Innervation of cutaneous structures in the mouse hind paw: a confocal microscopy immunohistochemical study.

Abstract:

:The normal innervation of structures in mouse foot pads was investigated with immunohistochemistry and confocal microscopy. Nerves were visualized by incubating Zamboni fixed, thick, frozen sections with antibodies to protein gene product 9.5 (PGP 9.5), vasoactive intestinal peptide, substance P, calcitonin gene-related peptide, and protein zero. The antibodies were localized using cyanine 3.18 labeled anti-rabbit gamma globulin. PGP 9.5 immunolocalization showed dense nerve bundles at the base of the foot pad with branches to larger blood vessels, sweat glands and epidermis. Sweat gland tubules were surrounded by numerous sudomotor axons; single fibers accompanied the sweat duct toward the skin's surface. Nerve bundles containing myelinated and unmyelinated axons ran through and around the centrally located sweat gland cluster to end in free nerve endings and Meissner's-like corpuscles at the apex of the foot pad. Other bundles running parallel to the epidermis gave arcuate branches that supplied epidermis on the sides of the pads with a rich nerve network, principally with free nerve endings that often reached the most superficial cell layers of epidermis. Calcitonin gene-related peptide-immunoreactive (-ir) nerves were distributed to dermis and epidermis in lower density than PGP 9.5-ir fibers. Substance P-ir fibers were less numerous; most terminated as free endings in deeper layers of epidermis. Vasoactive intestinal peptide-ir nerves almost exclusively innervated sweat glands, ducts and blood vessels, but not epidermis. The mouse hind paw has potential to serve as a model system for investigations of functional and morphological changes that affect peripheral and autonomic nerves under diverse experimental conditions.

journal_name

J Neurosci Res

authors

Navarro X,Verdú E,Wendelscafer-Crabb G,Kennedy WR

doi

10.1002/jnr.490410113

subject

Has Abstract

pub_date

1995-05-01 00:00:00

pages

111-20

issue

1

eissn

0360-4012

issn

1097-4547

journal_volume

41

pub_type

杂志文章
  • Statistical morphological analysis of hippocampal principal neurons indicates cell-specific repulsion of dendrites from their own cell.

    abstract::Traditionally, the sources of guidance cues for dendritic outgrowth are mainly associated with external bodies (A) rather than with the same neuron from which dendrites originate (B). To quantify the relationship between factors A and B as determinants of the adult dendritic shape, the morphology of 83 intracellularly...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10475

    authors: Samsonovich AV,Ascoli GA

    更新日期:2003-01-15 00:00:00

  • Inhibition of the synthesis of glycosphingolipids affects the translocation of proteolipid protein to the myelin membrane.

    abstract::Brain slices obtained from young rats were incubated with different radioactive precursors, in the presence and absence of L-cycloserine (an inhibitor of the synthesis of sphingosine) in order to explore the possibility that transport of proteolipids--and specifically of the major myelin proteolipid PLP--to the myelin...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490220309

    authors: Pasquini JM,Guarna MM,Besio-Moreno MA,Iturregui MT,Oteiza PI,Soto EF

    更新日期:1989-03-01 00:00:00

  • Aberrant astrocytic expression of chondroitin sulfate proteoglycan receptors in a rat model of amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease. Progressive and systemic loss of motor neurons with gliosis in the central nervous system (CNS) is a neuropathological hallmark of ALS. Chondroitin sulfate proteoglycans (CSPGs) are the major components of the extracellular matrix of the mammali...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.24127

    authors: Shijo T,Warita H,Suzuki N,Kitajima Y,Ikeda K,Akiyama T,Ono H,Mitsuzawa S,Nishiyama A,Izumi R,Aoki M

    更新日期:2018-02-01 00:00:00

  • P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice.

    abstract::The C57BL/6 mice strain is known to be reputedly resistant to induction of experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome in human by bovine peripheral myelin (BPM), and P2 protein or the P2 protein peptide 57-81. The P0 peptide 180-199 is a stronger neuritogenic antigen than the P2...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/1097-4547(20001201)62:5<717::AID-JNR11>3.0

    authors: Zou LP,Ljunggren HG,Levi M,Nennesmo I,Wahren B,Mix E,Winblad B,Schalling M,Zhu J

    更新日期:2000-12-01 00:00:00

  • Delayed leptin administration after stroke induces neurogenesis and angiogenesis.

    abstract::Leptin is a potent AMP kinase (AMPK) inhibitor that induces neuroprotection, neurogenesis, and angiogenesis when administered immediately after stroke. To dissociate these effects, we explored the effects of delayed administration of leptin, at 10 days after stroke onset, on neurogenesis and angiogenesis after stroke....

