Influence of factors secreted by wobbler astrocytes on neuronal and motoneuronal survival.

abstract：:Given the ubiquitous nature of opioids in the treatment of pain, it is an interesting paradox that this class of medications also represents one of the least understood components of clinical pain medicine. For many years, there has been intense interest in the mechanisms of opioid activity, but this has not resulted ...

journal_title：Journal of neuroscience research

authors： Montgomery LS

更新日期：2020-08-07 00:00:00

abstract：:An elevated expression of c-fos nuclear protooncogene (immediate early gene) has been shown repeatedly to correlate with long-term neuronal responses. This paper reviews recent data suggesting that neuronal plasticity, including learning and memory formation, may involve c-fos expression as well. On the basis of biolo...

journal_title：Journal of neuroscience research

authors： Kaczmarek L

更新日期：1993-03-01 00:00:00

abstract：:Recent experiments have shown that Arg, Lys, and Leu can be incorporated posttranslationally into proteins of regenerating sciatic nerves of rats. The present experiments investigate a mixture of 15 radioactive amino acids to determine if additional amino acids can be conjugated posttranslationally to proteins of rege...

journal_title：Journal of neuroscience research

authors： Chakraborty G,Yu M,Luo D,Sturman JA,Ingoglia NA

更新日期：1990-04-01 00:00:00

abstract：:Both protein kinase C (PKC) and ceramide play a critical role in cell signaling, but the relationship between PKC and ceramide is unclear. Low concentrations of ceramide were observed to transiently stimulate PKC zeta activity in vitro and in vivo, whereas high doses of ceramide lead to inhibition of PKC zeta. Inhibit...

journal_title：Journal of neuroscience research

authors： Wang YM,Seibenhener ML,Vandenplas ML,Wooten MW

更新日期：1999-02-01 00:00:00

abstract：:Differentiated human NT2-N neurons were shown to express CCR5 and CXCR4 chemokine receptor mRNA and protein, and to be responsive to the chemokines CCL5 and CXCL12. Using cDNA microarray technology, CCL5 was found to induce a distinct transcriptional program, with reproducible induction of 46 and 9 genes after 2 and 8...

journal_title：Journal of neuroscience research

authors： Valerio A,Ferrario M,Martinez FO,Locati M,Ghisi V,Bresciani LG,Mantovani A,Spano P

更新日期：2004-11-01 00:00:00

abstract：:Abdominal muscle electromyograms were monitored in response to graded mechanical loads added to either inspiration or expiration in anesthetized cats. The surgical preparation, the apparatus, and the levels of loads applied (resistive, tracheal occlusion, and continuous positive pressure) were matched with those emplo...

journal_title：Journal of neuroscience research

authors： Baker JP Jr,Frazier DT

更新日期：1985-01-01 00:00:00

abstract：:The expression of gangliosides of the lactosylceramide (LC) and of the gangliotetraosylceramide (GTC) series on the surface of cells from rat embryonic cerebellar tissue was investigated by double-color indirect immunofluorescence. GD3 was assumed to be representative of LC and was detected using a specific monoclonal...

journal_title：Journal of neuroscience research

authors： Gravotta D,Ferreira A,Busciglio J,Caceres A,Landa CA,Maccioni HJ

更新日期：1990-02-01 00:00:00

abstract：:A novel approach was developed to raise a panel of monoclonal antibodies (mAb) against brain antigens using Xenopus oocytes as immunological vectors. Xenopus oocytes were injected to express proteins encoded by brain-derived mRNA extracted from rat cerebral cortex. A crude membrane preparation from mRNA-injected oocyt...

journal_title：Journal of neuroscience research

authors： Matute C,Tigyi GJ,Miledi R

更新日期：1991-05-01 00:00:00

abstract：:Molecular mechanisms which underlie the heat shock response have commonly been analyzed using tissue culture systems, with less investigation of the intact mammal. In tissue culture, a temperature elevation of 5 degrees C is required to activate mammalian heat shock transcription factor 1 (HSF1) to the DNA-binding for...

journal_title：Journal of neuroscience research

authors： Brown IR,Rush SJ

更新日期：1996-04-01 00:00:00

abstract：:In the present study, following previous experience with electrolytic lesion of the rat brain, and subsequent reduction of reactive gliosis with 7 beta-hydroxycholesterol derivatives (Bochelen et al.: Neuroscience 51:827-834, 1992), we have performed a hemisection of the spinal cord in adult rats and investigated the ...

journal_title：Journal of neuroscience research

authors： Giménez y Ribotta M,Rajaofetra N,Morin-Richaud C,Alonso G,Bochelen D,Sandillon F,Legrand A,Mersel M,Privat A

