Effects of inducible glial fibrillary acidic protein on glioma cell motility and proliferation.

abstract：:T cell receptor (TCR) transgenic mice have been used extensively to study T cell development in vivo. Such studies have demonstrated high levels of expression of the TCR transgenes. Although a number of human T cell receptors appear to play a role in the development of autoimmune diseases, in vitro studies have proven...

journal_title：Journal of neuroscience research

authors： Baker AM,Wang Y,Richert JR

更新日期：1996-08-15 00:00:00

abstract：:In order to identify the relative number of benzodiazepine (BZ) receptors in Purkinje and granule cells, the Purkinje cell degeneration (pcd) mutant mouse was used at different ages. In these mice, Purkinje cells have degenerated almost completely by 45-50 days of age. Granule cell loss occurs only later, and is most ...

journal_title：Journal of neuroscience research

authors： Vaccarino FM,Ghetti B,Wade SE,Rea MA,Aprison MH

更新日期：1983-01-01 00:00:00

abstract：:The increase in myelin basic protein (MBP) synthesis observed in brain aggregate cultures supplemented with macrophages is reflected in elevated supernatant protein levels of the key promoters of oligodendrocyte proliferation, fibroblast growth factor-2 (FGF-2) and platelet-derived growth factor-AA (PDGF-AA), during t...

journal_title：Journal of neuroscience research

authors： Diemel LT,Jackson SJ,Cuzner ML

更新日期：2003-12-15 00:00:00

abstract：:The transplantation of dopaminergic (DA) progenitors derived from pluripotent stem cells improves the behavior of Parkinson's disease model animals. However, the survival of DA progenitors is low, and the final yield of DA neurons is only approximately 0.3%-2% the number of transplanted cells. Zonisamide (ZNS) increas...

journal_title：Journal of neuroscience research

authors： Miyawaki Y,Samata B,Kikuchi T,Nishimura K,Takahashi J

更新日期：2020-08-01 00:00:00

abstract：:The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...

journal_title：Journal of neuroscience research

authors： Avale ME,Nemirovsky SI,Raisman-Vozari R,Rubinstein M

更新日期：2004-10-15 00:00:00

abstract：:Apoptosis is a form of cell death historically defined by morphological and biochemical changes that occur in the cell body and nucleus. However, in contrast to nonneuronal cells in which apoptosis has been most intensively studied, neurons exhibit elaborate morphologies with synaptic connections often located at site...

journal_title：Journal of neuroscience research

authors： Mattson MP,Duan W

更新日期：1999-10-01 00:00:00

abstract：:The dentate gyrus is selectively reduced in size in the insulin-like growth factor 1 (IGF1) null mouse brain. The purpose of this study was to determine whether this defect is due to reduced granule cell numbers, and if so, to determine whether altered cell proliferation, survival, or both contribute to attenuation of...

journal_title：Journal of neuroscience research

authors： Cheng CM,Cohen M,Tseng V,Bondy CA

更新日期：2001-05-15 00:00:00

abstract：:Molecular and behavioral timekeeping is regulated by the circadian system which includes the brain's suprachiasmatic nucleus (SCN) that translates environmental light information into neuronal and endocrine signals aligning peripheral tissue rhythms to the time of day. Despite the critical role of circadian rhythms in...

journal_title：Journal of neuroscience research

authors： Yaw AM,Duong TV,Nguyen D,Hoffmann HM

更新日期：2021-01-01 00:00:00

abstract：:Oligodendrocyte responses in vitro to platelet-derived growth factor (PDGF) include proliferation, survival, migration, and changes in cell morphology and molecular expression. Studies of mixed glial cultures established that astrocytes secrete PDGF; thus astrocytes are considered to be key regulators of oligodendrocy...

journal_title：Journal of neuroscience research

authors： Ellison JA,Scully SA,de Vellis J

更新日期：1996-07-01 00:00:00

abstract：:Tau microtubule-associated proteins are believed to play a role in regulation of the growth of neuronal processes. In order to study the function of tau protein in vivo, we examined the inhibition of tau expression in PC12 cells by exposing the cells to tau antisense oligodeoxynucleotides. A specific retraction of neu...

journal_title：Journal of neuroscience research

authors： Hanemaaijer R,Ginzburg I

更新日期：1991-09-01 00:00:00

abstract：:Retinal microglia play an important role as resident immunocompetent and phagocytic cells in the event of injury and disease. Retinal microglia and microglia precursor transplantation show a rescue effect in ischemic retina and retinal degeneration. However, studies of retinal microglia have been hampered by the diffi...

