AI,Papadia D,Osypov A,Molchanov M,Paskevich S,Fisahn A,Zilberter M,Zilberter Y

更新日期：2017-11-01 00:00:00

abstract：:Adhesion responses triggered by integrin-class matrix receptors have been implicated in the synaptic reorganization events necessary for certain types of neuronal plasticity. Hippocampal slice cultures were used to test whether the related structural transformations elicited by NMDA receptor stimulation are regulated ...

journal_title：Journal of neuroscience research

authors： Bahr BA

更新日期：2000-03-15 00:00:00

abstract：:Ten days after bilateral injections of ibotenic acid into the nucleus basalis, rats injected daily (i.m.) with ganglioside GM1 were protected from anterograde degeneration of cholinergic projections to the fronto-lateral cortex. This protection was reflected by reduced losses (associated with ibotenic acid lesions) of...

journal_title：Journal of neuroscience research

authors： Mahadik SP,Vilim F,Korenovsky A,Karpiak SE

更新日期：1988-08-01 00:00:00

abstract：:Although upregulation of ryanodine receptor (RyR)-1 and -2 is mediated through the activation of dopamine D1 receptors (D1DRs) in the development of psychostimulant-induced place preference, little is known about how such increased expressions of RyRs are negatively regulated. This study investigated negative regulato...

journal_title：Journal of neuroscience research

authors： Kurokawa K,Mizuno K,Ohkuma S

更新日期：2012-08-01 00:00:00

abstract：:Traumatic injury to the adult central nervous system (CNS) results in a rapid response from resident astrocytes, a process often referred to as reactive astrogliosis or glial scarring. The robust formation of the glial scar and its associated extracellular matrix (ECM) molecules have been suggested to interfere with a...

journal_title：Journal of neuroscience research

authors： McGraw J,Hiebert GW,Steeves JD

更新日期：2001-01-15 00:00:00

abstract：:Enriched populations of human microglial cells were isolated from mixed cell cultures prepared from embryonic human telencephalon tissues. Human microglial cells exhibited cell type-specific antigens for macrophage-microglia lineage cells including CD11b (Mac-1), CD68, B7-2 (CD86), HLA-ABC, HLA-DR and ricinus communis...

journal_title：Journal of neuroscience research

authors： Lee YB,Nagai A,Kim SU

更新日期：2002-07-01 00:00:00

abstract：:The existence of endogenous neural progenitor cells (NPCs) in the adult spinal cord (sc) provides the potential for tailored repair therapies after spinal cord injury (SCI). This study investigates the impact of inflammatory mediators on properties of NPC cultures derived from adult rats after SCI. The Infinite Horizo...

journal_title：Journal of neuroscience research

authors： Knerlich-Lukoschus F,Krossa S,Krause J,Mehdorn HM,Scheidig A,Held-Feindt J

更新日期：2015-04-01 00:00:00

abstract：:The BM89 antigen, first identified in porcine brain by means of a monoclonal antibody, is a neuron-specific molecule widely distributed in the mammalian central and peripheral nervous system (Merkouri and Matsas: Neuroscience 50:53-68, 1992). Here we describe the purification of BM89 antigen from porcine and mouse bra...

journal_title：Journal of neuroscience research

authors： Gaitanou M,Mamalaki A,Merkouri E,Matsas R

更新日期：1997-06-15 00:00:00

abstract：:Culturing sympathetic ganglion neurons in vitro may modify phenotypic expression of some neurotransmitters. For dorsal root ganglia (DRG), contradictory results have been reported; most studies have used immature material. We have therefore performed a detailed immunocytochemical analysis of the transmitter content of...

journal_title：Journal of neuroscience research

authors： Schoenen J,Delree P,Leprince P,Moonen G

更新日期：1989-04-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is an extensively studied protein that is evolutionarily conserved and widely distributed in the brain of vertebrates. It acts via its cognate receptors TrkB and p75NTR and plays a central role in the developmental neurogenesis, neuronal survival, proliferation, differentiation...

