Regulation of cAMP levels by protein kinase C in C6 rat glioma cells.

abstract：:Dorsal root ganglia (DRG) neurons connect the spinal cord and uterine cervix, and are activated at parturition with subsequent stimulation of secondary neurons in the spinal dorsal horn and autonomic areas. Neuropeptide neurotransmitters and receptors have been studied in these areas, but amino acid transmitters, e.g....

journal_title：Journal of neuroscience research

authors： Ghosh C,Storey-Workley M,Usip S,Hafemeister J,Miller KE,Papka RE

更新日期：2007-05-01 00:00:00

abstract：:Traumatic brain injury (TBI) is a leading cause of death and disability among young adults and is highly prevalent among recently deployed military personnel. Survivors of TBI often experience cognitive and emotional deficits, suggesting that long-term effects of injury may disrupt neuronal function in critical brain ...

journal_title：Journal of neuroscience research

authors： Klein RC,Acheson SK,Qadri LH,Dawson AA,Rodriguiz RM,Wetsel WC,Moore SD,Laskowitz DT,Dawson HN

更新日期：2016-06-01 00:00:00

abstract：:Mitochondria are power organelles generating biochemical energy, ATP, in the cell. Mitochondria play a variety of roles, including integrating extracellular signals and executing critical intracellular events, such as neuronal cell survival and death. Increasing evidence suggests that a cross-talk mechanism between mi...

journal_title：Journal of neuroscience research

authors： Lee J,Sharma S,Kim J,Ferrante RJ,Ryu H

更新日期：2008-04-01 00:00:00

abstract：:CD200, a type I transmembrane glycoprotein, can interact with its receptor CD200R, which plays an inhibitory role in the activation of microglia-the resident macrophages of the central nervous system. In this study, the rat C6 glioma cell line (C6-1) that was previously characterized with high in vivo tumorigenicity w...

journal_title：Journal of neuroscience research

authors： Wang CY,Hsieh YT,Fang KM,Yang CS,Tzeng SF

更新日期：2016-12-01 00:00:00

abstract：:The expression of different muscarinic receptor subtypes was analyzed in immature Schwann cells obtained from sciatic nerve of 2-day neonatal rats. By using RT-PCR analysis, we demonstrated the presence of M1, M2, M3, and M4 receptor subtypes in cultured Schwann cells, with M2 displaying the highest expression levels....

journal_title：Journal of neuroscience research

authors： Loreti S,Vilaró MT,Visentin S,Rees H,Levey AI,Tata AM

更新日期：2006-07-01 00:00:00

abstract：:Four brain-specific, DNase I hypersensitive sites (HSS) have been mapped to the 5' flanking region of the mouse 68-kDa neurofilament gene. These sites are contained within a 1.7-kb sequence that confers neuronal specificity of expression of this gene in transgenic mice. To identify DNA sequences that might be involved...

journal_title：Journal of neuroscience research

authors： Ivanov TR,Brown IR

更新日期：1992-06-01 00:00:00

abstract：:Rho-GTPase has been implicated in the apoptosis of many cell types, including neurons, but the mechanism by which it acts is not fully understood. Here, we investigate the roles of Rho and ROCK in apoptosis during transplantation of embryonic stem cell-derived neural precursor cells. We find that dissociation of neura...

journal_title：Journal of neuroscience research

authors： Koyanagi M,Takahashi J,Arakawa Y,Doi D,Fukuda H,Hayashi H,Narumiya S,Hashimoto N

更新日期：2008-02-01 00:00:00

abstract：:The growth cone, the motile tip of developing neuronal processes, is considered responsible for the exact guidance of axons and synaptogenesis. High activity of tyrosine kinases in growth cones may contribute to the functions of growth cones. Our previous work revealed that vinculin is one of the endogenous substrates...

journal_title：Journal of neuroscience research

authors： Igarashi M,Komiya Y

更新日期：1991-09-01 00:00:00

abstract：:There is supporting evidence of alcohol negative effects on the brain: neuroimaging and psychophysiological studies finding anatomical and functional connectivity (FC) changes associated with the dependence process. Thus, the aim of this work was to evaluate brain FC and network characteristics of alcohol-dependent in...

journal_title：Journal of neuroscience research

authors： Sion A,Bruña Fernández R,Martínez Maldonado A,Domínguez Centeno I,Torrado-Carvajal A,Rubio G,Pereda E,Jurado-Barba R

更新日期：2020-10-01 00:00:00

abstract：:Fractionation of muscle microsomes rich in sarcoplasmic reticulum (SR) by isopicnic centrifugation yielded three types of membranes. Heavy (HM), intermediate (IM), and light membranes (LM), with isopicnic points of 38, 33, and 25% w/w sucrose, were rich in terminal cisternae/triads, longitudinal SR, and T-tubules, res...