journal_title：Journal of neuroscience research

authors： Jiang XS,Ni YQ,Liu TJ,Zhang M,Jiang R,Xu GZ

更新日期：2014-04-01 00:00:00

abstract：:In order to study the voltage-dependent ion channels in microglia, and their possible modulation by pro-inflammatory substances like lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) we employed the patch-clamp technique on purified rat microglial cell subcultures grown for 1 - 5 days in control condition or a...

journal_title：Journal of neuroscience research

authors： Visentin S,Agresti C,Patrizio M,Levi G

更新日期：1995-11-01 00:00:00

abstract：:Cannabinoids bind to two G-protein-coupled receptors, CB1 and CB2, expressed by neurons and cells of the immune system, respectively. Glioma cells (astrocyte-derived brain tumor cells) express cannabinoid receptors, and numerous in vitro and in vivo studies performed in rodents have concluded that apoptosis could be i...

journal_title：Journal of neuroscience research

authors： Widmer M,Hanemann CO,Zajicek J

更新日期：2008-11-01 00:00:00

abstract：:We have developed tendon chitosan tubes having the ability to bind peptides covalently, and the effectiveness of laminin peptides coupled to these tubular wall on nerve regeneration was examined in vivo. Bridge graft implantation (15 mm) into the sciatic nerve of SD rats was carried out using chitosan tubes having a t...

journal_title：Journal of neuroscience research

authors： Suzuki M,Itoh S,Yamaguchi I,Takakuda K,Kobayashi H,Shinomiya K,Tanaka J

更新日期：2003-06-01 00:00:00

abstract：:Previous animal studies have linked white matter damage to certain schizophrenia-like behaviors in cuprizone (CPZ)-exposed mouse. Mitochondrial dysfunction, oxidative stress, neuroinflammation, and oligodendrocyte loss coexist in the brain of such mice. The aim of this study was to examine effects of the antioxidant N...

journal_title：Journal of neuroscience research

authors： Zhang L,Xu S,Huang Q,Xu H

更新日期：2018-05-01 00:00:00

abstract：:Using subtype-specific Ca-channel blockers, we have characterised the voltage-sensitive Ca2+ currents as well as neurotransmitter release from cultured mouse cerebellar granule cells. The whole cell version of the patch clamp technique was adapted to monitor the isolated Ca-channel currents. The currents were activate...

journal_title：Journal of neuroscience research

authors： Varming T,Christopherson P,Schousboe A,Drejer J

更新日期：1997-04-01 00:00:00

abstract：:Traditionally, the sources of guidance cues for dendritic outgrowth are mainly associated with external bodies (A) rather than with the same neuron from which dendrites originate (B). To quantify the relationship between factors A and B as determinants of the adult dendritic shape, the morphology of 83 intracellularly...

journal_title：Journal of neuroscience research

authors： Samsonovich AV,Ascoli GA

更新日期：2003-01-15 00:00:00

abstract：:Tungstate treatment increases the phosphorylation of glycogen synthase kinase-3beta (GSK3beta) at serine 9, which triggers its inactivation both in cultured neural cells and in vivo. GSK3 phosphorylation is dependent on the activation of extracellular signal-regulated kinases 1/2 (ERK1/2) induced by tungstate. As a co...

journal_title：Journal of neuroscience research

authors： Gómez-Ramos A,Domínguez J,Zafra D,Corominola H,Gomis R,Guinovart JJ,Avila J

更新日期：2006-02-01 00:00:00

abstract：:Transgenic mice with glial fibrillary acidic protein (GFAP) promoter driven-astrocyte production of the cytokines interleukin-6 (IL-6) and tumor necrosis factor (TNF) were used to determine whether the pre-existing production of these cytokines in vivo might modulate the sensitivity of neurons to excitotoxic agents. L...

journal_title：Journal of neuroscience research

authors： Samland H,Huitron-Resendiz S,Masliah E,Criado J,Henriksen SJ,Campbell IL

更新日期：2003-07-15 00:00:00

abstract：:One premise regarding the mechanism of injury-evoked neuroregeneration is that injured cells induce the release of neurotrophic factors to trigger neurogenesis. Extracellular purine nucleotides exert multiple neurotrophic actions in the central nervous system mediated via activation of purinergic receptors. However, w...

