Anion channel blockers attenuate delayed neuronal cell death induced by transient forebrain ischemia.

abstract：:Regional estimates of type I and type II vestibular hair cells (HC) and supporting cell (SC) numbers were obtained from the horizontal crista ampullaris by using design-based stereology in human. Cristae were microdissected from temporal bones obtained post-mortem (N=16, age range 26-98 years). Three groups were made ...

journal_title：Journal of neuroscience research

authors： Lopez I,Ishiyama G,Tang Y,Tokita J,Baloh RW,Ishiyama A

更新日期：2005-11-01 00:00:00

abstract：:The brainstem nucleus of the solitary tract (NTS) is the key integrating relay in the central processing of sensory information from the thoracic and from most subdiaphragmatic viscera. Modulation of neuronal excitability and synaptic activity in the NTS by nicotinic agents can have potent effects on vital physiologic...

journal_title：Journal of neuroscience research

authors： Feng L,Uteshev VV

更新日期：2014-11-01 00:00:00

abstract：:Primary fibroblasts initiated from skin biopsies of Wistar rats were transfected with a plasmid that encodes the human growth hormone and the neomycin resistance genes. Cell clones selected for G418 resistance and expressing high levels of human growth hormone were propagated in vitro and subsequently transplanted int...

journal_title：Journal of neuroscience research

authors： Doering LC,Chang PL

更新日期：1991-07-01 00:00:00

abstract：:Axotomy of peripheral nerves in neonatal rats induces motoneuron death that can be delayed but not arrested by the application of several neurotrophic factors (NFs) or adenoviral vectors carrying genes for NFs. We tested whether an adenoviral vector carrying the gene for glial cell-line-derived neurotrophic factor (Ad...

journal_title：Journal of neuroscience research

authors： Baumgartner BJ,Shine HD

更新日期：1998-12-15 00:00:00

abstract：:5-Hydroxyoxindole has been identified as a urinary metabolite of indole, which is produced from tryptophane via the tryptophanase activity of gut bacteria. We have demonstrated recently that 5-hydroxyoxindole is an endogenous compound in blood and tissues of mammals, including humans. To date, 5-hydroxyoxindole's role...

journal_title：Journal of neuroscience research

authors： Crumeyrolle-Arias M,Tournaire MC,Rabot S,Malpaux B,Thiéry JC

更新日期：2008-01-01 00:00:00

abstract：:Transient global ischemia causes delayed white matter injury to the brain with oligodendrocyte (OLG) death and myelin breakdown. There is increasing evidence that hypoxia may be involved in several diseases of the white matter, including multiple sclerosis, vascular dementia, and ischemia. Matrix metalloproteinases (M...

journal_title：Journal of neuroscience research

authors： Walker EJ,Rosenberg GA

更新日期：2010-03-01 00:00:00

abstract：:Male and female rodents respond differently to acute stress. We tested our hypothesis that this sex difference is based on differences in stress sensitivity of forebrain areas, by determining possible effects of a single acute psychogenic stressor (1-hr restraint stress) on neuronal gene expression (c-Fos and FosB imm...

journal_title：Journal of neuroscience research

authors： Sterrenburg L,Gaszner B,Boerrigter J,Santbergen L,Bramini M,Roubos EW,Peeters BW,Kozicz T

更新日期：2012-01-01 00:00:00

abstract：:One premise regarding the mechanism of injury-evoked neuroregeneration is that injured cells induce the release of neurotrophic factors to trigger neurogenesis. Extracellular purine nucleotides exert multiple neurotrophic actions in the central nervous system mediated via activation of purinergic receptors. However, w...

journal_title：Journal of neuroscience research

authors： Kanekar S,Jia C,Hegg CC

更新日期：2009-05-01 00:00:00

abstract：:There are two types of calcium-activated neutral protease (CANP), m-CANP and mu-CANP, following the nomenclature of Suzuki et al to show that each requires mM and microM Ca2+, respectively, for its activation. We found mu-CANP activity in a crude CANP fraction extracted from the peripheral nerve, which degraded the ne...

journal_title：Journal of neuroscience research

authors： Kamakura K,Ishiura S,Suzuki K,Sugita H,Toyokura Y

更新日期：1985-01-01 00:00:00

abstract：:Fast oscillations at approximately 200 Hz, termed ripples, occur in the hippocampus and cortex of several species, including humans, and are thought to play a role in physiological (e.g., sensory information processing or memory consolidation) and pathological (e.g., seizures) processes. Blocking gamma-aminobutyric ac...