journal_title：Journal of neuroscience research

authors： Campoy FJ,Cabezas-Herrera J,Vidal CJ

更新日期：1992-12-01 00:00:00

abstract：:The prenatal and early postnatal stages represent a critical time window for human brain development. Interestingly, this window partly overlaps with the maturation of the intestinal flora (microbiota) that play a critical role in the bidirectional communication between the central and the enteric nervous systems (mic...

journal_title：Journal of neuroscience research

authors： Eltokhi A,Janmaat IE,Genedi M,Haarman BCM,Sommer IEC

更新日期：2020-07-01 00:00:00

abstract：:Data from a study in which 12 chronic mental patients and 12 control subject were given D-[3-14C] glucose intravenously in our arterio-venous technique for determining cerebral metabolism in vivo were reexamined. Previously unpublished whole-blood lactate determinations in these experiments indicated a cerebral produc...

journal_title：Journal of neuroscience research

authors： Sacks W,Schechter DC,Sacks S

更新日期：1981-01-01 00:00:00

abstract：:SH-SY5Y cells differentiate into neuronal-like cells and express marker proteins like growth-associated protein (GAP-43) and neuropeptide tyrosine when treated with a low concentration (16 nM) of the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) in the presence of growth factors or serum. Both control and d...

journal_title：Journal of neuroscience research

authors： Parrow V,Fagerström S,Meyerson G,Nånberg E,Påhlman S

更新日期：1995-08-15 00:00:00

abstract：:Cytomegalovirus (CMV) is a major cause of congenital brain disease, and its neuropathogenesis may be related to viral infection of rapidly dividing, susceptible neural precursor cells (NPCs). In the present study, we evaluated the susceptibility of human fetal brain-derived NPCs (nestin(+), A2B5(+), CD133(+)) to infec...

journal_title：Journal of neuroscience research

authors： Cheeran MC,Hu S,Ni HT,Sheng W,Palmquist JM,Peterson PK,Lokensgard JR

更新日期：2005-12-15 00:00:00

abstract：:An inflammatory response involving activated microglia in neuritic beta-amyloid plaques is found in Alzheimer's disease (AD) brain. Because HDL lipoproteins have been shown to carry the beta-amyloid peptide (Abeta) in plasma and CSF, we have investigated the influence of plasma high-density lipoprotein (HDL) and lipid...

journal_title：Journal of neuroscience research

authors： Cole GM,Beech W,Frautschy SA,Sigel J,Glasgow C,Ard MD

更新日期：1999-08-15 00:00:00

abstract：:This essay discusses the directional movements of metazoan tissue cells generally, with special emphasis on neurons, in an attempt to show that the directional movements of all share fundamental similarities. ...

journal_title：Journal of neuroscience research

authors： Trinkaus JP

更新日期：1985-01-01 00:00:00

abstract：:Music has a long history of healing or mitigating physical and mental illness in the clinical setting. We aimed to test changes in behavioral cognition and serum proteomics in rats undergoing music intervention (MI). The Morris water maze (MWM) was used to evaluate spatial learning and memory in rats. Serum protein ex...

journal_title：Journal of neuroscience research

authors： Xiong X,Han L,Liu S,Miao J,Luo M,Xue M,Wang X,Ni L,Yang J,Huang C

更新日期：2018-10-01 00:00:00

abstract：:The twitcher mouse is well known as a naturally occurring authentic mouse model of human globoid cell leukodystrophy (GLD; Krabbe disease) due to genetic deficiency of lysosomal galactosylceramidase. The twitcher mice used most commonly are on the C57BL/6J background. We generated twitcher mice that were on the mixed ...

journal_title：Journal of neuroscience research

authors： Tominaga K,Matsuda J,Kido M,Naito E,Yokota I,Toida K,Ishimura K,Suzuki K,Kuroda Y

更新日期：2004-08-15 00:00:00

abstract：:In recent years, several novel types of disorders have been characterized, including what have been termed polyalanine diseases, in which patients have expanded triplet repeats in specific genes, resulting in the translation of aberrantly elongated polyalanine stretches. In this study, we showed that yellow fluorescen...

journal_title：Journal of neuroscience research

authors： Toriumi K,Oma Y,Kino Y,Futai E,Sasagawa N,Ishiura S

更新日期：2008-05-15 00:00:00

abstract：:Astrocytes play a diverse role in central nervous system (CNS) injury. Production of the serine protease inhibitors (serpins) plasminogen activator inhibitor-1 (PAI-1) and protease nexin-1 (PN-1) by astrocytes may counterbalance excessive serine protease activity associated with CNS pathologies such as ischemic stroke...

journal_title：Journal of neuroscience research

authors： Hultman K,Blomstrand F,Nilsson M,Wilhelmsson U,Malmgren K,Pekny M,Kousted T,Jern C,Tjärnlund-Wolf A