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.23147

    authors: Avraham Y,Dayan M,Lassri V,Vorobiev L,Davidi N,Chernoguz D,Berry E,Leker RR

    更新日期:2013-02-01 00:00:00

  • Uptake, release, and binding of taurine in degenerated rat retinas.

    abstract::High-affinity uptake, potassium-stimulated release and receptor binding of gamma-aminobutyric acid (GABA) and taurine were studied in retinas of rats treated with monosodium glutamate (MSG) or iodoacetate-malate (IAM). Such treatments produce a selective damage of the inner retinal layers (MSG) or of the photoreceptor...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490080407

    authors: Salceda R,Pasantes-Morales H

    更新日期:1982-01-01 00:00:00

  • Purification of the 33,000-dalton ligand binding-protein constituent of the lymphoblast substance P receptor.

    abstract::Substance P (SP) acts as an immunoregulator by binding to specific functional cell surface receptors on a subpopulation of human T-helper lymphocytes. Receptors with similar properties have also been characterized on the human IM-9 B-lymphoblast cell line. Four distinct proteins of molecular weight (MW) 33,000, 58,000...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490180127

    authors: McGillis JP,Organist ML,Scriven KH,Payan DG

    更新日期:1987-01-01 00:00:00

  • Separation of radiolabelled protein from brain and spinal cord of spinal hemisected rats on SDS polyacrylamide slab gels.

    abstract::After hemisection of the spinal cord in rats, alterations in amino acid incorporation into protein have been observed in brain and spinal cord. Proteins mediating these changes have been studied in the present experiment. Male, Long-Evans hooded rats were given either a laminectomy and dura incision (sham) at spinal s...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490050108

    authors: Wells MR

    更新日期:1980-01-01 00:00:00

  • gamma-Aminobutyric acid-mediated regulation of the activity-dependent olfactory bulb dopaminergic phenotype.

    abstract::gamma-Aminobutyric acid (GABA) regulates the proliferation and migration of olfactory bulb (OB) interneuron progenitors derived from the subventricular zone (SVZ), but the role of GABA in the differentiation of these progenitors has been largely unexplored. This study examines the role of GABA in the differentiation o...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22055

    authors: Akiba Y,Sasaki H,Huerta PT,Estevez AG,Baker H,Cave JW

    更新日期:2009-08-01 00:00:00

  • Effects of neural stem cells on synaptic proteins and memory in a mouse model of Alzheimer's disease.

    abstract::Transplanting neural stem cells (NSC) to the damaged brain has been regarded as a potential treatment for neurodegenerative diseases such as Alzheimer's disease (AD), a condition characterized by memory loss. We hypothesized that transplantation of NSC into the hippocampal regions of APP + PS1 transgenic (Tg) mice, a ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.23299

    authors: Zhang W,Wang GM,Wang PJ,Zhang Q,Sha SH

    更新日期:2014-02-01 00:00:00

  • Circadian rhythms in the mouse reproductive axis during the estrous cycle and pregnancy.

    abstract::Molecular and behavioral timekeeping is regulated by the circadian system which includes the brain's suprachiasmatic nucleus (SCN) that translates environmental light information into neuronal and endocrine signals aligning peripheral tissue rhythms to the time of day. Despite the critical role of circadian rhythms in...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.24606

    authors: Yaw AM,Duong TV,Nguyen D,Hoffmann HM

    更新日期:2021-01-01 00:00:00

  • Role of central nervous system microvascular pericytes in activation of antigen-primed splenic T-lymphocytes.

    abstract::The cellular constituents of the blood-brain barrier (BBB) must make finely tuned, regulatory responses to maintain microvascular homeostasis. The mechanisms by which this task is accomplished are largely unknown. However, it is thought they involve a series of cross-talk mechanisms among endothelial cells (EC), peric...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19990301)55:5<578::AID-JNR

    authors: Balabanov R,Beaumont T,Dore-Duffy P

    更新日期:1999-03-01 00:00:00

  • Krabbe's leukodystrophy: Approaches and models in vitro.

    abstract::This Review describes some in vitro approaches used to investigate the mechanisms involved in Krabbe's disease, with particular regard to the cellular systems employed to study processes of inflammation, apoptosis, and angiogenesis. The aim was to update the knowledge on the results obtained from in vitro models of th...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.23846

    authors: Avola R,Graziano AC,Pannuzzo G,Alvares E,Cardile V

    更新日期:2016-11-01 00:00:00

  • Oligodendrocyte-specific gene expression in mouse brain: use of a myelin-forming cell type-specific promoter in an adeno-associated virus.

    abstract::To explore the feasibility of cell type-specific gene expression in oligodendrocytes as a possible therapeutic approach for demyelinating diseases, the cell specificity, tissue specificity, and duration of gene expression were investigated using recombinant adeno-associated viral vectors (rAAV) carrying a green fluore...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19990215)55:4<504::AID-JNR

    authors: Chen H,McCarty DM,Bruce AT,Suzuki K

    更新日期:1999-02-15 00:00:00

  • Hydrophobic dipeptide Leu-Ile protects against neuronal death by inducing brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor synthesis.