journal_title：Journal of neuroscience research

authors： D'Antuono M,de Guzman P,Kano T,Avoli M

更新日期：2005-04-01 00:00:00

abstract：:Pyruvate dehydrogenase complex (PDH) is a brain mitochondrial matrix enzyme. PDH impairment after stroke is particularly devastating given PDH's critical role in the link between anaerobic and aerobic metabolism. This study evaluates the restoration of oxidative metabolism and energy regulation with a therapeutic comb...

journal_title：Journal of neuroscience research

authors： Cai L,Thibodeau A,Peng C,Ji X,Rastogi R,Xin R,Singh S,Geng X,Rafols JA,Ding Y

更新日期：2016-08-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2), a key enzyme in prostanoid biosynthesis, may represent an important therapeutic target in Alzheimer's disease (AD). In the present study, we explored the regulation of COX-2 in the hippocampal formation in sporadic AD. Using semiquantitative immunocytochemical techniques, we found that in AD ...

journal_title：Journal of neuroscience research

authors： Ho L,Pieroni C,Winger D,Purohit DP,Aisen PS,Pasinetti GM

更新日期：1999-08-01 00:00:00

abstract：:Cell transplantation offers a potential new treatment for stroke. Animal studies using models that produce ischemic damage in both the striatum and the frontal cortex have shown beneficial effects when hNT cells (postmitotic immature neurons) were transplanted into the ischemic striatum. In this study, we investigated...

journal_title：Journal of neuroscience research

authors： Bliss TM,Kelly S,Shah AK,Foo WC,Kohli P,Stokes C,Sun GH,Ma M,Masel J,Kleppner SR,Schallert T,Palmer T,Steinberg GK

更新日期：2006-05-01 00:00:00

abstract：:The transport kinetics of the excitatory sulphur-containing amino acid (SAA) transmitter candidates, L-cysteine sulphinate (L-CSA), L-cysteate (L-CA), L-homocysteine sulphinate (L-HCSA), and L-homocysteate (L-HCA), together with their plasma membrane carrier specificity, was studied in cerebrocortical synaptosome frac...

journal_title：Journal of neuroscience research

authors： Grieve A,Butcher SP,Griffiths R

更新日期：1992-05-01 00:00:00

abstract：:Two fundamental questions about neuron cell culture were addressed. Can one serum-free medium that was developed for optimum growth of hippocampal neurons support the growth of neurons from other regions of the brain? Is the region specific state of differentiation maintained in culture? To answer these questions, we ...

journal_title：Journal of neuroscience research

authors： Brewer GJ

更新日期：1995-12-01 00:00:00

abstract：:Polyglutamine (polyQ) aggregate bodies are a hallmark of dentatorubral-pallidoluysian atrophy and related neurodegenerative disorders, although the relationship between aggregate body formation and cell death is not clear. We analyzed the kinetics of polyQ aggregate formation and the time intervals for cell death, tra...

journal_title：Journal of neuroscience research

authors： Toyoshima I,Sugawara M,Kato K,Wada C,Shimohata T,Koide R,Onodera O,Tsuji S

更新日期：2002-05-15 00:00:00

abstract：:The rationale for designing and synthesizing 24 different peptide analogs and subpeptides of residues 69-84 of guinea pig myelin basic protein is presented. The encephalitogenic potential of 19 of these peptides in Lewis rats is also given. ...

journal_title：Journal of neuroscience research

authors： Hashim GA,Day ED

更新日期：1987-01-01 00:00:00

abstract：:This Review describes the current status of poststroke epilepsy (PSE) with an emphasis on poststroke epileptogenesis modeling for testing new therapeutic agents. Stroke is a leading cause of epilepsy in an aging population. Late-onset "epileptic" seizures have been reported in up to 30% cases after stroke. Nevertheles...

journal_title：Journal of neuroscience research

authors： Reddy DS,Bhimani A,Kuruba R,Park MJ,Sohrabji F

更新日期：2017-04-01 00:00:00

abstract：:Scatchard analysis of saturation isotherms of [125I]-iodopindolol was used to characterize beta-adrenoceptor density (Bmax) and affinity constant (Kd) in female and male hamster Harderian glands. Single-point experiments were also completed in intact females, intact males, and castrated or superior cervical ganglionec...

journal_title：Journal of neuroscience research

authors： Pangerl A,Pangerl B,Buzzell GR,Jones DJ,Reiter RJ

更新日期：1989-04-01 00:00:00

abstract：:The cutaneous electroreceptor "tuberous organs" of the lateral line system of Eigenmannia virescens were studied at light and electron microscopic levels with immunohistochemical and autoradiographic techniques after sectioning of the posterior branch of the lateral line nerve. After deafferentation total degeneration...

