Chronic inhibition of brain glycolysis initiates epileptogenesis.

abstract：:During late postnatal development, mice with the autosomal recessive wobbler mutation (wr/wr) develop motoneuron degeneration associated with astrogliosis in the spinal cord. In vitro, primary wobbler astrocytes are also affected, exhibiting abnormal cell-cell contacts. To characterize further the wobbler disease, we ...

journal_title：Journal of neuroscience research

authors： Aït-Ikhlef A,Hantaz-Ambroise D,Henderson CE,Rieger F

更新日期：2000-01-01 00:00:00

abstract：:Recent studies have indicated that embryonic stem cells (ESCs) can be a source for the replacement of spiral ganglion neurons (SGNs), auditory primary neurons, and neurite projections from ESC-derived neurons to auditory sensory epithelia. However, the potential of ESC-derived neurons for synapse formation with audito...

journal_title：Journal of neuroscience research

authors： Matsumoto M,Nakagawa T,Kojima K,Sakamoto T,Fujiyama F,Ito J

更新日期：2008-11-01 00:00:00

abstract：:It has been demonstrated that L-pipecolic acid (L-PA), a major metabolic intermediate of L-lysine (L-Lys) in the mammalian and chicken brain, is involved in the functioning of the GABAergic system. A previous study has shown that intracerebroventricular (i.c.v.) injection of L-PA suppressed feeding and induced sleep-l...

journal_title：Journal of neuroscience research

authors： Takagi T,Bungo T,Tachibana T,Saito ES,Saito S,Yamasaki I,Tomonaga S,Denbow DM,Furuse M

更新日期：2003-07-15 00:00:00

abstract：:The remarkable quantities of myelin membrane produced by oligodendrocytes has led us to examine the mechanisms involved in the sorting and transport of proteins and lipids during myelinogenesis. Noting that it has been proposed that proteins destined for the apical surface of polarized epithelial cells co-cluster with...

journal_title：Journal of neuroscience research

authors： Kim T,Fiedler K,Madison DL,Krueger WH,Pfeiffer SE

更新日期：1995-10-15 00:00:00

abstract：:To scale up human neural stem/progenitor cell (NSPC) cultures for clinical use, we need to know how long these cells can live ex vivo without losing their ability to proliferate and differentiate; thus, a convenient method is needed to estimate the proliferative activity of human NSPCs grown in neurosphere cultures, a...

journal_title：Journal of neuroscience research

authors： Kanemura Y,Mori H,Kobayashi S,Islam O,Kodama E,Yamamoto A,Nakanishi Y,Arita N,Yamasaki M,Okano H,Hara M,Miyake J

更新日期：2002-09-15 00:00:00

abstract：:Recombinant adeno-associated viral (AAV)-mediated therapeutic gene transfer to dorsal root ganglia (DRG) is an effective and safe tool for treating chronic pain. However, AAV with various constitutively active promoters leads to transgene expression predominantly to neurons, while glial cells are refractory to AAV tra...

journal_title：Journal of neuroscience research

authors： Xiang H,Xu H,Fan F,Shin SM,Hogan QH,Yu H

更新日期：2018-03-01 00:00:00

abstract：:Multiple neurodegenerative disorders are associated with altered mitochondrial bioenergetics. Although mitochondrial O(2) consumption is frequently measured in isolated mitochondria, isolated synaptic nerve terminals (synaptosomes), or cultured cells, the absence of mature brain circuitry is a remaining limitation. He...

journal_title：Journal of neuroscience research

authors： Schuh RA,Clerc P,Hwang H,Mehrabian Z,Bittman K,Chen H,Polster BM

更新日期：2011-12-01 00:00:00

abstract：:The contribution of glucose carbon to the biosynthesis of cholesterol and phospholipids in distinct brain regions was studied quantitatively in the adult male rat. Rates of flow of glucose carbon into the lipids in vivo were calculated from two measurements: the curve representing the decrease in plasma 14C-glucose wi...

journal_title：Journal of neuroscience research

authors： Barkai AI

更新日期：1981-01-01 00:00:00

abstract：:Corticosterone (CORT), one of the glucocorticoids, causes neuronal damage in the hippocampus, but the mechanism(s) of action underlying its effects remains unknown. Brain-derived neurotrophic factor (BDNF) is a neurotrophic factor that belongs to the neurotrophin family, affects the survival and/or differentiation of ...

journal_title：Journal of neuroscience research

authors： Nitta A,Ohmiya M,Sometani A,Itoh M,Nomoto H,Furukawa Y,Furukawa S

更新日期：1999-07-15 00:00:00

abstract：:The incubation of murine thymocytes for 24 hr in the presence of cholinergic agonists induces selective proliferation of PNA- cells as measured by thymidine incorporation. The response of PNA- cells is mediated by the activation of nicotinic receptors. This conclusion is suggested by the inability of the muscarinic ag...