更新日期：1995-05-01 00:00:00

abstract：:The neural cell adhesion molecule L1 is a multidomain protein that plays important roles in cell adhesion, migration, and neurite outgrowth. It can interact with itself by a self-binding, i.e., homophilic adhesion mechanism (Kadmon et al.: J Cell Biol 110: 193-208, 1990a). To determine the domains of L1 involved in ho...

journal_title：Journal of neuroscience research

authors： Holm J,Appel F,Schachner M

更新日期：1995-09-01 00:00:00

abstract：:We investigated the role of kainate (KA) receptor activation and desensitization in inducing the increase in the intracellular free Ca(2+) concentration ([Ca(2+)](i)) in individual cultured rat hippocampal neurons. The rat hippocampal neurons in the cultures were shown to express kainate receptor subunits, KA2 and Glu...

journal_title：Journal of neuroscience research

authors： Silva AP,Malva JO,Ambrósio AF,Salgado AJ,Carvalho AP,Carvalho CM

更新日期：2001-09-01 00:00:00

abstract：:In offspring, an adequate maternal diet is important for neurodevelopment. One mechanism by which maternal diet impacts neurodevelopment is through its dynamic role in the development of the gut microbiota. Communication between the gut, and its associated microbiota, and the brain is facilitated by the vagus nerve, i...

journal_title：Journal of neuroscience research

authors： Al Rubaye H,Adamson CC,Jadavji NM

更新日期：2021-01-01 00:00:00

abstract：:Glutamate-induced neurotoxicity consequent to N-methyl-D-aspartic acid (NMDA) and 2-amino-3-(3-hydroxy-5-methyl-isoxazol-4-yl) propionic acid (AMPA) receptor activation underlies the pathogenesis of a wide range of central nervous system disorders, including brain ischemia. Prevention of ischemia/reperfusion (I/R)-ind...

journal_title：Journal of neuroscience research

authors： Liu L,Zhang R,Liu K,Zhou H,Tang Y,Su J,Yu X,Yang X,Tang M,Dong Q

更新日期：2009-12-01 00:00:00

abstract：:Asphyxia during delivery produces long-term deficits in brain development, including hippocampus. We investigated hippocampal plasticity after perinatal asphyxia, measuring postnatal apoptosis and neurogenesis. Asphyxia was performed by immersing rat fetuses with uterine horns removed from ready-to-deliver rats into a...

journal_title：Journal of neuroscience research

authors： Morales P,Fiedler JL,Andrés S,Berrios C,Huaiquín P,Bustamante D,Cardenas S,Parra E,Herrera-Marschitz M

更新日期：2008-09-01 00:00:00

abstract：:The expression of GABAB receptors in cultured mouse cerebellar granule cells was investigated in binding experiments using [3H](S,R)-baclofen as well as in functional assessment of the ability of (R)-baclofen to interact with depolarization (15-40 mM KCl) coupled changes in intracellular Ca2+ homeostasis and neurotran...

journal_title：Journal of neuroscience research

authors： Kardos J,Elster L,Damgaard I,Krogsgaard-Larsen P,Schousboe A

更新日期：1994-12-15 00:00:00

abstract：:Oxidative mechanisms of injury are important in many neurological disorders. Developing oligodendrocytes (pre-OLs) are particularly sensitive to oxidative stress-mediated injury. We previously demonstrated a novel function of phylloquinone (vitamin K(1)) and menaquinone 4 (MK-4; a major form of vitamin K2) in protecti...

journal_title：Journal of neuroscience research

authors： Li J,Wang H,Rosenberg PA

更新日期：2009-07-01 00:00:00

abstract：:Chondroitinase ABC (Ch'ase ABC) is a bacterial lyase that degrades chondroitin sulfate (CS), dermatan sulfate, and hyaluronan glycosaminoglycans (GAGs). This enzyme has received significant attention as a potential therapy for promoting central nervous system and peripheral nervous system repair based on its degradati...

journal_title：Journal of neuroscience research

authors： Tester NJ,Plaas AH,Howland DR

更新日期：2007-04-01 00:00:00

abstract：:Detergent-resistant lipid microdomains (Rafts) were isolated from human oligodendroglioma (HOG), human neuroblastoma (LA-N-5), and immortalized dorsal root ganglion (F-11) cell lines by sucrose-density gradient ultracentrifugation and shown to be enriched in cholesterol, sphingomyelin, and ceramide. [(3)H]palmitate la...

journal_title：Journal of neuroscience research

authors： Kilkus J,Goswami R,Testai FD,Dawson G

更新日期：2003-04-01 00:00:00

abstract：:Acoustic overstimulation causes apoptotic cell death in the cochlea. This death process is mediated, in part, by the mitochondrial signaling pathway involving Bcl-2 family proteins. Myeloid cell leukemia sequence 1 (Mcl-l) is an antiapoptotic member of the Bcl-2 family. Its involvement in noise-induced hair cell death...

