Abstract:
:There are two types of calcium-activated neutral protease (CANP), m-CANP and mu-CANP, following the nomenclature of Suzuki et al to show that each requires mM and microM Ca2+, respectively, for its activation. We found mu-CANP activity in a crude CANP fraction extracted from the peripheral nerve, which degraded the neurofilament (Nf) triplet (200 K, 160 K, 68 K), especially the 160 K component, at Ca2+ concentrations of 50 microM and 0.1 mM. The triplet was degraded in the order of the 160 K, 68 K, and 200 K components, respectively. In addition, the effects of partially purified mu-CANP of rabbit skeletal muscle, purified natural mu-CANP of bovine liver, derived mu-CANP prepared by autodigestion of chicken muscle m-CANP, m-CANP of chicken skeletal muscle, and cathepsin B of rat liver on the Nf were examined. Among the triplet components, the 160 K component was most rapidly degraded by all proteases so far tested. The difference in the effect of mu-CANP and m-CANP or cathepsin B on susceptibility of the 200 K component to degradation might be due to the difference of the relative amounts of enzymes to Nf.
journal_name
J Neurosci Resjournal_title
Journal of neuroscience researchauthors
Kamakura K,Ishiura S,Suzuki K,Sugita H,Toyokura Ydoi
10.1002/jnr.490130306subject
Has Abstractpub_date
1985-01-01 00:00:00pages
391-403issue
3eissn
0360-4012issn
1097-4547journal_volume
13pub_type
杂志文章abstract::Cultures of chicken day 8 embryo retinal cells, essentially free of contaminating non-neuronal elements, were used to examine the neurotoxicity of various excitatory amino acid transmitter receptor agonists. At 7 days in vitro, N-methyl-D-aspartate (NMDA), following 24 hr exposure to 0.1-1.0 mM, destroyed 60-70% of th...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490270210
更新日期:1990-10-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490060507
更新日期:1981-01-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
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更新日期:1991-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/jnr.23147
更新日期:2013-02-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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更新日期:2001-03-15 00:00:00
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pub_type: 杂志文章
doi:10.1002/jnr.22718
更新日期:2011-11-01 00:00:00
abstract::Muscarinic cholinergic receptors of the M5 subtype are expressed by dopamine-containing neurons of the ventral tegmentum. These M5 receptors modulate the activity of midbrain dopaminergic neurons, which play an important role in mediating reinforcing properties of abused psychostimulants like cocaine. The potential ro...
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pub_type: 杂志文章
doi:10.1002/jnr.10728
更新日期:2003-10-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:
更新日期:1999-08-15 00:00:00
abstract::Neuronal degeneration has been shown to be involved in various neurological disorders. Growth/trophic factors and their receptors are known to be important for the regeneration and survival of neurons. We report here the molecular cloning of a receptor-like protein tyrosine kinase, bsk, (for brain specific kinase). Bs...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490370117
更新日期:1994-01-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19971015)50:2<202::AID-JNR
更新日期:1997-10-15 00:00:00
abstract::Grafting fetal ventral mesencephalon has been utilized to alleviate the symptoms of Parkinson's disease. One obstacle in using this approach is the limited outgrowth from the transplanted dopamine neurons. Thus, it is important to evaluate factors that promote outgrowth from fetal dopamine neurons. Proteoglycans (PGs)...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21465
更新日期:2008-01-01 00:00:00
abstract::Autonomic neuropathy in several neurodegenerative disorders results from disturbance in physiological functions of different cell types in the central and peripheral nervous systems. For a clearer understanding of the etiology and pathogenesis of the autonomic disorders it is necessary to create animal models in which...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19980115)51:2<162::AID-JNR
更新日期:1998-01-15 00:00:00
abstract::High levels of the proto-oncogene product, pp60c-src, have been found in developing and adult neural tissues as well as in certain fully mature cells of the hematopoietic lineage, e.g., platelets and myelomonocytes. Adrenal medullary chromaffin cells exhibit characteristics of both types of cells, i.e., they are deriv...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490240107
更新日期:1989-09-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20827
更新日期:2006-05-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10533
更新日期:2003-03-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.21607
更新日期:2008-05-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22537
更新日期:2011-02-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10617
更新日期:2003-06-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490350409
更新日期:1993-07-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(19990215)55:4<504::AID-JNR
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490250110
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490430113
更新日期:1996-01-01 00:00:00
abstract::This Review describes some in vitro approaches used to investigate the mechanisms involved in Krabbe's disease, with particular regard to the cellular systems employed to study processes of inflammation, apoptosis, and angiogenesis. The aim was to update the knowledge on the results obtained from in vitro models of th...
journal_title:Journal of neuroscience research
pub_type: 杂志文章,评审
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更新日期:2016-11-01 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.10741
更新日期:2003-10-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20105
更新日期:2004-06-01 00:00:00
abstract::The effects of bilateral lesions of the ventral noradrenergic bundle (VNA) were studied in male rats. In contrast to data reported by others, hyperphagia and obesity were not observed following VNA lesions. Indeed, except for a depression during the first three postoperative days, food intake (FI) of the VNA lesioned ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.490020305
更新日期:1976-01-01 00:00:00
abstract::Zinc ion elevation contributes to acute excitotoxic brain injury and correlates with the severity of dementia in chronic neurodegenerative diseases. Downstream control of zinc-triggered signals is believed to be an efficient countermeasure. In the current study, we examined whether the flavonoid luteolin (Lu) could pr...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.22714
更新日期:2011-11-01 00:00:00
abstract::The olfactory ensheathing cell (OEC) is a unique glial cell able to support neurite outgrowth in the CNS throughout life. The OEC has been described as having both Schwann cell-like and astrocyte-like characteristics. The purpose of this study was to compare gap junctional communication and connexin (Cx) expression in...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.1182
更新日期:2001-09-15 00:00:00
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journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/(SICI)1097-4547(20000415)60:2<245::AID-JNR
更新日期:2000-04-15 00:00:00
abstract::The peroxisome proliferator-activated receptor-alpha (PPAR-alpha) plays a key role in lipid metabolism and inflammation. Recently, we demonstrated that administration of the PPAR-alpha agonists gemfibrozil and fenofibrate, inhibit the clinical signs of experimental autoimmune encephalomyelitis (EAE), the animal model ...
journal_title:Journal of neuroscience research
pub_type: 杂志文章
doi:10.1002/jnr.20518
更新日期:2005-08-01 00:00:00