journal_title：Journal of neuroscience research

authors： Anand SK,Mondal AC

更新日期：2020-05-01 00:00:00

abstract：:Astrocyte activation is an important feature in many disorders of the central nervous system, including chronic pain conditions. Activation of astrocytes is characterized by a change in morphology, including hypertrophy and increased size of processes, proliferation, and an increased production of proinflammatory medi...

journal_title：Journal of neuroscience research

authors： Norsted Gregory E,Delaney A,Abdelmoaty S,Bas DB,Codeluppi S,Wigerblad G,Svensson CI

更新日期：2013-02-01 00:00:00

abstract：:The brainstem nucleus of the solitary tract (NTS) is the key integrating relay in the central processing of sensory information from the thoracic and from most subdiaphragmatic viscera. Modulation of neuronal excitability and synaptic activity in the NTS by nicotinic agents can have potent effects on vital physiologic...

journal_title：Journal of neuroscience research

authors： Feng L,Uteshev VV

更新日期：2014-11-01 00:00:00

abstract：:Integrins comprise a large family of cell adhesion molecules that mediate interactions between the extracellular environment and the cytoplasm. During the last decade, analysis of the expression and function of these molecules has revealed that integrins regulate many aspects of cell behavior including cell death, pro...

journal_title：Journal of neuroscience research

authors： Milner R,Campbell IL

更新日期：2002-08-01 00:00:00

abstract：:Dopaminergic afferents from the mesencephalic areas, such as ventral tegmental area (VTA), synapse with the gamma-aminobutyric acid (GABA)-ergic interneurons in the prefrontal cortex (PFC). Pharmacological and electrophysiological data show that the reinforcement, the dependence-producing properties, as well as the ps...

journal_title：Journal of neuroscience research

authors： Li SP,Park MS,Kim JH,Kim MO

更新日期：2004-12-15 00:00:00

abstract：:The type 1 metabotropic glutamate receptor (mGluR1) plays an import role in the synaptic physiology and development of cerebellar Purkinje neurons. mGluR1 expression occurs early in the developmental program of Purkinje neurons, at an age that precedes expression of the dendritic structure. Few studies have investigat...

journal_title：Journal of neuroscience research

authors： Netzeband JG,Gruol DL

更新日期：2008-02-01 00:00:00

abstract：:Neuroanatomical studies suggest that neuronal atrophy and destruction occur over the course of many years in neurodegenerative conditions such as schizophrenia and Alzheimer's disease. In schizophrenia, early intervention with atypical neuroleptics such as olanzapine has been shown to prevent development of some of th...

journal_title：Journal of neuroscience research

authors： Wei Z,Bai O,Richardson JS,Mousseau DD,Li XM

更新日期：2003-08-01 00:00:00

abstract：:The demyelinative potential of the cytokines interleukin-1 alpha (IL-1 alpha), interferon-gamma (IFN-gamma), and tumor necrosis factor-alpha (TNF-alpha) has been investigated in myelinating aggregate brain cell cultures. Treatment of myelinated cultures with these cytokines resulted in a reduction in myelin basic prot...

journal_title：Journal of neuroscience research

authors： Loughlin AJ,Honegger P,Woodroofe MN,Comte V,Matthieu JM,Cuzner ML

更新日期：1994-04-01 00:00:00

abstract：:In chronic demyelinating lesions of the central nervous system, insufficient generation of oligodendrocytes (OLs) is not due to a lack of oligodendrocyte precursor cells (OPCs), because the accumulation of OPCs and premyelinating OLs can be observed within these lesions. Here we sought to identify the basis for the fa...

journal_title：Journal of neuroscience research

authors： Shimizu T,Tanaka KF,Takebayashi H,Higashi M,Wisesmith W,Ono K,Hitoshi S,Ikenaka K

更新日期：2013-02-01 00:00:00

abstract：:Damage to the lateral nucleus of the septum in the rat resulted in atypical learning to a previously meaningless stimulus. Nonreinforced preexposure to a stimulus normally makes more difficult subsequent use of that stimulus for learning. The effect of this preexposure on learning is termed latent inhibition and was d...

journal_title：Journal of neuroscience research

authors： Toga AW,Burton HA

更新日期：1979-01-01 00:00:00