journal_title：Journal of neuroscience research

authors： Hu BH,Cai Q

更新日期：2010-06-01 00:00:00

abstract：:Heat shock proteins (HSPs) are stress-responsive proteins that serve as important molecules contributing to cellular "protein triage." We and others have reported an increase of selected HSPs in multiple sclerosis (MS) lesions. However, the exact expression pattern of HSP family genes in MS is not known. The aim of ou...

journal_title：Journal of neuroscience research

authors： Mycko MP,Brosnan CF,Raine CS,Fendler W,Selmaj KW

更新日期：2012-10-01 00:00:00

abstract：:In our in vitro model, rasagiline a selective irreversible monoamine oxidase-B (MAO-B) inhibitor, protected nerve growth factor (NGF)-differentiated PC12 cells from cell death under oxygen and glucose deprivation (OGD). The severity of the OGD insult, as expressed by cell death, was time-dependent. Exposure of the cel...

journal_title：Journal of neuroscience research

authors： Abu-Raya S,Blaugrund E,Trembovler V,Shilderman-Bloch E,Shohami E,Lazarovici P

更新日期：1999-11-01 00:00:00

abstract：:The relationship between brain myelination and nutritional insufficiency in suckling rats whose dams had a restricted dietary intake was studied. The undernourished pups were characterized by body weight and brain weight that were 40-70% and 82-88% that of controls throughout the suckling period. Myelin concentrations...

journal_title：Journal of neuroscience research

authors： Yeh YY

更新日期：1988-03-01 00:00:00

abstract：:The non-receptor protein tyrosine kinase Fyn, which is a member of the Src family of kinases, has been shown to be essential for normal myelination and has been suggested to play a role in oligodendrocyte development. However, oligodendrocyte development has not been studied directly in cells lacking Fyn. Additionally...

journal_title：Journal of neuroscience research

authors： Sperber BR,McMorris FA

更新日期：2001-02-15 00:00:00

abstract：:We used the Plp1-overexpressing transgenic mouse model to investigate whether progressive demyelination of axons results in adaptive changes involving mitochondria within the axons. These models have myelinated axons from birth but gradually lose myelin and develop axonal loss associated with progressive neurological ...

journal_title：Journal of neuroscience research

authors： Hogan V,White K,Edgar J,McGill A,Karim S,McLaughlin M,Griffiths I,Turnbull D,Nichols P

更新日期：2009-02-01 00:00:00

abstract：:gamma-Aminobutyric acid (GABA) regulates the proliferation and migration of olfactory bulb (OB) interneuron progenitors derived from the subventricular zone (SVZ), but the role of GABA in the differentiation of these progenitors has been largely unexplored. This study examines the role of GABA in the differentiation o...

journal_title：Journal of neuroscience research

authors： Akiba Y,Sasaki H,Huerta PT,Estevez AG,Baker H,Cave JW

更新日期：2009-08-01 00:00:00

abstract：:The subcellular targeting of mRNAs encoding myelin proteins to the oligodendrocyte processes is an accepted fact in myelin formation. How these messengers are kept silent during their movement to the subcellular domain where they are turned on remains a mystery. This review focuses on aspects of mRNA targeting and spe...

journal_title：Journal of neuroscience research

authors： Boccaccio GL

更新日期：2000-11-15 00:00:00

abstract：:Nerve growth factor (NGF) is the best-characterized neurotrophic substance and has recently been shown to influence cholinergic neurons in the basal forebrain. Hippocampus and neocortex, the primary targets for these central neurons, have further been found to contain high levels of NGF. Using enzyme immunoassay and a...

journal_title：Journal of neuroscience research

authors： Lärkfors L,Strömberg I,Ebendal T,Olson L

更新日期：1987-01-01 00:00:00

abstract：:Unilateral eye removal results in an increased delivery of blood-borne glucose, norepinephrine, choline, and tyrosine, but not of proline, to the denervated optic lobes. Administration of reserpine to chicks increases penetrance of norepinephrine into the brain but not of tyrosine, choline, or proline. Selective alter...

journal_title：Journal of neuroscience research

authors： Walker JB,Walker JP,Bondy SC,Purdy J

更新日期：1975-01-01 00:00:00

abstract：:Hemin, the oxidized form of heme, is released from hemoglobin after CNS hemorrhage and may contribute to injury to surrounding tissue. The heme oxygenase (HO) enzymes catalyze the breakdown of hemin to biliverdin, carbon monoxide, and ferric iron. Although HO-2, the isoform expressed predominantly in neurons, accelera...

journal_title：Journal of neuroscience research

authors： Chen-Roetling J,Benvenisti-Zarom L,Regan RF

更新日期：2005-12-15 00:00:00