journal_title：Journal of neuroscience research

authors： Kanekar S,Jia C,Hegg CC

更新日期：2009-05-01 00:00:00

abstract：:The molecular mechanisms by which extracellular guidance cues regulate axonal morphology are not fully understood. Recent findings suggest that increased activity of the protein kinase Akt promotes dendritic branching and elongation in hippocampal neurons. We tested whether expression of constitutively active Akt (CA-...

journal_title：Journal of neuroscience research

authors： Grider MH,Park D,Spencer DM,Shine HD

更新日期：2009-11-01 00:00:00

abstract：:Abdominal muscle electromyograms were monitored in response to graded mechanical loads added to either inspiration or expiration in anesthetized cats. The surgical preparation, the apparatus, and the levels of loads applied (resistive, tracheal occlusion, and continuous positive pressure) were matched with those emplo...

journal_title：Journal of neuroscience research

authors： Baker JP Jr,Frazier DT

更新日期：1985-01-01 00:00:00

abstract：:Recent data indicate that molecular mimicry may play a role in the pathogenesis of human-T-lymphotropic virus type-1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), an immune-mediated disease of the central nervous system (CNS). Specifically, HAM/TSP patients developed antibodies that cross-reac...

journal_title：Journal of neuroscience research

authors： Kalume F,Lee SM,Morcos Y,Callaway JC,Levin MC

更新日期：2004-07-01 00:00:00

abstract：:Apolipoprotein E (ApoE) is the major brain lipoprotein and plays an important role in lipid transport. ApoE-deficient mice whose apoE gene has been knocked out have distinct cognitive and neurochemical deficits, and their recovery from brain injury is impaired. In the present study we examined the possibility that the...

journal_title：Journal of neuroscience research

authors： Lomnitski L,Oron L,Sklan D,Michaelson DM

更新日期：1999-11-15 00:00:00

abstract：:Finding inhibitors of the first step of the amyloid cascade, A beta (42) generation, is a major goal of Alzheimer's disease drug development. Two target protease activities, beta-and gamma-secretase, were detected more than 10 years ago but progress in this area has been slow because the enzymes were not identified. U...

journal_title：Journal of neuroscience research

authors： Citron M

更新日期：2002-11-01 00:00:00

abstract：:Cultures of rat C6 rat glioma cells exhibit a diminished response to isoproterenol and forskolin after being treated with phorbol 12,13-dibutyrate (PDbU). An IC50 for PDbU of 38 +/- 5 nM and 62 +/- 8 nM was observed in the isoproterenol and forskolin response, respectively. Similarly, C6 cultures exhibited a diminishe...

journal_title：Journal of neuroscience research

authors： Bressler JP,Tinsely P

更新日期：1990-01-01 00:00:00

abstract：:Structural microtubule-associated proteins (MAPs) interact with microtubules to regulate the various dynamic stages of microtubules. The purpose of this study was to measure the impact of myc-tagged MAP1a fragments on microtubule dynamic phases in vivo. Cells from an epithelial kidney cell line (LLCPK1) that had been ...

journal_title：Journal of neuroscience research

authors： Faller EM,Brown DL

更新日期：2009-04-01 00:00:00

abstract：:The medial prefrontal cortex (mPFC) is critical for selecting and shaping complex behavioral responses. In rodent models of neuropathic pain there is evidence for both structural and functional changes in the mPFC. Brain derived neurotrophic factor (BDNF) plays a critical role in the normal functioning of the mPFC. It...

journal_title：Journal of neuroscience research

authors： Kang JWM,Keay KA,Mor D

更新日期：2017-12-01 00:00:00

abstract：:The immunohistochemical distribution of microtubule-associated protein 2 (MAP2), being normally restricted to nerve cell bodies and dendrites, became altered in rat dorsal root ganglia and spinal cord neurons in cultures infected with rhesus rotavirus. MAP2 appeared in axons of both sources of neurons as displayed wit...

journal_title：Journal of neuroscience research

authors： Weclewicz K,Svensson L,Billger M,Holmberg K,Wallin M,Kristensson K

更新日期：1993-10-01 00:00:00

abstract：:The normal innervation of structures in mouse foot pads was investigated with immunohistochemistry and confocal microscopy. Nerves were visualized by incubating Zamboni fixed, thick, frozen sections with antibodies to protein gene product 9.5 (PGP 9.5), vasoactive intestinal peptide, substance P, calcitonin gene-relat...

journal_title：Journal of neuroscience research

authors： Navarro X,Verdú E,Wendelscafer-Crabb G,Kennedy WR

更新日期：1995-05-01 00:00:00