    abstract::We investigated whether certain hydrophobic dipeptides, Leu-Ile, Leu-Pro, and Pro-Ile, which partially resemble the site on FK506 that binds to immunophilin, could stimulate glial cell line-derived neurotrophic factor (GDNF) and brain-derived neurotrophic factor (BDNF) synthesis in cultured neurons and found only Leu-...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20258

    authors: Nitta A,Nishioka H,Fukumitsu H,Furukawa Y,Sugiura H,Shen L,Furukawa S

    更新日期:2004-10-15 00:00:00

  • Systemic and developmental exposure to lead causes spatial memory deficits and a reduction in COX-2 immunoreactivity in the hippocampus of male rats.

    abstract::Chronic lead exposure during development is known to produce learning deficits. In the present study, we investigated the effects of developmental exposure to lead on spatial memory, as shown in the Morris water maze, and on expression of inducible cyclooxygenase-2 protein in the hippocampi of male rats. Rats were sep...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21423

    authors: Soodi M,Sharifzadeh M,Naghdi N,Ostad N,Abdollahi M,Roghani A

    更新日期:2007-11-01 00:00:00

  • Pharmacological characterization of the glutamate receptor in cultured astrocytes.

    abstract::Cultured astrocytes from neonatal rat cerebral hemispheres are depolarized by the excitatory neurotransmitter glutamate. In this study we have used selective agonists of different neuronal glutamate receptor subtypes, namely, the N-methyl-D-aspartate (NMDA), kainate, and quisqualate type, to characterize pharmacologic...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490220307

    authors: Backus KH,Kettenmann H,Schachner M

    更新日期:1989-03-01 00:00:00

  • Inhibition of lipopolysaccharide-induced microglial activation by preexposure to neurotrophin-3.

    abstract::Microglia activated by neural injuries produce proinflammatory mediators, but activated microglia also appear in developing neural tissue to phagocytose cell debris resulting from programmed cell death without inducing tissue damage. Thus, factors associated with the developing CNS may modulate microglial activities. ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20586

    authors: Tzeng SF,Huang HY,Lee TI,Jwo JK

    更新日期:2005-09-01 00:00:00

  • ID2: A negative transcription factor regulating oligodendroglia differentiation.

    abstract::Remyelination of the central nervous system in multiple sclerosis patients is often incomplete. Remyelination depends on normal oligodendrogenesis and the differentiation of oligodendrocyte precursor cells (OPC) into mature oligodendrocytes (OL). Inhibitor of DNA binding (ID), a transcription factor, is thought to inh...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.22826

    authors: Chen XS,Zhang YH,Cai QY,Yao ZX

    更新日期:2012-05-01 00:00:00

  • Perisynaptic aggrecan-based extracellular matrix coats in the human lateral geniculate body devoid of perineuronal nets.

    abstract::The extracellular matrix surrounds different neuronal compartments in the mature nervous system. In a variety of vertebrates, most brain regions are loaded with a distinct type of extracellular matrix around the somatodendritic part of neurons, termed perineuronal nets. The present study reports that chondrotin sulfat...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22761

    authors: Lendvai D,Morawski M,Brückner G,Négyessy L,Baksa G,Glasz T,Patonay L,Matthews RT,Arendt T,Alpár A

    更新日期:2012-02-01 00:00:00

  • Nerve growth factor protein level increases in the adult rat hippocampus after a specific cholinergic lesion.

    abstract::Nerve growth factor (NGF) is the best-characterized neurotrophic substance and has recently been shown to influence cholinergic neurons in the basal forebrain. Hippocampus and neocortex, the primary targets for these central neurons, have further been found to contain high levels of NGF. Using enzyme immunoassay and a...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.490180404

    authors: Lärkfors L,Strömberg I,Ebendal T,Olson L

    更新日期:1987-01-01 00:00:00

  • Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil.

    abstract::Previously, we showed that in rat cortical neurons, chronic donepezil treatment (10 microM, 4 days) up-regulates nicotinic receptors (nAChR) and makes neurons more sensitive to the neuroprotective effect of donepezil. Here we examined the mechanism of donepezil-induced neuroprotection in neurons chronically treated wi...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21798

    authors: Takada-Takatori Y,Kume T,Ohgi Y,Izumi Y,Niidome T,Fujii T,Sugimoto H,Akaike A

    更新日期:2008-12-01 00:00:00

  • Evidence of neurodegeneration in obstructive sleep apnea: Relationship between obstructive sleep apnea and cognitive dysfunction in the elderly.