更新日期：2010-08-15 00:00:00

abstract：:To investigate the mechanism underlying the regulation of claudin-5, a tight junction protein that participates primarily in the constitution of the blood-brain barrier by bradykinin (BK), we established a primary culture of rat brain microvascular endothelial cells (BMECs). BMECs were treated with 10(-5) M BK, and ch...

journal_title：Journal of neuroscience research

authors： Zhou L,Yang B,Wang Y,Zhang HL,Chen RW,Wang YB

更新日期：2014-05-01 00:00:00

abstract：:The effects of the human immunodeficiency virus type 1 envelope protein gp120 on the release of GABA elicited by N-methyl-D-aspartate (NMDA) from rat hippocampal neurons in primary culture has been investigated. NMDA (1-300 microM) increased in a concentration-dependent manner (EC50 =37.9+/-12 microM) the release of [...

journal_title：Journal of neuroscience research

authors： Fontana G,Valenti L,Raiteri M

更新日期：1997-09-15 00:00:00

abstract：:The inward-rectifier K(+) channel Kir4.1 is responsible for maintaining cochlear homeostasis and restoring neural excitability. The large-conductance calcium-activated K(+) channel (BK(Ca)) plays a key role in phase locking signals in the mammalian inner ear. To evaluate the influence of mitochondrial dysfunction on t...

journal_title：Journal of neuroscience research

authors： Zou J,Zhang Y,Yin S,Wu H,Pyykkö I

更新日期：2009-01-01 00:00:00

abstract：:GM1 ganglioside has been shown to stimulate recovery of the damaged dopamine system under a number of different circumstances. In addition to rescue of damaged dopamine neurons, the present study assessed the ability of GM1 to enhance the synthesis of dopamine in remaining nigrostriatal neurons following 1-methyl-4-ph...

journal_title：Journal of neuroscience research

authors： Schneider JS,Kean A,DiStefano L

更新日期：1995-09-01 00:00:00

abstract：:Monocarboxylate transporters (MCTs) are involved in the uptake and release of lactate, pyruvate, and ketone bodies. Studies of their distribution at both the mRNA and protein levels have highlighted the specific expression of MCT1, MCT2, and more recently MCT4 in the central nervous system. MCT1 was found strongly exp...

journal_title：Journal of neuroscience research

authors： Pellerin L,Bergersen LH,Halestrap AP,Pierre K

更新日期：2005-01-01 00:00:00

abstract：:Human P0 is the main myelin glycoprotein of the peripheral nervous system. It can bind six different glycans, all linked to Asn(93) , the unique glycosylation site. Other myelin glycoproteins, also with a single glycosylation site (PMP22 at Asn(36) , MOG at Asn(31) ), bind only one glycan. The MAG has 10 glycosylation...

journal_title：Journal of neuroscience research

authors： Sedzik J,Jastrzebski JP,Grandis M

更新日期：2015-01-01 00:00:00

abstract：:Brain ageing leads to atrophy and degeneration of the cholinergic nervous system, resulting in profound neurobehavioral and cognitive dysfunction from decreased acetylcholine biosynthesis and reduced secretion of growth and neurotrophic factors. Human adipose tissue-derived mesenchymal stem cells (ADMSCs) were intrave...

journal_title：Journal of neuroscience research

authors： Park D,Yang G,Bae DK,Lee SH,Yang YH,Kyung J,Kim D,Choi EK,Choi KC,Kim SU,Kang SK,Ra JC,Kim YB

更新日期：2013-05-01 00:00:00

abstract：:Oligodendrocyte responses in vitro to platelet-derived growth factor (PDGF) include proliferation, survival, migration, and changes in cell morphology and molecular expression. Studies of mixed glial cultures established that astrocytes secrete PDGF; thus astrocytes are considered to be key regulators of oligodendrocy...

journal_title：Journal of neuroscience research

authors： Ellison JA,Scully SA,de Vellis J

更新日期：1996-07-01 00:00:00

abstract：:To determine whether acute hyperglycemia changes the hyperemic response to functional activation of brain, the area and magnitude of the activation were measured in healthy volunteers maintained at euglycemia and then at hyperglycemia using the hyperglycemic clamp technique. Activation of the visual cortex (8-16 Hz) w...

journal_title：Journal of neuroscience research

authors： Gruetter R,Uğurbil K,Seaquist ER

更新日期：2000-10-15 00:00:00

abstract：:Prothrombin and its active derivative thrombin are key members of the coagulation system. The only site of extra-hepatic thrombin expression is the central nervous system (CNS), where it is involved in brain development, protection, and regeneration. Thrombin affects various degenerative and ischemic CNS diseases like...

journal_title：Journal of neuroscience research

authors： Krenzlin H,Lorenz V,Alessandri B

更新日期：2017-10-01 00:00:00