journal_title：Journal of neuroscience research

authors： Bensouilah M,Denizot JP

更新日期：1994-12-01 00:00:00

abstract：:The birth of cells with neurogenic potential in the adult brain is assessed commonly by detection of exogenous S phase markers, such as bromodeoxyuridine (BrdU). Analysis of other phases of the cell cycle, however, can provide insight into how external factors, such as opiates, influence the cycling of newly born cell...

journal_title：Journal of neuroscience research

authors： Mandyam CD,Norris RD,Eisch AJ

更新日期：2004-06-15 00:00:00

abstract：:Male gerbils (Meriones unguiculatus) were bred and reared either grouped under enriched environmental conditions or isolated under impoverished environmental conditions. The objective of the present study was to examine the influence of social environment on structural and functional ontogeny of the medial prefrontal ...

journal_title：Journal of neuroscience research

authors： Winterfeld KT,Teuchert-Noodt G,Dawirs RR

更新日期：1998-04-15 00:00:00

abstract：:Macroautophagy is an evolutionally conserved membrane trafficking pathway that delivers intracellular materials to lysosomes for degradation and recycling. Rab7, as a member of the Rab GTPase superfamily, has a unique role in the regulation of macroautophagy, especially in modulating autophagy flux. The functional sta...

journal_title：Journal of neuroscience research

authors： Wen H,Zhan L,Chen S,Long L,Xu E

更新日期：2017-10-01 00:00:00

abstract：:The presence of the apolipoprotein E (apoE) allele epsilon4 is a major risk factor for the development of Alzheimer's disease (AD); however, the molecular mechanism underlying the acceleration of AD development in individuals with epsilon4 remains to be determined. To investigate the isoform-specific effects of apoE o...

journal_title：Journal of neuroscience research

authors： Michikawa M,Yanagisawa K

更新日期：1998-10-01 00:00:00

abstract：:We describe an experimental model to produce closed traumatic injuries to the spinal cord of adult rats. This model uses an inflatable balloon that is introduced in the dorsal subdural space and moved to a location rostral to the laminectomy site. The spinal cord trauma can be graded by varying either the duration of ...

journal_title：Journal of neuroscience research

authors： Martin D,Schoenen J,Delrée P,Gilson V,Rogister B,Leprince P,Stevenaert A,Moonen G

更新日期：1992-08-01 00:00:00

abstract：:Both IgCAMs and the actin cytoskeleton play critical roles in neuronal growth cone motility and guidance. However, it is unclear how IgCAM receptors transduce signals from the plasma membrane to induce actin remodeling. Previous studies have shown that local clustering and immobilization of apCAM, the Aplysia homolog ...

journal_title：Journal of neuroscience research

authors： Decourt B,Munnamalai V,Lee AC,Sanchez L,Suter DM

更新日期：2009-04-01 00:00:00

abstract：:Among the ion channels and pumps activated by growth factor stimulation, K+ channels have been implicated in the growth and proliferation of several cancer cell lines. The role of these channels in central nervous system tumors, however, has not been described. This study used the malignant astrocytoma cell lines U87 ...

journal_title：Journal of neuroscience research

authors： Chin LS,Park CC,Zitnay KM,Sinha M,DiPatri AJ Jr,Perillán P,Simard JM

更新日期：1997-04-15 00:00:00

abstract：:Increasing evidence has shown that β-amyloid (Aβ) induces hyperphosphorylation of tau and contributes to Aβ toxicity. Recently, tau hyperphosphorylation by glycogen synthase kinase-3β (GSK-3β) activation has been emphasized as one of the pathogenic mechanisms of Alzheimer's disease (AD). The phosphoinositide 3 kinase ...

journal_title：Journal of neuroscience research

authors： Zhang Z,Zhao R,Qi J,Wen S,Tang Y,Wang D

更新日期：2011-03-01 00:00:00

abstract：:The balance of bone morphogenic protein (BMP), transforming growth factor-β (TGFβ)/activin/nodal, and Wnt signals regulates the early lineage segregation of human embryonic stem cells (ESCs). Here we demonstrate that a combination of small-molecule inhibitors of BMP (Dorsomorphin) and TGFβ/activin/nodal (SB431542) sig...

journal_title：Journal of neuroscience research

authors： Morizane A,Doi D,Kikuchi T,Nishimura K,Takahashi J

更新日期：2011-02-01 00:00:00

abstract：:Astrocytes are the most abundant glial cell in the central nervous system. They modulate synaptic function through a variety of mechanisms, and yet remain relatively understudied with respect to overall neuronal circuit function. Exploiting the tractability of the mouse olfactory system, we manipulated astrocyte activ...

journal_title：Journal of neuroscience research

authors： Ung K,Tepe B,Pekarek B,Arenkiel BR,Deneen B

更新日期：2020-08-01 00:00:00