    abstract::The incidence of dementia and obstructive sleep apnea (OSA) increases with age. Late-onset Alzheimer's disease (AD) is an irreversible neurodegenerative disease of the elderly characterized by amyloid β (Aβ) plaques and neurofibrillary tangles. The disease involves widespread synaptic loss in the neocortex and the hip...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章,评审

    doi:10.1002/jnr.23634

    authors: Daulatzai MA

    更新日期:2015-12-01 00:00:00

  • Elevated serotonin is involved in hyperactivity but not in the paradoxical effect of amphetamine in mice neonatally lesioned with 6-hydroxydopamine.

    abstract::The neonatal lesion with 6-hydroxydopamine (6-OHDA) in rodents induces juvenile hyperactivity and paradoxical hypolocomotor response to psychostimulants, in striking contrast to what is observed when similar lesions are carried out in adults. The early disruption of central dopaminergic pathways is followed by increas...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20245

    authors: Avale ME,Nemirovsky SI,Raisman-Vozari R,Rubinstein M

    更新日期:2004-10-15 00:00:00

  • Hypoglycemia reduces the blood-oxygenation level dependent signal in primary auditory and visual cortex: a functional magnetic resonance imaging study.

    abstract::Studies of the effects of hypoglycemia on the brain using neurocognitive testing have suggested that mainly complex functions subserved by secondary and tertiary cortex are affected by mild to moderate hypoglycemia and that intensively treated patients with Type I diabetes mellitus (T1DM) may have altered sensitivity ...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.21146

    authors: Driesen NR,Goldberg PA,Anderson AW,Tang L,Flanagan DE,Sherwin RS,Gore JC

    更新日期:2007-02-15 00:00:00

  • Preferential interneuron survival in the transition zone of 3-NP-induced striatal injury in rats.

    abstract::Histology, immunohistochemistry, and Western blotting were used to characterize the changes in morphology, distribution pattern, and marker protein expression of striatal interneurons in the transition zone of striatal injury induced by 3-NP. The 3-NP treatment in rats yielded movement, motor coordination, and cogniti...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.22591

    authors: Mu S,OuYang L,Liu B,Zhu Y,Li K,Zhan M,Liu Z,Jia Y,Lei W,Reiner A

    更新日期:2011-05-01 00:00:00

  • Elucidation of the quantitative significance of pyruvate carboxylation in cultured cerebellar neurons and astrocytes.

    abstract::Pyruvate carboxylation was studied in cerebellar astrocytes and granule neurons. The cells were incubated in medium containing [U-(13)C]glucose (2.5 mM) and [U-(13)C]lactate (1 mM) and varying amounts of 3-nitropropionic acid (3-NPA) plus/minus aspartate. 3-NPA alone clearly stopped tricarboxylic acid (TCA) cycle acti...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.10061

    authors: Waagepetersen HS,Qu H,Schousboe A,Sonnewald U

    更新日期:2001-12-01 00:00:00

  • Chemokines induce migration and changes in actin polymerization in adult rat brain microglia and a human fetal microglial cell line in vitro.

    abstract::Microglia, the resident macrophages of the central nervous system, are the primary cells to respond to injury in the brain, both in inflammation, e.g., in multiple sclerosis, and trauma. Chemokines are potential mediators of microglial cell recruitment to sites of injury; thus, the ability of microglia to migrate in r...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19990101)55:1<17::AID-JNR3

    authors: Cross AK,Woodroofe MN

    更新日期:1999-01-01 00:00:00

  • Open brain gene product Rab23: expression pattern in the adult mouse brain and functional characterization.

    abstract::The gene mutated in the mouse open brain (opb) phenotype antagonizes sonic hedgehog-mediated signaling and encodes a small GTPase of the Rab family, Rab23. To date, the brain expression profile and exact mechanism of function of the Rab23 protein has remained unknown. Specific antibodies generated against Rab23 showed...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/jnr.20788

    authors: Guo A,Wang T,Ng EL,Aulia S,Chong KH,Teng FY,Wang Y,Tang BL

    更新日期:2006-05-01 00:00:00

  • Hypergravity exposure decreases gamma-aminobutyric acid immunoreactivity in axon terminals contacting pyramidal cells in the rat somatosensory cortex: a quantitative immunocytochemical image analysis.

    abstract::Quantitative evaluation of gamma-aminobutyric acid immunoreactivity (GABA-IR) in the hindlimb representation of the rat somatosensory cortex after 14 days of exposure to hypergravity (hyper-G) was conducted by using computer-assisted image processing. The area of GABA-IR axosomatic terminals apposed to pyramidal cells...

    journal_title:Journal of neuroscience research

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-4547(19980715)53:2<135::AID-JNR

    authors: D'Amelio F,Wu LC,Fox RA,Daunton NG,Corcoran ML,Polyakov I

    更新日期:1998-07-15 00:00:00