journal_title：Journal of neuroscience research

authors： Rossi A,Tria MA,Baschieri S,Doria G,Frasca D

更新日期：1989-11-01 00:00:00

abstract：:Oligodendrocyte-specific protein (OSP/claudin-11) is a major component of CNS myelin and has been recently added to the claudin family of tight junction proteins. In this study, the developmental expression of OSP/claudin-11 was determined using in situ hybridization, immunohistochemistry (IH), and Western blot analys...

journal_title：Journal of neuroscience research

authors： Bronstein JM,Chen K,Tiwari-Woodruff S,Kornblum HI

更新日期：2000-05-01 00:00:00

abstract：:The effects of extracellular acidification on the synaptic function and neuronal excitability were investigated on the hippocampal CA1 neurons. A decrease of extracellular pH from 7.4 to 6.7 did not alter either the resting membrane potential or the neuronal membrane input resistance. Extracellularly recorded field ex...

journal_title：Journal of neuroscience research

authors： Hsu KS,Liang YC,Huang CC

更新日期：2000-11-01 00:00:00

abstract：:Neural expression of constitutive hsc70 mRNA and hyperthermia-inducible hsp70 mRNA is examined using radioactive and non-radioactive in situ hybridization procedures. A strong induction of hsp70 mRNA was noted in cell populations in cerebellar layers and in the brainstem which demonstrated expression of mRNA encoding ...

journal_title：Journal of neuroscience research

authors： Foster JA,Rush SJ,Brown IR

更新日期：1995-08-01 00:00:00

abstract：:Neuron expression of the cytokine tumor necrosis factor-alpha (TNF), and the regulation of the levels of TNF by alpha(2)-adrenergic receptor activation were investigated. Adult rat hippocampal neurons and phorbol ester (PMA)-differentiated SH-SY5Y cells were examined. Intracellular levels of TNF mRNA accumulation, as ...

journal_title：Journal of neuroscience research

authors： Renauld AE,Spengler RN

更新日期：2002-01-15 00:00:00

abstract：:Human fetal brain is a potential source of neural stem cells (NSCs) for cell replacement therapy in neurodegenerative diseases. We explored whether NSCs isolated from cortex and striatum of human fetuses, aged 6-9 weeks post-conception, maintain their regional identity and differentiate into specific neuron types in c...

journal_title：Journal of neuroscience research

authors： Kallur T,Darsalia V,Lindvall O,Kokaia Z

更新日期：2006-12-01 00:00:00

abstract：:In a nominally calcium-free medium, a toxic phospholipase A2, paradoxin, PDX (1-200nM) was able to significantly decrease glutamate uptake by rat hippocampal mini-slices. Under the same experimental conditions, PDX could also inhibit the reuptake of choline and dopamine, suggesting a nonselective action. Furthermore, ...

journal_title：Journal of neuroscience research

authors： Dorandeu F,Antier D,Pernot-Marino I,Lapeyre P,Lallement G

更新日期：1998-02-01 00:00:00

abstract：:The occurrence of type-1 plasminogen activator inhibitor (PAI-1) in human cerebrospinal fluid (CSF) has not previously been reported. As a member of the serpin superfamily of serine protease inhibitors and an acute phase response component, PAI-1 has powerful potential roles in nervous system homeostasis. We have dete...

journal_title：Journal of neuroscience research

authors： Rao JS,Chen M,Festoff BW

更新日期：1993-02-15 00:00:00

abstract：:We have developed a silicone nerve regeneration chamber that is partitioned into two compartments by a strip of nitrocellulose paper. The modified two-compartment chamber allows the investigation of the effects on rat sciatic nerve regeneration of trophic or growth factors that are initially bound to the nitrocellulos...

journal_title：Journal of neuroscience research

authors： Danielsen N,Pettmann B,Vahlsing HL,Manthorpe M,Varon S

更新日期：1988-07-01 00:00:00

abstract：:The companion study showed that acoustic overstimulation of adult chinchillas, with a noise level sufficient to damage the cochlea, led to cytological changes and degeneration of synaptic endings in the cochlear nucleus within 1-16 weeks. In the present study, the same stimulus was used to study the long-term effects ...

journal_title：Journal of neuroscience research

authors： Kim JJ,Gross J,Potashner SJ,Morest DK

更新日期：2004-09-15 00:00:00

abstract：:In a number of pathological states of the brain, the activation of the inducible nitric oxide synthase (iNOS) plays a major role. Interleukin (IL)-1beta is believed to be an essential factor in the induction of iNOS. However, little is known about the cascade of events culminating in iNOS expression in vivo. To identi...

journal_title：Journal of neuroscience research

authors： Hartlage-Rübsamen M,Lemke R,Schliebs R

更新日期：1999-08-01 00:00:00

abstract：:By using two different approaches, ubiquitin C-terminal hydrolase 1 (UCHL1) was identified as a potential cerebrospinal fluid (CSF) biomarker of neuronal loss in aneurysmal subarachnoid hemorrhage (ASAH) and presumably other CNS damage and disease states. Appropriate antibodies and a sensitive ELISA were generated, an...

journal_title：Journal of neuroscience research

authors： Lewis SB,Wolper R,Chi YY,Miralia L,Wang Y,Yang C,Shaw G

更新日期：2010-05-15 00:00:00

abstract：:The effects of the human immunodeficiency virus type 1 envelope protein gp120 on the release of GABA elicited by N-methyl-D-aspartate (NMDA) from rat hippocampal neurons in primary culture has been investigated. NMDA (1-300 microM) increased in a concentration-dependent manner (EC50 =37.9+/-12 microM) the release of [...

journal_title：Journal of neuroscience research

authors： Fontana G,Valenti L,Raiteri M

更新日期：1997-09-15 00:00:00

abstract：:The expression of GABAB receptors in cultured mouse cerebellar granule cells was investigated in binding experiments using [3H](S,R)-baclofen as well as in functional assessment of the ability of (R)-baclofen to interact with depolarization (15-40 mM KCl) coupled changes in intracellular Ca2+ homeostasis and neurotran...

journal_title：Journal of neuroscience research

authors： Kardos J,Elster L,Damgaard I,Krogsgaard-Larsen P,Schousboe A

更新日期：1994-12-15 00:00:00

abstract：:The distribution of neuronal intermediate filament proteins in the developing mouse olfactory bulb and olfactory epithelium was characterized by immunocytochemical approach. Antibodies against alpha-internexin, neurofilament triplet proteins (NFTPs; NF-L, NF-M, and NF-H) and peripherin were used to determine their exp...

journal_title：Journal of neuroscience research

authors： Chien CL,Lee TH,Lu KS

更新日期：1998-11-01 00:00:00

abstract：:The mutant hypogonadal (hpg) mouse lacks a functioning gene for the neurohormone gonadotropin releasing hormone (GnRH). Previous studies from our laboratory had indicated that the initiation and maintenance of reproductive function in these mice could be brought about by the implantation of normal fetal grafts into ad...

journal_title：Journal of neuroscience research

authors： Silverman RC,Gibson MJ,Silverman AJ

更新日期：1992-01-01 00:00:00

abstract：:The extension of filopodia from growth cones of regenerating neurites from rat superior cervical ganglion neurons in tissue culture was studied. Cultures were grown on a thin layer of fibrous collagen and maintained in a medium containing serum and nerve growth factor. Time-lapse cinematography and computer-assisted m...

journal_title：Journal of neuroscience research

authors： Argiro V,Bunge MB,Johnson MI

更新日期：1985-01-01 00:00:00

abstract：:Although alterations in adenylate cyclase (AC) activity and somatostatin (SRIF) receptor density have been reported in Alzheimer's disease, the effects of amyloid beta-peptide (Abeta) on these parameters in the hippocampus are unknown. Our aim was to investigate whether the peptide fragment Abeta(25-35) can affect the...

journal_title：Journal of neuroscience research

authors： Burgos-Ramos E,Hervás-Aguilar A,Puebla-Jiménez L,Boyano-Adánez MC,Arilla-Ferreiro E

更新日期：2007-02-01 00:00:00

abstract：:High levels of the proto-oncogene product, pp60c-src, have been found in developing and adult neural tissues as well as in certain fully mature cells of the hematopoietic lineage, e.g., platelets and myelomonocytes. Adrenal medullary chromaffin cells exhibit characteristics of both types of cells, i.e., they are deriv...

journal_title：Journal of neuroscience research

authors： Oddie KM,Litz JS,Balserak JC,Payne DM,Creutz CE,Parsons SJ

更新日期：1989-09-01 00:00:00

abstract：:Chloride efflux is known to be involved in the progression of apoptosis in various cell types. We have recently shown that the volume-sensitive outwardly rectifying (VSOR) anion channel serves as the pathway for apoptotic chloride efflux in some cells. In the present study, we tested the neuroprotective effects of dru...

journal_title：Journal of neuroscience research

authors： Inoue H,Ohtaki H,Nakamachi T,Shioda S,Okada Y

更新日期：2007-05-15 00:00:00

abstract：:Preterm birth and associated brain injury are the primary cause of cerebral palsy and developmental disabilities and are among the most serious global health issues that modern society faces. Current therapy for infants suffering from premature brain injury is still mainly supportive, and there are no effective treatm...

journal_title：Journal of neuroscience research

authors： Peng X,Song J,Li B,Zhu C,Wang X

更新日期：2020-05-01 00:00:00